-
1
-
-
0030175348
-
Contribution of the S4 segment to gating charge in the Shaker K+ channel
-
Aggarwal, S.K., and R. MacKinnon. 1996. Contribution of the S4 segment to gating charge in the Shaker K+ channel. Neuron. 16:1169-1177. http://dx.doi.org/10.1016/S0896-6273(00)80143-9
-
(1996)
Neuron
, vol.16
, pp. 1169-1177
-
-
Aggarwal, S.K.1
MacKinnon, R.2
-
2
-
-
0017796425
-
Gating currents and charge movements in excitable membranes
-
Almers, W. 1978. Gating currents and charge movements in excitable membranes. Rev. Physiol. Biochem. Pharmacol. 82:96-190. http://dx.doi.org/10.1007/BFb0030498
-
(1978)
Rev. Physiol. Biochem. Pharmacol.
, vol.82
, pp. 96-190
-
-
Almers, W.1
-
3
-
-
0034971172
-
Integrated allosteric model of voltage gating of HCN channels
-
Altomare, C., A. Bucchi, E. Camatini, M. Baruscotti, C. Viscomi, A. Moroni, and D. DiFrancesco. 2001. Integrated allosteric model of voltage gating of HCN channels. J. Gen. Physiol. 117:519-532. http://dx.doi.org/10.1085/jgp.117.6.519
-
(2001)
J. Gen. Physiol.
, vol.117
, pp. 519-532
-
-
Altomare, C.1
Bucchi, A.2
Camatini, E.3
Baruscotti, M.4
Viscomi, C.5
Moroni, A.6
DiFrancesco, D.7
-
4
-
-
78649475177
-
Molecular mechanism of allosteric modification of voltagedependent sodium channels by local anesthetics
-
Arcisio-Miranda, M., Y. Muroi, S. Chowdhury, and B. Chanda. 2010. Molecular mechanism of allosteric modification of voltagedependent sodium channels by local anesthetics. J. Gen. Physiol. 136:541-554. http://dx.doi.org/10.1085/jgp.201010438
-
(2010)
J. Gen. Physiol.
, vol.136
, pp. 541-554
-
-
Arcisio-Miranda, M.1
Muroi, Y.2
Chowdhury, S.3
Chanda, B.4
-
5
-
-
77951547997
-
An intersubunit interaction between S4-S5 linker and S6 is responsible for the slow off-gating component in Shaker K+ channels
-
Batulan, Z., G.A. Haddad, and R. Blunck. 2010. An intersubunit interaction between S4-S5 linker and S6 is responsible for the slow off-gating component in Shaker K+ channels. J. Biol. Chem. 285:14005-14019. http://dx.doi.org/10.1074/jbc.M109.097717
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 14005-14019
-
-
Batulan, Z.1
Haddad, G.A.2
Blunck, R.3
-
7
-
-
0034017867
-
The voltage sensor in voltage-dependent ion channels
-
Bezanilla, F. 2000. The voltage sensor in voltage-dependent ion channels. Physiol. Rev. 80:555-592.
-
(2000)
Physiol. Rev.
, vol.80
, pp. 555-592
-
-
Bezanilla, F.1
-
8
-
-
79956127921
-
Functional interactions between residues in the S1, S4, and S5 domains of Kv2
-
Bocksteins, E., N. Ottschytsch, J.P. Timmermans, A.J. Labro, and D.J. Snyders. 2011. Functional interactions between residues in the S1, S4, and S5 domains of Kv2.1. Eur. Biophys. J. 40:783-793. http://dx.doi.org/10.1007/s00249-011-0694-3
-
(2011)
1. Eur. Biophys. J.
, vol.40
, pp. 783-793
-
-
Bocksteins, E.1
Ottschytsch, N.2
Timmermans, J.P.3
Labro, A.J.4
Snyders, D.J.5
-
9
-
-
0035949603
-
The S4-S5 linker couples voltage sensing and activation of pacemaker channels
-
Chen, J., J.S. Mitcheson, M. Tristani-Firouzi, M. Lin, and M.C. Sanguinetti. 2001. The S4-S5 linker couples voltage sensing and activation of pacemaker channels. Proc. Natl. Acad. Sci. USA. 98:11277-11282. http://dx.doi.org/10.1073/pnas.201250598
-
(2001)
Proc. Natl. Acad. Sci. USA.
, vol.98
, pp. 11277-11282
-
-
Chen, J.1
Mitcheson, J.S.2
Tristani-Firouzi, M.3
Lin, M.4
Sanguinetti, M.C.5
-
10
-
-
33846647992
-
Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels
-
Chen, S., J. Wang, L. Zhou, M.S. George, and S.A. Siegelbaum. 2007. Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels. J. Gen. Physiol. 129:175-188. http://dx.doi.org/10.1085/jgp.200609585
-
(2007)
J. Gen. Physiol.
, vol.129
, pp. 175-188
-
-
Chen, S.1
Wang, J.2
Zhou, L.3
George, M.S.4
Siegelbaum, S.A.5
-
11
-
-
78650433230
-
Deconstructing thermodynamic parameters of a coupled system from site-specific observables
-
Chowdhury, S., and B. Chanda. 2010. Deconstructing thermodynamic parameters of a coupled system from site-specific observables. Proc. Natl. Acad. Sci. USA. 107:18856-18861. http://dx.doi.org/10.1073/pnas.1003609107
-
(2010)
Proc. Natl. Acad. Sci. USA.
, vol.107
, pp. 18856-18861
-
-
Chowdhury, S.1
Chanda, B.2
-
12
-
-
84855489518
-
Estimating the voltagedependent free energy change of ion channels using the median voltage for activation
-
Chowdhury, S., and B. Chanda. 2012. Estimating the voltagedependent free energy change of ion channels using the median voltage for activation. J. Gen. Physiol. 139:3-17. http://dx.doi.org/10.1085/jgp.201110722
-
(2012)
J. Gen. Physiol.
, vol.139
, pp. 3-17
-
-
Chowdhury, S.1
Chanda, B.2
-
13
-
-
83755207202
-
A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels
-
Clapham, D.E., and C. Miller. 2011. A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels. Proc. Natl. Acad. Sci. USA. 108:19492-19497. http://dx.doi.org/10.1073/pnas.1117485108
-
(2011)
Proc. Natl. Acad. Sci. USA.
, vol.108
, pp. 19492-19497
-
-
Clapham, D.E.1
Miller, C.2
-
14
-
-
0023035967
-
Interdomain motion in liver alcohol dehydrogenase Structural and energetic analysis of the hinge bending mode
-
Colonna-Cesari, F., D. Perahia, M. Karplus, H. Eklund, C.I. Brädén, and O. Tapia. 1986. Interdomain motion in liver alcohol dehydrogenase. Structural and energetic analysis of the hinge bending mode. J. Biol. Chem. 261:15273-15280.
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 15273-15280
-
-
Colonna-Cesari, F.1
Perahia, D.2
Karplus, M.3
Eklund, H.4
Brädén, C.I.5
Tapia, O.6
-
15
-
-
79959655732
-
A multipoint hydrogen-bond network underlying KcsA C-type inactivation
-
Cordero-Morales, J.F., V. Jogini, S. Chakrapani, and E. Perozo. 2011. A multipoint hydrogen-bond network underlying KcsA C-type inactivation. Biophys. J. 100:2387-2393. http://dx.doi.org/10.1016/j.bpj.2011.01.073
-
(2011)
Biophys. J.
, vol.100
, pp. 2387-2393
-
-
Cordero-Morales, J.F.1
Jogini, V.2
Chakrapani, S.3
Perozo, E.4
-
16
-
-
0030968558
-
Allosteric gating of a large conductance Ca-activated K+ channel
-
Cox, D.H., J. Cui, and R.W. Aldrich. 1997. Allosteric gating of a large conductance Ca-activated K+ channel. J. Gen. Physiol. 110:257-281. http://dx.doi.org/10.1085/jgp.110.3.257
-
(1997)
J. Gen. Physiol.
, vol.110
, pp. 257-281
-
-
Cox, D.H.1
Cui, J.2
Aldrich, R.W.3
-
17
-
-
0030998787
-
Intrinsic voltage dependence and Ca2+ regulation of mslo large conductance Ca-activated K+ channels
-
Cui, J., D.H. Cox, and R.W. Aldrich. 1997. Intrinsic voltage dependence and Ca2+ regulation of mslo large conductance Ca-activated K+ channels. J. Gen. Physiol. 109:647-673. http://dx.doi.org/10.1085/jgp.109.5.647
-
(1997)
J. Gen. Physiol.
, vol.109
, pp. 647-673
-
-
Cui, J.1
Cox, D.H.2
Aldrich, R.W.3
-
18
-
-
1842740890
-
Voltage-dependent gating of hyperpolarization-activated, cyclic nucleotide-gated pacemaker channels: molecular coupling between the S4-S5 and C-linkers
-
Decher, N., J. Chen, and M.C. Sanguinetti. 2004. Voltage-dependent gating of hyperpolarization-activated, cyclic nucleotide-gated pacemaker channels: molecular coupling between the S4-S5 and C-linkers. J. Biol. Chem. 279:13859-13865. http://dx.doi.org/10.1074/jbc.M313704200
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 13859-13865
-
-
Decher, N.1
Chen, J.2
Sanguinetti, M.C.3
-
19
-
-
0034688285
-
Blocker protection in the pore of a voltage-gated K+ channel and its structural implications
-
del Camino, D., M. Holmgren, Y. Liu, and G. Yellen. 2000. Blocker protection in the pore of a voltage-gated K+ channel and its structural implications. Nature. 403:321-325. http://dx.doi.org/10.1038/35002099
-
(2000)
Nature
, vol.403
, pp. 321-325
-
-
del Camino, D.1
Holmgren, M.2
Liu, Y.3
Yellen, G.4
-
20
-
-
0032478818
-
The structure of the potassium channel: molecular basis of K+ conduction and selectivity
-
Doyle, D.A., J. Morais Cabral, R.A. Pfuetzner, A. Kuo, J.M. Gulbis, S.L. Cohen, B.T. Chait, and R. MacKinnon. 1998. The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science. 280:69-77. http://dx.doi.org/10.1126/science.280.5360.69
-
(1998)
Science
, vol.280
, pp. 69-77
-
-
Doyle, D.A.1
Morais Cabral, J.2
Pfuetzner, R.A.3
Kuo, A.4
Gulbis, J.M.5
Cohen, S.L.6
Chait, B.T.7
MacKinnon, R.8
-
21
-
-
33744951682
-
The S4-S5 linker directly couples voltage sensor movement to the activation gate in the human ether-a'-go-go-related gene (hERG) K+ channel
-
Ferrer, T., J. Rupp, D.R. Piper, and M. Tristani-Firouzi. 2006. The S4-S5 linker directly couples voltage sensor movement to the activation gate in the human ether-a'-go-go-related gene (hERG) K+ channel. J. Biol. Chem. 281:12858-12864. http://dx.doi.org/10.1074/jbc.M513518200
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 12858-12864
-
-
Ferrer, T.1
Rupp, J.2
Piper, D.R.3
Tristani-Firouzi, M.4
-
22
-
-
84859963646
-
Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals
-
Gonzalez-Gutierrez, G., T. Lukk, V. Agarwal, D. Papke, S.K. Nair, and C. Grosman. 2012. Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals. Proc. Natl. Acad. Sci. USA. 109:6331-6336. http://dx.doi.org/10.1073/pnas.1119268109
-
(2012)
Proc. Natl. Acad. Sci. USA.
, vol.109
, pp. 6331-6336
-
-
Gonzalez-Gutierrez, G.1
Lukk, T.2
Agarwal, V.3
Papke, D.4
Nair, S.K.5
Grosman, C.6
-
23
-
-
0036016539
-
Scanning the intracellular S6 activation gate in the shaker K+ channel
-
Hackos, D.H., T.H. Chang, and K.J. Swartz. 2002. Scanning the intracellular S6 activation gate in the shaker K+ channel. J. Gen. Physiol. 119:521-532. http://dx.doi.org/10.1085/jgp.20028569
-
(2002)
J. Gen. Physiol.
, vol.119
, pp. 521-532
-
-
Hackos, D.H.1
Chang, T.H.2
Swartz, K.J.3
-
24
-
-
79956125732
-
Mode shift of the voltage sensors in Shaker K+ channels is caused by energetic coupling to the pore domain
-
Haddad, G.A., and R. Blunck. 2011. Mode shift of the voltage sensors in Shaker K+ channels is caused by energetic coupling to the pore domain. J. Gen. Physiol. 137:455-472. http://dx.doi.org/10.1085/jgp.201010573
-
(2011)
J. Gen. Physiol.
, vol.137
, pp. 455-472
-
-
Haddad, G.A.1
Blunck, R.2
-
25
-
-
0028267224
-
Mutations in the K+ channel signature sequence
-
Heginbotham, L., Z. Lu, T. Abramson, and R. MacKinnon. 1994. Mutations in the K+ channel signature sequence. Biophys. J. 66: 1061-1067. http://dx.doi.org/10.1016/S0006-3495(94)80887-2
-
(1994)
Biophys. J.
, vol.66
, pp. 1061-1067
-
-
Heginbotham, L.1
Lu, Z.2
Abramson, T.3
MacKinnon, R.4
-
27
-
-
0029610155
-
Transfer of twelve charges is needed to open skeletal muscle Na+ channels
-
Hirschberg, B., A. Rovner, M. Lieberman, and J. Patlak. 1995. Transfer of twelve charges is needed to open skeletal muscle Na+ channels. J. Gen. Physiol. 106:1053-1068. http://dx.doi.org/10.1085/jgp.106.6.1053
-
(1995)
J. Gen. Physiol.
, vol.106
, pp. 1053-1068
-
-
Hirschberg, B.1
Rovner, A.2
Lieberman, M.3
Patlak, J.4
-
28
-
-
0025126043
-
Strategy for analysing the cooperativity of intramolecular interactions in peptides and proteins
-
Horovitz, A., and A.R. Fersht. 1990. Strategy for analysing the cooperativity of intramolecular interactions in peptides and proteins. J. Mol. Biol. 214:613-617. http://dx.doi.org/10.1016/0022-2836(90)90275-Q
-
(1990)
J. Mol. Biol.
, vol.214
, pp. 613-617
-
-
Horovitz, A.1
Fersht, A.R.2
-
29
-
-
0032771042
-
Allosteric voltage gating of potassium channels II Mslo channel gating charge movement in the absence of Ca(2+)
-
Horrigan, F.T., and R.W. Aldrich. 1999. Allosteric voltage gating of potassium channels II. Mslo channel gating charge movement in the absence of Ca(2+). J. Gen. Physiol. 114:305-336. http://dx.doi.org/10.1085/jgp.114.2.305
-
(1999)
J. Gen. Physiol.
, vol.114
, pp. 305-336
-
-
Horrigan, F.T.1
Aldrich, R.W.2
-
30
-
-
0036714915
-
Coupling between voltage sensor activation Ca2+ binding and channel opening in large conductance (BK) potassium channels
-
Horrigan, F.T., and R.W. Aldrich. 2002. Coupling between voltage sensor activation, Ca2+ binding and channel opening in large conductance (BK) potassium channels. J. Gen. Physiol. 120:267-305. http://dx.doi.org/10.1085/jgp.20028605
-
(2002)
J. Gen. Physiol.
, vol.120
, pp. 267-305
-
-
Horrigan, F.T.1
Aldrich, R.W.2
-
31
-
-
0032811552
-
Allosteric voltage gating of potassium channels I Mslo ionic currents in the absence of Ca(2+)
-
Horrigan, F.T., J. Cui, and R.W. Aldrich. 1999. Allosteric voltage gating of potassium channels I. Mslo ionic currents in the absence of Ca(2+). J. Gen. Physiol. 114:277-304. http://dx.doi.org/10.1085/jgp.114.2.277
-
(1999)
J. Gen. Physiol.
, vol.114
, pp. 277-304
-
-
Horrigan, F.T.1
Cui, J.2
Aldrich, R.W.3
-
32
-
-
0032693966
-
Voltage sensitivity and gating charge in Shaker and Shab family potassium channels
-
Islas, L.D., and F.J. Sigworth. 1999. Voltage sensitivity and gating charge in Shaker and Shab family potassium channels. J. Gen. Physiol. 114:723-742. http://dx.doi.org/10.1085/jgp.114.5.723
-
(1999)
J. Gen. Physiol.
, vol.114
, pp. 723-742
-
-
Islas, L.D.1
Sigworth, F.J.2
-
33
-
-
5144223114
-
Stabilizing the closed S6 gate in the Shaker Kv channel through modification of a hydrophobic seal
-
Kitaguchi, T., M. Sukhareva, and K.J. Swartz. 2004. Stabilizing the closed S6 gate in the Shaker Kv channel through modification of a hydrophobic seal. J. Gen. Physiol. 124:319-332. http://dx.doi.org/10.1085/jgp.200409098
-
(2004)
J. Gen. Physiol.
, vol.124
, pp. 319-332
-
-
Kitaguchi, T.1
Sukhareva, M.2
Swartz, K.J.3
-
34
-
-
77951278810
-
Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP
-
Kohout, S.C., S.C. Bell, L. Liu, Q. Xu, D.L. Minor Jr., and E.Y. Isacoff. 2010. Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP. Nat. Chem. Biol. 6:369-375. http://dx.doi.org/10.1038/nchembio.349
-
(2010)
Nat. Chem. Biol.
, vol.6
, pp. 369-375
-
-
Kohout, S.C.1
Bell, S.C.2
Liu, L.3
Xu, Q.4
Minor Jr., D.L.5
Isacoff, E.Y.6
-
35
-
-
0032614825
-
Folding funnels and conformational transitions via hinge-bending motions
-
Kumar, S., B. Ma, C.J. Tsai, H. Wolfson, and R. Nussinov. 1999. Folding funnels and conformational transitions via hinge-bending motions. Cell Biochem. Biophys. 31:141-164. http://dx.doi.org/10.1007/BF02738169
-
(1999)
Cell Biochem. Biophys.
, vol.31
, pp. 141-164
-
-
Kumar, S.1
Ma, B.2
Tsai, C.J.3
Wolfson, H.4
Nussinov, R.5
-
36
-
-
77954483652
-
Interdependence of receptor activation and ligand binding in HCN2 pacemaker channels
-
Kusch, J., C. Biskup, S. Thon, E. Schulz, V. Nache, T. Zimmer, F. Schwede, and K. Benndorf. 2010. Interdependence of receptor activation and ligand binding in HCN2 pacemaker channels. Neuron. 67:75-85. http://dx.doi.org/10.1016/j.neuron.2010.05.022
-
(2010)
Neuron
, vol.67
, pp. 75-85
-
-
Kusch, J.1
Biskup, C.2
Thon, S.3
Schulz, E.4
Nache, V.5
Zimmer, T.6
Schwede, F.7
Benndorf, K.8
-
37
-
-
59649096789
-
Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by noninteracting residues
-
Labro, A.J., A.L. Raes, A. Grottesi, D. Van Hoorick, M.S. Sansom, and D.J. Snyders. 2008. Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by noninteracting residues. J. Gen. Physiol. 132:667-680. http://dx.doi.org/10.1085/jgp.200810048
-
(2008)
J. Gen. Physiol.
, vol.132
, pp. 667-680
-
-
Labro, A.J.1
Raes, A.L.2
Grottesi, A.3
Van Hoorick, D.4
Sansom, M.S.5
Snyders, D.J.6
-
38
-
-
78650959213
-
The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure
-
Labro, A.J., I.R. Boulet, F.S. Choveau, E. Mayeur, T. Bruyns, G. Loussouarn, A.L. Raes, and D.J. Snyders. 2011. The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure. J. Biol. Chem. 286:717-725. http://dx.doi.org/10.1074/jbc.M110.146977
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 717-725
-
-
Labro, A.J.1
Boulet, I.R.2
Choveau, F.S.3
Mayeur, E.4
Bruyns, T.5
Loussouarn, G.6
Raes, A.L.7
Snyders, D.J.8
-
39
-
-
0032894433
-
Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation
-
Ledwell, J.L., and R.W. Aldrich. 1999. Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation. J. Gen. Physiol. 113:389-414. http://dx.doi.org/10.1085/jgp.113.3.389
-
(1999)
J. Gen. Physiol.
, vol.113
, pp. 389-414
-
-
Ledwell, J.L.1
Aldrich, R.W.2
-
40
-
-
66149157329
-
Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels
-
Lee, S.Y., A. Banerjee, and R. MacKinnon. 2009. Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels. PLoS Biol. 7:e47. http://dx.doi.org/10.1371/journal.pbio.1000047
-
(2009)
PLoS Biol
, vol.7
-
-
Lee, S.Y.1
Banerjee, A.2
MacKinnon, R.3
-
42
-
-
0030795112
-
Gated access to the pore of a voltage-dependent K+ channel
-
Liu, Y., M. Holmgren, M.E. Jurman, and G. Yellen. 1997. Gated access to the pore of a voltage-dependent K+ channel. Neuron. 19:175-184. http://dx.doi.org/10.1016/S0896-6273(00)80357-8
-
(1997)
Neuron
, vol.19
, pp. 175-184
-
-
Liu, Y.1
Holmgren, M.2
Jurman, M.E.3
Yellen, G.4
-
43
-
-
23244456428
-
Crystal structure of a mammalian voltage-dependent Shaker family K+ channel
-
Long, S.B., E.B. Campbell, and R. Mackinnon. 2005a. Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science. 309:897-903. http://dx.doi.org/10.1126/science.1116269
-
(2005)
Science
, vol.309
, pp. 897-903
-
-
Long, S.B.1
Campbell, E.B.2
Mackinnon, R.3
-
44
-
-
23244441222
-
Voltage sensor of Kv1 2: structural basis of electromechanical coupling
-
Long, S.B., E.B. Campbell, and R. Mackinnon. 2005b. Voltage sensor of Kv1.2: structural basis of electromechanical coupling. Science. 309:903-908. http://dx.doi.org/10.1126/science.1116270
-
(2005)
Science
, vol.309
, pp. 903-908
-
-
Long, S.B.1
Campbell, E.B.2
Mackinnon, R.3
-
45
-
-
36248982122
-
Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment
-
Long, S.B., X. Tao, E.B. Campbell, and R. MacKinnon. 2007. Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature. 450:376-382. http://dx.doi.org/10.1038/nature06265
-
(2007)
Nature
, vol.450
, pp. 376-382
-
-
Long, S.B.1
Tao, X.2
Campbell, E.B.3
MacKinnon, R.4
-
46
-
-
0036846783
-
Coupling between voltage sensors and activation gate in voltage-gated K+ channels
-
Lu, Z., A.M. Klem, and Y. Ramu. 2002. Coupling between voltage sensors and activation gate in voltage-gated K+ channels. J. Gen. Physiol. 120:663-676. http://dx.doi.org/10.1085/jgp.20028696
-
(2002)
J. Gen. Physiol.
, vol.120
, pp. 663-676
-
-
Lu, Z.1
Klem, A.M.2
Ramu, Y.3
-
47
-
-
33644610046
-
Role of charged residues in the S1-S4 voltage sensor of BK channels
-
Ma, Z., X.J. Lou, and F.T. Horrigan. 2006. Role of charged residues in the S1-S4 voltage sensor of BK channels. J. Gen. Physiol. 127:309-328. http://dx.doi.org/10.1085/jgp.200509421
-
(2006)
J. Gen. Physiol.
, vol.127
, pp. 309-328
-
-
Ma, Z.1
Lou, X.J.2
Horrigan, F.T.3
-
48
-
-
0025818388
-
A role for hydrophobic residues in the voltage-dependent gating of Shaker K+ channels
-
McCormack, K., M.A. Tanouye, L.E. Iverson, J.W. Lin, M. Ramaswami, T. McCormack, J.T. Campanelli, M.K. Mathew, and B. Rudy. 1991. A role for hydrophobic residues in the voltage-dependent gating of Shaker K+ channels. Proc. Natl. Acad. Sci. USA. 88:2931-2935. http://dx.doi.org/10.1073/pnas.88.7.2931
-
(1991)
Proc. Natl. Acad. Sci. USA.
, vol.88
, pp. 2931-2935
-
-
McCormack, K.1
Tanouye, M.A.2
Iverson, L.E.3
Lin, J.W.4
Ramaswami, M.5
McCormack, T.6
Campanelli, J.T.7
Mathew, M.K.8
Rudy, B.9
-
49
-
-
0027381085
-
Substitution of a hydrophobic residue alters the conformational stability of Shaker K+ channels during gating and assembly
-
McCormack, K., L. Lin, and F.J. Sigworth. 1993. Substitution of a hydrophobic residue alters the conformational stability of Shaker K+ channels during gating and assembly. Biophys. J. 65:1740-1748. http://dx.doi.org/10.1016/S0006-3495(93)81202-5
-
(1993)
Biophys. J.
, vol.65
, pp. 1740-1748
-
-
McCormack, K.1
Lin, L.2
Sigworth, F.J.3
-
50
-
-
76349097096
-
Molecular determinants of coupling between the domain III voltage sensor and pore of a sodium channel
-
Muroi, Y., M. Arcisio-Miranda, S. Chowdhury, and B. Chanda. 2010. Molecular determinants of coupling between the domain III voltage sensor and pore of a sodium channel. Nat. Struct. Mol. Biol. 17:230-237. http://dx.doi.org/10.1038/nsmb.1749
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 230-237
-
-
Muroi, Y.1
Arcisio-Miranda, M.2
Chowdhury, S.3
Chanda, B.4
-
51
-
-
78651087721
-
KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate
-
Osteen, J.D., C. Gonzalez, K.J. Sampson, V. Iyer, S. Rebolledo, H.P. Larsson, and R.S. Kass. 2010. KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate. Proc. Natl. Acad. Sci. USA. 107:22710-22715. http://dx.doi.org/10.1073/pnas.1016300108
-
(2010)
Proc. Natl. Acad. Sci. USA.
, vol.107
, pp. 22710-22715
-
-
Osteen, J.D.1
Gonzalez, C.2
Sampson, K.J.3
Iyer, V.4
Rebolledo, S.5
Larsson, H.P.6
Kass, R.S.7
-
52
-
-
84860802371
-
Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels
-
Osteen, J.D., R. Barro-Soria, S. Robey, K.J. Sampson, R.S. Kass, and H.P. Larsson. 2012. Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels. Proc. Natl. Acad. Sci. USA. 109:7103-7108. http://dx.doi.org/10.1073/pnas.1201582109
-
(2012)
Proc. Natl. Acad. Sci. USA.
, vol.109
, pp. 7103-7108
-
-
Osteen, J.D.1
Barro-Soria, R.2
Robey, S.3
Sampson, K.J.4
Kass, R.S.5
Larsson, H.P.6
-
53
-
-
33846627734
-
Molecular properties of Kcv, a virus encoded K+ channel
-
Pagliuca, C., T.A. Goetze, R. Wagner, G. Thiel, A. Moroni, and D. Parcej. 2007. Molecular properties of Kcv, a virus encoded K+ channel. Biochemistry. 46:1079-1090. http://dx.doi.org/10.1021/bi061530w
-
(2007)
Biochemistry
, vol.46
, pp. 1079-1090
-
-
Pagliuca, C.1
Goetze, T.A.2
Wagner, R.3
Thiel, G.4
Moroni, A.5
Parcej, D.6
-
54
-
-
79960621367
-
The crystal structure of a voltage-gated sodium channel
-
Payandeh, J., T. Scheuer, N. Zheng, and W.A. Catterall. 2011. The crystal structure of a voltage-gated sodium channel. Nature. 475:353-358. http://dx.doi.org/10.1038/nature10238
-
(2011)
Nature
, vol.475
, pp. 353-358
-
-
Payandeh, J.1
Scheuer, T.2
Zheng, N.3
Catterall, W.A.4
-
55
-
-
84870776387
-
Charge movement in gating-locked HCN channels reveals weak coupling of voltage sensors and gate
-
Ryu, S., and G. Yellen. 2012. Charge movement in gating-locked HCN channels reveals weak coupling of voltage sensors and gate. J. Gen. Physiol. 140:469-479. http://dx.doi.org/10.1085/jgp.201210850
-
(2012)
J. Gen. Physiol.
, vol.140
, pp. 469-479
-
-
Ryu, S.1
Yellen, G.2
-
56
-
-
0033082093
-
Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes
-
Sanguinetti, M.C., and Q.P. Xu. 1999. Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes. J. Physiol. 514:667-675. http://dx.doi.org/10.1111/j.1469-7793.1999.667ad.x
-
(1999)
J. Physiol.
, vol.514
, pp. 667-675
-
-
Sanguinetti, M.C.1
Xu, Q.P.2
-
57
-
-
59649113542
-
Molecular template for a voltage sensor in a novel K+ channel III. Functional reconstitution of a sensorless pore module from a prokaryotic Kv channel
-
Santos, J.S., S.M. Grigoriev, and M. Montal. 2008. Molecular template for a voltage sensor in a novel K+ channel. III. Functional reconstitution of a sensorless pore module from a prokaryotic Kv channel. J. Gen. Physiol. 132:651-666. http://dx.doi.org/10.1085/jgp.200810077
-
(2008)
J. Gen. Physiol.
, vol.132
, pp. 651-666
-
-
Santos, J.S.1
Grigoriev, S.M.2
Montal, M.3
-
58
-
-
0026594721
-
The size of gating charge in wild-type and mutant Shaker potassium channels
-
Schoppa, N.E., K. McCormack, M.A. Tanouye, and F.J. Sigworth. 1992. The size of gating charge in wild-type and mutant Shaker potassium channels. Science. 255:1712-1715. http://dx.doi.org/10.1126/science.1553560
-
(1992)
Science
, vol.255
, pp. 1712-1715
-
-
Schoppa, N.E.1
McCormack, K.2
Tanouye, M.A.3
Sigworth, F.J.4
-
59
-
-
0028841033
-
A prokaryotic potassium ion channel with two predicted transmembrane segments from Streptomyces lividans
-
Schrempf, H., O. Schmidt, R. Kümmerlen, S. Hinnah, D. Müller, M. Betzler, T. Steinkamp, and R. Wagner. 1995. A prokaryotic potassium ion channel with two predicted transmembrane segments from Streptomyces lividans. EMBO J. 14:5170-5178.
-
(1995)
EMBO J
, vol.14
, pp. 5170-5178
-
-
Schrempf, H.1
Schmidt, O.2
Kümmerlen, R.3
Hinnah, S.4
Müller, D.5
Betzler, M.6
Steinkamp, T.7
Wagner, R.8
-
60
-
-
0030175867
-
Voltage-sensing residues in the S2 and S4 segments of the Shaker K+ channel
-
Seoh, S.A., D. Sigg, D.M. Papazian, and F. Bezanilla. 1996. Voltage-sensing residues in the S2 and S4 segments of the Shaker K+ channel. Neuron. 16:1159-1167. http://dx.doi.org/10.1016/S0896-6273(00)80142-7
-
(1996)
Neuron
, vol.16
, pp. 1159-1167
-
-
Seoh, S.A.1
Sigg, D.2
Papazian, D.M.3
Bezanilla, F.4
-
61
-
-
0026493924
-
Crystallographic evidence of a large ligand-induced hinge-twist motion between the two domains of the maltodextrin binding protein involved in active transport and chemotaxis
-
Sharff, A.J., L.E. Rodseth, J.C. Spurlino, and F.A. Quiocho. 1992. Crystallographic evidence of a large ligand-induced hinge-twist motion between the two domains of the maltodextrin binding protein involved in active transport and chemotaxis. Biochemistry. 31:10657-10663. http://dx.doi.org/10.1021/bi00159a003
-
(1992)
Biochemistry
, vol.31
, pp. 10657-10663
-
-
Sharff, A.J.1
Rodseth, L.E.2
Spurlino, J.C.3
Quiocho, F.A.4
-
62
-
-
79961050460
-
Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins
-
Shaya, D., M. Kreir, R.A. Robbins, S. Wong, J. Hammon, A. Brüggemann, and D.L. Minor Jr. 2011. Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins. Proc. Natl. Acad. Sci. USA. 108:12313-12318. http://dx.doi.org/10.1073/pnas.1106811108
-
(2011)
Proc. Natl. Acad. Sci. USA.
, vol.108
, pp. 12313-12318
-
-
Shaya, D.1
Kreir, M.2
Robbins, R.A.3
Wong, S.4
Hammon, J.5
Brüggemann, A.6
Minor Jr., D.L.7
-
63
-
-
0031015351
-
Total charge movement per channel The relation between gating charge displacement and the voltage sensitivity of activation
-
Sigg, D., and F. Bezanilla. 1997. Total charge movement per channel. The relation between gating charge displacement and the voltage sensitivity of activation. J. Gen. Physiol. 109:27-39. http://dx.doi.org/10.1085/jgp.109.1.27
-
(1997)
J. Gen. Physiol.
, vol.109
, pp. 27-39
-
-
Sigg, D.1
Bezanilla, F.2
-
64
-
-
0031905513
-
Role of the S4 in cooperativity of voltage-dependent potassium channel activation
-
Smith-Maxwell, C.J., J.L. Ledwell, and R.W. Aldrich. 1998a. Role of the S4 in cooperativity of voltage-dependent potassium channel activation. J. Gen. Physiol. 111:399-420. http://dx.doi.org/10.1085/jgp.111.3.399
-
(1998)
J. Gen. Physiol.
, vol.111
, pp. 399-420
-
-
Smith-Maxwell, C.J.1
Ledwell, J.L.2
Aldrich, R.W.3
-
65
-
-
0031929388
-
Uncharged S4 residues and cooperativity in voltage-dependent potassium channel activation
-
Smith-Maxwell, C.J., J.L. Ledwell, and R.W. Aldrich. 1998b. Uncharged S4 residues and cooperativity in voltage-dependent potassium channel activation. J. Gen. Physiol. 111:421-439. http://dx.doi.org/10.1085/jgp.111.3.421
-
(1998)
J. Gen. Physiol.
, vol.111
, pp. 421-439
-
-
Smith-Maxwell, C.J.1
Ledwell, J.L.2
Aldrich, R.W.3
-
66
-
-
33750975638
-
Functional interactions at the interface between voltage-sensing and pore domains in the Shaker K(v) channel
-
Soler-Llavina, G.J., T.H. Chang, and K.J. Swartz. 2006. Functional interactions at the interface between voltage-sensing and pore domains in the Shaker K(v) channel. Neuron. 52:623-634. http://dx.doi.org/10.1016/j.neuron.2006.10.005
-
(2006)
Neuron
, vol.52
, pp. 623-634
-
-
Soler-Llavina, G.J.1
Chang, T.H.2
Swartz, K.J.3
-
67
-
-
0242498592
-
Constitutive activation of the Shaker Kv channel
-
Sukhareva, M., D.H. Hackos, and K.J. Swartz. 2003. Constitutive activation of the Shaker Kv channel. J. Gen. Physiol. 122:541-556. http://dx.doi.org/10.1085/jgp.200308905
-
(2003)
J. Gen. Physiol.
, vol.122
, pp. 541-556
-
-
Sukhareva, M.1
Hackos, D.H.2
Swartz, K.J.3
-
68
-
-
57749196006
-
Sensing voltage across lipid membranes
-
Swartz, K.J. 2008. Sensing voltage across lipid membranes. Nature. 456:891-897. http://dx.doi.org/10.1038/nature07620
-
(2008)
Nature
, vol.456
, pp. 891-897
-
-
Swartz, K.J.1
-
69
-
-
44349157807
-
Molecular mechanism of pH sensing in KcsA potassium channels
-
Thompson, A.N., D.J. Posson, P.V. Parsa, and C.M. Nimigean. 2008. Molecular mechanism of pH sensing in KcsA potassium channels. Proc. Natl. Acad. Sci. USA. 105:6900-6905. http://dx.doi.org/10.1073/pnas.0800873105
-
(2008)
Proc. Natl. Acad. Sci. USA.
, vol.105
, pp. 6900-6905
-
-
Thompson, A.N.1
Posson, D.J.2
Parsa, P.V.3
Nimigean, C.M.4
-
70
-
-
0037166248
-
Interactions between S4-S5 linker and S6 transmembrane domain modulate gating of HERG K+ channels
-
Tristani-Firouzi, M., J. Chen, and M.C. Sanguinetti. 2002. Interactions between S4-S5 linker and S6 transmembrane domain modulate gating of HERG K+ channels. J. Biol. Chem. 277:18994-19000. http://dx.doi.org/10.1074/jbc.M200410200
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 18994-19000
-
-
Tristani-Firouzi, M.1
Chen, J.2
Sanguinetti, M.C.3
-
71
-
-
79961067787
-
Mechanism of activation gating in the full-length KcsA K+ channel
-
Uysal, S., L.G. Cuello, D.M. Cortes, S. Koide, A.A. Kossiakoff, and E. Perozo. 2011. Mechanism of activation gating in the full-length KcsA K+ channel. Proc. Natl. Acad. Sci. USA. 108:11896-11899. http://dx.doi.org/10.1073/pnas.1105112108
-
(2011)
Proc. Natl. Acad. Sci. USA.
, vol.108
, pp. 11896-11899
-
-
Uysal, S.1
Cuello, L.G.2
Cortes, D.M.3
Koide, S.4
Kossiakoff, A.A.5
Perozo, E.6
-
72
-
-
78349240756
-
Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels
-
Van Slyke, A.C., S. Rezazadeh, M. Snopkowski, P. Shi, C.R. Allard, and T.W. Claydon. 2010. Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels. Biophys. J. 99:2841-2852. http://dx.doi.org/10.1016/j.bpj.2010.08.030
-
(2010)
Biophys. J.
, vol.99
, pp. 2841-2852
-
-
Van Slyke, A.C.1
Rezazadeh, S.2
Snopkowski, M.3
Shi, P.4
Allard, C.R.5
Claydon, T.W.6
-
73
-
-
79961017278
-
Double mutant cycle analysis identified a critical leucine residue in the IIS4S5 linker for the activation of the Ca(V)2 3 calcium channel
-
Wall-Lacelle, S., M.I. Hossain, R. Sauvé, R. Blunck, and L. Parent. 2011. Double mutant cycle analysis identified a critical leucine residue in the IIS4S5 linker for the activation of the Ca(V)2.3 calcium channel. J. Biol. Chem. 286:27197-27205. http://dx.doi.org/10.1074/jbc.M111.237412
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 27197-27205
-
-
Wall-Lacelle, S.1
Hossain, M.I.2
Sauvé, R.3
Blunck, R.4
Parent, L.5
-
74
-
-
0000977357
-
Allosteric linkage
-
Wyman, J. 1967. Allosteric linkage. J. Am. Chem. Soc. 89:2202-2218. http://dx.doi.org/10.1021/ja00985a037
-
(1967)
J. Am. Chem. Soc.
, vol.89
, pp. 2202-2218
-
-
Wyman, J.1
-
75
-
-
0037131520
-
Energetics of pore opening in a voltage-gated K(+) channel
-
Yifrach, O., and R. MacKinnon. 2002. Energetics of pore opening in a voltage-gated K(+) channel. Cell. 111:231-239. http://dx.doi.org/10.1016/S0092-8674(02)01013-9
-
(2002)
Cell
, vol.111
, pp. 231-239
-
-
Yifrach, O.1
MacKinnon, R.2
-
76
-
-
4143078013
-
Hill coefficient for estimating the magnitude of cooperativity in gating transitions of voltage-dependent ion channels
-
Yifrach, O. 2004. Hill coefficient for estimating the magnitude of cooperativity in gating transitions of voltage-dependent ion channels. Biophys. J. 87:822-830. http://dx.doi.org/10.1529/biophysj.104.040410
-
(2004)
Biophys. J.
, vol.87
, pp. 822-830
-
-
Yifrach, O.1
-
77
-
-
77957220001
-
Examining cooperative gating phenomena in voltage-dependent potassium channels: taking the energetic approach
-
Yifrach, O., N. Zandany, and T. Shem-Ad. 2009. Examining cooperative gating phenomena in voltage-dependent potassium channels: taking the energetic approach. Methods Enzymol. 466:179-209. http://dx.doi.org/10.1016/S0076-6879(09)66008-0
-
(2009)
Methods Enzymol
, vol.466
, pp. 179-209
-
-
Yifrach, O.1
Zandany, N.2
Shem-Ad, T.3
|