-
1
-
-
33845558788
-
Bisbenzylisoquinoline alkaloids - a review
-
Guha, K.P.; Mucherjee, B.; Mucherjee, R. Bisbenzylisoquinoline alkaloids - a review. J. Nat. Prod., 1979, 42, 1-84.
-
(1979)
J. Nat. Prod
, vol.42
, pp. 1-84
-
-
Guha, K.P.1
Mucherjee, B.2
Mucherjee, R.3
-
2
-
-
84871122161
-
New antagonists of acetylcholine [in russian]
-
Kharkevich, D.A.; Skoldinov, A.P. New antagonists of acetylcholine [in russian], Mendeleev Commun., 1970, 145-155.
-
(1970)
Mendeleev Commun
, pp. 145-155
-
-
Kharkevich, D.A.1
Skoldinov, A.P.2
-
3
-
-
44449139969
-
Characterization of the epithelial permeation enhancing effect of basic butylated methacrylate copolymer - in vitro studies
-
Grube, S.; Wolfrum, U.; Langguth, P. Characterization of the epithelial permeation enhancing effect of basic butylated methacrylate copolymer - in vitro studies. Biomacromolecules., 2008, 9, 1398-1405.
-
(2008)
Biomacromolecules
, vol.9
, pp. 1398-1405
-
-
Grube, S.1
Wolfrum, U.2
Langguth, P.3
-
4
-
-
50249177032
-
Discovery of Novel and Long Acting Muscarinic Acetylcholine Receptor Antagonists
-
Jin, J.; Wang, Y.; Shi, D.; Wang, F.; Davis, R.S.; Jin, Q.; Fu, W.; Foley, J.J.; Webb, E.F.; Dehaas, C.J.; Berlanga, M.; Burman, M.; Sarau, H.M.; Morrow, D.M.; Rao, P.; Kallal, L.A.; Moore, M.L.; Rivero, R.A.; Palovich, M.; Salmon, M.; Belmonte, K.E.; Busch- Petersen, J. Discovery of Novel and Long Acting Muscarinic Acetylcholine Receptor Antagonists. J. Med. Chem., 2008, 51, 4866-4869.
-
(2008)
J. Med. Chem
, vol.51
, pp. 4866-4869
-
-
Jin, J.1
Wang, Y.2
Shi, D.3
Wang, F.4
Davis, R.S.5
Jin, Q.6
Fu, W.7
Foley, J.J.8
Webb, E.F.9
Dehaas, C.J.10
Berlanga, M.11
Burman, M.12
Sarau, H.M.13
Morrow, D.M.14
Rao, P.15
Kallal, L.A.16
Moore, M.L.17
Rivero, R.A.18
Palovich, M.19
Salmon, M.20
Belmonte, K.E.21
Busch-Petersen, J.22
more..
-
5
-
-
33947471582
-
Quaternary Ammonium Compounds. IV. Antiacetylcholinesterase Activity and Ring Size in Aromatic Quaternary Ammonium Compounds
-
Thomas, J. Quaternary Ammonium Compounds. IV. Antiacetylcholinesterase Activity and Ring Size in Aromatic Quaternary Ammonium Compounds J. Med. Chem., 1963, 6 (4), 456-457.
-
(1963)
J. Med. Chem
, vol.6
, Issue.4
, pp. 456-457
-
-
Thomas, J.1
-
7
-
-
33947489181
-
The Alkaloids of Hunteria eburnea Pichon. 11. The Quaternary Bases
-
Bartlett, M.F.; Korzun, B.; Sklar, R.; Smith, A.F.; Taylor, V.I. The Alkaloids of Hunteria eburnea Pichon. 11. The Quaternary Bases. J. Org. Chem., 1963, 28, 1445-1449.
-
(1963)
J. Org. Chem
, vol.28
, pp. 1445-1449
-
-
Bartlett, M.F.1
Korzun, B.2
Sklar, R.3
Smith, A.F.4
Taylor, V.I.5
-
8
-
-
0034613368
-
Eight-Membered-Ring Solid-State Conformational Interconversion via the Atom-Flip Mechanism, a CPMAS 13C NMR and Crystallographic Stereochemical Study
-
Glaser, R.; Novoselsky, A.; Shiftan, D. Eight-Membered-Ring Solid-State Conformational Interconversion via the Atom-Flip Mechanism, a CPMAS 13C NMR and Crystallographic Stereochemical Study. J. Org. Chem., 2000, 65, 6345-6353.
-
(2000)
J. Org. Chem
, vol.65
, pp. 6345-6353
-
-
Glaser, R.1
Novoselsky, A.2
Shiftan, D.3
-
9
-
-
33947462240
-
Antispasmodics. VIII. Derivatives
-
Moffett, R.B.; Aspergren, B.D. Antispasmodics. VIII. Derivatives. J. Am. Chem. Soc., 1956, 78, 3448-3453.
-
(1956)
J. Am. Chem. Soc
, vol.78
, pp. 3448-3453
-
-
Moffett, R.B.1
Aspergren, B.D.2
-
10
-
-
0021082671
-
Studies on Native Medicinal Plants. I. The Quaternary Alkaloids of Thalictrum javanicum
-
Bahadur, S.; Shukla, A. K. Studies on Native Medicinal Plants. I. The Quaternary Alkaloids of Thalictrum javanicum. J. Nat. Prod., 1983, 46, 454-457
-
(1983)
J. Nat. Prod
, vol.46
, pp. 454-457
-
-
Bahadur, S.1
Shukla, A.K.2
-
11
-
-
33947453596
-
Synthesis Curare Substitutes from aliphatic dicarboxylic acid aninoethyl esters
-
Phillips, A.P. Synthesis Curare Substitutes from aliphatic dicarboxylic acid aninoethyl esters. J. Am. Chem. Soc., 1949, 71, 3264.
-
(1949)
J. Am. Chem. Soc
, vol.71
, pp. 3264
-
-
Phillips, A.P.1
-
13
-
-
0015077188
-
Quaternary Ammonium Salts of Tertiary Aminoalkyl Amides
-
Mod, R.R.; Magne, F.C.; Skau, E.I.; Sumrell, G. Quaternary Ammonium Salts of Tertiary Aminoalkyl Amides. J. Med. Chem., 1971, 14, 558-560.
-
(1971)
J. Med. Chem
, vol.14
, pp. 558-560
-
-
Mod, R.R.1
Magne, F.C.2
Skau, E.I.3
Sumrell, G.4
-
14
-
-
33645486703
-
Curariform Activity and Chemical Structure. III. Syntheses in the 3-Indolylmethylamine Series
-
Craig, L.E.; Tarbell, D.S. Curariform Activity and Chemical Structure. III. Syntheses in the 3-Indolylmethylamine Series. J. Am. Chem. Soc., 1949, 71, 462-465.
-
(1949)
J. Am. Chem. Soc
, vol.71
, pp. 462-465
-
-
Craig, L.E.1
Tarbell, D.S.2
-
15
-
-
33645495208
-
Curariform Activity and Chemical Structure. IV. Syntheses in the Piperidine Series
-
Craig, L.E.; Tarbell, D.S. Curariform Activity and Chemical Structure. IV. Syntheses in the Piperidine Series. J. Am. Chem. Soc., 1949, 71, 465-467.
-
(1949)
J. Am. Chem. Soc
, vol.71
, pp. 465-467
-
-
Craig, L.E.1
Tarbell, D.S.2
-
16
-
-
13844250420
-
Curariform Activity and Chemical Structure. II. Syntheses in the Benzyltetrahydroisoquinoline Series
-
Craig, L.E.; Tarbell, D.S. Curariform Activity and Chemical Structure. II. Syntheses in the Benzyltetrahydroisoquinoline Series. J. Am. Chem. Soc., 1948 70, 2783-2785.
-
(1948)
J. Am. Chem. Soc
, vol.70
, pp. 2783-2785
-
-
Craig, L.E.1
Tarbell, D.S.2
-
17
-
-
0000423559
-
Curariform Activity and Chemical Structure. VI. Syntheses in the β- and λ-Carboline Series
-
Boekelheide, V.; Ainsworth, C. Curariform Activity and Chemical Structure. VI. Syntheses in the β- and λ-Carboline Series. J. Am. Chem. Soc., 1950 72, 2132-2134.
-
(1950)
J. Am. Chem. Soc
, vol.2
, pp. 132-2134
-
-
Boekelheide, V.1
Ainsworth, C.2
-
18
-
-
33645495489
-
Curariform Activity and Chemical Structure. VII. Some 1-Skatylisoqunoline Derivatives and a Novel Method for their Synthesis
-
Boekelheide, V.; Ainsworth, C. Curariform Activity and Chemical Structure. VII. Some 1-Skatylisoqunoline Derivatives and a Novel Method for their Synthesis. J. Am. Chem. Soc., 1950 72, 2134-2137.
-
(1950)
J. Am. Chem. Soc
, vol.72
, pp. 2134-2137
-
-
Boekelheide, V.1
Ainsworth, C.2
-
19
-
-
0010661789
-
Curariform Activity and Chemical Structure. V. Syntheses in the Quinolizidine Series
-
Boekelheide, V.; Rothchild, S. Curariform Activity and Chemical Structure. V. Syntheses in the Quinolizidine Series. J. Am. Chem. Soc., 1949 71, 879-886.
-
(1949)
J. Am. Chem. Soc
, vol.71
, pp. 879-886
-
-
Boekelheide, V.1
Rothchild, S.2
-
20
-
-
0343573261
-
Curariform Activity and Chemical Structure
-
Craig, L.E. Curariform Activity and Chemical Structure. Chem. Rev., 1948, 42, 285-410.
-
(1948)
Chem. Rev
, vol.42
, pp. 285-410
-
-
Craig, L.E.1
-
21
-
-
0035846072
-
Hypoxia-Selective Antitumor Agents. 16. Nitroarylmethyl Quaternary Salts as Bioreductive Prodrugs of the Alkylating Agent Mechlorethamine
-
Tercel, M.; Lee, A.E.; Hogg, A.; Anderson, R. F.; Lee, H.H.; Siim, B. G.; Denny, W. A.; Wilson, W. R. Hypoxia-Selective Antitumor Agents. 16. Nitroarylmethyl Quaternary Salts as Bioreductive Prodrugs of the Alkylating Agent Mechlorethamine J. Med. Chem., 2001, 44 (21), 3511-3522.
-
(2001)
J. Med. Chem
, vol.44
, Issue.21
, pp. 3511-3522
-
-
Tercel, M.1
Lee, A.E.2
Hogg, A.3
Anderson, R.F.4
Lee, H.H.5
Siim, B.G.6
Denny, W.A.7
Wilson, W.R.8
-
22
-
-
27844466279
-
Antitumor Polycyclic Acridines. 17. Synthesis and Pharmaceutical Profiles of Pentacyclic Acridinium Salts Designed To Destabilize Telomeric Integrity
-
Cookson, J. C.; Heald, R. A.; Stevens, M. F. G. Antitumor Polycyclic Acridines. 17. Synthesis and Pharmaceutical Profiles of Pentacyclic Acridinium Salts Designed To Destabilize Telomeric Integrity. J. Med. Chem., 2005, 48, 7198-7207.
-
(2005)
J. Med. Chem
, vol.48
, pp. 7198-7207
-
-
Cookson, J.C.1
Heald, R.A.2
Stevens, M.F.G.3
-
23
-
-
0037046575
-
Synthesis and in vitro Evaluation of Quaternary Ammonium Derivatives of Chlorambucil and Melphalan, Anticancer Drugs Designed for the Chemotherapy of Chondrosarcoma
-
Giraud, I.; Rapp, M.; Maurizis, J.-C.; Madelmont, J.-C. Synthesis and in vitro Evaluation of Quaternary Ammonium Derivatives of Chlorambucil and Melphalan, Anticancer Drugs Designed for the Chemotherapy of Chondrosarcoma. J. Med. Chem., 2002, 45 (10), 2116-2119.
-
(2002)
J. Med. Chem
, vol.45
, Issue.10
, pp. 2116-2119
-
-
Giraud, I.1
Rapp, M.2
Maurizis, J.-C.3
Madelmont, J.-C.4
-
24
-
-
0037413550
-
Synthesis and Structure-Activity Relationships of 6,7-Disubstituted 4- Anilinoquinoline-3-carbonitriles. The Design of an Orally Active, Irreversible Inhibitor of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor (EGFR) and the Human Epidermal Growth Factor Receptor-2 (HER-2)
-
Wissner, A.; Overbeek, E.; Reich, M. F.; Floyd, M. B.; Johnson, B. D.; Mamuya, N.; Rosfjord, E. C.; Discafani, C.; Davis, R.; Shi, X.; Rabindran, S. K.; Gruber, B. C.; Ye, F.; Hallett, W. A.; Nilakantan, R.; Shen, R.; Wang, Y.-F.; Greenberger, L.M; Tsou, H.-R. Synthesis and Structure-Activity Relationships of 6,7-Disubstituted 4- Anilinoquinoline-3-carbonitriles. The Design of an Orally Active, Irreversible Inhibitor of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor (EGFR) and the Human Epidermal Growth Factor Receptor-2 (HER-2). J. Med. Chem., 2003, 46 (1), 49-63.
-
(2003)
J. Med. Chem
, vol.46
, Issue.1
, pp. 49-63
-
-
Wissner, A.1
Overbeek, E.2
Reich, M.F.3
Floyd, M.B.4
Johnson, B.D.5
Mamuya, N.6
Rosfjord, E.C.7
Discafani, C.8
Davis, R.9
Shi, X.10
Rabindran, S.K.11
Gruber, B.C.12
Ye, F.13
Hallett, W.A.14
Nilakantan, R.15
Shen, R.16
Wang, Y.-F.17
Greenberger, L.M.18
Tsou, H.-R.19
-
25
-
-
0034117636
-
Discovery of Novel, Potent, and Selective Small- Molecule CCR5 Antagonists as Anti-HIV-1 Agents: Synthesis and Biological Evaluation of Anilide Derivatives with a Quaternary Ammonium Moiety
-
Shiraishi, M.; Aramaki, Y.; Seto, M.; Imoto, H.; Nishikawa, Y.; Kanzaki, N.; Okamoto, M.; Sawada, H.; Nishimura, O.; Baba, M.; Fujino, M. Discovery of Novel, Potent, and Selective Small- Molecule CCR5 Antagonists as Anti-HIV-1 Agents: Synthesis and Biological Evaluation of Anilide Derivatives with a Quaternary Ammonium Moiety. J. Med. Chem., 2000, 43 (10), 2049-2063.
-
(2000)
J. Med. Chem
, vol.43
, Issue.10
, pp. 2049-2063
-
-
Shiraishi, M.1
Aramaki, Y.2
Seto, M.3
Imoto, H.4
Nishikawa, Y.5
Kanzaki, N.6
Okamoto, M.7
Sawada, H.8
Nishimura, O.9
Baba, M.10
Fujino, M.11
-
26
-
-
37049015171
-
Potent Antimalarial Activity of 2- Aminopyridinium Salts, Amidines, and Guanidines
-
Calas, M.; Ouattara, M.; Piquet, G.; Ziora, Z.; Bordat, Y.; Ancelin, M. L.; Escale, R.; Vial, H. Potent Antimalarial Activity of 2- Aminopyridinium Salts, Amidines, and Guanidines. J. Med. Chem., 2007, 50 (25), 6307-6315.
-
(2007)
J. Med. Chem
, vol.50
, Issue.25
, pp. 6307-6315
-
-
Calas, M.1
Ouattara, M.2
Piquet, G.3
Ziora, Z.4
Bordat, Y.5
Ancelin, M.L.6
Escale, R.7
Vial, H.8
-
27
-
-
0007604525
-
Synthesis and Hypotensive Activity of Unsymmetrically Substituted Acetylenic Bis-Quaternary Ammonium Compounds and Certain of Their Reduction Products
-
Neumeyer, J.L.; Cannon, J.G. Synthesis and Hypotensive Activity of Unsymmetrically Substituted Acetylenic Bis-Quaternary Ammonium Compounds and Certain of Their Reduction Products. J. Med. Chem., 1962, 5 (4), 784-792.
-
(1962)
J. Med. Chem
, vol.5
, Issue.4
, pp. 784-792
-
-
Neumeyer, J.L.1
Cannon, J.G.2
-
28
-
-
84871142570
-
-
[in Russian], Medicine, Moscow
-
Mashkovskii, M.D. Pharmaceuticals [in Russian], Medicine, Moscow, 1993, Vol. 1.
-
(1993)
Pharmaceuticals
, vol.1
-
-
Mashkovskii, M.D.1
-
30
-
-
0019766795
-
Biodegradable neuromuscular blocking agents. Part 4. Atracurium besylate and related polyalkylene di-esters
-
Stenlake, J. B.; Waigh, R. D.; Dewar, G. A.; Hughes, R.; Chapple, D. J.; Coker, G. G. Biodegradable neuromuscular blocking agents. Part 4. Atracurium besylate and related polyalkylene di-esters. Eur. J. Med. Chem., 1981, 16, 515-524.
-
(1981)
Eur. J. Med. Chem
, vol.16
, pp. 515-524
-
-
Stenlake, J.B.1
Waigh, R.D.2
Dewar, G.A.3
Hughes, R.4
Chapple, D.J.5
Coker, G.G.6
-
31
-
-
0026808876
-
Neuromuscular blocking agents. Some approaches to short acting compounds
-
Stenlake, J. B.; Dhar, N. C.; Haddow, J.; McDonald, I. M.; Maehr, R. B.; Wastila, W. B. Neuromuscular blocking agents. Some approaches to short acting compounds. Eur. J. Med. Chem., 1992, 27, 463-477.
-
(1992)
Eur. J. Med. Chem
, vol.27
, pp. 463-477
-
-
Stenlake, J.B.1
Dhar, N.C.2
Haddow, J.3
McDonald, I.M.4
Maehr, R.B.5
Wastila, W.B.6
-
32
-
-
0027157790
-
Neuromuscular blocking agents. Approaches to short-acting compounds 2. Bisthiazolium salts
-
Stenlake, J. B.; Dhar, N. C.; Henderson, C. F.; Maehr, R. B.; Scharver, J.; Wastila, W. B.; Midgley, J. M. Neuromuscular blocking agents. Approaches to short-acting compounds 2. Bisthiazolium salts. Eur. J. Med. Chem., 1993, 28, 415-418.
-
(1993)
Eur. J. Med. Chem
, vol.28
, pp. 415-418
-
-
Stenlake, J.B.1
Dhar, N.C.2
Henderson, C.F.3
Maehr, R.B.4
Scharver, J.5
Wastila, W.B.6
Midgley, J.M.7
-
33
-
-
0030061060
-
Approaches to Short-Acting Neuromuscular Blocking Agents: Nonsymmetrical Bistetrahydroisoquinolinium Mono- and Diesters
-
Dhar, N.C.; Maehr, R. B; Masterson, L. A.; Midgley, J. M.; Stenlake, J. B.; Wastila, W. B. Approaches to Short-Acting Neuromuscular Blocking Agents: Nonsymmetrical Bistetrahydroisoquinolinium Mono- and Diesters. J. Med. Chem., 1996, 39, 556-561.
-
(1996)
J. Med. Chem
, vol.39
, pp. 556-561
-
-
Dhar, N.C.1
Maehr, R.B.2
Masterson, L.A.3
Midgley, J.M.4
Stenlake, J.B.5
Wastila, W.B.6
-
34
-
-
0029166159
-
Succinylcholine/suxamethonium
-
Belmont, M.R. Succinylcholine/suxamethonium. Curr. Opin. Anesthesiol., 1995, 8, 362-366.
-
(1995)
Curr. Opin. Anesthesiol
, vol.8
, pp. 362-366
-
-
Belmont, M.R.1
-
36
-
-
0030480565
-
Is suxamethonium now obsolete?
-
Mahajan, R.P. Is suxamethonium now obsolete? Curr. Anaesth. Crit. Care, 1996, 7, 289-294.
-
(1996)
Curr. Anaesth. Crit. Care
, vol.7
, pp. 289-294
-
-
Mahajan, R.P.1
-
37
-
-
0032930927
-
Bis- and Mixed- Tetrahydroisoquinolinium Chlorofumarates: New Ultra-Short- Acting Nondepolarizing Neuromuscular Blockers
-
Boros, E.E.; Bigham, E. C.; Boswell, G.E.; Mook, R.A.; Patel, S.S; Savarese, J.J.; Ray, J. A.; Thompson, J. B.; Hashim, M. A.; Wisowaty, J.C.; Feldman, P.L.; Samano, V. Bis- and Mixed- Tetrahydroisoquinolinium Chlorofumarates: New Ultra-Short- Acting Nondepolarizing Neuromuscular Blockers. J. Med. Chem., 1999, 42, 206-209.
-
(1999)
J. Med. Chem
, vol.42
, pp. 206-209
-
-
Boros, E.E.1
Bigham, E.C.2
Boswell, G.E.3
Mook, R.A.4
Patel, S.S.5
Savarese, J.J.6
Ray, J.A.7
Thompson, J.B.8
Hashim, M.A.9
Wisowaty, J.C.10
Feldman, P.L.11
Samano, V.12
-
38
-
-
0033576442
-
Synthesis of Ultra-Short-Acting Neuromuscular Blocker GW 0430: A Remarkably Stereo- and Regioselective Synthesis of Mixed Tetrahydroisoqunolinium Chlorofumarates
-
Samano, V.; Ray, J. A.; Thompson, J. B.; Mook, R.A.; Jung, D.K.; Koble, C.S.; Martin, M.T.; Bigham, E. C.; Regitz, C.S.; Feldman, P.L.; Boros, E.E. Synthesis of Ultra-Short-Acting Neuromuscular Blocker GW 0430: A Remarkably Stereo- and Regioselective Synthesis of Mixed Tetrahydroisoqunolinium Chlorofumarates. Org. Lett., 1999, 1 (12), 1993-1996.
-
(1999)
Org. Lett
, vol.1
, Issue.12
, pp. 1993-1996
-
-
Samano, V.1
Ray, J.A.2
Thompson, J.B.3
Mook, R.A.4
Jung, D.K.5
Koble, C.S.6
Martin, M.T.7
Bigham, E.C.8
Regitz, C.S.9
Feldman, P.L.10
Boros, E.E.11
-
39
-
-
0035906475
-
Stereocontrolled Synthesis of cis-Dibenzoquinolizine Chlorofumarates: Curare-Like Agents of Ultrashort Duration
-
Kaldor, I.; Feldmanm, P. L.; Mook, R.A. Jr.; Ray, J.A.; Samano, V.; Sefler, A.M.; Thompson, J.B.; Travis, B.R.; Boros, E.E. Stereocontrolled Synthesis of cis-Dibenzoquinolizine Chlorofumarates: Curare-Like Agents of Ultrashort Duration. J. Org. Chem., 2001, 66, 3495-3501.
-
(2001)
J. Org. Chem
, vol.66
, pp. 3495-3501
-
-
Kaldor, I.1
Feldmanm, P.L.2
Mook Jr., R.A.3
Ray, J.A.4
Samano, V.5
Sefler, A.M.6
Thompson, J.B.7
Travis, B.R.8
Boros, E.E.9
-
40
-
-
0029823523
-
Synthesis, Molecular Modeling, and K+ Channel-Blocking Activity of Dequalinium Analogues Having Semirigid Linkers
-
Rosa, J.C.; Galanakis, D.; Ganellin, C. R.; Dunn, P. M. Synthesis, Molecular Modeling, and K+ Channel-Blocking Activity of Dequalinium Analogues Having Semirigid Linkers. J. Med. Chem., 1996, 39, 4247-4254.
-
(1996)
J. Med. Chem
, vol.39
, pp. 4247-4254
-
-
Rosa, J.C.1
Galanakis, D.2
Ganellin, C.R.3
Dunn, P.M.4
-
41
-
-
0029841367
-
Synthesis and Pharmacological Testing of Dequalinium Analogues as Blockers of the Apamin-Sensitive Ca2+-Activated K+ Channel: Variation of the Length of the Alkylene Chain
-
Galanakis, D.; Ganellin, C. R.; Malik, S.; Dunn, P. M. Synthesis and Pharmacological Testing of Dequalinium Analogues as Blockers of the Apamin-Sensitive Ca2+-Activated K+ Channel: Variation of the Length of the Alkylene Chain. J. Med. Chem., 1996, 39, 3592-3595.
-
(1996)
J. Med. Chem
, vol.39
, pp. 3592-3595
-
-
Galanakis, D.1
Ganellin, C.R.2
Malik, S.3
Dunn, P.M.4
-
42
-
-
0031603012
-
Bis-Quinolinium Cyclophanes: 6,10-Diaza-3(1,3),8(1,4)- dibenzena-1,5(1,4)-diquinolinacyclodecaphane (UCL 1684), the First Nanomolar, Non-Peptidic Blocker of the Apamin-Sensitive Ca2+-Activated K+ Channel
-
Rosa, J. C.; Galanakis, D.; Ganellin, C. R.; Dunn, P. M.; Jenkinson, D. H. Bis-Quinolinium Cyclophanes: 6,10-Diaza-3(1,3),8(1,4)- dibenzena-1,5(1,4)-diquinolinacyclodecaphane (UCL 1684), the First Nanomolar, Non-Peptidic Blocker of the Apamin-Sensitive Ca2+-Activated K+ Channel. J. Med. Chem., 1998, 41, 2-5.
-
(1998)
J. Med. Chem
, vol.41
, pp. 2-5
-
-
Rosa, J.C.1
Galanakis, D.2
Ganellin, C.R.3
Dunn, P.M.4
Jenkinson, D.H.5
-
43
-
-
0034628524
-
Synthesis, Molecular Modeling, and Pharmacological Testing of Bis-Quinolinium Cyclophanes: Potent, Non-Peptidic Blockers of the Apamin-Sensitive Ca2+-Activated K+ Channel
-
Rosa, J.C.; Galanakis, D.; Piergentili, A.; Bhandari, K.; Ganellin, C. R.; Dunn, P. M.; Jenkinson, D. H. Synthesis, Molecular Modeling, and Pharmacological Testing of Bis-Quinolinium Cyclophanes: Potent, Non-Peptidic Blockers of the Apamin-Sensitive Ca2+-Activated K+ Channel. J. Med. Chem., 2000, 43 (3), 420-431.
-
(2000)
J. Med. Chem
, vol.43
, Issue.3
, pp. 420-431
-
-
Rosa, J.C.1
Galanakis, D.2
Piergentili, A.3
Bhandari, K.4
Ganellin, C.R.5
Dunn, P.M.6
Jenkinson, D.H.7
-
44
-
-
0029131932
-
Synthesis and Quantitative Structure-Activity Relationship of Dequalinium Analogs as K+ Channel Blockers: Investigations on the Role of the Substituent at Position 4 of the Quinoline Ring
-
Galanakis, D.; Calder, J. A. D.; Ganellin, C.R.; Owen, C. S.; Dunn, P.M. Synthesis and Quantitative Structure-Activity Relationship of Dequalinium Analogs as K+ Channel Blockers: Investigations on the Role of the Substituent at Position 4 of the Quinoline Ring. J. Med. Chem., 1995, 38 (18), 3536-3546
-
(1995)
J. Med. Chem
, vol.38
, Issue.18
, pp. 3536-3546
-
-
Galanakis, D.1
Calder, J.A.D.2
Ganellin, C.R.3
Owen, C.S.4
Dunn, P.M.5
-
45
-
-
0029032656
-
Synthesis and Structure-Activity Relationships of Dequalinium Analogues as K+ Channel Blockers. Investigations on the Role of the Charged Heterocycle
-
Galanakis, D.; Davis, C. A.; Herrero, B. D.; Ganellin, C. R.; Dunn, P. M.; Jenkinson, D. H. Synthesis and Structure-Activity Relationships of Dequalinium Analogues as K+ Channel Blockers. Investigations on the Role of the Charged Heterocycle. J. Med. Chem., 1995, 38, 595-606.
-
(1995)
J. Med. Chem
, vol.38
, pp. 595-606
-
-
Galanakis, D.1
Davis, C.A.2
Herrero, B.D.3
Ganellin, C.R.4
Dunn, P.M.5
Jenkinson, D.H.6
-
46
-
-
0034699376
-
Bis-Quinolinium Cyclophanes: 8,14-Diaza-1,7(1,4)- diquinolinacyclotetradecaphane (UCL 1848), a Highly Potent and Selective, Nonpeptidic Blocker of the Apamin-Sensitive Ca2+- Activated K+ Channel
-
Chen, J.-Q.; Galanakis, D.; Ganellin, C. R.; Dunn, P. M.; Jenkinson, D. H. Bis-Quinolinium Cyclophanes: 8,14-Diaza-1,7(1,4)- diquinolinacyclotetradecaphane (UCL 1848), a Highly Potent and Selective, Nonpeptidic Blocker of the Apamin-Sensitive Ca2+- Activated K+ Channel. J. Med. Chem., 2000, 43, 3478-3481.
-
(2000)
J. Med. Chem
, vol.43
, pp. 3478-3481
-
-
Chen, J.-Q.1
Galanakis, D.2
Ganellin, C.R.3
Dunn, P.M.4
Jenkinson, D.H.5
-
47
-
-
0030030509
-
Synthesis and Quantitative Structure-Activity Relationship of a Novel Series of Small Conductance Ca2+-Activated K+ Channel Blockers Related to Dequalinium
-
Galanakis, D.; Davis, C.A.; Ganellin, C. R.; Dunn, P. M. Synthesis and Quantitative Structure-Activity Relationship of a Novel Series of Small Conductance Ca2+-Activated K+ Channel Blockers Related to Dequalinium. J. Med. Chem., 1996, 39, 359-370.
-
(1996)
J. Med. Chem
, vol.39
, pp. 359-370
-
-
Galanakis, D.1
Davis, C.A.2
Ganellin, C.R.3
Dunn, P.M.4
-
48
-
-
84871148017
-
Pharmacology of the alkaloid, thesine [in Russian]
-
Mashkovskii, M.D. Pharmacology of the alkaloid, thesine [in Russian]. Farmakol. i Toksikol. 1943. 6. 25-32.
-
(1943)
Farmakol. I Toksikol
, vol.6
, pp. 25-32
-
-
Mashkovskii, M.D.1
-
49
-
-
77049272333
-
About curariform properties of an alkaloid thesine and its methyl diiodide [in Russian]
-
Mashkovskii, M.D. About curariform properties of an alkaloid thesine and its methyl diiodide [in Russian] Farmakol. i. Toksikol., 1955, 18, 3-9.
-
(1955)
Farmakol. I. Toksikol
, vol.18
, pp. 3-9
-
-
Mashkovskii, M.D.1
-
50
-
-
84871131200
-
Synthesis and curariform action bisquaternary salts of aminomethyldioxalanylehtane and ethylene [in Russian]
-
Sokolov, G.P.; Klusha, V.E.; Kimenis, A.A.; Giller, S.A. Synthesis and curariform action bisquaternary salts of aminomethyldioxalanylehtane and ethylene [in Russian]. Khim. Farm. Zh., 1968, 3, 3-10.
-
(1968)
Khim. Farm. Zh
, vol.3
, pp. 3-10
-
-
Sokolov, G.P.1
Klusha, V.E.2
Kimenis, A.A.3
Giller, S.A.4
-
51
-
-
73849165130
-
Curariform properties of dichloride 1,6-di(3',3'-benzylhynukledil-1',1') hexane (Qualidil) [in Russian]
-
Mashkovskii, M.D.; Sadritdinov, F. Curariform properties of dichloride 1,6-di(3',3'-benzylhynukledil-1',1') hexane (Qualidil) [in Russian]. Farmakol.i Toksikol., 1962, 25, 685-691.
-
(1962)
Farmakol.i Toksikol
, vol.25
, pp. 685-691
-
-
Mashkovskii, M.D.1
Sadritdinov, F.2
-
52
-
-
84871114419
-
-
US Patent WO 9921854 A1. CA 130:325090
-
Gyermek, L.; Lee, C.; Cho, Y-M. US Patent WO 9921854 A1. CA 130:325090.
-
-
-
Gyermek, L.1
Lee, C.2
Cho, Y.-M.3
-
53
-
-
0038766577
-
A new series of cholinesterase inhibitors
-
Long, J.P.; Schueler, F.W. A new series of cholinesterase inhibitors. J. Amer. Pharm. Ass., 1954, 43, 79-84.
-
(1954)
J. Amer. Pharm. Ass
, vol.43
, pp. 79-84
-
-
Long, J.P.1
Schueler, F.W.2
-
54
-
-
33947477283
-
The peripheral actions of the hemicholinium compounds
-
Long, J.P. The peripheral actions of the hemicholinium compounds. J. Med. and Pharm. Chem. 1961, 4, 505-510.
-
(1961)
J. Med. and Pharm. Chem
, vol.4
, pp. 505-510
-
-
Long, J.P.1
-
55
-
-
0001741705
-
A new group of respiratory paralyrants. I The hemicholiniums
-
Schueler, F.W. A new group of respiratory paralyrants. I The hemicholiniums. J. Pharmacol., 1955, 115, 127-131.
-
(1955)
J. Pharmacol
, vol.115
, pp. 127-131
-
-
Schueler, F.W.1
-
56
-
-
70449290288
-
Pharmacological studies on some compounds structurally related to the hemicholinium HC-3
-
Marshall, F.N.; Long, J.P. Pharmacological studies on some compounds structurally related to the hemicholinium HC-3. J.Pharmacol., 1959, 127, 236-341.
-
(1959)
J.Pharmacol
, vol.127
, pp. 236-341
-
-
Marshall, F.N.1
Long, J.P.2
-
57
-
-
0034649649
-
Nondepolarizing Neuromuscular Blocking Activity of Bisquaternary Amino Di- and Tripeptide Derivatives
-
Booij, L. H. D. J.; van der Broek, L. A. G. M.; Caulfield, W.; Dommerholt-Caris, B. M. G.; Clark, J. K.; van Egmond, J.; McGuire, R; Muir, A. W.; Ottenheijm, H. C. J.; Rees, D. C. Nondepolarizing Neuromuscular Blocking Activity of Bisquaternary Amino Di- and Tripeptide Derivatives. J. Med. Chem., 2000, 43, 4822-4833.
-
(2000)
J. Med. Chem
, vol.43
, pp. 4822-4833
-
-
Booij, L.H.D.J.1
van der Broek, L.A.G.M.2
Caulfield, W.3
Dommerholt-Caris, B.M.G.4
Clark, J.K.5
van Egmond, J.6
McGuire, R.7
Muir, A.W.8
Ottenheijm, H.C.J.9
Rees, D.C.10
-
58
-
-
84871166123
-
Synthesis and pharmacological properties of some basic ethers of pyrrolidin acids [in Russian]
-
Lebedeva, A.S.; Likhosherstov, A.M.; Mitrofanov, V.S.; Runova, M.F.; Skoldinov, A.P.; Kharkevich, A.D. Synthesis and pharmacological properties of some basic ethers of pyrrolidin acids [in Russian]. Khim. Farm. Zh., 1967, 26-30.
-
(1967)
Khim. Farm. Zh
, pp. 26-30
-
-
Lebedeva, A.S.1
Likhosherstov, A.M.2
Mitrofanov, V.S.3
Runova, M.F.4
Skoldinov, A.P.5
Kharkevich, A.D.6
-
59
-
-
78651122202
-
A ganglioblocking substances among diquaternized salts of alkylaminoalkyls ethers of N-methyl-λ-hyrrolidincarbonic acid. [in Russian]
-
Kharkevich, A.D. A ganglioblocking substances among diquaternized salts of alkylaminoalkyls ethers of N-methyl-λ-hyrrolidincarbonic acid. [in Russian] Farmakol.i Toksikol., 1963, 26, 172-177.
-
(1963)
Farmakol.i Toksikol
, vol.26
, pp. 172-177
-
-
Kharkevich, A.D.1
-
60
-
-
84871173983
-
About some dependences between a structure and curariform activity among diquaternized derivative of cyclobutandicarbonic acids. [in Russian]
-
Kharkevich, A.D.; Kravchuk, L.A. About some dependences between a structure and curariform activity among diquaternized derivative of cyclobutandicarbonic acids. [in Russian] Farmakol. i Toksikol., 1963, 26, 702-707.
-
(1963)
Farmakol. I Toksikol
, vol.26
, pp. 702-707
-
-
Kharkevich, A.D.1
Kravchuk, L.A.2
-
61
-
-
18344404933
-
Dependence of curariform activity of cyclobutandicarbonic acids derivatives from a structure of the central part of a molecule. [in Russian]
-
Kharkevich, A.D. Dependence of curariform activity of cyclobutandicarbonic acids derivatives from a structure of the central part of a molecule. [in Russian] Farmakol. i Toksikol., 1966, 29, 715-720.
-
(1966)
Farmakol. I Toksikol
, vol.29
, pp. 715-720
-
-
Kharkevich, A.D.1
-
62
-
-
0009565527
-
Researches among cyclobutandicarbonic acids. IV. Synthesis of diquaternized salts of alkylamino ethers of truxillic acid. [in Russian]
-
Arendaruk, A.P.; Skoldinov, A.P.; Kharkevich, A.D. Researches among cyclobutandicarbonic acids. IV. Synthesis of diquaternized salts of alkylamino ethers of truxillic acid. [in Russian]. Khim. Farm. Zh., 1967, 4, 3-7.
-
(1967)
Khim. Farm. Zh
, vol.4
, pp. 3-7
-
-
Arendaruk, A.P.1
Skoldinov, A.P.2
Kharkevich, A.D.3
-
63
-
-
84871174818
-
Researches among cyclobutandicarbonic acids. VI. Dependence of curariform activity from a structure among alkylamino derivatives of cyclobutandicarbonic acids. [in Russian]
-
Arendaruk, A.P.; Skoldinov, A.P.; Kharkevich, A.D. Researches among cyclobutandicarbonic acids. VI. Dependence of curariform activity from a structure among alkylamino derivatives of cyclobutandicarbonic acids. [in Russian]. Khim. Farm. Zh., 1968, 3, 7-12.
-
(1968)
Khim. Farm. Zh
, vol.3
, pp. 7-12
-
-
Arendaruk, A.P.1
Skoldinov, A.P.2
Kharkevich, A.D.3
-
64
-
-
84933000219
-
Researches among cyclobutandicarbonic acids. V. Synthesis of diquaternized salts of alkylamino ethers and stereoisomeric truxillic acids. [in Russian]
-
Arendaruk, A.P.; Skoldinov, A.P.; Kharkevich, A.D. Researches among cyclobutandicarbonic acids. V. Synthesis of diquaternized salts of alkylamino ethers and stereoisomeric truxillic acids. [in Russian] Khim. Farm. Zh., 1967, 8, 18-24.
-
(1967)
Khim. Farm. Zh
, vol.8
, pp. 18-24
-
-
Arendaruk, A.P.1
Skoldinov, A.P.2
Kharkevich, A.D.3
-
65
-
-
84871106325
-
On Methods for Synthesizing New Antidepolarizing Myorelaxants
-
[in Russian], Kharkevich, A.D., Ed.; Meditsina, Leningrad
-
Kharkevich, A.D. On Methods for Synthesizing New Antidepolarizing Myorelaxants. In Achievements in Modern Pharmacology [in Russian], Kharkevich, A.D., Ed.; Meditsina, Leningrad, 1976, 170-178.
-
(1976)
In Achievements In Modern Pharmacology
, pp. 170-178
-
-
Kharkevich, A.D.1
-
66
-
-
33947458409
-
Dicarboxylic Acid Dicarboxylic Acid Bis-λ-tertiaryaminoalkyl Amides and their Quaternary Ammonium Salts as Curare Substitutes
-
Phillips, A.P. Dicarboxylic Acid Dicarboxylic Acid Bis-λ-tertiaryaminoalkyl Amides and their Quaternary Ammonium Salts as Curare Substitutes. J. Am. Chem. Soc. 1951, 73(12), 5822-5824.
-
(1951)
J. Am. Chem. Soc
, vol.73
, Issue.12
, pp. 5822-5824
-
-
Phillips, A.P.1
-
67
-
-
33947453596
-
Synthetic Curare Substitutes from Aliphatic Dicarboxylic Acid Aminoethyl Esters
-
Phillips, A.P. Synthetic Curare Substitutes from Aliphatic Dicarboxylic Acid Aminoethyl Esters. J. Am. Chem. Soc., 1949, 71, 3264.
-
(1949)
J. Am. Chem. Soc
, vol.71
, pp. 3264
-
-
Phillips, A.P.1
-
68
-
-
26844450240
-
Bis-ammonium Salts. Derivatives of Fluorene, Carbazole and Phenothiazine
-
Cavallito, C.J.; Gray, A.P.; Spinner, E.E. Bis-ammonium Salts. Derivatives of Fluorene, Carbazole and Phenothiazine. J. Amer. Chem. Soc., 1954, 76(7), 1862-1866.
-
(1954)
J. Amer. Chem. Soc
, vol.76
, Issue.7
, pp. 1862-1866
-
-
Cavallito, C.J.1
Gray, A.P.2
Spinner, E.E.3
-
69
-
-
33947471152
-
Potential Curare-Like Compounds Derived from Bisdialkylaminoalkyl Esters of Some 3-Phenylglutaric Acid
-
Smith, W.T.; Ryan, J.W. Potential Curare-Like Compounds Derived from Bisdialkylaminoalkyl Esters of Some 3-Phenylglutaric Acid. J. Org. Chem., 1961, 26(10), 3856-3858.
-
(1961)
J. Org. Chem
, vol.26
, Issue.10
, pp. 3856-3858
-
-
Smith, W.T.1
Ryan, J.W.2
-
70
-
-
0014067935
-
The Synthesis and Pharmacology of 1311-Labeled l,l0-Bis(trimethylammonium)-5-chloro-6-iodo-5-decene Dihalide and Related Neuromuscular Blocking Agents
-
Nedergaard, O.A.; Taylor, D.B. The Synthesis and Pharmacology of 1311-Labeled l,l0-Bis(trimethylammonium)-5-chloro-6-iodo-5-decene Dihalide and Related Neuromuscular Blocking Agents. J. Med. Chem., 1967, 10(2), 231-235.
-
(1967)
J. Med. Chem
, vol.10
, Issue.2
, pp. 231-235
-
-
Nedergaard, O.A.1
Taylor, D.B.2
-
71
-
-
0028576838
-
Bis-Catechol-Substituted Redox-Reactive Analogues of Hexamethonium and Decamethonium: Stimulated Affinity-Dependent Reactivity through Iron Peroxide Catalysis
-
Gu, Y.; Lee, H.; Hudson, R. A. Bis-Catechol-Substituted Redox-Reactive Analogues of Hexamethonium and Decamethonium: Stimulated Affinity-Dependent Reactivity through Iron Peroxide Catalysis. J. Med. Chem., 1994, 37, 4417-4420.
-
(1994)
J. Med. Chem
, vol.37
, pp. 4417-4420
-
-
Gu, Y.1
Lee, H.2
Hudson, R.A.3
-
72
-
-
50849135894
-
Polymer-Based Open-Channel Blockers for the Acetylcholine Receptor: The Effect of Spacer Length on Blockade Kinetics
-
Lin, W-C.; Licht, S. Polymer-Based Open-Channel Blockers for the Acetylcholine Receptor: The Effect of Spacer Length on Blockade Kinetics. Biochemistry, 2008, 47, 9163-9173.
-
(2008)
Biochemistry
, vol.47
, pp. 9163-9173
-
-
Lin, W.-C.1
Licht, S.2
-
74
-
-
0015537845
-
Steroids and Related Studies. Part XX. 4,17a-Diaza-d-homo-steroids
-
Singh, H.; Paul, D.; Parashar, V.V. Steroids and Related Studies. Part XX. 4,17a-Diaza-d-homo-steroids. J. Chem. Soc. Perkin Trans. I, 1973, 1204-1206.
-
(1973)
J. Chem. Soc. Perkin Trans. I
, pp. 1204-1206
-
-
Singh, H.1
Paul, D.2
Parashar, V.V.3
-
75
-
-
0016007625
-
Steroids and Related Studies. Part XXV. Chandonium iodide (17α-methyl -3β-pyrrolidino-17α-aza-D-homoandrost-5-ene dimethyliodide) and other quaternary ammonium steroid analogues
-
Singh, H.; Paul, D. Steroids and Related Studies. Part XXV. Chandonium iodide (17α-methyl -3β-pyrrolidino-17α-aza-D-homoandrost-5-ene dimethyliodide) and other quaternary ammonium steroid analogues. J. Chem. Soc. Perkin Trans. I, 1974, 1475-1480.
-
(1974)
J. Chem. Soc. Perkin Trans. I
, pp. 1475-1480
-
-
Singh, H.1
Paul, D.2
-
76
-
-
0018904760
-
Synthesis of 2β, 16β-Bis-(4'-dimethyl-1'-piperazino)-3α, 17β-diacetoxy-5α-androstyane Dibromide and Related Compounds
-
Tuba, Z. Synthesis of 2β, 16β-Bis-(4'-dimethyl-1'-piperazino)-3α, 17β-diacetoxy-5α-androstyane Dibromide and Related Compounds. Arzneimittel Forschung, 1980, 30(1), 342-346.
-
(1980)
Arzneimittel Forschung
, vol.30
, Issue.1
, pp. 342-346
-
-
Tuba, Z.1
-
77
-
-
0037283263
-
Synthesis and Biological Evaluation of 16β-Pyrrolidinosteroidal Derivatives
-
Jindal, D.P.; Piplani, P.; Fajrak, H.; Marshall, I.G. Synthesis and Biological Evaluation of 16β-Pyrrolidinosteroidal Derivatives. Arzneimittel Forschung, 2003, 2, 73-79.
-
(2003)
Arzneimittel Forschung
, vol.2
, pp. 73-79
-
-
Jindal, D.P.1
Piplani, P.2
Fajrak, H.3
Marshall, I.G.4
-
78
-
-
0027157790
-
Neuromuscular blocking agents. Approaches to short-acting compounds 2. Bisthiazolium salts
-
Stenlake, J. B.; Dhar, N. C.; Henderson, C.F.; Maehr, R. B.; Scharver, J.; Wastila, W. B.; Midgley, J.M. Neuromuscular blocking agents. Approaches to short-acting compounds 2. Bisthiazolium salts. Eur. J. Med. Chem., 1993, 28, 415-418.
-
(1993)
Eur. J. Med. Chem
, vol.28
, pp. 415-418
-
-
Stenlake, J.B.1
Dhar, N.C.2
Henderson, C.F.3
Maehr, R.B.4
Scharver, J.5
Wastila, W.B.6
Midgley, J.M.7
-
79
-
-
84871109609
-
α,ω-Bis(trialkylammoniomethyl)-oligodimethylsiloxane Dihalides: New Curarelike Compounds
-
[in Russian]
-
Voronkov, M.G.; Steiling, L.; Keiko, V.V.; Kirpichenko, S.V.; Kuznetsova, E.E. α,ω-Bis(trialkylammoniomethyl)-oligodimethylsiloxane Dihalides: New Curarelike Compounds. Izv. Akad. Nauk SSSR, Ser. Khim., [in Russian], 1979, 6, 1418-1419.
-
(1979)
Izv. Akad. Nauk SSSR, Ser. Khim
, vol.6
, pp. 418-1419
-
-
Voronkov, M.G.1
Steiling, L.2
Keiko, V.V.3
Kirpichenko, S.V.4
Kuznetsova, E.E.5
-
80
-
-
0345625533
-
Synthesis and Pharmacology of Some Spiroindolenines and Indolines
-
Weisbach, J.A.; Macko, E.; De Sanctis, N.J.; Cava, M.P.; Douglas, B. Synthesis and Pharmacology of Some -Spiroindolenines and Indolines. J. Med. Chem., 1964, 7, 735-739.
-
(1964)
J. Med. Chem
, vol.7
, pp. 735-739
-
-
Weisbach, J.A.1
Macko, E.2
de Sanctis, N.J.3
Cava, M.P.4
Douglas, B.5
-
81
-
-
3042548152
-
Probing the Pharmacophore for Allosteric Ligands of Muscarinic M2 Receptors: SAR and QSAR Studies in a Series of Bisquaternary Salts of Caracurine V and Related Ring Systems
-
Zlotos, D. P.; Buller, S.; Stiefl, N.; Baumann, K.; Mohr, K. Probing the Pharmacophore for Allosteric Ligands of Muscarinic M2 Receptors: SAR and QSAR Studies in a Series of Bisquaternary Salts of Caracurine V and Related Ring Systems. J. Med. Chem., 2004, 47, 3561-3571.
-
(2004)
J. Med. Chem
, vol.47
, pp. 3561-3571
-
-
Zlotos, D.P.1
Buller, S.2
Stiefl, N.3
Baumann, K.4
Mohr, K.5
-
82
-
-
33947467889
-
Bis Ammonium Salts. Derivatives of Some Carboline and Related Heterocyclic Bases
-
Gray, A.P.; Spinner, E.E.; Cavallito, C.J. Bis Ammonium Salts. Derivatives of Some Carboline and Related Heterocyclic Bases. J. Am. Chem. Soc., 1954, 76(10), 2792-2797.
-
(1954)
J. Am. Chem. Soc
, vol.76
, Issue.10
, pp. 2792-2797
-
-
Gray, A.P.1
Spinner, E.E.2
Cavallito, C.J.3
|