Neurological disability correlates with spinal cord axonal loss and reduced N-acetyl aspartate in chronic multiple sclerosis patients

Annals of Neurology

Volumn 48, Issue 6, 2000, Pages 893-901

  Bjartmar, Carl ^a   Kidd, Grahame ^a   Mörk, Sverre ^b   Rudick, Richard ^a   Trapp, Bruce D ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

N ACETYLASPARTIC ACID;

ADULT; AGED; ARTICLE; AUTOPSY; CHRONIC DISEASE; CORRELATION FUNCTION; DEMYELINATION; DISEASE ASSOCIATION; FEMALE; GRAY MATTER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MALE; MULTIPLE SCLEROSIS; NERVE FIBER DEGENERATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; SPINAL CORD ATROPHY; SPINAL CORD NERVE CELL; WHITE MATTER;

ADULT; AGED; AGED, 80 AND OVER; ASPARTIC ACID; AXONS; CHRONIC DISEASE; DISABILITY EVALUATION; FEMALE; HUMANS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; SPINAL CORD;

EID: 0033663894     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/1531-8249(200012)48:6<893::AID-ANA10>3.0.CO;2-B     Document Type: Article

References (46)

1. Defining the clinical course of multiple sclerosis: Results of an international survey
2. Management of multiple sclerosis
3. Neurodegeneration in multiple sclerosis: Relationship to neurological disability
4. The longstanding MS lesion
5. Use of proton magnetic resonance spectroscopy for monitoring disease progression in multiple sclerosis
6. Persistent functional deficit in multiple sclerosis and autosomal dominant cerebellar ataxia is associated with axon loss
7. Axonal damage in acute multiple sclerosis lesions
8. Imaging of axonal damage in multiple sclerosis: Spatial distribution of magnetic resonance imaging lesions
9. Neuropathology in multiple sclerosis: New concepts
10. Axonal transection in the lesions of multiple sclerosis
11. Axonal loss in multiple sclerosis lesions: Magnetic resonance imaging insights into substrates of disability
12. Progressive cerebral atrophy in multiple sclerosis: A serial MRI study
13. A longitudinal study of brain atrophy in relapsing multiple sclerosis
14. Use of the brain parenchymal fraction to measure whole brain atrophy in relapsing-remitting MS
15. Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions
16. Putting magnetic resonance spectroscopy studies in context: Axonal damage and disability in multiple sclerosis
17. Serial proton magnetic resonance spectroscopic imaging, contrast-enhanced magnetic resonance imaging, and quantitative lesion volumetry in multiple sclerosis
18. 1H-NMR spectroscopic studies of brain
19. Immunohistochemical localization of N-acetylaspartate in rat brain
20. Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies
21. Synthesis of N-acetyl-L-aspartate by rat brain mitochondria and involvement in mitochondrial/cytosolic carbon transport
22. A relationship of N-acetylaspartate biosynthesis to neuronal protein synthesis
23. Immunohistochemistry and biosynthesis of N-acetylaspartylglutamate in spinal sensory ganglia
24. Brief report: Organic osmolytes in the brain of an infant with hypernatremia
25. The cervical cord in multiple sclerosis
26. Spinal cord MRI using multi-array coils and fast spin echo. I. Technical aspects and findings in healthy adults
27. Spinal cord atrophy and disability in multiple sclerosis: A new reproducible and sensitive MRI method with potential to monitor disease progression
28. In situ changes in purine nucleotide and N-acetyl concentrations upon inducing global ischemia in cat brain
29. 1H magnetic resonance spectroscopy
30. Spinal cord MRI using multi-array coils and fast spin echo. II. Findings in multiple sclerosis
31. Neurochemical and immunocytochemical studies on the distribution of N-acetylaspartylglutamate and N-acetyl-aspartate in rat spinal cord and some peripheral nervous tissues
32. Spinal cord axonal loss in multiple sclerosis: A post-mortem study
33. Biotechnological agents for the immunotherapy of multiple sclerosis. Principles, problems and perspectives
34. Axonal pathology in demyelinating diseases
35. Axonal pathology in myelin disorders
36. Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis: Results of a longitudinal magnetic resonance spectroscopy study
37. Measures of brain and spinal cord atrophy in multiple sclerosis
38. The distribution of plaques in the cerebrum in multiple sclerosis
39. Cortical lesions in multiple sclerosis
40. Inflammatory central nervous system demyelination: Correlation of magnetic resonance imaging findings with lesion pathology
41. Proton magnetic resonance spectroscopy of cerebral lactate and other metabolites in stroke patients
42. Detection of cortical neuron loss in motor neuron disease by proton magnetic resonance spectroscopic imaging in vivo
43. Correlates of executive function in multiple sclerosis: The use of magnetic resonance spectroscopy as an index of focal pathology
44. Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells
45. 1H magnetic resonance spectroscopy study
46. Total brain N-acetylaspartate. A new measure of disease load in MS