Synthesis and pharmacological testing of dequalinium analogues as blockers of the apamin-sensitive Ca2+-activated K+ channel: Variation of the length of the alkylene chain

Journal of Medicinal Chemistry

Volumn 39, Issue 18, 1996, Pages 3592-3595

  Galanakis, Dimitrios ^a,b   Ganellin, C Robin ^a   Malik, Sajeed ^a   Dunn, Philip M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

APAMIN; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; DEQUALINIUM; DEQUALINIUM DERIVATIVE; PANCURONIUM; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; TUBOCURARINE CHLORIDE; UNCLASSIFIED DRUG;

ACTION POTENTIAL; AFTERHYPERPOLARIZATION; ANIMAL CELL; ARTICLE; CHANNEL GATING; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; INTRACELLULAR RECORDING; NONHUMAN; PHARMACOLOGICAL BLOCKING; RAT; SYMPATHETIC NERVE CELL;

ACTION POTENTIALS; AMINO ACID SEQUENCE; ANIMALS; APAMIN; CALCIUM; DEQUALINIUM; GANGLIA, SYMPATHETIC; MOLECULAR SEQUENCE DATA; POTASSIUM CHANNEL BLOCKERS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029841367     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950838a     Document Type: Article

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