Glutamine Supplementation Stimulates Protein-Synthetic and Inhibits Protein-Degradative Signaling Pathways in Skeletal Muscle of Diabetic Rats

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Lambertucci, Adriana C ^a   Lambertucci, Rafael H ^a,b   Hirabara, Sandro M ^a   Curi, Rui ^b   Moriscot, Anselmo S ^b   Alba Loureiro, Tatiana C ^b   Guimarães Ferreira, Lucas ^c   Levada Pires, Adriana C ^a   Vasconcelos, Diogo A A ^b   Sellitti, Donald F ^d   Pithon Curi, Tania C ^a  

^a UNIVERSIDADE CRUZEIRO DO SUL   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c FEDERAL UNIVERSITY OF ESPÍRITO SANTO   (Brazil)

^d Uniformed Services University of the Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATROGIN 1; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; GLYCOGEN SYNTHASE KINASE 3; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MUSCLE RING FINGER 1 PROTEIN; PROTEIN KINASE B;

AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; MALE; MORPHOLOGY; MUSCLE ATROPHY; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SOLEUS MUSCLE; STREPTOZOCIN DIABETES; WESTERN BLOTTING;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIETARY SUPPLEMENTS; GLUTAMINE; HUMANS; MALE; MUSCLE, SKELETAL; PROTEIN BIOSYNTHESIS; PROTEINS; PROTEOLYSIS; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 84871147438     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050390     Document Type: Article

References (40)

1. Wu M, Falasca M, Blough ER, (2010) Akt/Protein kinase B in skeletal muscle physiology and pathology. J Cell Physiol 226: 29-36.
2. Glass DJ, (2010) Signaling pathways perturbing muscle mass. Curr Opin Clin Nutr Metab Care 13: 225-229.
3. Medeiros C, Frederico MJ, da Luz G, Pauli JR, Silva AS, et al. (2011) Exercise training reduces insulin resistance and upregulates the mTOR/p70S6k pathway in cardiac muscle of diet-induced obesity rats. J Cell Physiol 226: 666-674.
4. Whiting DR, Guariguata L, Weil C, Shaw J, (2011) IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 94: 311-321.
5. Newsholme P, Abdulkader F, Rebelato E, Romanatto T, Pinheiro CH, et al. (2011) Amino acids and diabetes: implications for endocrine, metabolic and immune function. Front Biosci 1: 315-339.
6. Wolfe RR, (2002) Regulation of muscle protein by amino acids. J Nutr 132: 3219S-3224S.
7. Pallafacchina G, Calabria E, Serrano AL, Kalhovde JM, Schiaffino S, (2001) A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification. Proc Natl Acad Sci USA 99: 9213-9218.
8. Ohanna M, Sobering AK, Lapointe T, Lorenzo L, Praud C, et al. (2005) Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control. Nat Cell Biol 7: 286-294.
9. Hara K, Yonezawa K, Kozlowski MT, Sugimoto T, Andrabi K, et al. (1997) Regulation of eIF-4E BP1 phosphorylation by mTOR. J Biol Chem 272: 26457-26463.
10. Bodine SC, Latres E, Baumhueter S, Lai VK, Nunez L, et al. (2001) Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 294: 1704-1708.
11. Gomes MD, Lecker SH, Jagoe RT, Navon A, Goldberg AL, (2001) Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. Proc Natl Acad Sci U S A 98: 14440-14445.
12. Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, et al. (2004) Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 117: 399-412.
13. Stitt TN, Drujan D, Clarke BA, Panaro F, Timofeyva Y, et al. (2004) The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Mol Cell 14: 395-403.
14. Greer EL, Brunet A, (2005) FOXO transcription factors at the interface between longevity and tumor supression. Oncogene 24: 7410-7425.
15. Latres E, Amini AR, Amini AA, Griffiths J, Martin FJ, et al. (2005) Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway. J Biol Chem 280: 2737-2744.
16. Nicklin P, Bergman P, Zhang B, Triantafellow, Wang H, et al. (2009) Bidirectional transport of amino acids regulates mTOR and autophagy. Cell 136: 521-534.
17. Curi R, Lagranha CJ, Doi SQ, Sellitti DF, Procopio J, et al. (2005) Molecular mechanisms of glutamine action. J Cell Physiol 204: 392-401 Review.
18. Pithon-Curi TC, Schumacher RI, Freitas JJ, Lagranha C, Newsholme P, et al. (2003) Glutamine delays spontaneous apoptosis in neutrophils. Am J Physiol Cell Physiol 284: 1355-1361.
19. Xi P, Jiang Z, Zheng C, Lin Y, Wu G, (2011) Regulation of protein metabolism by glutamine: implications for nutrition and health. Front Biosci 1: 578-597.
20. Lagranha CJ, Senna SM, de Lima TM, Silva EP, Doi SQ, et al. (2004) Beneficial effect of glutamine on exercise-induced apoptosis of rat neutrophils. Med Sci Sports Exerc 36: 210-217.
21. Windmueller HG, Spaeth AE, (1974) Uptake and metabolism of plasma glutamine by the small intestine. J Biol Chem 249: 5070-5079.
22. Bradford MM, (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
23. Higuchi R, Dollinger G, Walsh PS, Griffith R, (1992) Simultaneous amplification and detection of specific DNA sequences. Biotechnology (N Y) 10: 413-417.
24. Hellemans J, Mortier G, De Paepe A, Speleman F, Vandesompele J, (2007) qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data. Genome Biol 8: R19.
25. Nicot N, Hausman JF, Hoffmann L, Evers D, (2005) Housekeeping gene selection for real-time RT-PCR normalization in potato during biotic and abiotic stress. J Exp Bot 56: 2907-2914.
26. Peters SJ, van Helvoort A, Kegler D, Argilès JM, Luiking YC, et al. (2011) Dose-dependent effects of leucine supplementation on preservation of muscle mass in cancer cachectic mice. Oncol Rep 26: 247-254.
27. Curi R, Newsholme P, Procopio J, Lagranha C, Gorjão R, et al. (2007) Glutamine, gene expression, and cell function. Front Biosci 1 12: 344-357.
28. Wijekoon EP, Skinner C, Brosnan ME, Brosnan JT, (2004) Amino acid metabolism in the Zucker diabetic fatty rat: effects of insulin resistance and of type 2 diabetes. Can J Physiol Pharmacol 82: 506-514.
29. Sugita H, Kaneki M, Sugita M, Yasukawa T, Yasuhara S, et al. (2005) Burn injury impairs insulin-stimulated Akt/PKB activation in skeletal muscle. Am J Physiol Endocrinol Metab 288: E585-591.
30. Saha AK, Xu XJ, Lawson E, Deoliveira R, Brandon AE, et al. (2010) Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle. Diabetes 59: 2426-2434.
31. Vary TC, (2007) Acute oral leucine administration stimulates protein synthesis during chronic sepsis through enhanced association of eukaryotic initiation factor 4G with eukaryotic initiation factor 4E in rats. J Nutr 137: 2074-2079.
32. O'Neill ED, Wilding JP, Kahn CR, Van Remmen H, McArdle A, et al. (2010) Absence of insulin signalling in skeletal muscle is associated with reduced muscle mass and function: evidence for decreased protein synthesis and not increased degradation. Age 32: 209-222.
33. Baptista IL, Leal ML, Artoli GG, Aoki MS, Fiamoncini J, et al. (2010) Leucine attenuates skeletal muscle wasting via inhibition of ubiquitin ligases. Muscle Nerve 41: 800-808.
34. Kandarian SC, Jackman RW, (2006) Intracellular signaling during skeletal muscle atrophy. Muscle Nerve 33: 155-165.
35. Kim J, Guan KL, (2011) Amino acid signaling in TOR activation. Annu Rev Biochem 80: 1001-1032.
36. Jope RS, Johnson GV, (2004) The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci 2: 95-102.
37. Dokken BB, Sloniger JA, Henriksen EJ, (2005) Acute selective glycogen synthase kinase-3 inhibition enhances insulin signaling in prediabetic insulin-resistant rat skeletal muscle. Am J Physiol Endocrinol Metab 288: 1188-1194.
38. Semiz S, Orvig C, McNeill JH, (2002) Effects of diabetes, vanadium, and insulin on glycogen synthase activation in Wistar rats. Mol Cell Biochem 231: 23-35.
39. Kimball SR, Jefferson LS, (2004) Amino acids as regulators of gene expression. Nutr Metab (Lond) 1: 3.
40. Nobukuni T, Joaquin M, Roccio M, Dann SG, Kim SY, et al. (2005) Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OHkinase. Proc Natl Acad Sci U S A 102: 14238-14243.