Co-exposure to environmental lead and manganese affects the intelligence of school-aged children

NeuroToxicology

Volumn 30, Issue 4, 2009, Pages 564-571

  Kim, Yeni ^a   Kim, Bung Nyun ^a   Hong, Yun Chul ^b   Shin, Min Sup ^a   Yoo, Hee Jeong ^c   Kim, Jae Won ^a   Bhang, Soo Young ^d   Cho, Soo Churl ^a  

^a Institute of Medicine and Human Rights   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c Seoul National University Bundang Hospital   (South Korea)

^d Ulsan University College of Medicine   (South Korea)

Author keywords

Co exposure; Intelligence; Lead; Manganese; Neurodevelopment

Indexed keywords

HEAVY METAL; LEAD; MANGANESE;

ARTICLE; BLOOD EXAMINATION; BLOOD LEVEL; CHILD; COGNITIVE DEFECT; ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; INTELLECTUAL IMPAIRMENT; INTELLIGENCE; INTELLIGENCE QUOTIENT; KOREA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; QUESTIONNAIRE; SCHOOL CHILD;

CHILD; CROSS-SECTIONAL STUDIES; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; INTELLIGENCE; INTELLIGENCE TESTS; LEAD; LEAD POISONING; MALE; MANGANESE; MANGANESE POISONING; NEUROPSYCHOLOGICAL TESTS;

EID: 67651005621     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2009.03.012     Document Type: Article

References (59)

1. Alexander L.M., Heaven A., Delves H.T., Moreton J., and Trenouth M.J. Relative exposure of children to lead from dust and drinking water. Arch Environ Health 48 (1993) 392-400
2. Bellinger D.C. Lead neurotoxicity and socioeconomic status: conceptual and analytical issues. Neurotoxicology 29 (2008) 828-832
3. Bellinger D.C. Neurological and behavioral consequences of childhood lead exposure. PLoS Med 5 (2008) e115
4. Bellinger D.C. Very low lead exposures and children's neurodevelopment. Curr Opin Pediatr 20 (2008) 172-177
5. Bouchard M., Laforest F., Vandelac L., Bellinger D., and Mergler D. Hair manganese and hyperactive behaviors: pilot study of school-age children exposed through tap water. Environ Health Perspect 115 (2007) 122-127
6. Bowers T.S., and Beck B.D. What is the meaning of non-linear dose-response relationships between blood lead concentrations and IQ?. Neurotoxicology 27 (2006) 520-524
7. Bowler R.M., Mergler D., Sassine M.P., Larribe F., and Hudnell K. Neuropsychiatric effects of manganese on mood. Neurotoxicology 20 (1999) 367-378
8. Bressler J., Kim K.A., Chakraborti T., and Goldstein G. Molecular mechanisms of lead neurotoxicity. Neurochem Res 24 (1999) 595-600
9. Canfield R.L., Henderson Jr. C.R., Cory-Slechta D.A., Cox C., Jusko T.A., and Lanphear B.P. Intellectual impairment in children with blood lead concentrations below 10 μg per deciliter. N Engl J Med 348 (2003) 1517-1526
10. Canzoniero L.M., Sensi S.L., and Choi D.W. Measurement of intracellular free zinc in living neurons. Neurobiol Dis 4 (1997) 275-279
11. CDC. Preventing lead poisoning in young children (1991), US Department of Health and Human Services, Atlanta, GA
12. Chandra A.V., Ali M.M., Saxena D.K., and Murthy R.C. Behavioral and neurochemical changes in rats simultaneously exposed to manganese and lead. Arch Toxicol 49 (1981) 49-56
13. Chandra S.V., Murthy R.C., Saxena D.K., and Lal B. Effects of pre- and postnatal combined exposure to Pb and Mn on brain development in rats. Ind Health 21 (1983) 273-279
14. Chen A., Cai B., Dietrich K.N., Radcliffe J., and Rogan W.J. Lead exposure, IQ, and behavior in urban 5- to 7-year-olds: does lead affect behavior only by lowering IQ?. Pediatrics 119 (2007) e650-e658
15. Chiodo L.M., Jacobson S.W., and Jacobson J.L. Neurodevelopmental effects of postnatal lead exposure at very low levels. Neurotoxicol Teratol 26 (2004) 359-371
16. Cory-Slechta D.A., Weiss B., and Cranmer J. The environmental etiologies of neurobehavioral deficits and disorders: weaving complex outcomes and risk modifiers into the equation. Neurotoxicology 29 (2008) 759-760
17. Cromwell P.F., Abadie B.R., Stephens J.T., and Kyler M. Hair mineral analysis: biochemical imbalances and violent criminal behavior. Psychol Rep 64 (1989) 259-266
18. Devoto P., Flore G., Ibba A., Fratta W., and Pani L. Lead intoxication during intrauterine life and lactation but not during adulthood reduces nucleus accumbens dopamine release as studied by brain microdialysis. Toxicol Lett 121 (2001) 199-206
19. Ericson J.E., Crinella F.M., Clarke-Stewart K.A., Allhusen V.D., Chan T., and Robertson R.T. Prenatal manganese levels linked to childhood behavioral disinhibition. Neurotoxicol Teratol 29 (2007) 181-187
20. Eriksson H., Gillberg P.G., Aquilonius S.M., Hedstrom K.G., and Heilbronn E. Receptor alterations in manganese intoxicated monkeys. Arch Toxicol 66 (1992) 359-364
21. Fell J.M., Reynolds A.P., Meadows N., Khan K., Long S.G., Quaghebeur G., et al. Manganese toxicity in children receiving long-term parenteral nutrition. Lancet 347 (1996) 1218-1221
22. Finkelstein Y., Milatovic D., and Aschner M. Modulation of cholinergic systems by manganese. Neurotoxicology 28 (2007) 1003-1014
23. Fulton M., Raab G., Thomson G., Laxen D., Hunter R., and Hepburn W. Influence of blood lead on the ability and attainment of children in Edinburgh. Lancet 1 (1987) 1221-1226
24. Goldstein G.W. Evidence that lead acts as a calcium substitute in second messenger metabolism. Neurotoxicology 14 (1993) 97-101
25. He P., Liu D.H., and Zhang G.Q. Effects of high-level-manganese sewage irrigation on children's neurobehavior. Zhonghua Yu Fang Yi Xue Za Zhi 28 (1994) 216-218
26. Hu H., Tellez-Rojo M.M., Bellinger D., Smith D., Ettinger A.S., Lamadrid-Figueroa H., et al. Fetal lead exposure at each stage of pregnancy as a predictor of infant mental development. Environ Health Perspect 114 (2006) 1730-1735
27. Jusko T.A., Henderson C.R., Lanphear B.P., Cory-Slechta D.A., Parsons P.J., and Canfield R.L. Blood lead concentrations <10 μg/dL and child intelligence at 6 years of age. Environ Health Perspect 116 (2008) 243-248
28. Kaufman A.S. A four test short form of the WISC-R. Comtemp Educ Psychol 1 (1976) 180-196
29. Kordas K., Canfield R.L., Lopez P., Rosado J.L., Vargas G.G., Cebrian M.E., et al. Deficits in cognitive function and achievement in Mexican first-graders with low blood lead concentrations. Environ Res 100 (2006) 371-386
30. Landrigan P.J. Pediatric lead poisoning: is there a threshold?. Public Health Rep 115 (2000) 530-531
31. Lanphear B.P., Hornung R., Khoury J., Yolton K., Baghurst P., Bellinger D.C., et al. Low-level environmental lead exposure and children's intellectual function: an international pooled analysis. Environ Health Perspect 113 (2005) 894-899
32. Lanphear B.P., and Roghmann K.J. Pathways of lead exposure in urban children. Environ Res 74 (1997) 67-73
33. Lidsky T.I., and Schneider J.S. Lead neurotoxicity in children: basic mechanisms and clinical correlates. Brain 126 (2003) 5-19
34. Lockman P.R., Roder K.E., and Allen D.D. Inhibition of the rat blood-brain barrier choline transporter by manganese chloride. J Neurochem 79 (2001) 588-594
35. Long G.J., Rosen J.F., and Schanne F.A. Lead activation of protein kinase C from rat brain. Determination of free calcium, lead, and zinc by 19F NMR. J Biol Chem 269 (1994) 834-837
36. Malhotra K.M., Murthy R.C., Srivastava R.S., and Chandra S.V. Concurrent exposure of lead and manganese to iron-deficient rats: effect on lipid peroxidation and contents of some metals in the brain. J Appl Toxicol 4 (1984) 22-25
37. Mergler D. Neurotoxic effects of low level exposure to manganese in human populations. Environ Res 80 (1999) 99-102
38. Mergler D., Baldwin M., Belanger S., Larribe F., Beuter A., Bowler R., et al. Manganese neurotoxicity, a continuum of dysfunction: results from a community based study. Neurotoxicology 20 (1999) 327-342
39. Miller G.D., Massaro T.F., and Massaro E.J. Interactions between lead and essential elements: a review. Neurotoxicology 11 (1990) 99-119
40. MMWR. Blood lead levels in residents of homes with elevated lead in tap water-District of Columbia. Morbidity and Mortality Weekly Report 2004;53:1-3.
41. Monnet-Tschudi F., Zurich M.G., Boschat C., Corbaz A., and Honegger P. Involvement of environmental mercury and lead in the etiology of neurodegenerative diseases. Rev Environ Health 21 (2006) 105-117
42. Naess O., Piro F.N., Nafstad P., Smith G.D., and Leyland A.H. Air pollution, social deprivation, and mortality: a multilevel cohort study. Epidemiology 18 (2007) 686-694
43. Needleman H.L. Childhood lead poisoning: a disease for the history texts. Am J Public Health 81 (1991) 685-687
44. Park K.S., Yoon J.Y., Park H.J., Park H.J., and Kwon K.U. Development of KEDI-WISC, individual intelligence test for Korean children (1996), Korean Educational Development Institute, Seoul
45. Pocock S.J., Smith M., and Baghurst P. Environmental lead and children's intelligence: a systematic review of the epidemiological evidence. BMJ 309 (1994) 1189-1197
46. Ranke M.B., Vollmer B., Traunecker R., Wollmann H.A., Goelz R.R., Seibold-Weiger K., et al. Growth and development are similar in VLBW children born appropriate and small for gestational age: an interim report on 97 preschool children. J Pediatr Endocrinol Metab 20 (2007) 1017-1026
47. Schnaas L., Rothenberg S.J., Flores M.F., Martinez S., Hernandez C., Osorio E., et al. Reduced intellectual development in children with prenatal lead exposure. Environ Health Perspect 114 (2006) 791-797
48. Schwartz J. Low-level lead exposure and children's IQ: a meta-analysis and search for a threshold. Environ Res 65 (1994) 42-55
49. 2+. Eur J Biochem 234 (1995) 178-183
50. Spranger M., Schwab S., Desiderato S., Bonmann E., Krieger D., and Fandrey J. Manganese augments nitric oxide synthesis in murine astrocytes: a new pathogenetic mechanism in manganism?. Exp Neurol 149 (1998) 277-283
51. Surkan P.J., Zhang A., Trachtenberg F., Daniel D.B., McKinlay S., and Bellinger D.C. Neuropsychological function in children with blood lead levels <10 μg/dL. Neurotoxicology 28 (2007) 1170-1177
52. Takser L., Mergler D., Hellier G., Sahuquillo J., and Huel G. Manganese, monoamine metabolite levels at birth, and child psychomotor development. Neurotoxicology 24 (2003) 667-674
53. Tellez-Rojo M.M., Bellinger D.C., Arroyo-Quiroz C., Lamadrid-Figueroa H., Mercado-Garcia A., Schnaas-Arrieta L., et al. Longitudinal associations between blood lead concentrations lower than 10 μg/dL and neurobehavioral development in environmentally exposed children in Mexico City. Pediatrics 118 (2006) e323-e330
54. Tong I.S., and Lu Y. Identification of confounders in the assessment of the relationship between lead exposure and child development. Ann Epidemiol 11 (2001) 38-45
55. Verity M.A. Manganese neurotoxicity: a mechanistic hypothesis. Neurotoxicology 20 (1999) 489-497
56. Wasserman G.A., Liu X., Parvez F., Ahsan H., Levy D., Factor-Litvak P., et al. Water manganese exposure and children's intellectual function in Araihazar, Bangladesh. Environ Health Perspect 114 (2006) 124-129
57. Weiss B., and Bellinger D.C. Social ecology of children's vulnerability to environmental pollutants. Environ Health Perspect 114 (2006) 1479-1485
58. Wright R.O., Amarasiriwardena C., Woolf A.D., Jim R., and Bellinger D.C. Neuropsychological correlates of hair arsenic, manganese, and cadmium levels in school-age children residing near a hazardous waste site. Neurotoxicology 27 (2006) 210-216
59. Zheng W., Ren S., and Graziano J.H. Manganese inhibits mitochondrial aconitase: a mechanism of manganese neurotoxicity. Brain Res 799 (1998) 334-342