Separate fusion of outer and inner mitochondrial membranes

EMBO Reports

Volumn 6, Issue 9, 2005, Pages 853-859

  Malka, Florence ^a   Guillery, Olwenn ^a   Cifuentes Diaz, Carmen ^a   Guillou, Emmanuelle ^b   Belenguer, Pascale ^b   Lombés, Anne ^a   Rojo, Manuel ^a  

^a INSERM   (France)

^b Université de Toulouse Paul Sabatier   (France)

Author keywords

Drp1; Membrane fusion; Membrane potential; Mitochondrial fission; Mitochondrial fusion

Indexed keywords

IONOPHORE; POTASSIUM ION; PROTON;

ARTICLE; BIOASSAY; CELL FUNCTION; CELL STRUCTURE; CONTROLLED STUDY; GLYCOLYSIS; HUMAN; HUMAN CELL; MEMBRANE FUSION; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; STRUCTURE ANALYSIS;

ADENOSINE TRIPHOSPHATE; ANTIMYCIN A; CARBONYL CYANIDE M-CHLOROPHENYL HYDRAZONE; CELL LINE; DEOXYGLUCOSE; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; LUMINESCENT PROTEINS; MEMBRANE FUSION; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; NERVE TISSUE PROTEINS; OLIGOMYCINS; PHOSPHORYLATION; VALINOMYCIN;

EID: 30944446045     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/sj.embor.7400488     Document Type: Article

References (16)

1. Bernardi P (1999) Mitochondrial transport of cations: Channels, exchangers, and permeability transition. Physiol Rev 79: 1127-1155
2. Chen H, Detmer SA, Ewald AJ, Griffin EE, Fraser SE, Chan DC (2003) Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J Cell Biol 160: 189-200
3. Cipolat S, de Brito OM, Dal Zilio B, Scorrano L (2004) OPA1 requires mitofusin 1 to promote mitochondrial fusion. Proc Natl Acad Sci USA 101: 15927-15932
4. Frey TG, Mannella CA (2000) The internal structure of mitochondria. Trends Biochem Sci 25: 319-324
5. Fritz S, Rapaport D, Klanner E, Neupert W, Westermann B (2001) Connection of the mitochondrial outer and inner membranes by Fzo1 is critical for organellar fusion. J Cell Biol 152: 683-692
6. Griparic L, Van Der Wel NN, Orozco IJ, Peters PJ, Van Der Bliek AM (2004) Loss of the intermembrane space protein Mgm1/Opa1 induces swelling and localized constrictions along the lengths of mitochondria. J Biol Chem 279: 18792-18798
7. Hackenbrock CR, Rehn TG, Weinbach EC, Lemasters JJ (1971) Oxidative phosphorylation and ultrastructural transformation in mitochondria in the intact ascites tumor cell. J Cell Biol 51: 123-137
8. Legros F, Lombes A, Frachon P, Rojo M (2002) Mitochondrial fusion in human cells is efficient, requires the inner membrane potential and is mediated by mitofusins. Mol Biol Cell 13: 4343-4354
9. Legros F, Malka F, Frachon P, Lombès A, Rojo M (2004) Organization and dynamics of human mitochondrial DNA. J Cell Sci 117: 2653-2662
10. Meeusen S, McCaffery JM, Nunnari J (2004) Mitochondrial fusion intermediates revealed in vitro. Science 305: 1747-1752
11. Okamoto K, Perlman PS, Butow RA (1998) The sorting of mitochondrial DNA and mitochondrial proteins in zygotes: Preferential transmission of mitochondrial DNA to the medial bud. J Cell Biol 142: 613-623
12. Olichon A, Baricault L, Gas N, Guillou E, Valette A, Belenguer P, Lenaers G (2003) Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. J Biol Chem 278: 7743-7746
13. Rojo M, Legros F, Chateau D, Lombes A (2002) Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo. J Cell Sci 115: 1663-1674
14. Sesaki H, Jensen RE (2004) Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusion. J Biol Chem 279: 28298-28303
15. Waterhouse NJ, Ricci JE, Green DR (2002) And all of a sudden it's over: mitochondrial outer-membrane permeabilization in apoptosis. Biochimie 84: 113-121
16. Wong ED, Wagner JA, Scott SV, Okreglak V, Holewinske TJ, Cassidy-Stone A, Nunnari J (2003) The intramitochondrial dynamin-related GTPase, Mgm1p, is a component of a protein complex that mediates mitochondrial fusion. J Cell Biol 160: 303-311