A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes

Nature Genetics

Volumn 40, Issue 2, 2008, Pages 249-254

  Cree, Lynsey M ^a   Samuels, David C ^b   De Sousa Lopes, Susana Chuva ^c   Rajasimha, Harsha Karur ^b   Wonnapinij, Passorn ^b   Mann, Jeffrey R ^d,e   Dahl, Hans Henrik M ^e   Chinnery, Patrick F ^a,f  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b VIRGINIA BIOINFORMATICS INSTITUTE   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d Division of Biology   (United States)

^e UNIVERSITY OF MELBOURNE   (Australia)

^f NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA REPLICATION; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; GENE SEGREGATION; GENOTYPE; GERM CELL; HETEROPLASMY; MALE; MOLECULE; MOUSE; NIDATION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROGENY;

ALLELES; ANIMALS; BLASTOCYST; BLASTOMERES; CELL LINEAGE; COMPUTER SIMULATION; CROSSES, GENETIC; DNA REPLICATION; DNA, MITOCHONDRIAL; EMBRYO TRANSFER; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; FEMALE; GENE DOSAGE; GENE FREQUENCY; GENETIC MARKERS; GENOTYPE; GREEN FLUORESCENT PROTEINS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, INBRED STRAINS; MICE, TRANSGENIC; MICROINJECTIONS; MITOCHONDRIA; MODELS, GENETIC; OOCYTES; POLYMORPHISM, GENETIC; PREGNANCY; REPRESSOR PROTEINS;

MAMMALIA; MUS;

EID: 38649091334     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.2007.63     Document Type: Article

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