Absence of insulin signalling in skeletal muscle is associated with reduced muscle mass and function: Evidence for decreased protein synthesis and not increased degradation

Age

Volumn 32, Issue 2, 2010, Pages 209-222

  O'Neill, Elaine D ^a   Wilding, John P H ^a   Kahn, C Ronald ^b   Van Remmen, Holly ^c   McArdle, Anne ^a   Jackson, Malcolm J ^a   Close, Graeme L ^a,d  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

Author keywords

Ageing; Muscle; ROS

Indexed keywords

ATROGIN 1; INSULIN; MESSENGER RNA; MUSCLE RING FINGER 1 PROTEIN; PROTEASOME; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; S6 KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; EXTENSOR DIGITORUM LONGUS MUSCLE; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; INSULIN RESISTANCE; KNOCKOUT MOUSE; MALE; MOUSE; MUSCLE ATROPHY; MUSCLE FUNCTION; MUSCLE MASS; MUSCLE TETANIC CONTRACTION; NONHUMAN; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

ANIMALS; ATROPHY; BODY MASS INDEX; FEMALE; INSULIN; ISOMETRIC CONTRACTION; MALE; MICE; MICE, KNOCKOUT; MUSCLE, SKELETAL; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; REACTIVE OXYGEN SPECIES; RNA STABILITY; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 77953027226     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-009-9125-0     Document Type: Article

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