Pyrrolidine dithiocarbamate augments Hg2+-mediated induction of macrophage cell death via oxidative stress-induced apoptosis and necrosis signaling pathways

Toxicology Letters

Volumn 214, Issue 1, 2012, Pages 33-45

  Huang, Chun Fa ^a,b   Liu, Shing Hwa ^b   Lin Shiau, Shoei Yn ^b  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Caspase 3 7; HgCl2; Necrosis; PDTC; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; ACRIDINE ORANGE; ANTIOXIDANT; CASPASE 3; CASPASE 7; CYTOCHROME C; ETHIDIUM BROMIDE; GLUTATHIONE; MERCURY; MERCURY CHLORIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PYRROLIDINE DITHIOCARBAMATE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL STRAIN; CELL STRAIN RAW 264 7; CONTROLLED STUDY; CYTOTOXICITY; DETOXIFICATION; DNA FRAGMENTATION; DRUG MECHANISM; FLOW CYTOMETRY; MACROPHAGE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TOXICITY TESTING;

ANIMALS; BIOLOGICAL MARKERS; CELL DEATH; CELL LINE; DRUG INTERACTIONS; GENE EXPRESSION REGULATION; MACROPHAGES; MERCURY; MICE; OXIDATIVE STRESS; PYRROLIDINES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; THIOCARBAMATES;

MAMMALIA; MURINAE;

EID: 84865571732     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.08.006     Document Type: Article

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