Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 18, 2012, Pages 7103-7108

  Osteen, Jeremiah D ^a,c   Barro Soria, Rene ^b   Robey, Seth ^a   Sampson, Kevin J ^a   Kass, Robert S ^a   Larsson, H Peter ^b  

^a Columbia University ^*  (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Allosteric model; Cardiac; Fluorescence; IKs potassium channel; KCNE1

Indexed keywords

POTASSIUM CHANNEL KCNQ1;

ALLOSTERISM; ANIMAL CELL; ARTICLE; DEPOLARIZATION; ELECTRIC POTENTIAL; FLUOROMETRY; HUMAN; HYPERPOLARIZATION; NONHUMAN; PHASE TRANSITION; POINT MUTATION; PRIORITY JOURNAL; SENSOR; VOLTAGE CLAMP FLUOROMETRY;

ALLOSTERIC SITE; AMINO ACID SUBSTITUTION; ANIMALS; FEMALE; HUMANS; ION CHANNEL GATING; KCNQ1 POTASSIUM CHANNEL; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN MULTIMERIZATION; RECOMBINANT PROTEINS; XENOPUS LAEVIS;

EID: 84860802371     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1201582109     Document Type: Article

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