Bis-quinolinium cyclophanes: 8,14-diaza-1,7(1,4)-diquinolinacyclotetradecaphane (UCL 1848), a highly portent and selective nonpeptidic blocker of the apamin-sensitive Ca2+-activated K+ channel [2]

Journal of Medicinal Chemistry

Volumn 43, Issue 19, 2000, Pages 3478-3481

  Chen, J Q ^a   Galanakis, D ^a   Ganellin, C R ^a   Dunn, P M ^a   Jenkinson, D H ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

8,14 DIAZA 1,7(1,4)DIQUINOLINACYCLOTETRADECAPHANE; APAMIN; BISQUINOLINIUM CYCLOPHANE; CYCLOPHANE; DEQUALINIUM; UCL 1530; UCL 1684; UCL 1848; UNCLASSIFIED DRUG;

BINDING AFFINITY; CALCIUM CHANNEL; CHROMAFFIN CELL; CRYSTALLIZATION; DRUG POTENCY; DRUG SELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPERPOLARIZATION; LEARNING; LETTER; MEMORY; MOLECULAR CLONING; POTASSIUM CHANNEL; POTASSIUM CURRENT; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANIMAL; APAMIN; CALCIUM; CELLS, CULTURED; NEURONS; POTASSIUM CHANNEL BLOCKERS; QUINOLINIUM COMPOUNDS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T;

EID: 0034699376     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000904v     Document Type: Letter

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37. + channel
38. + channel
39. + channel
40. + channels in rat adrenal chromaffin cells in culture
41. + channels
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46. + channels with nanomolar affinity