Regulation of muscle protein by amino acids

Journal of Nutrition

Volumn 132, Issue 10, 2002, Pages

  Wolfe, Robert R ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Amino acids; Anabolism; Net balance; Skeletal muscle; Stable isotope

Indexed keywords

AMINO ACID; ISOTOPE; MUSCLE PROTEIN;

CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; ENERGY EXPENDITURE; HUMAN; ISOTOPE LABELING; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

EID: 0036790054     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/131.10.3219s     Document Type: Conference Paper

References (28)

1. Biolo, G., Fleming, R. Y., Maggi, S. P. & Wolfe, R. R. (1995) Transmembrane transport and intracellular kinetics of amino acids in human skeletal muscle. Am. J. Physiol. 268: E75-E84.
2. Carraro, F., Stuart, C. A., Hartl, W. H., Rosenblatt, J. & Wolfe, R. R. (1990) Effect of exercise and recovery on muscle protein synthesis in human subjects. Am. J. Physiol. 259: E470-E476.
3. Biolo, G., Tipton, K. D., Klein, S. & Wolfe, R. R. (1997) An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein. Am. J. Physiol. 36: E122-E129.
4. Anthony, J. C., Anthony, T. G., Kimball, S. R., Vary, T. C. & Jefferson, L. S. (2000) Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation. J. Nutr. 130: 139-145.
5. Wolfe, R. R. & Miller, S. L. (1999) Amino acid availability controls muscle protein metabolism. Diabetes Nutr. Metab. 12: 322-328.
6. Pain, V. M. (1996) Initiation of protein synthesis in eukaryotic cells. Eur. J. Biochem. 236: 747-771.
7. Voorma, H. O., Thomas, A. A. & Van Heugten, H. A. (1994) Initiation of protein synthesis in eukaryotes. Mol. Biol. Rep. 19: 139-145.
8. Adibi, S. A., Modesto, T. A., Morse, E. L. & Amin, P. M. (1973) Amino acid levels in plasma, liver, and skeletal muscle during protein deprivation. Am. J. Physiol. 225: 408-414.
9. Lunn, P. G., Whitehead, R. G. & Baker, B. A. (1976) The relative effects of a low-protein-high-carbohydrate diet on the free amino acid composition of liver and muscle. Br. J. Nutr. 36: 219-230.
10. Heard, C. R., Frangi, S. M & Wright, P.M. (1977) Biochemical characteristics of different forms of protein-energy malnutrition: an experimental model using young rats. Br. J. Nutr. 37: 1-21.
11. Rogers, Q. R. (1976) In: Protein Metabolism and Nutrition (Cole, D. J., Boorman, K. N., Bittery, P. J., Lewis, D., Neale, R. J. & Swan, H, eds.), pp. 279-301. Butterworth, London, UK.
12. Jamaa, K., Kimball, S. R. & Jefferson, L. S. (1993) Aminoacylation of initiator methionyl-tRNAi under conditions of inhibitory initiation of protein synthesis. Am. J. Physiol. 264: E257-E263.
13. Bauman, P. Q., Stirewalt, W. S., O'Rourke, B. D., Howard, D. & Nair, K. S. (1994) Precursor pools of protein synthesis: a stable isotope study in swine model. Am. J. Physiol. 267: E203-E209.
14. Mortimore, G. E., Wert, J. J., Miotto, G., Venerando, R. & Kadowaki, M. (1994) Leucine-specific binding of photoreactive Leu-7-MAP to a high molecular weight protein on the plasma membrane of the isolated rat hepatocyte. Biochem. Biophys. Res. Commun. 203: 200-208.
15. Biolo, G., Fleming, R. Y., Maggi, S. P., Nguyen, T. T., Herndon, D. N. & Wolfe, R. R. (2002) Inverse regulation of protein turnover and amino acid transport in skeletal muscle of hypercatabolic patients. J. Clin. Endocrinol. Metab. 87: 3378-3384.
16. Tipton, K. D., Gurkin, B. E., Matin, S. & Wolfe, R. R. (1999) Nonessential amino acids are not necessary to stimulate net muscle protein synthesis in healthy volunteers. J. Nutr. Biochem. 10: 89-95.
17. Volpi, E., Mittendorfer, B., Rasmussen, B. B. & Wolfe, R. R. (2000) The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly. J. Clin. Endocrinol. Metab. 85: 4481-4490.
18. Wolfe, R. R. & Volpi, E. (2001) Insulin and protein metabolism. In: Handbook of Physiology. Section 7. Vol. II (Jefferson, L. S. & Cherrington, A. D. eds.), pp. 735-757. Oxford, New York, NY.
19. Biolo, G., Fleming, R. Y. & Wolfe, R. R. (1995) Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle. J. Clin. Invest. 95: 811-819.
20. Hillier, T. A., Fryburg, D. A., Jahn, L. A. & Barrett, E. J. (1998) Extreme hyperinsulinemia unmasks insulin effect to stimulate protein synthesis in the human forearm. Am. J. Physiol. 274: E1067-E1074.
21. Phillips, S. M., Tipton, K. D., Ferrando, A. A. & Wolfe, R. R. (1999) Resistance training reduces the acute exercise-induced increase in muscle protein turnover. Am. J. Physiol. 276: E118-E124.
22. Biolo, G., Maggi, S. P., Williams, B. D., Tipton, K. & Wolfe, R. R. (1995) Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans. Am. J. Physiol. 268: E514-E520.
23. Biolo, G., Williams, B. D., Fleming, R. Y. & Wolfe, R. R. (1999) Insulin action on muscle protein kinetics and amino acid transport during recovery after resistance exercise. Diabetes 48: 949-957.
24. Rasmussen, B., Tipton, K. D., Miller, S. L., Wolf, S. E. & Wolfe, R. R. (2000) An oral essential amino acid-carbohydrate supplement enhances muscle protein anabolism after resistance exercise. J. Appl. Physiol. 88: 386-392.
25. Tipton, K. D., Rasmussen, B. B., Miller, S. L., Wolf, S. E., Owens-Stovall, S. K., Petrini, B. E. & Wolfe, R. R. (2001) Timing of amino acid-carbohydrate ingestion alters anabolic response of muscle to resistance exercise. Am. J. Physiol. 281: E197-E206.
26. Pacy, P. J., Price, G. M., Halliday, D., Quevedo, M. R. & Millward, D. J. (1994) Nitrogen homeostasis in man: the diurnal responses of protein synthesis and degradation and amino acid oxidation to diets with increasing protein intakes. Clin. Sci. (Lond.) 86: 103-116.
27. Hegsted, D. M. (1978) Assessment of nitrogen requirements. Am. J. Clin. Nutr. 31: 1669-1677.
28. Hibbert, J. M., Broemeling, L., Isenberg, J. N. & Wolfe, R. R. (1994) Determinants of total free-living energy expenditure in lean and obese women measured by the doubly-labeled water method. J. Obesity 2: 44-53.