Synthesis, molecular modeling, and pharmacological testing of bis- quinolinium cyclophanes: Potent, non-peptidic blockers of the apamin- sensitive Ca2+-activated K+ channel

Journal of Medicinal Chemistry

Volumn 43, Issue 3, 2000, Pages 420-431

  Rosa, Joaquin Campos ^a,b   Galanakis, Dimitrios ^a,c   Piergentili, Alessandro ^a   Bhandari, Kalpana ^a,d   Ganellin, C Robin ^a   Dunn, Philip M ^a   Jenkinson, Donald H ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF GRANADA   (Spain)

^c ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^d CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

APAMIN; CALCIUM; CYCLOPHANE; POTASSIUM CHANNEL; QUINOLINE DERIVATIVE;

ARTICLE; DRUG ACTIVITY; DRUG CONFORMATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; MOLECULAR MODEL; SYNTHESIS;

ALKANES; ANIMALS; APAMIN; CELLS, CULTURED; MODELS, MOLECULAR; MOLECULAR CONFORMATION; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; QUINOLINIUM COMPOUNDS; RATS; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPERIOR CERVICAL GANGLION;

EID: 0034628524     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9902537     Document Type: Article

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