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Volumn , Issue OCT, 2012, Pages

Numb and Alzheimers disease: The current picture

Author keywords

Alzheimers disease; Neurogenesis; Notch signaling; Numb

Indexed keywords

COLLAPSIN RESPONSE MEDIATOR PROTEIN 2; EPHRIN B2; GLYCOGEN SYNTHASE KINASE 3; MEMBRANE PROTEIN; NEUROTROPHIN; NOTCH1 RECEPTOR; NUMB PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN; VOLTAGE GATED CALCIUM CHANNEL;

EID: 84870868801     PISSN: 16624548     EISSN: 1662453X     Source Type: Journal    
DOI: 10.3389/fnins.2012.00145     Document Type: Short Survey
Times cited : (10)

References (84)
  • 2
    • 0032771052 scopus 로고    scopus 로고
    • Notch1 inhibits neurite outgrowth in postmitotic primary neurons
    • Berezovska, O., McLean, P., Knowles, R., Frosh, M., Lu, F. M., Lux, S. E., et al. (1999). Notch1 inhibits neurite outgrowth in postmitotic primary neurons. Neuroscience 93, 433-439.
    • (1999) Neuroscience , vol.93 , pp. 433-439
    • Berezovska, O.1    McLean, P.2    Knowles, R.3    Frosh, M.4    Lu, F.M.5    Lux, S.E.6
  • 3
    • 0031847249 scopus 로고    scopus 로고
    • Notch is expressed in adult brain, is coex-pressed with presenilin-1, and is altered in Alzheimer disease
    • Berezovska, O., Xia, M. Q., and Hyman, B. T. (1998). Notch is expressed in adult brain, is coex-pressed with presenilin-1, and is altered in Alzheimer disease. J. Neu-ropathol. Exp. Neurol. 57, 738-745.
    • (1998) J. Neu-ropathol. Exp. Neurol. , vol.57 , pp. 738-745
    • Berezovska, O.1    Xia, M.Q.2    Hyman, B.T.3
  • 4
    • 38049177209 scopus 로고    scopus 로고
    • Notch regulates cell fate and den-drite morphology of newborn neurons in the postnatal dentate gyrus
    • Breunig, J. J., Silbereis, J., Vaccarino, F. M., Sestan, N., and Rakic, R. (2007). Notch regulates cell fate and den-drite morphology of newborn neurons in the postnatal dentate gyrus. Proc. Natl. Acad. Sci. U.S.A. 104, 20558-20563.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 20558-20563
    • Breunig, J.J.1    Silbereis, J.2    Vaccarino, F.M.3    Sestan, N.4    Rakic, R.5
  • 5
    • 67349183264 scopus 로고    scopus 로고
    • Intracellular trafficking of Notch receptors and ligands
    • Brou, C. (2009). Intracellular trafficking of Notch receptors and ligands. Exp. Cell Res. 315, 1549-1555.
    • (2009) Exp. Cell Res. , vol.315 , pp. 1549-1555
    • Brou, C.1
  • 6
    • 0030836345 scopus 로고    scopus 로고
    • Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathollogic evidence for a mechanism of increased β-amyloidogenesis
    • Cataldo, A. M., Barnett, J. L., Pieroni, C., and Nixon, R. (1997). Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathollogic evidence for a mechanism of increased β-amyloidogenesis. J. Neurosci. 17, 6142-6151.
    • (1997) J. Neurosci. , vol.17 , pp. 6142-6151
    • Cataldo, A.M.1    Barnett, J.L.2    Pieroni, C.3    Nixon, R.4
  • 7
    • 0036363731 scopus 로고    scopus 로고
    • Numb modifies neuronal vulnerability to amyloid beta-peptide in an isoform-specific manner by a mechanism involving altered calcium homeosta-sis: implications for neuronal death in Alzheimer's disease
    • Chan, S. L., Pedersen, W. A., Zhu, H., and Mattson, M. P. (2002). Numb modifies neuronal vulnerability to amyloid beta-peptide in an isoform-specific manner by a mechanism involving altered calcium homeosta-sis: implications for neuronal death in Alzheimer's disease. Neuromolec-ular Med. 1, 55-67.
    • (2002) Neuromolec-ular Med , vol.1 , pp. 55-67
    • Chan, S.L.1    Pedersen, W.A.2    Zhu, H.3    Mattson, M.P.4
  • 8
    • 70350130798 scopus 로고    scopus 로고
    • Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome
    • Chang, K. T., and Min, K. T. (2009). Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome. Proc. Natl. Acad. Sci. U.S.A. 106, 17117-17122.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 17117-17122
    • Chang, K.T.1    Min, K.T.2
  • 9
    • 33644962142 scopus 로고    scopus 로고
    • Visualization of APP dimerization and APP-Notch2 heterodimerization in living cells using bimolecular fluorescence complementation
    • Chen,C.D.,Oh,S.Y., Hinman,J.D.,and Abraham, C. R. (2006). Visualization of APP dimerization and APP-Notch2 heterodimerization in living cells using bimolecular fluorescence complementation. J. Neurochem. 97, 30-43.
    • (2006) J. Neurochem. , vol.97 , pp. 30-43
    • Chen, C.D.1    Oh, S.Y.2    Hinman, J.D.3    Abraham, C.R.4
  • 10
    • 79955039830 scopus 로고    scopus 로고
    • Evidence for altered Numb isoform levels in Alzheimer's disease patients and a triple transgenic mouse model
    • Chigurupati, S., Madan, M., Okun, E., Wei, Z., Pattisapu, J. V., Mughal, M. R., et al. (2011). Evidence for altered Numb isoform levels in Alzheimer's disease patients and a triple transgenic mouse model. J. Alzheimers Dis. 24, 349-361.
    • (2011) J. Alzheimers Dis. , vol.24 , pp. 349-361
    • Chigurupati, S.1    Madan, M.2    Okun, E.3    Wei, Z.4    Pattisapu, J.V.5    Mughal, M.R.6
  • 11
    • 41549155927 scopus 로고    scopus 로고
    • Endocytosis is required for synaptic activity dependent release of amyloid-β in vivo
    • Cirrito, J. R., Kang, J. E., Lee, J., Stewart, F. R., Verges, D. K., Silverio, L. M., et al. (2008). Endocytosis is required for synaptic activity dependent release of amyloid-β in vivo. Neuron 58, 42-51.
    • (2008) Neuron , vol.58 , pp. 42-51
    • Cirrito, J.R.1    Kang, J.E.2    Lee, J.3    Stewart, F.R.4    Verges, D.K.5    Silverio, L.M.6
  • 12
    • 78650970378 scopus 로고    scopus 로고
    • Reversing EphB2 depletion rescues cognitive functions in Alzheimer model
    • Cisse, M., Halabisky, B., Harris, J., Devidze, N., Dubal, D. B., Sun, B., et al. (2011). Reversing EphB2 depletion rescues cognitive functions in Alzheimer model. Nature 469, 47-52.
    • (2011) Nature , vol.469 , pp. 47-52
    • Cisse, M.1    Halabisky, B.2    Harris, J.3    Devidze, N.4    Dubal, D.B.5    Sun, B.6
  • 14
    • 9644276856 scopus 로고    scopus 로고
    • GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons
    • Cole, A. R., Knebel, A., Morrice, N. A., Robertson, L. A., Irving, A. J., Connolly, C. N., et al. (2004). GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons. J. Biol. Chem. 279, 50176-50180.
    • (2004) J. Biol. Chem. , vol.279 , pp. 50176-50180
    • Cole, A.R.1    Knebel, A.2    Morrice, N.A.3    Robertson, L.A.4    Irving, A.J.5    Connolly, C.N.6
  • 15
    • 35248821113 scopus 로고    scopus 로고
    • Collapsin response mediator protein-2 hyper-phosphorylation is an early event in Alzheimer's disease progression
    • Cole, A. R., Noble, W., van Aalten, L., Plattner, F., Meimaridou, R., Hogan, D., et al. (2007). Collapsin response mediator protein-2 hyper-phosphorylation is an early event in Alzheimer's disease progression. J. Neurochem. 103, 1132-1144.
    • (2007) J. Neurochem. , vol.103 , pp. 1132-1144
    • Cole, A.R.1    Noble, W.2    van Aalten, L.3    Plattner, F.4    Meimaridou, R.5    Hogan, D.6
  • 18
    • 33748298775 scopus 로고    scopus 로고
    • Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: structural determinants of numb association with the cortical membrane
    • Dho,S. E., Trejo, J., Siderovski, D. P., and McGlade,C. J. (2006). Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: structural determinants of numb association with the cortical membrane. Mol. Biol. Cell 17, 4142-4155.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 4142-4155
    • Dho, S.E.1    Trejo, J.2    Siderovski, D.P.3    McGlade, C.J.4
  • 19
    • 33645301867 scopus 로고    scopus 로고
    • Down regulation of trk but not p75 gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease
    • Ginsberg, S. D., Che, S., Wuu, J., Counts, S. E.,and Mufson,E.J.(2006). Down regulation of trk but not p75 gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease. J. Neurochem. 97, 475-487.
    • (2006) J. Neurochem. , vol.97 , pp. 475-487
    • Ginsberg, S.D.1    Che, S.2    Wuu, J.3    Counts, S.E.4    Mufson, E.J.5
  • 21
    • 79956111926 scopus 로고    scopus 로고
    • Characterization and role of NUMB in the human extravillous trophop-blast
    • Haider, M., Qiu, Q., Bani-Yaghoub, M., Tsang, B. K., and Gruslin, A. (2011). Characterization and role of NUMB in the human extravillous trophop-blast. Placenta 32, 441-449.
    • (2011) Placenta , vol.32 , pp. 441-449
    • Haider, M.1    Qiu, Q.2    Bani-Yaghoub, M.3    Tsang, B.K.4    Gruslin, A.5
  • 22
    • 84860862964 scopus 로고    scopus 로고
    • The contributions of unscheduled neuronal cell cycle events to the death of neurons in Alzheimer's disease
    • Herrup, K. (2012). The contributions of unscheduled neuronal cell cycle events to the death of neurons in Alzheimer's disease. Front. Biosci. 4, 2101-2109.
    • (2012) Front. Biosci. , vol.4 , pp. 2101-2109
    • Herrup, K.1
  • 23
    • 0028077881 scopus 로고
    • Neurotrophin signalling
    • Heumann, R.(1994). Neurotrophin signalling. Curr. Opin. Neurobiol. 4, 668-679.
    • (1994) Curr. Opin. Neurobiol. , vol.4 , pp. 668-679
    • Heumann, R.1
  • 24
    • 77749336752 scopus 로고    scopus 로고
    • Essential roles of Notch signaling in maintenance of neural stem cells in developing and adult brains
    • Imayoshi, I., Sakamoto, M., Yamaguchi, M., Mori, K., and Kageyama, R. (2010). Essential roles of Notch signaling in maintenance of neural stem cells in developing and adult brains. J. Neurosci. 30, 3489-3498.
    • (2010) J. Neurosci. , vol.30 , pp. 3489-3498
    • Imayoshi, I.1    Sakamoto, M.2    Yamaguchi, M.3    Mori, K.4    Kageyama, R.5
  • 25
    • 44149086912 scopus 로고    scopus 로고
    • Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP
    • Kawahara, H., Imai, T., Imataka, H., Tsujimoto, M., Matsumoto, K., and Okano, H. (2008). Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP. J. Cell Biol. 18, 639-653.
    • (2008) J. Cell Biol. , vol.18 , pp. 639-653
    • Kawahara, H.1    Imai, T.2    Imataka, H.3    Tsujimoto, M.4    Matsumoto, K.5    Okano, H.6
  • 26
    • 0037827785 scopus 로고    scopus 로고
    • X11alpha modulates secretory and endocytic trafficking and metabolism of amyloid precursor protein: mutational analysis of the YENPTY sequence
    • King, G. D., Perez, R. G., Steinhilb, M. L., Gaut, J. R., and Turner, R. S. (2003). X11alpha modulates secretory and endocytic trafficking and metabolism of amyloid precursor protein: mutational analysis of the YENPTY sequence. Neuroscience 120, 143-154.
    • (2003) Neuroscience , vol.120 , pp. 143-154
    • King, G.D.1    Perez, R.G.2    Steinhilb, M.L.3    Gaut, J.R.4    Turner, R.S.5
  • 27
    • 0345743462 scopus 로고    scopus 로고
    • Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk? Exp
    • King, G. D., and Turner, R. S. (2004). Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk? Exp. Neurol. 185, 208-219.
    • (2004) Neurol , vol.185 , pp. 208-219
    • King, G.D.1    Turner, R.S.2
  • 28
    • 84856752586 scopus 로고    scopus 로고
    • GSK3 and Alzheimer's disease: facts and fiction
    • doi:10.3389/fnmol.2011.00017
    • Kremer, A., Louis, J. V., Jaworski, T., and VanLeuven, F. (2011). GSK3 and Alzheimer's disease: facts and fiction. Front. Mol. Neurosci. 4:17. doi:10.3389/fnmol.2011.00017
    • (2011) Front. Mol. Neurosci. , vol.4
    • Kremer, A.1    Louis, J.V.2    Jaworski, T.3    VanLeuven, F.4
  • 29
    • 57149092998 scopus 로고    scopus 로고
    • Cyclic stretch induced miR-146a upregu-lation delays C2C12 myogenic differentiation through inhibition of Numb
    • Kuang, W., Tan, J., Duan, Y., Duan, J., Wang, W., Jin, F., et al. (2009). Cyclic stretch induced miR-146a upregu-lation delays C2C12 myogenic differentiation through inhibition of Numb. Biochem. Biophys. Res. Com-mun. 378, 259-263.
    • (2009) Biochem. Biophys. Res. Com-mun. , vol.378 , pp. 259-263
    • Kuang, W.1    Tan, J.2    Duan, Y.3    Duan, J.4    Wang, W.5    Jin, F.6
  • 30
    • 33845401909 scopus 로고    scopus 로고
    • Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche
    • Kuo, C. T., Mirzadeh, Z., Soriano-Navarro, M., Rasin, M., Wang, D., Shen, J., et al. (2006). Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Cell 127, 1253-1264.
    • (2006) Cell , vol.127 , pp. 1253-1264
    • Kuo, C.T.1    Mirzadeh, Z.2    Soriano-Navarro, M.3    Rasin, M.4    Wang, D.5    Shen, J.6
  • 31
    • 77949883589 scopus 로고    scopus 로고
    • Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel
    • Kyriazis, G. A., Belal, C., Madan, M., Taylor, D. G., Wang, J., Wei, Z., et al. (2010). Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel. J. Biol. Chem. 285, 6811-6825.
    • (2010) J. Biol. Chem. , vol.285 , pp. 6811-6825
    • Kyriazis, G.A.1    Belal, C.2    Madan, M.3    Taylor, D.G.4    Wang, J.5    Wei, Z.6
  • 32
    • 54449093012 scopus 로고    scopus 로고
    • Numb endocytic adapter proteins regulate the transport and processing of the amyloid precursor proteinin an isoform-dependent manner: implications for Alzheimer disease pathogenesis
    • Kyriazis, G. A., Wei, Z., Vandermey, M., Jo, D. G., Xin, O., Mattson, M. P., et al. (2008). Numb endocytic adapter proteins regulate the transport and processing of the amyloid precursor proteinin an isoform-dependent manner: implications for Alzheimer disease pathogenesis. J. Biol. Chem. 283, 25492-25502.
    • (2008) J. Biol. Chem. , vol.283 , pp. 25492-25502
    • Kyriazis, G.A.1    Wei, Z.2    Vandermey, M.3    Jo, D.G.4    Xin, O.5    Mattson, M.P.6
  • 33
    • 0037218819 scopus 로고    scopus 로고
    • Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo
    • Lai, K., Kaspar, B. K., Gage, F. H., and Schaffer, D. V. (2003). Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nat. Neurosci. 6, 21-27.
    • (2003) Nat. Neurosci. , vol.6 , pp. 21-27
    • Lai, K.1    Kaspar, B.K.2    Gage, F.H.3    Schaffer, D.V.4
  • 34
    • 68649122864 scopus 로고    scopus 로고
    • Synapse development and plasticity: roles of ephrin/Eph receptor signaling
    • Lai, K. O., and Ip, N. Y. (2009). Synapse development and plasticity: roles of ephrin/Eph receptor signaling. Curr. Opin. Neurobiol. 19, 275-283.
    • (2009) Curr. Opin. Neurobiol. , vol.19 , pp. 275-283
    • Lai, K.O.1    Ip, N.Y.2
  • 35
    • 77952543738 scopus 로고    scopus 로고
    • Neurogenesis and Alzheimer's disease: at the crossroads
    • Lazarov, O., and Marr, R. A. (2010). Neurogenesis and Alzheimer's disease: at the crossroads. Exp. Neurol. 223, 267-281.
    • (2010) Exp. Neurol. , vol.223 , pp. 267-281
    • Lazarov, O.1    Marr, R.A.2
  • 36
    • 0142123260 scopus 로고    scopus 로고
    • APP processing is regulated by cytoplasmic phosphorylation
    • Lee, M. S., Kao, S. C., Lemere, C. A., Xia, W., Tseng, H. C., Zhou, Y., et al. (2003). APP processing is regulated by cytoplasmic phosphorylation. J. Cell Biol. 163, 83-95.
    • (2003) J. Cell Biol. , vol.163 , pp. 83-95
    • Lee, M.S.1    Kao, S.C.2    Lemere, C.A.3    Xia, W.4    Tseng, H.C.5    Zhou, Y.6
  • 37
    • 0346732391 scopus 로고    scopus 로고
    • Inactivation of numb and numblike in embryonic dorsal forebrain impairs neurogene-sis and disrupts cortical morphogenesis
    • Li, H. S., Wang, D., Shen, Q., Schone-mann, M. D., Gorski, J. A., Jones, K. R., et al. (2003). Inactivation of numb and numblike in embryonic dorsal forebrain impairs neurogene-sis and disrupts cortical morphogenesis. Neuron 40, 1105-1118.
    • (2003) Neuron , vol.40 , pp. 1105-1118
    • Li, H.S.1    Wang, D.2    Shen, Q.3    Schone-mann, M.D.4    Gorski, J.A.5    Jones, K.R.6
  • 38
    • 23844558036 scopus 로고    scopus 로고
    • Ectopic expression of Musashi-1 in Alzheimer disease and Pick disease
    • Lovell, M. A., and Markesbery, W. R. (2005). Ectopic expression of Musashi-1 in Alzheimer disease and Pick disease. J. Neuropathol. Exp. Neurol. 64, 675-680.
    • (2005) J. Neuropathol. Exp. Neurol. , vol.64 , pp. 675-680
    • Lovell, M.A.1    Markesbery, W.R.2
  • 39
    • 67349224648 scopus 로고    scopus 로고
    • Numb-mediated neurite outgrowth is isoform-dependent, and requires activation of voltage-dependent calcium channels
    • Lu, C. B., Fu, W., Xu, X., and Mattson, M. P. (2009). Numb-mediated neurite outgrowth is isoform-dependent, and requires activation of voltage-dependent calcium channels.Neuro-science 161, 403-412.
    • (2009) Neuro-science , vol.161 , pp. 403-412
    • Lu, C.B.1    Fu, W.2    Xu, X.3    Mattson, M.P.4
  • 40
    • 33751503224 scopus 로고    scopus 로고
    • Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch dependent ubiquitination
    • Marcotullio,L. D., Ferretti, E., Greco, A., De Smaele, E., Po, A., Sico, M. A., et al. (2006). Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch dependent ubiquitination. Nat. Cell Biol. 8, 1415-1423.
    • (2006) Nat. Cell Biol. , vol.8 , pp. 1415-1423
    • Marcotullio, L.D.1    Ferretti, E.2    Greco, A.3    De Smaele, E.4    Po, A.5    Sico, M.A.6
  • 42
    • 34547701950 scopus 로고    scopus 로고
    • Dynamic aspects of CNS synapse formation
    • McAllister, A. K. (2007). Dynamic aspects of CNS synapse formation. Annu. Rev. Neurosci. 30, 425-450.
    • (2007) Annu. Rev. Neurosci. , vol.30 , pp. 425-450
    • McAllister, A.K.1
  • 43
    • 70350374350 scopus 로고    scopus 로고
    • Numb regulates post-endocytic trafficking and degradation of Notch1
    • McGill, M. A., Dho, S. E., Weinmaster, G., and McGlade, C. J. (2009). Numb regulates post-endocytic trafficking and degradation of Notch1. J. Biol. Chem. 284, 26427-26438.
    • (2009) J. Biol. Chem. , vol.284 , pp. 26427-26438
    • McGill, M.A.1    Dho, S.E.2    Weinmaster, G.3    McGlade, C.J.4
  • 44
    • 0037663379 scopus 로고    scopus 로고
    • Mammalian Numb proteins promote Notch1 receptor ubiqui-tination and degradation of the Notch1 intracellular domain
    • McGill, M. A., and McGlade, C. J. (2003). Mammalian Numb proteins promote Notch1 receptor ubiqui-tination and degradation of the Notch1 intracellular domain. J. Biol. Chem. 278, 23196-23203.
    • (2003) J. Biol. Chem. , vol.278 , pp. 23196-23203
    • McGill, M.A.1    McGlade, C.J.2
  • 45
    • 0037080811 scopus 로고    scopus 로고
    • LNX functions as a RING type E3 ubiqui-tin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation
    • Nie, J., McGill, M. A., Dermer, M., Dho, S. E., Wolting, C. D., and McGlade, C. J. (2002). LNX functions as a RING type E3 ubiqui-tin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation.EMBO J.21, 93-102.
    • (2002) EMBO J , vol.21 , pp. 93-102
    • Nie, J.1    McGill, M.A.2    Dermer, M.3    Dho, S.E.4    Wolting, C.D.5    McGlade, C.J.6
  • 47
    • 34250820373 scopus 로고    scopus 로고
    • Numb controls integrin endocyto-sis for directional cell migration with aPKC and PAR-3
    • Nishimura, T., and Kaibuchi, K. (2007). Numb controls integrin endocyto-sis for directional cell migration with aPKC and PAR-3. Dev. Cell 13, 15-28.
    • (2007) Dev. Cell , vol.13 , pp. 15-28
    • Nishimura, T.1    Kaibuchi, K.2
  • 48
    • 33644858848 scopus 로고    scopus 로고
    • Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2
    • Nishimura,T.,Yamaguchi,T.,Tokunaga, A., Hara, A., Hamaguchi, T., Kato, K., et al. (2006). Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2. Mol. Biol. Cell 17, 1273-1285.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 1273-1285
    • Nishimura, T.1    Yamaguchi, T.2    Tokunaga, A.3    Hara, A.4    Hamaguchi, T.5    Kato, K.6
  • 49
    • 79851473226 scopus 로고    scopus 로고
    • γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs
    • Oehlrich, D., Berthelot,D. J., and Gijsen, H. J. (2011). γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs. J. Med. Chem. 54, 669-698.
    • (2011) J. Med. Chem. , vol.54 , pp. 669-698
    • Oehlrich, D.1    Berthelot, D.J.2    Gijsen, H.J.3
  • 50
    • 7244250027 scopus 로고    scopus 로고
    • Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis
    • Pece, S., Serresi, M., Santolini, E., Capra, M., Hulleman, E., Galimberti, V., et al. (2004). Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J. Cell Biol. 167, 215-221.
    • (2004) J. Cell Biol. , vol.167 , pp. 215-221
    • Pece, S.1    Serresi, M.2    Santolini, E.3    Capra, M.4    Hulleman, E.5    Galimberti, V.6
  • 51
    • 0036678724 scopus 로고    scopus 로고
    • Numb isoforms containing a short PTB domain promote neurotrophic factor-induced differentiation and neurotrophic factor withdrawal-induced death of PC12 cells
    • Pedersen, W. A., Chan, S. L., Zhu, H., Abdur-Rahman, L. A., Verdi, J. M., and Mattson, M. P. (2002). Numb isoforms containing a short PTB domain promote neurotrophic factor-induced differentiation and neurotrophic factor withdrawal-induced death of PC12 cells. J. Neu-rochem. 82, 976-986.
    • (2002) J. Neu-rochem. , vol.82 , pp. 976-986
    • Pedersen, W.A.1    Chan, S.L.2    Zhu, H.3    Abdur-Rahman, L.A.4    Verdi, J.M.5    Mattson, M.P.6
  • 52
    • 0037206889 scopus 로고    scopus 로고
    • Progenitor cell maintenance requires numb and numblike during mouse neurogenesis
    • Petersen, P. H., Zou, K., Hwang, J. K., Jan, Y. N., and Zhong, W. (2002). Progenitor cell maintenance requires numb and numblike during mouse neurogenesis.Nature 419, 929-934.
    • (2002) Nature , vol.419 , pp. 929-934
    • Petersen, P.H.1    Zou, K.2    Hwang, J.K.3    Jan, Y.N.4    Zhong, W.5
  • 53
    • 3342938070 scopus 로고    scopus 로고
    • Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis
    • Petersen, P. H., Zou, K., Krauss, S., and Zhong, W. (2004). Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis. Nat. Neurosci. 7, 803-811.
    • (2004) Nat. Neurosci. , vol.7 , pp. 803-811
    • Petersen, P.H.1    Zou, K.2    Krauss, S.3    Zhong, W.4
  • 54
    • 0036543312 scopus 로고    scopus 로고
    • Rho proteins, mental retardation and the cellular basis of cognition
    • Ramakers, G. J. (2002). Rho proteins, mental retardation and the cellular basis of cognition. Trends Neurosci. 25, 191-199.
    • (2002) Trends Neurosci , vol.25 , pp. 191-199
    • Ramakers, G.J.1
  • 55
    • 34347359603 scopus 로고    scopus 로고
    • Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors
    • Rasin, M. R., Gazula, V. R., Breunig, J. J., Kwan, K. Y., Johnson, M. B., Liu-Chen, S., et al. (2007). Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors. Nat. Neurosci. 10, 819-827.
    • (2007) Nat. Neurosci. , vol.10 , pp. 819-827
    • Rasin, M.R.1    Gazula, V.R.2    Breunig, J.J.3    Kwan, K.Y.4    Johnson, M.B.5    Liu-Chen, S.6
  • 57
    • 0037076398 scopus 로고    scopus 로고
    • The g-secretase-generated intracel-lular domain of b-amyloid precursor protein binds Numb and inhibits Notch signaling
    • Roncarati, R., Sestan, N., Scheinfeld, M. H., Berechid, B. E., Lopez, P. A., Meucci, O., et al. (2002). The g-secretase-generated intracel-lular domain of b-amyloid precursor protein binds Numb and inhibits Notch signaling. Proc. Natl. Acad. Sci. U.S.A. 99, 7102-7107.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 7102-7107
    • Roncarati, R.1    Sestan, N.2    Scheinfeld, M.H.3    Berechid, B.E.4    Lopez, P.A.5    Meucci, O.6
  • 58
    • 0030930853 scopus 로고    scopus 로고
    • Binding specificity andinvivotargetsof the EH domain, a novel protein-protein interaction module
    • Salcini,A. E., Confalonieri,S., Doria,M., Santolini, E., Tassi, E., Minenkova, O., et al. (1997). Binding specificity andinvivotargetsof theEHdomain, a novel protein-protein interaction module. Genes Dev. 11, 2239-2249.
    • (1997) Genes Dev , vol.11 , pp. 2239-2249
    • Salcini, A.E.1    Confalonieri, S.2    Doria, M.3    Santolini, E.4    Tassi, E.5    Minenkova, O.6
  • 59
    • 80054998431 scopus 로고    scopus 로고
    • Corridors of migrating neurons in the human brain and their decline during infancy
    • Sanai, N., Nguyen, T., Ihrie, R. A., Mirzadeh, Z., Tsai, H. H., Wong, M., et al. (2011). Corridors of migrating neurons in the human brain and their decline during infancy. Nature 478, 382-386.
    • (2011) Nature , vol.478 , pp. 382-386
    • Sanai, N.1    Nguyen, T.2    Ihrie, R.A.3    Mirzadeh, Z.4    Tsai, H.H.5    Wong, M.6
  • 61
    • 80052233722 scopus 로고    scopus 로고
    • Numb controls E-cadherin endocytosis through p120 catenin with aPKC
    • Sato, K., Watanabe, T., Wang, S., Kakeno, M., Matsuzawa, K., Matsui, T., et al. (2011). Numb controls E-cadherin endocytosis through p120 catenin with aPKC. Mol. Biol. Cell 22, 3103-3119.
    • (2011) Mol. Biol. Cell , vol.22 , pp. 3103-3119
    • Sato, K.1    Watanabe, T.2    Wang, S.3    Kakeno, M.4    Matsuzawa, K.5    Matsui, T.6
  • 62
    • 84864836812 scopus 로고    scopus 로고
    • Numb regulates stability and localization of the mitotic kinase PLK1 and is required for transit through mitosis
    • Schmit, T. L., Nihal, M., Ndiaye, M., Setaluri, V., Spiegelman, V. S., and Ahmad, N. (2012). Numb regulates stability and localization of the mitotic kinase PLK1 and is required for transit through mitosis. Cancer Res. 72, 3864-3872.
    • (2012) Cancer Res , vol.72 , pp. 3864-3872
    • Schmit, T.L.1    Nihal, M.2    Ndiaye, M.3    Setaluri, V.4    Spiegelman, V.S.5    Ahmad, N.6
  • 63
    • 33644532847 scopus 로고    scopus 로고
    • Expression cloning screen for modifiers of amyloid precursor protein shedding
    • Schobel, S., Neumann, S., Seed, B., and Lichtenthaler, S. F. (2006). Expression cloning screen for modifiers of amyloid precursor protein shedding. Int. J. Dev. Neurosci. 24, 141-148.
    • (2006) Int. J. Dev. Neurosci. , vol.24 , pp. 141-148
    • Schobel, S.1    Neumann, S.2    Seed, B.3    Lichtenthaler, S.F.4
  • 64
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimers disease: genes, proteins, and therapy
    • Selkoe, D. J. (2001). Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81, 741-766.
    • (2001) Physiol. Rev. , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 65
    • 0029004341 scopus 로고
    • Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
    • Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., et al. (1995). Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760.
    • (1995) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1    Rogaev, E.I.2    Liang, Y.3    Rogaeva, E.A.4    Levesque, G.5    Ikeda, M.6
  • 66
    • 33749042749 scopus 로고    scopus 로고
    • Sorting throught the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis
    • Small, S. A., and Gandy, S. (2006). Sorting throught the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis. Neuron 52, 15-31.
    • (2006) Neuron , vol.52 , pp. 15-31
    • Small, S.A.1    Gandy, S.2
  • 67
    • 3343014893 scopus 로고    scopus 로고
    • The cell fate determinant Numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling
    • Smith, C. A., Dho, S. E., Donaldson, J., Tepass, U., and McGlade, C. J. (2004). The cell fate determinant Numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling. Mol. Biol. Cell 15, 3698-3708.
    • (2004) Mol. Biol. Cell , vol.15 , pp. 3698-3708
    • Smith, C.A.1    Dho, S.E.2    Donaldson, J.3    Tepass, U.4    McGlade, C.J.5
  • 68
    • 33846513022 scopus 로고    scopus 로고
    • aPKC-mediated phos-phorylation regulates asymmetric membrane localization of the cell fatedeterminantNumb
    • Smith, C. A., Lau, K. M., Rahmani, Z., Dho, S. E., Brothers, G., She, Y. M., et al. (2007). aPKC-mediated phos-phorylation regulates asymmetric membrane localization of the cell fatedeterminantNumb.EMBOJ. 26, 468-480.
    • (2007) EMBOJ , vol.26 , pp. 468-480
    • Smith, C.A.1    Lau, K.M.2    Rahmani, Z.3    Dho, S.E.4    Brothers, G.5    She, Y.M.6
  • 69
    • 84862833670 scopus 로고    scopus 로고
    • Inhibition of Polo-like kinase 1 reduces beta-amyloid-induced neuronal cell death in Alzheimer's disease
    • Song, B., Davis, K., Liu, S. X., Lee, H., Smith, M., and Liu, X. (2011). Inhibition of Polo-like kinase 1 reduces beta-amyloid-induced neuronal cell death in Alzheimer's disease. Aging 3, 846-851.
    • (2011) Aging , vol.3 , pp. 846-851
    • Song, B.1    Davis, K.2    Liu, S.X.3    Lee, H.4    Smith, M.5    Liu, X.6
  • 70
    • 51849103321 scopus 로고    scopus 로고
    • AAK1 regulates numb function at an early step in clathrin-mediated Endocytosis
    • Sorensen, E. B., and Conner, S. D. (2008). AAK1 regulates numb function at an early step in clathrin-mediated Endocytosis. Traffic 9, 1791-1800.
    • (2008) Traffic , vol.9 , pp. 1791-1800
    • Sorensen, E.B.1    Conner, S.D.2
  • 71
    • 77549084517 scopus 로고    scopus 로고
    • The dysregulation of intracellular calcium in Alzheimer disease
    • Supnet, C., and Bezprozvanny,I. (2010). The dysregulation of intracellular calcium in Alzheimer disease. Cell Calcium 47, 183-189.
    • (2010) Cell Calcium , vol.47 , pp. 183-189
    • Supnet, C.1    Bezprozvanny, I.2
  • 73
    • 69049118186 scopus 로고    scopus 로고
    • The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracel-lular domains
    • Tamayev, R., Zhou, D., and d'Adamio, L. (2009). The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracel-lular domains. Mol. Neurodegener. 4, 28.
    • (2009) Mol. Neurodegener. , vol.4 , pp. 28
    • Tamayev, R.1    Zhou, D.2    d'Adamio, L.3
  • 74
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: synapse loss isthe major correlate of cognitive impairment
    • Terry, R. D., Masliah, E., Salmon, D. R., Butters, N., De Teresa, R., Hill, R., et al. (1991). Physical basis of cognitive alterations in Alzheimer's disease: synapse loss isthe major correlate of cognitive impairment. Ann. Neurol. 30, 572-580.
    • (1991) Ann. Neurol. , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.R.3    Butters, N.4    De Teresa, R.5    Hill, R.6
  • 75
    • 27444431599 scopus 로고    scopus 로고
    • Phosphorylation of Numb family proteins Possible involvement of Ca2+/calmodulin-dependent protein kinases
    • Tokumitsu,H., Hatano,N., Inuzuka,H., Sueyoshi, Y., Yokokura, S., Ichimura, T., et al. (2005). Phosphorylation of Numb family proteins. Possible involvement of Ca2+/calmodulin-dependent protein kinases. J. Biol. Chem. 280, 35108-35118.
    • (2005) J. Biol. Chem. , vol.280 , pp. 35108-35118
    • Tokumitsu, H.1    Hatano, N.2    Inuzuka, H.3    Sueyoshi, Y.4    Yokokura, S.5    Ichimura, T.6
  • 76
    • 69249135065 scopus 로고    scopus 로고
    • Tickets to ride: selecting cargo for clathrin-regulated internalization
    • Traub, L. M. (2009). Tickets to ride: selecting cargo for clathrin-regulated internalization. Nat. Rev. Mol. Cell Biol. 10, 583-596.
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 583-596
    • Traub, L.M.1
  • 77
    • 0024980213 scopus 로고
    • Numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos
    • Uemura, T., Shepherd, S., Ackerman, L., Jan, L. Y., and Jan, Y. N. (1989). Numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos. Cell 58, 346-360.
    • (1989) Cell , vol.58 , pp. 346-360
    • Uemura, T.1    Shepherd, S.2    Ackerman, L.3    Jan, L.Y.4    Jan, Y.N.5
  • 78
    • 19444366758 scopus 로고    scopus 로고
    • Pincher-mediated macroendocyto-sis underlies retrograde signaling by neurotrophin receptors
    • Valdez, G., Akmentin, W., Philip-pidou, P., Kuruvilla, R., Ginty, D. D., and Halegoua, S. (2005). Pincher-mediated macroendocyto-sis underlies retrograde signaling by neurotrophin receptors. J. Neurosci. 25, 5236-5247.
    • (2005) J. Neurosci. , vol.25 , pp. 5236-5247
    • Valdez, G.1    Akmentin, W.2    Philip-pidou, P.3    Kuruvilla, R.4    Ginty, D.D.5    Halegoua, S.6
  • 81
    • 33750963813 scopus 로고    scopus 로고
    • Nerve growth factor in treatment and pathogenesis of Alzheimer's disease
    • Williams, B. J., Eriksdotter-Jonhagen, M., and Granholm, A. C. (2006). Nerve growth factor in treatment and pathogenesis of Alzheimer's disease. Prog. Neurobiol. 80, 114-128.
    • (2006) Prog. Neurobiol. , vol.80 , pp. 114-128
    • Williams, B.J.1    Eriksdotter-Jonhagen, M.2    Granholm, A.C.3
  • 82
    • 77950962922 scopus 로고    scopus 로고
    • Cdk5 supresses the neu-ronal cell cycle by disrupting the E2F1-DP1 complex
    • Zhang, J., Li, H., Yabut, O., Fitzpatrick, H., D'Arcangelo, G., and Herrup, K. (2010). Cdk5 supresses the neu-ronal cell cycle by disrupting the E2F1-DP1 complex. J. Neurosci. 30, 5219-5228.
    • (2010) J. Neurosci. , vol.30 , pp. 5219-5228
    • Zhang, J.1    Li, H.2    Yabut, O.3    Fitzpatrick, H.4    D'Arcangelo, G.5    Herrup, K.6
  • 83
    • 56249138246 scopus 로고    scopus 로고
    • Timing cell-fate determination during asymmetric cell divisions
    • Zhong, W. (2008). Timing cell-fate determination during asymmetric cell divisions. Curr. Opin. Neurobiol. 18, 472-478.
    • (2008) Curr. Opin. Neurobiol. , vol.18 , pp. 472-478
    • Zhong, W.1
  • 84
    • 79955880811 scopus 로고    scopus 로고
    • Numb links extracellular cues to intracellular polarity machinery to promote chemotaxis
    • Zhou, P., Alfaro, J., Chang, E. H., Zhao, X., Porcionatto, M., and Segal, R. A. (2011). Numb links extracellular cues to intracellular polarity machinery to promote chemotaxis. Dev. Cell 20, 610-622.
    • (2011) Dev. Cell , vol.20 , pp. 610-622
    • Zhou, P.1    Alfaro, J.2    Chang, E.H.3    Zhao, X.4    Porcionatto, M.5    Segal, R.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.