Non-Random mtDNA Segregation Patterns Indicate a Metastable Heteroplasmic Segregation Unit in m.3243A>G Cybrid Cells

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Raap, Anton K ^a   Jahangir Tafrechi, Roshan S ^a   van de Rijke, Frans M ^a   Pyle, Angela ^b   Wählby, Carolina ^c,d   Szuhai, Karoly ^a   Ravelli, Raimond B G ^a   de Coo, René F M ^e   Rajasimha, Harsha K ^f   Nilsson, Mats ^d   Chinnery, Patrick F ^b   Samuels, David C ^f   Janssen, George M C ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d UPPSALA UNIVERSITY   (Sweden)

^e ERASMUS MEDICAL CENTER   (Netherlands)

^f VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; GUANINE; MITOCHONDRIAL DNA;

ARTICLE; CELL TYPE; CONTROLLED STUDY; CYBRID; CYBRID CELL; GENE REPLICATION; GENE SEGREGATION; GENETIC DRIFT; HETEROPLASMY; MITOSIS; PARSIMONY ANALYSIS; PHENOTYPE; POINT MUTATION;

DNA, MITOCHONDRIAL; EVOLUTION, MOLECULAR; GENETIC HETEROGENEITY; GENOMIC INSTABILITY; HUMANS; MITOCHONDRIAL DISEASES; MITOSIS; MUTATION; POINT MUTATION;

EID: 84871260095     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052080     Document Type: Article

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