Numb modifies neuronal vulnerability to amyloid β-peptide in an isoform-specific manner by a mechanism involving altered calcium homeostasis: Implications for neuronal death in Alzheimer's disease

NeuroMolecular Medicine

Volumn 1, Issue 1, 2002, Pages 55-67

  Chan, Sic L ^a   Pedersen, Ward A ^a   Zhu, Hiayan ^b   Mattson, Mark P ^a,c  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Calcium; Learning and memory; Neurotrophic factor; NMDA; Patch clamp; Staurosporine

Indexed keywords

4 HYDROXYNONENAL; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; BINDING PROTEIN; BRADYKININ; BRAIN PROTEIN; CALCIUM; DANTROLENE; DIMETHYL SULFOXIDE; GAMMA SECRETASE; ISOPROTEIN; LIPID PEROXIDE; NOTCH RECEPTOR; PHOSPHOTYROSINE; PRESENILIN 1; PROLINE; PROTEIN NUMB; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; NERVE PROTEIN; NUMB PROTEIN, MOUSE; RECOMBINANT PROTEIN;

AGE DISTRIBUTION; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL DEATH; CELL FATE; CELL SPECIFICITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SUBSTRATE; GENE MUTATION; HEREDITY; HIPPOCAMPUS; LIPID PEROXIDATION; MEMBRANE TRANSPORT; MOUSE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NERVOUS SYSTEM DEVELOPMENT; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; ONSET AGE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; WILD TYPE; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL STRAIN; DISEASE MODEL; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; HOMEOSTASIS; MALE; METABOLISM; MOUSE MUTANT; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; TRANSGENIC MOUSE;

ANIMALIA;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; CALCIUM; CELL DEATH; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; HOMEOSTASIS; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NEURONS; PC12 CELLS; PROTEIN ISOFORMS; RATS; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 0036363731     PISSN: 15351084     EISSN: None     Source Type: Journal    
DOI: 10.1385/NMM:1:1:55     Document Type: Article

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