Electrospray Ionization Quadrupole Ion-Mobility Time-of-Flight Mass Spectrometry as a Tool to Distinguish the Lot-to-Lot Heterogeneity in N-Glycosylation Profile of the Therapeutic Monoclonal Antibody Trastuzumab

Journal of the American Society for Mass Spectrometry

Volumn 20, Issue 11, 2009, Pages 2021-2033

  Damen, Carola W N ^a   Chen, Weibin ^b   Chakraborty, Asish B ^b   van Oosterhout, Mike ^c   Mazzeo, Jeffrey R ^b   Gebler, John C ^b   Schellens, Jan H M ^a,d   Rosing, Hilde ^a   Beijnen, Jos H ^a,d  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b WATERS CORPORATION   (United States)

^c Waters Chromatography BV   (Netherlands)

^d Beta Faculty   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE RESIDUE; COLLISION CELLS; ELECTROSPRAYS; FAST-LC; GLYCAN STRUCTURES; GLYCOFORMS; GLYCOPEPTIDES; GLYCOSYLATED; MASS SPECTRA; N-GLYCOSYLATION; PRODUCTION BATCHES; QUADRUPOLES; RAPID ANALYSIS; RELATIVE ABUNDANCE; SEPARATION FUNCTIONS; THERAPEUTIC MONOCLONAL ANTIBODIES; TIME OF FLIGHT MASS SPECTROMETRY; TRASTUZUMAB;

ALLERGIES; CELL MEMBRANES; ELECTROSPRAY IONIZATION; GLYCOSYLATION; IONS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; MERGERS AND ACQUISITIONS; MONOCLONAL ANTIBODIES; SURFACE PLASMON RESONANCE;

ESTERIFICATION;

GLYCAN; GLYCOPEPTIDE; ISOPROTEIN; TRASTUZUMAB;

ARTICLE; COLLISIONALLY ACTIVATED DISSOCIATION; COMPARATIVE STUDY; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; FRAGMENTATION REACTION; GLYCOSYLATION; ION MOBILITY SPECTROMETRY; LIQUID CHROMATOGRAPHY; PROTEIN STRUCTURE; SEPARATION TECHNIQUE; TIME OF FLIGHT MASS SPECTROMETRY;

ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, LIQUID; GLYCOSYLATION; MASS SPECTROMETRY; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TIME FACTORS;

EID: 70349762761     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jasms.2009.07.017     Document Type: Article

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