Carmustine induces ERK- and JNK-dependent cell death of neuronally-differentiated PC12 cells via generation of reactive oxygen species

Toxicology in Vitro

Volumn 25, Issue 7, 2011, Pages 1359-1365

  An, Jeong Mi ^a   Kim, Seon Sook ^b   Rhie, Jin Hak ^a   Shin, Dong Min ^a   Seo, Su Ryeon ^b   Seo, Jeong Taeg ^a  

^a Yonsei University College of Dentistry   (South Korea)

^b Kangwon National University   (South Korea)

Author keywords

Carmustine; ERK; JNK; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; CARMUSTINE; CASPASE 3; GLUTATHIONE; GLUTATHIONE REDUCTASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CELL STRAIN; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME METABOLISM; NERVE CELL DIFFERENTIATION; NERVE CELL NECROSIS; NEUROTOXICITY; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ACETYLCYSTEINE; ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CARMUSTINE; CASPASE 3; CELL DEATH; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUTATHIONE REDUCTASE; MAP KINASE KINASE 4; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PC12 CELLS; PHOSPHORYLATION; RATS; REACTIVE OXYGEN SPECIES;

EID: 84860394100     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.05.006     Document Type: Article

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