Uncharged S4 residues and cooperativity in voltage-dependent potassium channel activation

Journal of General Physiology

Volumn 111, Issue 3, 1998, Pages 421-439

  Smith Maxwell, Catherine J ^a   Ledwell, Jennifer L ^a   Aldrich, Richard W ^a,b,c  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Gating; Ion channel; Patch clamp; Shaker

Indexed keywords

ION CHANNEL; POTASSIUM CHANNEL;

AMINO ACID SUBSTITUTION; ARTICLE; CHEMICAL REACTION; CONFORMATIONAL TRANSITION; ELECTROPHYSIOLOGY; ION CURRENT; MOLECULAR INTERACTION; NONHUMAN; PATCH CLAMP; RESIDUE ANALYSIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ELECTRIC STIMULATION; ION CHANNEL GATING; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; XENOPUS LAEVIS;

EID: 0031929388     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.111.3.421     Document Type: Article

References (47)

1. + channel. Neuron. 16:1169-1177.
2. Almers, W. 1978. Gating currents and charge movements in excitable membranes. Rev. Physiol. Biochem. Pharmacol. 82:96-190.
3. + channels: II. The components of gating currents and a model of channel activation. Biophys. J. 66:1011-1021.
4. Butler, A., A. Wei, K. Baker, and L. Salkoff. 1989. A family of putative potassium channel genes in Drosophila. Science. 243:943-947.
5. + channels. In Handbook of Receptors and Channels. Ligand-and Voltage-Gated Ion Channels. R.A. North, editor. CRC Press, Boca Raton, FL. 1-71.
6. Creighton, T.E. 1993. Proteins. Structures and Molecular Properties. 2nd ed. W.H. Freeman and Co., New York. 507 pp.
7. Eriksson, A.E., W.A. Baase, and B.W. Mathews. 1993. Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences. J. Mol. Biol. 229:747-769.
8. Eriksson, A.E., W.A. Baase, X.J. Zhang, D.W. Heinz, M. Blaber, E.P. Baldwin, and B.W. Matthews. 1992. Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect. Science. 255:178-183.
9. Hamill, O.P., A. Marty, B. Neher, B. Sakmann, and F.J. Sigworth. 1981. Improved patch clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Archiv. 391:85-100.
10. Hurst, R.S., M.P. Kavanaugh, J. Yakel, J.P. Adelman, and R.A. North. 1992. Cooperative interactions among subunits of a voltage-dependent potassium channel. J. Biol. Chem. 267:23742-23745.
11. Hurst, R.S., R.A. North, and J.P. Adelman. 1995. Potassium channel assembly from concatenated subunits: effects of proline substitutions in S4 segments. Receptors Channels. 3:263-272.
12. + channel S4. Neuron. 16:387-397.
13. Ledwell, J.L., C. Smith-Maxwell, and R.W. Aldrich. 1997. Conservative substitutions at noncharged residues in S4 that slow a cooperative transition in the activation pathway greatly alter voltage-dependence of gating. Biophys. J. 72:A341. (Abstr.)
14. + channel. Nature. 353:752-756.
15. + channels are due to the specific charge content of their respective S4 regions. Neuron. 10:1121-1129.
16. + channel result in corresponding decreases in gating charge. Neuron. 8:531-540.
17. + channels. Neuron. 7:327-336.
18. Mannuzzu, L.M., M.M. Moronne, and E.Y. Isacoff. 1996. Direct physical measure of conformational rearrangement underlying potassium channel gating. Science. 271:213-216.
19. + channels. Neuron. 12:301-315.
20. + channels during gating and assembly. Biophys. J. 65:1740-1748.
21. + channels. Proc. Natl. Acad. Sci. USA. 88:2931-2935.
22. + channel. Neuron. 14:1293-1301.
23. Papazian, D.M., L.C. Timpe, Y.N. Jan, and L.Y. Jan. 1991. Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence. Nature. 349:305-310.
24. + channel selectively modulates channel gating. Proc. Natl. Acad. Sci. USA. 92:9422-9426.
25. + channels. Neuron. 11:353-358.
26. Perozo, E., L. Santacruz-Toloza, E. Stefani, F. Bezanilla, and D.M. Papazian. 1994. S4 mutations alter gating currents of Shaker K channels. Biophys. J. 66:345-354.
27. Richardson, J.S., and D.C. Richardson. 1989. Principles and patterns of protein conformation. In Prediction of Protein Structure and the Principles of Protein Conformation. G.D. Fasman, editor. Plenum Publishing Corp., New York. 1-98.
28. Sanger, F., S. Nicklen, and A.R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA. 74: 5463-5467.
29. Schoppa, N.E., K. McCormack, M.A. Tanouye, and F.J. Sigworth. 1992. The size of gating charge in wild-type and mutant Shaker potassium channels. Science. 255:1712-1715.
30. Schwarz, T.L., B.L. Tempel, D.M. Papazian, Y.N. Jan, and L.Y. Jan. 1988. Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila. Nature. 331: 137-142.
31. + channel. Neuron. 16:1159-1167.
32. Sigg, D., and F. Bezanilla. 1997. Total charge movement per channel. The relation between gating charge displacement and the voltage sensitivity of activation. J. Gen. Physiol 109:27-39.
33. Sigworth, F.J. 1993. Voltage gating of ion channels. Q. Rev. Biophys. 27:1-40.
34. Smith-Maxwell, C.J., M. Kanevsky, and R.W. Aldrich. 1993. Potassium channel activation can be slowed by mutations in the S4 and S4-S5 linker regions. Biophys. J. 64:A200. (Abstr.)
35. Smith-Maxwell, C.J., J.L. Ledwell, and R.W. Aldrich. 1998. Role of the S4 in cooperativity of voltage-dependent potassium channel activation. J. Gen. Physiol. 111:399-420.
36. Smith-Maxwell, C.J., R.A. Taylor, and R.W. Aldrich. 1994. Amino acids responsible for slowing activation kinetics in Shaker potassium channel mutants. Soc. Neurosci. Abstr. 20:863. (Abstr.)
37. Starkus, J.G., T. Schlief, M.D. Rayner, and S.H. Heinemann. 1995. Unilateral exposure of Shaker B potassium channels to hyperosmolar solutions. Biophys. J. 69:860-872.
38. Taglialatela, M., L. Toro, and E. Stefani. 1992. Novel voltage clamp to record small, fast currents from ion channels expressed in Xenopus oocytes. Biophys. J. 61:78-82.
39. + channel. J. Gen. Physiol. 109:301-311.
40. Tempel, B.L., D.M. Papazian, T.L. Schwarz, Y.N. Jan, and L.Y. Jan. 1987. Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila. Science. 237:770-775.
41. + channel subunits. Biophys. J. 72:1489-1500.
42. Tytgat, J., and P. Hess. 1992. Evidence for cooperative interactions in potassium channel gating. Nature. 359:420-423.
43. Yang, N., A.L. George, Jr., and R. Horn. 1996. Molecular basis of charge movement in voltage-gated sodium channels. Neuron. 16: 113-122.
44. Yang, N., and R. Horn. 1995. Evidence for voltage-dependent S4 movement in sodium channels. Neuron. 15:213-218.
45. Yusaf, S.P., D. Wray, and A. Sivaprasadarao. 1996. Measurement of the movement of the S4 segment during the activation of a voltage-gated potassium channel. Pflügers Archiv. 433:91-97.
46. Zagotta, W.N., T. Hoshi, and R.W. Aldrich. 1994a. Shaker potassium channel gating III: evaluation of kinetic models for activation. J. Gen. Physiol. 103:321-362.
47. Zagotta, W.N., T. Hoshi, J. Dittman, and R.W. Aldrich. 1994b. Shaker potassium channel gating II: transitions in the activation pathway. J. Gen. Physiol. 103:279-319.