Acquired channelopathies in nerve injury and MS

Neurology

Volumn 56, Issue 12, 2001, Pages 1621-1627

  Waxman, Stephen G ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SODIUM CHANNEL;

GENE EXPRESSION; GENE MUTATION; MULTIPLE SCLEROSIS; NERVE CELL EXCITABILITY; PATHOPHYSIOLOGY; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; PURKINJE CELL; REVIEW; SENSORY NERVE CELL;

EID: 0035954344     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.56.12.1621     Document Type: Review

References (62)

1. Cellular and molecular biology of voltage-gated sodium channels
2. Nomenclature of voltage-gated sodium channels
3. The neuron as a dynamic electrogenic machine: Modulation of sodium channel expression as a basis for functional plasticity in neurons
4. Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+2
5. The pathophysiology of damaged peripheral nerves
6. Long-term regenerated nerve fibres retain sensitivity to potassium channel blocking agents
7. Maturation of mammalian myelinated fibers: Changes in action potential characteristics following 4-aminopyridine application
8. Down-regulation of transcripts for Na channel α-SNS in spinal sensory neurons following axotomy
9. NaN, a novel voltage-gated Na channel preferentially expressed in peripheral sensory neurons and down-regulated following axotomy
10. Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is re-expressed following axotomy
11. Upregulation of a silent sodium channel after peripheral, but not central, nerve injury in DRG neurons
12. Changes in expression of two tetrodotoxin-resistant sodium channels and their currents in dorsal root ganglion neurons following sciatic nerve injury, but not rhizotomy
13. Down-regulation of tetrodotoxin-resistant sodium currents and up-regulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons following nerve injury
14. Sodium channels and the molecular pathophysiology of pain
15. Plasticity of sodium channel expression in DRG neurons in the chronic constriction model of neuropathic pain
16. Sodium channels and pain
17. Ionic channel organization of normal and regenerating mammalian axons
18. Immunolocalization of SNS/PN3 and NaN/SNS2 sodium channels in human pain states
19. Remyelination in relation to clinical lesions of the central nervous system
20. Demyelinating diseases: New pathological insights, new therapeutic targets
21. Axonal transection in the lesions of multiple sclerosis
22. Axonal damage in acute multiple sclerosis lesions
23. Imaging of axonal damage in multiple sclerosis: Spatial distribution of magnetic resonance imaging lesions
24. The pathological evolution of multiple sclerosis
25. Persistent functional deficit in multiple sclerosis and autosomal dominant cerebellar ataxia is associated with axon loss
26. Conduction in myelinated, unmyelinated, and demyelinated fibers
27. The density of sodium channels in mammalian myelinated nerve fibers and the nature of the axonal membrane under the myelin sheath
28. The internodal axon membrane: Electrical excitability and continuous conduction in segmental demyelination
29. Reorganization of the axonal membrane of demyelinated nerve fibers: Morphological evidence
30. Increased numbers of sodium channels form along demyelinated axons
31. Conduction in segmentally demyelinated mammalian central axons
32. Abnormal expression of SNS/PN3 sodium channel in cerebellar Purkinje cells following loss of myelin in the Taiep rat
33. The Taiep rat: A myelin mutant with an associated oligodendrocyte microtubular defect
34. A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons
35. Structure and function of a novel voltage-gated tetrodotoxin-resistant sodium channel specific to sensory neurons
36. Sensory neuron specific sodium channel SNS is abnormally expressed in the brains of mice with experimental allergic encephalomyelitis and humans with multiple sclerosis
37. Induction of chronic relapsing experimental allergic encephalomyelitis in biozzi mice
38. Cannabinoids control spasticity and tremor in a multiple sclerosis model
39. Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices
40. Initiation and spread of sodium action potentials in cerebellar Purkinje cells
41. Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons
42. Altered subthreshold sodium currents and disrupted firing patterns in Purkinje neurons of Scn81 mutant mice
43. A missense mutation in the sodium channel Scn8a is responsible for cerebellar ataxia in the mouse mutant jolting
44. Characterization of TTX-sensitive and TTX-resistant sodium currents in small cells from adult rat dorsal root ganglia
45. Insertion of a SNS-specific tetrapeptide in the S3-S4 linker of D4 accelerates recovery from inactivation of skeletal muscle voltage-gated Na channel μ1 in HEK293 cells
46. Cellular mechanisms underlying spontaneous firing in rat suprachiasmatic nucleus: Involvement of a slowly inactivating component of sodium current
47. + current heterogeneity in rat nodose neurons and its impact on neuronal discharge
48. + channel inactivation and bursting discharge in a simple model axon: Implications for neuropathic pain
49. The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways
50. + channels in hypomyelinated axons of shiverer mouse brain
51. Reduction in potassium currents in identified cutaneous afferent dorsal root ganglion neurons after axotomy
52. Changes in expression of voltage-gated potassium channels in dorsal root ganglion neurons following axotomy
53. Voltage-gated calcium currents in axotomized adult rat cutaneous afferent neurons
54. Electrical activity, cAMP, and cytosolic calcium regulate mRNA encoding sodium channel α subunits in rat muscle cells
55. + channel mRNA following sensory deprivation of tufted cells in the neonatal rat olfactory bulb
56. A single pulse of nerve growth factor triggers long-term neuronal excitability through sodium channel gene induction
57. Rescue of α-SNS sodium channel expression in small dorsal root ganglion neurons after axotomy by nerve growth factor in vivo
58. GDNF upregulates expression of functional SNS and NaN sodium channels and their currents in axotomized DRG neurons
59. + channel expression increases in dorsal root ganglion neurons in the carrageenan inflammatory pain model
60. + conductance in rat optic nerve axons