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Volumn 13, Issue 11, 2012, Pages 14470-14491

Experimental and therapeutic opportunities for stem cells in multiple sclerosis

Author keywords

Embryonic stem cells (ESCs); Induced pluripotent stem cells (iPSCs); Multiple sclerosis (MS); Neurodegenerative disease; Pluripotent stem cells (PSCs)

Indexed keywords

AXONAL INJURY; CELL FATE; CELL POPULATION; CELL REGENERATION; DEMYELINATION; DISEASE ACTIVITY; DISEASE MODEL; EMBRYONIC STEM CELL; HUMAN; MULTIPLE SCLEROSIS; NERVE CELL DIFFERENTIATION; NEUROPROTECTION; NONHUMAN; NUCLEAR REPROGRAMMING; OLIGODENDROGLIA; PATHOPHYSIOLOGY; PLURIPOTENT STEM CELL; REMYELINIZATION; REVIEW; STEM CELL TRANSPLANTATION; THERAPY EFFECT; ANIMAL; BIOLOGICAL THERAPY; CYTOLOGY; STEM CELL;

EID: 84870681930     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms131114470     Document Type: Review
Times cited : (6)

References (157)
  • 1
    • 0037029424 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Compston, A.; Coles, A. Multiple sclerosis. Lancet 2002, 359, 1221-1231.
    • (2002) Lancet , vol.359 , pp. 1221-1231
    • Compston, A.1    Coles, A.2
  • 2
    • 0031002545 scopus 로고    scopus 로고
    • Axonal damage in acute multiple sclerosis lesions
    • Ferguson, B.; Matyszak, M.K.; Esiri, M.M.; Perry, V.H. Axonal damage in acute multiple sclerosis lesions. Brain 1997, 120, 393-399.
    • (1997) Brain , vol.120 , pp. 393-399
    • Ferguson, B.1    Matyszak, M.K.2    Esiri, M.M.3    Perry, V.H.4
  • 3
    • 0033663894 scopus 로고    scopus 로고
    • Neurological disability correlates with spinal cord axonal loss and reduced N-acetyl aspartate in chronic multiple sclerosis patients
    • Bjartmar, C.; Kidd, G.; Mörk, S.; Rudick, R.; Trapp, B.D. Neurological disability correlates with spinal cord axonal loss and reduced N-acetyl aspartate in chronic multiple sclerosis patients. Ann. Neurol. 2000, 48, 893-901.
    • (2000) Ann. Neurol. , vol.48 , pp. 893-901
    • Bjartmar, C.1    Kidd, G.2    Mörk, S.3    Rudick, R.4    Trapp, B.D.5
  • 5
    • 0033022892 scopus 로고    scopus 로고
    • From enhancing lesions to brain atrophy in relapsing MS
    • Simon, J.H. From enhancing lesions to brain atrophy in relapsing MS. J. Neuroimmunol. 1999, 98, 7-15.
    • (1999) J. Neuroimmunol. , vol.98 , pp. 7-15
    • Simon, J.H.1
  • 7
    • 0034104079 scopus 로고    scopus 로고
    • Quantitative pathological evidence for axonal loss in normal appearing white matter in multiple sclerosis
    • Evangelou, N.; Esiri, M.M.; Smith, S.; Palace, J.; Matthews, P.M. Quantitative pathological evidence for axonal loss in normal appearing white matter in multiple sclerosis. Ann. Neurol. 2000, 47, 391-395.
    • (2000) Ann. Neurol. , vol.47 , pp. 391-395
    • Evangelou, N.1    Esiri, M.M.2    Smith, S.3    Palace, J.4    Matthews, P.M.5
  • 9
    • 0037012844 scopus 로고    scopus 로고
    • Axonal self-destruction and neurodegeneration
    • Raff, M.C.; Whitmore, A.V.; Finn, J.T. Axonal self-destruction and neurodegeneration. Science 2002, 296, 868-871.
    • (2002) Science , vol.296 , pp. 868-871
    • Raff, M.C.1    Whitmore, A.V.2    Finn, J.T.3
  • 11
    • 0024409098 scopus 로고
    • Axonal dystrophy as a consequence of long-term demyelination
    • Raine, C.S.; Cross, A.H. Axonal dystrophy as a consequence of long-term demyelination. Lab. Invest. 1989, 60, 714-725.
    • (1989) Lab. Invest. , vol.60 , pp. 714-725
    • Raine, C.S.1    Cross, A.H.2
  • 12
    • 0033870097 scopus 로고    scopus 로고
    • Multiple sclerosis and chronic autoimmune encephalomyelitis: A comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions
    • Kornek, B.; Storch, M.K.; Weissert, R.; Wallstroem, E.; Stefferl, A.; Olsson, T.; Linington, C.; Schmidbauer, M.; Lassmann, H. Multiple sclerosis and chronic autoimmune encephalomyelitis: A comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions. Am. J. Pathol. 2000, 157, 267-276.
    • (2000) Am. J. Pathol. , vol.157 , pp. 267-276
    • Kornek, B.1    Storch, M.K.2    Weissert, R.3    Wallstroem, E.4    Stefferl, A.5    Olsson, T.6    Linington, C.7    Schmidbauer, M.8    Lassmann, H.9
  • 13
    • 0037379348 scopus 로고    scopus 로고
    • A function of myelin is to protect axons from subsequent injury: Implications for deficits in multiple sclerosis
    • Rodriguez, M. A function of myelin is to protect axons from subsequent injury: Implications for deficits in multiple sclerosis. Brain 2003, 126, 751-752.
    • (2003) Brain , vol.126 , pp. 751-752
    • Rodriguez, M.1
  • 15
    • 34247862406 scopus 로고    scopus 로고
    • Remyelination can be extensive in multiple sclerosis despite a long disease course
    • Patani, R.; Balaratnam, M.; Vora, A.; Reynolds, R. Remyelination can be extensive in multiple sclerosis despite a long disease course. Neuropathol. Appl. Neurobiol. 2007, 33, 277-287.
    • (2007) Neuropathol. Appl. Neurobiol. , vol.33 , pp. 277-287
    • Patani, R.1    Balaratnam, M.2    Vora, A.3    Reynolds, R.4
  • 16
    • 0016348545 scopus 로고
    • Pattern of remyelination in the CNS
    • Blakemore, W.F. Pattern of remyelination in the CNS. Nature 1974, 249, 577-578.
    • (1974) Nature , vol.249 , pp. 577-578
    • Blakemore, W.F.1
  • 17
    • 0021267932 scopus 로고
    • Long-term remyelination fails to reconstitute normal thickness of central myelin sheaths
    • Ludwin, S.K.; Maitland, M. Long-term remyelination fails to reconstitute normal thickness of central myelin sheaths. J. Neurol. Sci. 1984, 64, 193-198.
    • (1984) J. Neurol. Sci. , vol.64 , pp. 193-198
    • Ludwin, S.K.1    Maitland, M.2
  • 18
    • 0031050183 scopus 로고    scopus 로고
    • Locomotor deficits induced by experimental spinal cord demyelination are abolished by spontaneous remyelination
    • Jeffery, N.D.; Blakemore, W.F. Locomotor deficits induced by experimental spinal cord demyelination are abolished by spontaneous remyelination. Brain 1997, 120, 27-37.
    • (1997) Brain , vol.120 , pp. 27-37
    • Jeffery, N.D.1    Blakemore, W.F.2
  • 19
    • 33748420494 scopus 로고    scopus 로고
    • Effects of commissural de-and remyelination on motor skill behaviour in the cuprizone mouse model of multiple sclerosis
    • Liebetanz, D.; Merkler, D. Effects of commissural de-and remyelination on motor skill behaviour in the cuprizone mouse model of multiple sclerosis. Exp. Neurol. 2006, 202, 217-224.
    • (2006) Exp. Neurol. , vol.202 , pp. 217-224
    • Liebetanz, D.1    Merkler, D.2
  • 20
    • 0030767405 scopus 로고    scopus 로고
    • Conduction in segmentally demyelinated mammalian central axons
    • Felts, P.A.; Baker, T.A.; Smith, K.J. Conduction in segmentally demyelinated mammalian central axons. J. Neurosci. 1997, 17, 7267-7277.
    • (1997) J. Neurosci. , vol.17 , pp. 7267-7277
    • Felts, P.A.1    Baker, T.A.2    Smith, K.J.3
  • 21
    • 2542619146 scopus 로고    scopus 로고
    • Molecular changes in neurons in multiple sclerosis: Altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger
    • Craner, M.J.; Newcombe, J.; Black, J.A.; Hartle, C.; Cuzner, M.L.; Waxman, S.G. Molecular changes in neurons in multiple sclerosis: Altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger. Proc. Natl. Acad. Sci. USA 2004, 101, 8168-8173.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 8168-8173
    • Craner, M.J.1    Newcombe, J.2    Black, J.A.3    Hartle, C.4    Cuzner, M.L.5    Waxman, S.G.6
  • 22
    • 0028218020 scopus 로고
    • The role of oligodendrocytes and myelin on axon maturation in the developing rat retinofugal pathway
    • Colello, R.J.; Pott, U.; Schwab, M.E. The role of oligodendrocytes and myelin on axon maturation in the developing rat retinofugal pathway. J. Neurosci. 1994, 14, 2594-2605.
    • (1994) J. Neurosci. , vol.14 , pp. 2594-2605
    • Colello, R.J.1    Pott, U.2    Schwab, M.E.3
  • 23
    • 0029781743 scopus 로고    scopus 로고
    • Oligodendroglia regulate the regional expansion of axon caliber and local accumulation of neurofilaments during development independently of myelin formation
    • Sánchez, I.; Hassinger, L.; Paskevich, P.A.; Shine, H.D.; Nixon, R.A. Oligodendroglia regulate the regional expansion of axon caliber and local accumulation of neurofilaments during development independently of myelin formation. J. Neurosci. 1996, 16, 5095-5105.
    • (1996) J. Neurosci. , vol.16 , pp. 5095-5105
    • Sánchez, I.1    Hassinger, L.2    Paskevich, P.A.3    Shine, H.D.4    Nixon, R.A.5
  • 24
    • 0034650970 scopus 로고    scopus 로고
    • Unwrapping new layers of complexity in axon/glial relationships
    • Witt, A.; Brady, S.T. Unwrapping new layers of complexity in axon/glial relationships. Glia 2000, 29, 112-117.
    • (2000) Glia , vol.29 , pp. 112-117
    • Witt, A.1    Brady, S.T.2
  • 25
    • 0035025620 scopus 로고    scopus 로고
    • Differential control of clustering of the sodium channels Na(v)1.2 and Na(v)1.6 at developing CNS nodes of Ranvier
    • Kaplan, M.R.; Cho, M.H.; Ullian, E.M.; Isom, L.L.; Levinson, S.R.; Barres, B.A. Differential control of clustering of the sodium channels Na(v)1.2 and Na(v)1.6 at developing CNS nodes of Ranvier. Neuron 2001, 30, 105-119.
    • (2001) Neuron , vol.30 , pp. 105-119
    • Kaplan, M.R.1    Cho, M.H.2    Ullian, E.M.3    Isom, L.L.4    Levinson, S.R.5    Barres, B.A.6
  • 27
    • 0035954344 scopus 로고    scopus 로고
    • Acquired channelopathies in nerve injury and MS
    • Waxman, S.G. Acquired channelopathies in nerve injury and MS. Neurology 2001, 56, 1621-1627.
    • (2001) Neurology , vol.56 , pp. 1621-1627
    • Waxman, S.G.1
  • 28
    • 15144362148 scopus 로고    scopus 로고
    • Trophic factors attenuate nitric oxide mediated neuronal and axonal injury in vitro: Roles and interactions of mitogen-activated protein kinase signalling pathways
    • Wilkins, A.; Compston, A. Trophic factors attenuate nitric oxide mediated neuronal and axonal injury in vitro: Roles and interactions of mitogen-activated protein kinase signalling pathways. J. Neurochem. 2005, 92, 1487-1496.
    • (2005) J. Neurochem. , vol.92 , pp. 1487-1496
    • Wilkins, A.1    Compston, A.2
  • 29
    • 0038452761 scopus 로고    scopus 로고
    • Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms: A novel role for oligodendrocyte-derived glial cell line-derived neurotrophic factor
    • Wilkins, A.; Majed, H.; Layfield, R.; Compston, A.; Chandran, S. Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms: A novel role for oligodendrocyte-derived glial cell line-derived neurotrophic factor. J. Neurosci. 2003, 23, 4967-4974.
    • (2003) J. Neurosci. , vol.23 , pp. 4967-4974
    • Wilkins, A.1    Majed, H.2    Layfield, R.3    Compston, A.4    Chandran, S.5
  • 30
    • 0034794081 scopus 로고    scopus 로고
    • A role for oligodendrocyte-derived IGF-1 in trophic support of cortical neurons
    • Wilkins, A.; Chandran, S.; Compston, A. A role for oligodendrocyte-derived IGF-1 in trophic support of cortical neurons. Glia 2001, 36, 48-57.
    • (2001) Glia , vol.36 , pp. 48-57
    • Wilkins, A.1    Chandran, S.2    Compston, A.3
  • 33
    • 0032948049 scopus 로고    scopus 로고
    • Axonal pathology in demyelinating diseases
    • Scherer, S. Axonal pathology in demyelinating diseases. Ann. Neurol. 1999, 45, 6-7.
    • (1999) Ann. Neurol. , vol.45 , pp. 6-7
    • Scherer, S.1
  • 34
    • 13844264520 scopus 로고    scopus 로고
    • Young and excitable: The function of new neurons in the adult mammalian brain
    • Doetsch, F.; Hen, R. Young and excitable: The function of new neurons in the adult mammalian brain. Curr. Opin. Neurobiol. 2005, 15, 121-128.
    • (2005) Curr. Opin. Neurobiol. , vol.15 , pp. 121-128
    • Doetsch, F.1    Hen, R.2
  • 35
    • 0026526516 scopus 로고
    • A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes
    • Reynolds, B.A.; Tetzlaff, W.; Weiss, S. A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes. J. Neurosci. 1992, 12, 4565-4574.
    • (1992) J. Neurosci. , vol.12 , pp. 4565-4574
    • Reynolds, B.A.1    Tetzlaff, W.2    Weiss, S.3
  • 36
    • 0026535505 scopus 로고
    • Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system
    • Reynolds, B.A.; Weiss, S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 1992, 255, 1707-1710.
    • (1992) Science , vol.255 , pp. 1707-1710
    • Reynolds, B.A.1    Weiss, S.2
  • 37
    • 0028306827 scopus 로고
    • Early recruitment of oligodendrocyte precursors in CNS demyelination
    • Carroll, W.M.; Jennings, A.R. Early recruitment of oligodendrocyte precursors in CNS demyelination. Brain 1994, 117, 563-578.
    • (1994) Brain , vol.117 , pp. 563-578
    • Carroll, W.M.1    Jennings, A.R.2
  • 38
    • 0030861649 scopus 로고    scopus 로고
    • Endogenous progenitors remyelinate demyelinated axons in the adult CNS
    • Gensert, J.M.; Goldman, J.E. Endogenous progenitors remyelinate demyelinated axons in the adult CNS. Neuron 1997, 19, 197-203.
    • (1997) Neuron , vol.19 , pp. 197-203
    • Gensert, J.M.1    Goldman, J.E.2
  • 40
    • 0037106212 scopus 로고    scopus 로고
    • Differentiation of proliferated NG2-positive glial progenitor cells in a remyelinating lesion
    • Watanabe, M.; Toyama, Y.; Nishiyama, A. Differentiation of proliferated NG2-positive glial progenitor cells in a remyelinating lesion. J. Neurosci. Res. 2002, 69, 826-836.
    • (2002) J. Neurosci. Res. , vol.69 , pp. 826-836
    • Watanabe, M.1    Toyama, Y.2    Nishiyama, A.3
  • 41
    • 0033616730 scopus 로고    scopus 로고
    • Adult brain retains the potential to generate oligodendroglial progenitors with extensive myelination capacity
    • Zhang, S.C.; Ge, B.; Duncan, I.D. Adult brain retains the potential to generate oligodendroglial progenitors with extensive myelination capacity. Proc. Natl. Acad. Sci. USA 1999, 96, 4089-4094.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 4089-4094
    • Zhang, S.C.1    Ge, B.2    Duncan, I.D.3
  • 42
    • 0037106148 scopus 로고    scopus 로고
    • Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated lesions of the rat brain
    • Windrem, M.S.; Roy, N.S.; Wang, J.; Nunes, M.; Benraiss, A.; Goodman, R.; McKhann, G.M., II; Goldman, S.A. Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated lesions of the rat brain. J. Neurosci. Res. 2002, 69, 966-975.
    • (2002) J. Neurosci. Res. , vol.69 , pp. 966-975
    • Windrem, M.S.1    Roy, N.S.2    Wang, J.3    Nunes, M.4    Benraiss, A.5    Goodman, R.6    McKhann II, G.M.7    Goldman, S.A.8
  • 43
    • 0036720034 scopus 로고    scopus 로고
    • Why does remyelination fail in multiple sclerosis?
    • Franklin, R.J. Why does remyelination fail in multiple sclerosis? Nat. Rev. Neurosci. 2002, 3, 705-714.
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 705-714
    • Franklin, R.J.1
  • 44
    • 0037085715 scopus 로고    scopus 로고
    • Efficient recolonisation of progenitor-depleted areas of the CNS by adult oligodendrocyte progenitor cells
    • Chari, D.M.; Blakemore, W.F. Efficient recolonisation of progenitor-depleted areas of the CNS by adult oligodendrocyte progenitor cells. Glia 2002, 37, 307-313.
    • (2002) Glia , vol.37 , pp. 307-313
    • Chari, D.M.1    Blakemore, W.F.2
  • 45
    • 0038692009 scopus 로고    scopus 로고
    • Impaired remyelination and depletion of oligodendrocyte progenitors does not occur following repeated episodes of focal demyelination in the rat central nervous system
    • Penderis, J.; Shields, S.A.; Franklin, R.J. Impaired remyelination and depletion of oligodendrocyte progenitors does not occur following repeated episodes of focal demyelination in the rat central nervous system. Brain 2003, 126, 1382-1391.
    • (2003) Brain , vol.126 , pp. 1382-1391
    • Penderis, J.1    Shields, S.A.2    Franklin, R.J.3
  • 46
    • 0018950016 scopus 로고
    • Chronic demyelination inhibits remyelination in the central nervous system. An analysis of contributing factors
    • Ludwin, S.K. Chronic demyelination inhibits remyelination in the central nervous system. An analysis of contributing factors. Lab. Invest. 1980, 43, 382-387.
    • (1980) Lab. Invest. , vol.43 , pp. 382-387
    • Ludwin, S.K.1
  • 47
  • 48
    • 54249124952 scopus 로고    scopus 로고
    • Remyelination in the CNS: From biology to therapy
    • Franklin, R.J.; Ffrench-Constant, C. Remyelination in the CNS: From biology to therapy. Nat. Rev. Neurosci. 2008, 9, 839-855.
    • (2008) Nat. Rev. Neurosci. , vol.9 , pp. 839-855
    • Franklin, R.J.1    Ffrench-Constant, C.2
  • 49
    • 0033844764 scopus 로고    scopus 로고
    • Patients with active relapsing-remitting multiple sclerosis synthesize antibodies recognizing oligodendrocyte progenitor cell surface protein: Implications for remyelination
    • Niehaus, A.; Shi, J.; Grzenkowski, M.; Diers-Fenger, M.; Archelos, J.; Hartung, H.P.; Toyka, K.; Brück, W.; Trotter, J. Patients with active relapsing-remitting multiple sclerosis synthesize antibodies recognizing oligodendrocyte progenitor cell surface protein: Implications for remyelination. Ann. Neurol. 2000, 48, 362-371.
    • (2000) Ann. Neurol. , vol.48 , pp. 362-371
    • Niehaus, A.1    Shi, J.2    Grzenkowski, M.3    Diers-Fenger, M.4    Archelos, J.5    Hartung, H.P.6    Toyka, K.7    Brück, W.8    Trotter, J.9
  • 51
    • 0031962240 scopus 로고    scopus 로고
    • Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells
    • Wolswijk, G. Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells. J. Neurosci. 1998, 18, 601-609.
    • (1998) J. Neurosci. , vol.18 , pp. 601-609
    • Wolswijk, G.1
  • 52
    • 0037122960 scopus 로고    scopus 로고
    • Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis
    • Chang, A.; Tourtellotte, W.W.; Rudick, R.; Trapp, B.D. Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis. N. Engl. J. Med. 2002, 346, 165-173.
    • (2002) N. Engl. J. Med. , vol.346 , pp. 165-173
    • Chang, A.1    Tourtellotte, W.W.2    Rudick, R.3    Trapp, B.D.4
  • 53
    • 0034281366 scopus 로고    scopus 로고
    • NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions
    • Chang, A.; Nishiyama, A.; Peterson, J.; Prineas, J.; Trapp, B.D. NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions. J. Neurosci. 2000, 20, 6404-6412.
    • (2000) J. Neurosci. , vol.20 , pp. 6404-6412
    • Chang, A.1    Nishiyama, A.2    Peterson, J.3    Prineas, J.4    Trapp, B.D.5
  • 54
    • 46849098585 scopus 로고    scopus 로고
    • Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis
    • Kuhlmann, T.; Miron, V.; Cui, Q.; Wegner, C.; Antel, J.; Brück, W. Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis. Brain 2008, 131, 1749-1758.
    • (2008) Brain , vol.131 , pp. 1749-1758
    • Kuhlmann, T.1    Miron, V.2    Cui, Q.3    Wegner, C.4    Antel, J.5    Brück, W.6
  • 55
    • 30644476095 scopus 로고    scopus 로고
    • Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation
    • Kotter, M.R.; Li, W.-W.; Zhao, C.; Franklin, R.J.M. Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation. J. Neurosci. 2006, 26, 328-332.
    • (2006) J. Neurosci. , vol.26 , pp. 328-332
    • Kotter, M.R.1    Li, W.-W.2    Zhao, C.3    Franklin, R.J.M.4
  • 56
    • 11844253894 scopus 로고    scopus 로고
    • Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression
    • Kotter, M.R.; Zhao, C.; van Rooijen, N.; Franklin, R.J. Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression. Neurobiol. Dis. 2005, 18, 166-175.
    • (2005) Neurobiol. Dis. , vol.18 , pp. 166-175
    • Kotter, M.R.1    Zhao, C.2    van Rooijen, N.3    Franklin, R.J.4
  • 57
    • 0033215282 scopus 로고    scopus 로고
    • Remyelination occurs as extensively but more slowly in old rats compared to young rats following gliotoxin-induced CNS demyelination
    • Shields, S.A.; Gilson, J.M.; Blakemore, W.F.; Franklin, R.J. Remyelination occurs as extensively but more slowly in old rats compared to young rats following gliotoxin-induced CNS demyelination. Glia 1999, 28, 77-83.
    • (1999) Glia , vol.28 , pp. 77-83
    • Shields, S.A.1    Gilson, J.M.2    Blakemore, W.F.3    Franklin, R.J.4
  • 58
    • 0036723599 scopus 로고    scopus 로고
    • Re-expression of PSA-NCAM by demyelinated axons: An inhibitor of remyelination in multiple sclerosis?
    • Charles, P.; Reynolds, R.; Seilhean, D.; Rougon, G.; Aigrot, M.S.; Niezgoda, A.; Zalc, B.; Lubetzki, C. Re-expression of PSA-NCAM by demyelinated axons: An inhibitor of remyelination in multiple sclerosis? Brain 2002, 125, 1972-1979.
    • (2002) Brain , vol.125 , pp. 1972-1979
    • Charles, P.1    Reynolds, R.2    Seilhean, D.3    Rougon, G.4    Aigrot, M.S.5    Niezgoda, A.6    Zalc, B.7    Lubetzki, C.8
  • 60
    • 0032533690 scopus 로고    scopus 로고
    • In vivo proliferation of oligodendrocyte progenitors expressing PDGFalphaR during early remyelination
    • Redwine, J.M.; Armstrong, R.C. In vivo proliferation of oligodendrocyte progenitors expressing PDGFalphaR during early remyelination. J. Neurobiol. 1998, 37, 413-428.
    • (1998) J. Neurobiol. , vol.37 , pp. 413-428
    • Redwine, J.M.1    Armstrong, R.C.2
  • 61
    • 34548206670 scopus 로고    scopus 로고
    • Astrocytes-Friends or foes in multiple sclerosis?
    • Williams, A.; Piaton, G.; Lubetzki, C. Astrocytes-Friends or foes in multiple sclerosis? Glia 2007, 55, 1300-1312.
    • (2007) Glia , vol.55 , pp. 1300-1312
    • Williams, A.1    Piaton, G.2    Lubetzki, C.3
  • 62
    • 0038725881 scopus 로고    scopus 로고
    • Astrocytes produce CNTF during the remyelination phase of viral-induced spinal cord demyelination to stimulate FGF-2 production
    • Albrecht, P.J.; Murtie, J.C.; Ness, J.K.; Redwine, J.M.; Enterline, J.R.; Armstrong, R.C.; Levison, S.W. Astrocytes produce CNTF during the remyelination phase of viral-induced spinal cord demyelination to stimulate FGF-2 production. Neurobiol. Dis. 2003, 13, 89-101.
    • (2003) Neurobiol. Dis. , vol.13 , pp. 89-101
    • Albrecht, P.J.1    Murtie, J.C.2    Ness, J.K.3    Redwine, J.M.4    Enterline, J.R.5    Armstrong, R.C.6    Levison, S.W.7
  • 63
    • 33748437057 scopus 로고    scopus 로고
    • Females remyelinate more efficiently than males following demyelination in the aged but not young adult CNS
    • Li, W.W.; Penderis, J.; Zhao, C.; Schumacher, M.; Franklin, R.J. Females remyelinate more efficiently than males following demyelination in the aged but not young adult CNS. Exp. Neurol. 2006, 202, 250-254.
    • (2006) Exp. Neurol. , vol.202 , pp. 250-254
    • Li, W.W.1    Penderis, J.2    Zhao, C.3    Schumacher, M.4    Franklin, R.J.5
  • 64
    • 13244299201 scopus 로고    scopus 로고
    • Genetically dominant spinal cord repair in a murine model of chronic progressive multiple sclerosis
    • Bieber, A.J.; Ure, D.R.; Rodriguez, M. Genetically dominant spinal cord repair in a murine model of chronic progressive multiple sclerosis. J. Neuropathol. Exp. Neurol. 2005, 64, 46-57.
    • (2005) J. Neuropathol. Exp. Neurol. , vol.64 , pp. 46-57
    • Bieber, A.J.1    Ure, D.R.2    Rodriguez, M.3
  • 65
    • 1642281535 scopus 로고    scopus 로고
    • Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion
    • Barnett, M.H.; Prineas, J.W. Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion. Ann. Neurol. 2004, 55, 458-468.
    • (2004) Ann. Neurol. , vol.55 , pp. 458-468
    • Barnett, M.H.1    Prineas, J.W.2
  • 67
    • 46849092175 scopus 로고    scopus 로고
    • Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis
    • Anderson, J.M.; Hampton, D.W.; Patani, R.; Pryce, G.; Crowther, R.A.; Reynolds, R.; Franklin, R.J.; Giovannoni, G.; Compston, D.A.; Baker, D.; et al. Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis. Brain 2008, 131, 1736-1748.
    • (2008) Brain , vol.131 , pp. 1736-1748
    • Anderson, J.M.1    Hampton, D.W.2    Patani, R.3    Pryce, G.4    Crowther, R.A.5    Reynolds, R.6    Franklin, R.J.7    Giovannoni, G.8    Compston, D.A.9    Baker, D.10
  • 70
    • 0029921818 scopus 로고    scopus 로고
    • Evidence for direct connections between the hand region of the supplementary motor area and cervical motoneurons in the macaque monkey
    • Rouiller, E.M.; Moret, V.; Tanne, J.; Boussaoud, D. Evidence for direct connections between the hand region of the supplementary motor area and cervical motoneurons in the macaque monkey. Eur. J. Neurosci. 1996, 8, 1055-1059.
    • (1996) Eur. J. Neurosci. , vol.8 , pp. 1055-1059
    • Rouiller, E.M.1    Moret, V.2    Tanne, J.3    Boussaoud, D.4
  • 71
    • 0344872757 scopus 로고    scopus 로고
    • Direct and indirect pathways for corticospinal control of upper limb motoneurons in the primate
    • Lemon, R.N.; Kirkwood, P.A.; Maier, M.A.; Nakajima, K.; Nathan, P. Direct and indirect pathways for corticospinal control of upper limb motoneurons in the primate. Prog. Brain Res. 2004, 143, 263-279.
    • (2004) Prog. Brain Res. , vol.143 , pp. 263-279
    • Lemon, R.N.1    Kirkwood, P.A.2    Maier, M.A.3    Nakajima, K.4    Nathan, P.5
  • 72
    • 24144441717 scopus 로고    scopus 로고
    • Comparing the function of the corticospinal system in different species: Organizational differences for motor specialization?
    • Lemon, R.N.; Griffiths, J. Comparing the function of the corticospinal system in different species: organizational differences for motor specialization? Muscle Nerve 2005, 32, 261-279.
    • (2005) Muscle Nerve , vol.32 , pp. 261-279
    • Lemon, R.N.1    Griffiths, J.2
  • 73
    • 33745012950 scopus 로고    scopus 로고
    • Neural subtype specification from embryonic stem cells
    • Zhang, S.C. Neural subtype specification from embryonic stem cells. Brain Pathol. 2006, 16, 132-142.
    • (2006) Brain Pathol. , vol.16 , pp. 132-142
    • Zhang, S.C.1
  • 74
    • 0035986888 scopus 로고    scopus 로고
    • Evolution of transcription factor binding sites in Mammalian gene regulatory regions: Conservation and turnover
    • Dermitzakis, E.T.; Clark, A.G. Evolution of transcription factor binding sites in Mammalian gene regulatory regions: Conservation and turnover. Mol. Biol. Evol. 2002, 19, 1114-1121.
    • (2002) Mol. Biol. Evol. , vol.19 , pp. 1114-1121
    • Dermitzakis, E.T.1    Clark, A.G.2
  • 76
    • 77954214164 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration
    • Hardingham, G.E.; Patani, R.; Baxter, P.; Wyllie, D.J.; Chandran, S. Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration. Mol. Neurobiol. 2010, 42, 97-102.
    • (2010) Mol. Neurobiol. , vol.42 , pp. 97-102
    • Hardingham, G.E.1    Patani, R.2    Baxter, P.3    Wyllie, D.J.4    Chandran, S.5
  • 77
    • 34548746306 scopus 로고    scopus 로고
    • Myocardial reperfusion injury
    • Yellon, D.M.; Hausenloy, D.J. Myocardial reperfusion injury. N. Engl. J. Med. 2007, 357, 1121-1135.
    • (2007) N. Engl. J. Med. , vol.357 , pp. 1121-1135
    • Yellon, D.M.1    Hausenloy, D.J.2
  • 78
    • 34247859379 scopus 로고    scopus 로고
    • Reperfusion injury in humans: A review of clinical trials on reperfusion injury inhibitory strategies
    • Dirksen, M.T.; Laarman, G.J.; Simoons, M.L.; Duncker, D.J. Reperfusion injury in humans: A review of clinical trials on reperfusion injury inhibitory strategies. Cardiovasc. Res. 2007, 74, 343-355.
    • (2007) Cardiovasc. Res. , vol.74 , pp. 343-355
    • Dirksen, M.T.1    Laarman, G.J.2    Simoons, M.L.3    Duncker, D.J.4
  • 81
    • 79956212343 scopus 로고    scopus 로고
    • Constructing and deconstructing stem cell models of neurological disease
    • Han, S.S.; Williams, L.A.; Eggan, K.C. Constructing and deconstructing stem cell models of neurological disease. Neuron 2011, 70, 626-644.
    • (2011) Neuron , vol.70 , pp. 626-644
    • Han, S.S.1    Williams, L.A.2    Eggan, K.C.3
  • 86
    • 45849146018 scopus 로고    scopus 로고
    • Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules
    • Li, X.J.; Hu, B.Y.; Jones, S.A.; Zhang, Y.S.; Lavaute, T.; Du, Z.W.; Zhang, S.C. Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules. Stem Cells 2008, 26, 886-893.
    • (2008) Stem Cells , vol.26 , pp. 886-893
    • Li, X.J.1    Hu, B.Y.2    Jones, S.A.3    Zhang, Y.S.4    Lavaute, T.5    Du, Z.W.6    Zhang, S.C.7
  • 88
    • 70350191753 scopus 로고    scopus 로고
    • Activin/nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity
    • Patani, R.; Compston, A.; Puddifoot, C.A.; Wyllie, D.J.A.; Hardingham, G.E.; Allen, N.D.; Chandran, S. Activin/nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity. PLoS One 2009, 4, e7327.
    • (2009) PLoS One , vol.4
    • Patani, R.1    Compston, A.2    Puddifoot, C.A.3    Wyllie, D.J.A.4    Hardingham, G.E.5    Allen, N.D.6    Chandran, S.7
  • 90
    • 79958128131 scopus 로고    scopus 로고
    • Specification of transplantable astroglial subtypes from human pluripotent stem cells
    • Krencik, R.; Weick, J.P.; Liu, Y.; Zhang, Z.-J.; Zhang, S.-C. Specification of transplantable astroglial subtypes from human pluripotent stem cells. Nat. Biotechnol. 2011, 29, 528-534.
    • (2011) Nat. Biotechnol. , vol.29 , pp. 528-534
    • Krencik, R.1    Weick, J.P.2    Liu, Y.3    Zhang, Z.-J.4    Zhang, S.-C.5
  • 92
    • 13544264789 scopus 로고    scopus 로고
    • Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation
    • Nistor, G.I.; Totoiu, M.O.; Haque, N.; Carpenter, M.K.; Keirstead, H.S. Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation. Glia 2005, 49, 385-396.
    • (2005) Glia , vol.49 , pp. 385-396
    • Nistor, G.I.1    Totoiu, M.O.2    Haque, N.3    Carpenter, M.K.4    Keirstead, H.S.5
  • 93
    • 18644384444 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury
    • Keirstead, H.S.; Nistor, G.; Bernal, G.; Totoiu, M.; Cloutier, F.; Sharp, K.; Steward, O. Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J. Neurosci. 2005, 25, 4694-4705.
    • (2005) J. Neurosci. , vol.25 , pp. 4694-4705
    • Keirstead, H.S.1    Nistor, G.2    Bernal, G.3    Totoiu, M.4    Cloutier, F.5    Sharp, K.6    Steward, O.7
  • 94
    • 30444459785 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived oligodendrocyte progenitors for the treatment of spinal cord injury
    • Faulkner, J.; Keirstead, H.S. Human embryonic stem cell-derived oligodendrocyte progenitors for the treatment of spinal cord injury. Transpl. Immunol. 2005, 15, 131-142.
    • (2005) Transpl. Immunol. , vol.15 , pp. 131-142
    • Faulkner, J.1    Keirstead, H.S.2
  • 95
    • 67649212160 scopus 로고    scopus 로고
    • Human oligodendrocytes from embryonic stem cells: Conserved SHH signaling networks and divergent FGF effects
    • Hu, B.Y.; Du, Z.W.; Li, X.J.; Ayala, M.; Zhang, S.C. Human oligodendrocytes from embryonic stem cells: Conserved SHH signaling networks and divergent FGF effects. Development 2009, 136, 1443-1452.
    • (2009) Development , vol.136 , pp. 1443-1452
    • Hu, B.Y.1    Du, Z.W.2    Li, X.J.3    Ayala, M.4    Zhang, S.C.5
  • 96
    • 34249880066 scopus 로고    scopus 로고
    • Generation of germline-competent induced pluripotent stem cells
    • Okita, K.; Ichisaka, T.; Yamanaka, S. Generation of germline-competent induced pluripotent stem cells. Nature 2007, 448, 313-317.
    • (2007) Nature , vol.448 , pp. 313-317
    • Okita, K.1    Ichisaka, T.2    Yamanaka, S.3
  • 97
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi, K.; Tanabe, K.; Ohnuki, M.; Narita, M.; Ichisaka, T.; Tomoda, K.; Yamanaka, S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131, 861-872.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 98
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi, K.; Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126, 663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 101
    • 1242276404 scopus 로고    scopus 로고
    • Feeder layer-and serum-free culture of human embryonic stem cells
    • Amit, M.; Shariki, C.; Margulets, V.; Itskovitz-Eldor, J. Feeder layer-and serum-free culture of human embryonic stem cells. Biol. Reprod. 2004, 70, 837-845.
    • (2004) Biol. Reprod. , vol.70 , pp. 837-845
    • Amit, M.1    Shariki, C.2    Margulets, V.3    Itskovitz-Eldor, J.4
  • 103
    • 57549095977 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells in adherent and in chemically defined culture conditions
    • doi:10.1002/9780470151808.sc01d04s4
    • Vallier, L.; Pedersen, R. Differentiation of human embryonic stem cells in adherent and in chemically defined culture conditions. Curr. Protoc. Stem Cell Biol. 2008, doi:10.1002/9780470151808.sc01d04s4.
    • (2008) Curr. Protoc. Stem Cell Biol.
    • Vallier, L.1    Pedersen, R.2
  • 105
    • 0001981347 scopus 로고
    • Sexually mature individuals of Xenopus laevis from the transplantation of single somatic nuclei
    • Gurdon, J.B.; Elsdale, T.R.; Fischberg, M. Sexually mature individuals of Xenopus laevis from the transplantation of single somatic nuclei. Nature 1958, 182, 64-65.
    • (1958) Nature , vol.182 , pp. 64-65
    • Gurdon, J.B.1    Elsdale, T.R.2    Fischberg, M.3
  • 106
    • 0029967424 scopus 로고    scopus 로고
    • Sheep cloned by nuclear transfer from a cultured cell line
    • Campbell, K.H.; McWhir, J.; Ritchie, W.A.; Wilmut, I. Sheep cloned by nuclear transfer from a cultured cell line. Nature 1996, 380, 64-66.
    • (1996) Nature , vol.380 , pp. 64-66
    • Campbell, K.H.1    McWhir, J.2    Ritchie, W.A.3    Wilmut, I.4
  • 107
    • 23944457397 scopus 로고    scopus 로고
    • Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells
    • Cowan, C.A.; Atienza, J.; Melton, D.A.; Eggan, K. Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science 2005, 309, 1369-1373.
    • (2005) Science , vol.309 , pp. 1369-1373
    • Cowan, C.A.1    Atienza, J.2    Melton, D.A.3    Eggan, K.4
  • 108
    • 70350571742 scopus 로고    scopus 로고
    • Tgfbeta signal inhibition cooperates in the induction of iPSCs and replaces Sox2 and cMyc
    • Maherali, N.; Hochedlinger, K. Tgfbeta signal inhibition cooperates in the induction of iPSCs and replaces Sox2 and cMyc. Curr. Biol. 2009, 19, 1718-1723.
    • (2009) Curr. Biol. , vol.19 , pp. 1718-1723
    • Maherali, N.1    Hochedlinger, K.2
  • 110
    • 68249149638 scopus 로고    scopus 로고
    • Induced pluripotent stem cells free of exogenous reprogramming factors
    • Abujarour, R.; Ding, S. Induced pluripotent stem cells free of exogenous reprogramming factors. Genome Biol. 2009, 10, 220.
    • (2009) Genome Biol. , vol.10 , pp. 220
    • Abujarour, R.1    Ding, S.2
  • 111
    • 77649162059 scopus 로고    scopus 로고
    • Direct conversion of fibroblasts to functional neurons by defined factors
    • Vierbuchen, T.; Ostermeier, A.; Pang, Z.P.; Kokubu, Y.; Südhof, T.C.; Wernig, M. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 2010, 463, 1035-1041.
    • (2010) Nature , vol.463 , pp. 1035-1041
    • Vierbuchen, T.1    Ostermeier, A.2    Pang, Z.P.3    Kokubu, Y.4    Südhof, T.C.5    Wernig, M.6
  • 114
    • 70450159769 scopus 로고    scopus 로고
    • Coordination of sonic hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells
    • Li, X.J.; Zhang, X.; Johnson, M.A.; Wang, Z.B.; Lavaute, T.; Zhang, S.C. Coordination of sonic hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells. Development 2009, 136, 4055-4063.
    • (2009) Development , vol.136 , pp. 4055-4063
    • Li, X.J.1    Zhang, X.2    Johnson, M.A.3    Wang, Z.B.4    Lavaute, T.5    Zhang, S.C.6
  • 115
    • 84864136403 scopus 로고    scopus 로고
    • Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis
    • Patani, R.; Lewis, P.A.; Trabzuni, D.; Puddifoot, C.A.; Wyllie, D.J.; Walker, R.; Smith, C.; Hardingham, G.E.; Weale, M.; Hardy, J.; et al. Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis. J. Neurochem. 2012, 122, 738-751.
    • (2012) J. Neurochem. , vol.122 , pp. 738-751
    • Patani, R.1    Lewis, P.A.2    Trabzuni, D.3    Puddifoot, C.A.4    Wyllie, D.J.5    Walker, R.6    Smith, C.7    Hardingham, G.E.8    Weale, M.9    Hardy, J.10
  • 116
    • 77954137428 scopus 로고    scopus 로고
    • What can pluripotent stem cells teach us about neurodegenerative diseases?
    • Wichterle, H.; Przedborski, S. What can pluripotent stem cells teach us about neurodegenerative diseases? Nat. Neurosci. 2010, 13, 800-804.
    • (2010) Nat. Neurosci. , vol.13 , pp. 800-804
    • Wichterle, H.1    Przedborski, S.2
  • 119
    • 78149488365 scopus 로고    scopus 로고
    • A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells
    • Marchetto, M.C.; Carromeu, C.; Acab, A.; Yu, D.; Yeo, G.W.; Mu, Y.; CHen, G.; Gage, F.H.; Muotri, A.R. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell 2010, 143, 527-539.
    • (2010) Cell , vol.143 , pp. 527-539
    • Marchetto, M.C.1    Carromeu, C.2    Acab, A.3    Yu, D.4    Yeo, G.W.5    Mu, Y.6    CHen, G.7    Gage, F.H.8    Muotri, A.R.9
  • 122
    • 0030735088 scopus 로고    scopus 로고
    • Emergence of oligodendrocytes from human neural spheres
    • Murray, K.; Dubois-Dalcq, M. Emergence of oligodendrocytes from human neural spheres. J. Neurosci. Res. 1997, 50, 146-156.
    • (1997) J. Neurosci. Res. , vol.50 , pp. 146-156
    • Murray, K.1    Dubois-Dalcq, M.2
  • 123
    • 0033199313 scopus 로고    scopus 로고
    • Lineage restriction of neuroepithelial precursor cells from fetal human spinal cord
    • Quinn, S.M.; Walters, W.M.; Vescovi, A.L.; Whittemore, S.R. Lineage restriction of neuroepithelial precursor cells from fetal human spinal cord. J. Neurosci. Res. 1999, 57, 590-602.
    • (1999) J. Neurosci. Res. , vol.57 , pp. 590-602
    • Quinn, S.M.1    Walters, W.M.2    Vescovi, A.L.3    Whittemore, S.R.4
  • 124
    • 0034141281 scopus 로고    scopus 로고
    • Tracing human oligodendroglial development in vitro
    • Zhang, S.C.; Ge, B.; Duncan, I.D. Tracing human oligodendroglial development in vitro. J. Neurosci. Res. 2000, 59, 421-429.
    • (2000) J. Neurosci. Res. , vol.59 , pp. 421-429
    • Zhang, S.C.1    Ge, B.2    Duncan, I.D.3
  • 125
    • 4644305940 scopus 로고    scopus 로고
    • Differential generation of oligodendrocytes from human and rodent embryonic spinal cord neural precursors
    • Chandran, S.; Compston, A.; Jauniaux, E.; Gilson, J.; Blakemore, W.; Svendsen, C. Differential generation of oligodendrocytes from human and rodent embryonic spinal cord neural precursors. Glia 2004, 47, 314-324.
    • (2004) Glia , vol.47 , pp. 314-324
    • Chandran, S.1    Compston, A.2    Jauniaux, E.3    Gilson, J.4    Blakemore, W.5    Svendsen, C.6
  • 127
    • 80055069793 scopus 로고    scopus 로고
    • Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease
    • Zou, J.; Mali, P.; Huang, X.; Dowey, S.N.; Cheng, L. Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease. Blood 2011, 118, 4599-4608.
    • (2011) Blood , vol.118 , pp. 4599-4608
    • Zou, J.1    Mali, P.2    Huang, X.3    Dowey, S.N.4    Cheng, L.5
  • 128
    • 79957587075 scopus 로고    scopus 로고
    • Oxidase-deficient neutrophils from X-linked chronic granulomatous disease iPS cells: Functional correction by zinc finger nuclease-mediated safe harbor targeting
    • Zou, J.; Sweeney, C.L.; Chou, B.K.; Choi, U.; Pan, J.; Wang, H.; Dowey, S.N.; Cheng, L.; Malech, H.L. Oxidase-deficient neutrophils from X-linked chronic granulomatous disease iPS cells: Functional correction by zinc finger nuclease-mediated safe harbor targeting. Blood 2011, 117, 5561-5572.
    • (2011) Blood , vol.117 , pp. 5561-5572
    • Zou, J.1    Sweeney, C.L.2    Chou, B.K.3    Choi, U.4    Pan, J.5    Wang, H.6    Dowey, S.N.7    Cheng, L.8    Malech, H.L.9
  • 130
    • 74349110228 scopus 로고    scopus 로고
    • Zinc-finger nucleases meet iPS cells: Zinc positive: Tailored genome engineering meets reprogramming
    • Cathomen, T.; Schambach, A. Zinc-finger nucleases meet iPS cells: Zinc positive: tailored genome engineering meets reprogramming. Gene Ther. 2010, 17, 1-3.
    • (2010) Gene Ther. , vol.17 , pp. 1-3
    • Cathomen, T.1    Schambach, A.2
  • 131
    • 56549096129 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation
    • Di Giorgio, F.P.; Boulting, G.L.; Bobrowicz, S.; Eggan, K.C. Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation. Cell Stem Cell 2008, 3, 637-648.
    • (2008) Cell Stem Cell , vol.3 , pp. 637-648
    • di Giorgio, F.P.1    Boulting, G.L.2    Bobrowicz, S.3    Eggan, K.C.4
  • 132
    • 34247473080 scopus 로고    scopus 로고
    • Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model
    • Di Giorgio, F.P.; Carrasco, M.A.; Siao, M.C.; Maniatis, T.; Eggan, K. Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nat. Neurosci. 2007, 10, 608-614.
    • (2007) Nat. Neurosci. , vol.10 , pp. 608-614
    • di Giorgio, F.P.1    Carrasco, M.A.2    Siao, M.C.3    Maniatis, T.4    Eggan, K.5
  • 135
    • 33750706917 scopus 로고    scopus 로고
    • Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes
    • Roy, N.S.; Cleren, C.; Singh, S.K.; Yang, L.; Beal, M.F.; Goldman, S.A. Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat. Med. 2006, 12, 1259-1268.
    • (2006) Nat. Med. , vol.12 , pp. 1259-1268
    • Roy, N.S.1    Cleren, C.2    Singh, S.K.3    Yang, L.4    Beal, M.F.5    Goldman, S.A.6
  • 136
    • 0032529351 scopus 로고    scopus 로고
    • Transplanted olfactory ensheathing cells remyelinate and enhance axonal conduction in the demyelinated dorsal columns of the rat spinal cord
    • Imaizumi, T.; Lankford, K.L.; Waxman, S.G.; Greer, C.A.; Kocsis, J.D. Transplanted olfactory ensheathing cells remyelinate and enhance axonal conduction in the demyelinated dorsal columns of the rat spinal cord. J. Neurosci. 1998, 18, 6176-6185.
    • (1998) J. Neurosci. , vol.18 , pp. 6176-6185
    • Imaizumi, T.1    Lankford, K.L.2    Waxman, S.G.3    Greer, C.A.4    Kocsis, J.D.5
  • 137
    • 0023867013 scopus 로고
    • Extensive oligodendrocyte remyelination following injection of cultured central nervous system cells into demyelinating lesions in adult central nervous system
    • Blakemore, W.F.; Crang, A.J. Extensive oligodendrocyte remyelination following injection of cultured central nervous system cells into demyelinating lesions in adult central nervous system. Dev. Neurosci. 1988, 10, 1-11.
    • (1988) Dev. Neurosci. , vol.10 , pp. 1-11
    • Blakemore, W.F.1    Crang, A.J.2
  • 138
    • 0031024177 scopus 로고    scopus 로고
    • Transplanting oligodendrocyte progenitors into the adult CNS
    • Franklin, R.J.; Blakemore, W.F. Transplanting oligodendrocyte progenitors into the adult CNS. J. Anat. 1997, 190, 23-33.
    • (1997) J. Anat. , vol.190 , pp. 23-33
    • Franklin, R.J.1    Blakemore, W.F.2
  • 141
    • 0033198197 scopus 로고    scopus 로고
    • Polysialylated neural cell adhesion molecule-positive CNS precursors generate both oligodendrocytes and Schwann cells to remyelinate the CNS after transplantation
    • Keirstead, H.S.; Ben-Hur, T.; Rogister, B.; O'Leary, M.T.; Dubois-Dalcq, M.; Blakemore, W.F. Polysialylated neural cell adhesion molecule-positive CNS precursors generate both oligodendrocytes and Schwann cells to remyelinate the CNS after transplantation. J. Neurosci. 1999, 19, 7529-7536.
    • (1999) J. Neurosci. , vol.19 , pp. 7529-7536
    • Keirstead, H.S.1    Ben-Hur, T.2    Rogister, B.3    O'Leary, M.T.4    Dubois-Dalcq, M.5    Blakemore, W.F.6
  • 142
    • 0035109748 scopus 로고    scopus 로고
    • Transplantation of cryopreserved adult human Schwann cells enhances axonal conduction in demyelinated spinal cord
    • Kohama, I.; Lankford, K.L.; Preiningerova, J.; White, F.A.; Vollmer, T.L.; Kocsis, J.D. Transplantation of cryopreserved adult human Schwann cells enhances axonal conduction in demyelinated spinal cord. J. Neurosci. 2001, 21, 944-950.
    • (2001) J. Neurosci. , vol.21 , pp. 944-950
    • Kohama, I.1    Lankford, K.L.2    Preiningerova, J.3    White, F.A.4    Vollmer, T.L.5    Kocsis, J.D.6
  • 144
    • 0036703491 scopus 로고    scopus 로고
    • Remyelination of the rat spinal cord by transplantation of identified bone marrow stromal cells
    • Akiyama, Y.; Radtke, C.; Kocsis, J.D. Remyelination of the rat spinal cord by transplantation of identified bone marrow stromal cells. J. Neurosci. 2002, 22, 6623-6630.
    • (2002) J. Neurosci. , vol.22 , pp. 6623-6630
    • Akiyama, Y.1    Radtke, C.2    Kocsis, J.D.3
  • 146
    • 0030198318 scopus 로고    scopus 로고
    • Schwann cell-like myelination following transplantation of an olfactory bulb-ensheathing cell line into areas of demyelination in the adult CNS
    • Franklin, R.J.; Gilson, J.M.; Franceschini, I.A.; Barnett, S.C. Schwann cell-like myelination following transplantation of an olfactory bulb-ensheathing cell line into areas of demyelination in the adult CNS. Glia 1996, 17, 217-224.
    • (1996) Glia , vol.17 , pp. 217-224
    • Franklin, R.J.1    Gilson, J.M.2    Franceschini, I.A.3    Barnett, S.C.4
  • 147
    • 4744347671 scopus 로고    scopus 로고
    • Identified olfactory ensheathing cells transplanted into the transected dorsal funiculus bridge the lesion and form myelin
    • Sasaki, M.; Lankford, K.L.; Zemedkun, M.; Kocsis, J.D. Identified olfactory ensheathing cells transplanted into the transected dorsal funiculus bridge the lesion and form myelin. J. Neurosci. 2004, 24, 8485-8493.
    • (2004) J. Neurosci. , vol.24 , pp. 8485-8493
    • Sasaki, M.1    Lankford, K.L.2    Zemedkun, M.3    Kocsis, J.D.4
  • 148
    • 0344826483 scopus 로고    scopus 로고
    • Olfactory ensheathing cells induce less host astrocyte response and chondroitin sulphate proteoglycan expression than Schwann cells following transplantation into adult CNS white matter
    • Lakatos, A.; Barnett, S.C.; Franklin, R.J. Olfactory ensheathing cells induce less host astrocyte response and chondroitin sulphate proteoglycan expression than Schwann cells following transplantation into adult CNS white matter. Exp. Neurol. 2003, 184, 237-246.
    • (2003) Exp. Neurol. , vol.184 , pp. 237-246
    • Lakatos, A.1    Barnett, S.C.2    Franklin, R.J.3
  • 149
    • 0033668134 scopus 로고    scopus 로고
    • Olfactory ensheathing cells and Schwann cells differ in their in vitro interactions with astrocytes
    • Lakatos, A.; Franklin, R.J.; Barnett, S.C. Olfactory ensheathing cells and Schwann cells differ in their in vitro interactions with astrocytes. Glia 2000, 32, 214-225.
    • (2000) Glia , vol.32 , pp. 214-225
    • Lakatos, A.1    Franklin, R.J.2    Barnett, S.C.3
  • 150
    • 0035096330 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis pathogenesis: Implications for diagnosis and therapy
    • Lassmann, H.; Bruck, W.; Lucchinetti, C. Heterogeneity of multiple sclerosis pathogenesis: Implications for diagnosis and therapy. Trends Mol. Med. 2001, 7, 115-121.
    • (2001) Trends Mol. Med. , vol.7 , pp. 115-121
    • Lassmann, H.1    Bruck, W.2    Lucchinetti, C.3
  • 151
    • 3042601986 scopus 로고    scopus 로고
    • The pathology of primary progressive multiple sclerosis
    • Lucchinetti, C.; Bruck, W. The pathology of primary progressive multiple sclerosis. Mult. Scler. 2004, 10, S23-S30.
    • (2004) Mult. Scler. , vol.10
    • Lucchinetti, C.1    Bruck, W.2
  • 153
    • 15044357461 scopus 로고    scopus 로고
    • Inflammation stimulates remyelination in areas of chronic demyelination
    • Foote, A.K.; Blakemore, W.F. Inflammation stimulates remyelination in areas of chronic demyelination. Brain 2005, 128, 528-539.
    • (2005) Brain , vol.128 , pp. 528-539
    • Foote, A.K.1    Blakemore, W.F.2
  • 157
    • 84856023693 scopus 로고    scopus 로고
    • Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: An open-label phase 2a proof-of-concept study
    • Connick, P.; Kolappan, M.; Crawley, C.; Webber, D.J.; Patani, R.; Michell, A.W.; Du, M.Q.; Luan, S.L.; Altmann, D.R.; Thompson, A.J.; et al. Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: An open-label phase 2a proof-of-concept study. Lancet Neurol. 2012, 11, 150-156.
    • (2012) Lancet Neurol. , vol.11 , pp. 150-156
    • Connick, P.1    Kolappan, M.2    Crawley, C.3    Webber, D.J.4    Patani, R.5    Michell, A.W.6    Du, M.Q.7    Luan, S.L.8    Altmann, D.R.9    Thompson, A.J.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.