Automatic disulfide bond assignment using a1 ion screening by mass spectrometry for structural characterization of protein pharmaceuticals

Analytical Chemistry

Volumn 84, Issue 11, 2012, Pages 4900-4906

  Huang, Sheng Yu ^a   Hsieh, Yu Ting ^b   Chen, Chun Hao ^b   Chen, Chao Chi ^a   Sung, Wang Chou ^c   Chou, Min Yuan ^d   Chen, Sung Fang ^b  

^a Mithra Biotechnology Inc   (Taiwan)

^b NATIONAL TAIWAN NORMAL UNIVERSITY   (Taiwan)

^c NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^d INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOMATIC METHOD; COLLISION-INDUCED DISSOCIATION; CONFIDENCE LEVELS; CUSTOMIZED SOFTWARE; DISULFIDE BONDS; DISULFIDE LINKAGES; FRAGMENT IONS; MANUFACTURING PROCESS; N-TERMINALS; PEPTIDE PAIRS; PRIOR KNOWLEDGE; PROTEIN PHARMACEUTICALS; PROTEIN SEPARATIONS; RECOMBINANT MONOCLONAL ANTIBODY; STRUCTURAL CHARACTERIZATION; THERAPEUTIC PROTEIN;

AMINO ACIDS; CHARACTERIZATION; COVALENT BONDS; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; PEPTIDES; RADAR; RECOMBINANT PROTEINS; SULFUR COMPOUNDS;

IONS;

DISULFIDE; ION; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CHEMISTRY; COMPUTER PROGRAM; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; MOLECULAR GENETICS; STAINING; TANDEM MASS SPECTROMETRY;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; CHEMISTRY, PHARMACEUTICAL; DISULFIDES; HUMANS; IONS; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; SOFTWARE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STAINING AND LABELING; TANDEM MASS SPECTROMETRY;

EID: 84861862180     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac3005007     Document Type: Article

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