메뉴 건너뛰기




Volumn 4, Issue 11, 2012, Pages 2786-2805

Arenaviruses and lethal mutagenesis. prospects for new ribavirin-based interventions

Author keywords

5 fluorouracil; Antiviral treatment; Lymphocytic choriomeningitis virus; Viral quasispecies

Indexed keywords

FLUOROURACIL; RIBAVIRIN; VIRUS RNA;

EID: 84870603707     PISSN: 19994915     EISSN: None     Source Type: Journal    
DOI: 10.3390/v4112786     Document Type: Review
Times cited : (24)

References (102)
  • 1
    • 84870587671 scopus 로고    scopus 로고
    • Current Topics in Microbiol. and Immunol: Berlin, Heidelberg,; Vol. 262 and 263. Springer-Verlag
    • Oldstone, M.B.A. Arenaviruses I and III. Current Topics in Microbiol. and Immunol: Berlin, Heidelberg, 2002; Vol. 262 and 263. Springer-Verlag.
    • (2002) Arenaviruses I and III
    • Oldstone, M.B.A.1
  • 5
    • 0030052809 scopus 로고    scopus 로고
    • Lymphocytic choriomeningitis virus: A neglected central nervous system pathogen
    • Barton, L.L. Lymphocytic choriomeningitis virus: a neglected central nervous system pathogen. Clin. Infect. Dis. 1996, 22, 197.
    • (1996) Clin. Infect. Dis. , vol.22 , pp. 197
    • Barton, L.L.1
  • 7
    • 33646770959 scopus 로고    scopus 로고
    • Lymphocytic choriomeningitis virus: An emerging obstetric pathogen?
    • Jamieson, D.J.; Kourtis, A.P.; Bell, M.; Rasmussen, S.A. Lymphocytic choriomeningitis virus: an emerging obstetric pathogen? Am. J. Obstet. Gynecol. 2006, 194(6), 1532-1536.
    • (2006) Am. J. Obstet. Gynecol. , vol.194 , Issue.6 , pp. 1532-1536
    • Jamieson, D.J.1    Kourtis, A.P.2    Bell, M.3    Rasmussen, S.A.4
  • 13
    • 56649102052 scopus 로고    scopus 로고
    • Treatment of late stage disease in a model of arenaviral hemorrhagic fever: T-705 efficacy and reduced toxicity suggests an alternative to ribavirin
    • Gowen, B.B.; Smee, D.F.; Wong, M.H.; Hall, J.O.; Jung, K.H.; Bailey, K.W.; Stevens, J.R.; Furuta, Y.; Morrey, J.D. Treatment of late stage disease in a model of arenaviral hemorrhagic fever: T-705 efficacy and reduced toxicity suggests an alternative to ribavirin. PLoS One 2008, 3, e3725.
    • (2008) PLoS One , vol.3
    • Gowen, B.B.1    Smee, D.F.2    Wong, M.H.3    Hall, J.O.4    Jung, K.H.5    Bailey, K.W.6    Stevens, J.R.7    Furuta, Y.8    Morrey, J.D.9
  • 17
    • 33847210305 scopus 로고    scopus 로고
    • Fitness landscape of human immunodeficiency virus type 1 protease quasispecies
    • Fernandez, G.; Clotet, B.; Martinez, M.A. Fitness landscape of human immunodeficiency virus type 1 protease quasispecies. J. Virol. 2007, 81, 2485-2496.
    • (2007) J. Virol. , vol.81 , pp. 2485-2496
    • Fernandez, G.1    Clotet, B.2    Martinez, M.A.3
  • 20
    • 0025913807 scopus 로고
    • Molecular basis of organ-specific selection of viral variants during chronic infection
    • Ahmed, R.; Hahn, C.S.; Somasundaram, T.; Villarete, L.; Matloubian, M.; Strauss, J.H. Molecular basis of organ-specific selection of viral variants during chronic infection. J. Virol. 1991, 65, 4242-4247.
    • (1991) J. Virol. , vol.65 , pp. 4242-4247
    • Ahmed, R.1    Hahn, C.S.2    Somasundaram, T.3    Villarete, L.4    Matloubian, M.5    Strauss, J.H.6
  • 21
    • 0023734872 scopus 로고
    • Genetic analysis of in vivo-selected viral variants causing chronic infection: Importance of mutation in the L RNA segment of lymphocytic choriomeningitis virus
    • Ahmed, R.; Simon, R.S.; Matloubian, M.; Kolhekar, S.R.; Southern, P.J.; Freedman, D.M. Genetic analysis of in vivo-selected viral variants causing chronic infection: importance of mutation in the L RNA segment of lymphocytic choriomeningitis virus. J. Virol. 1988, 62, 3301-3308.
    • (1988) J. Virol. , vol.62 , pp. 3301-3308
    • Ahmed, R.1    Simon, R.S.2    Matloubian, M.3    Kolhekar, S.R.4    Southern, P.J.5    Freedman, D.M.6
  • 22
    • 0029926534 scopus 로고    scopus 로고
    • Variants able to cause growth hormone deficiency syndrome are present within the disease-nil WE strain of lymphocytic choriomeningitis virus
    • Buesa-Gomez, J.; Teng, M.N.; Oldstone, C.E.; Oldstone, M.B.; de la Torre, J.C. Variants able to cause growth hormone deficiency syndrome are present within the disease-nil WE strain of lymphocytic choriomeningitis virus. J. Virol. 1996, 70, 8988-8992.
    • (1996) J. Virol. , vol.70 , pp. 8988-8992
    • Buesa-Gomez, J.1    Teng, M.N.2    Oldstone, C.E.3    Oldstone, M.B.4    de la Torre, J.C.5
  • 24
    • 0030067698 scopus 로고    scopus 로고
    • Competitive selection in vivo by a cell for one variant over another: Implications for RNA virus quasispecies in vivo
    • Dockter, J.; Evans, C.F.; Tishon, A.; Oldstone, M.B. Competitive selection in vivo by a cell for one variant over another: implications for RNA virus quasispecies in vivo. J. Virol. 1996, 70, 1799-1803.
    • (1996) J. Virol. , vol.70 , pp. 1799-1803
    • Dockter, J.1    Evans, C.F.2    Tishon, A.3    Oldstone, M.B.4
  • 25
    • 0027948131 scopus 로고
    • Virus-induced immunosuppression: Kinetic analysis of the selection of a mutation associated with viral persistence
    • Evans, C.F.; Borrow, P.; de la Torre, J.C.; Oldstone, M.B. Virus-induced immunosuppression: kinetic analysis of the selection of a mutation associated with viral persistence. J. Virol. 1994, 68, 7367-7373.
    • (1994) J. Virol. , vol.68 , pp. 7367-7373
    • Evans, C.F.1    Borrow, P.2    de la Torre, J.C.3    Oldstone, M.B.4
  • 26
    • 0027361735 scopus 로고
    • Molecular determinants of macrophage tropism and viral persistence: Importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus
    • Matloubian, M.; Kolhekar, S.R.; Somasundaram, T.; Ahmed, R. Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus. J. Virol. 1993, 67, 7340-7349.
    • (1993) J. Virol. , vol.67 , pp. 7340-7349
    • Matloubian, M.1    Kolhekar, S.R.2    Somasundaram, T.3    Ahmed, R.4
  • 27
    • 0025155817 scopus 로고
    • Genetic basis of viral persistence: Single amino acid change in the viral glycoprotein affects ability of lymphocytic choriomeningitis virus to persist in adult mice
    • Matloubian, M.; Somasundaram, T.; Kolhekar, S.R.; Selvakumar, R.; Ahmed, R. Genetic basis of viral persistence: single amino acid change in the viral glycoprotein affects ability of lymphocytic choriomeningitis virus to persist in adult mice. J. Exp. Med. 1990, 172, 1043-1048.
    • (1990) J. Exp. Med. , vol.172 , pp. 1043-1048
    • Matloubian, M.1    Somasundaram, T.2    Kolhekar, S.R.3    Selvakumar, R.4    Ahmed, R.5
  • 29
    • 0026088714 scopus 로고
    • Molecular basis of viral persistence: A single amino acid change in the glycoprotein of lymphocytic choriomeningitis virus is associated with suppression of the antiviral cytotoxic T-lymphocyte response and establishment of persistence
    • Salvato, M.; Borrow, P.; Shimomaye, E.; Oldstone, M.B. Molecular basis of viral persistence: a single amino acid change in the glycoprotein of lymphocytic choriomeningitis virus is associated with suppression of the antiviral cytotoxic T-lymphocyte response and establishment of persistence. J. Virol. 1991, 65, 1863-1869.
    • (1991) J. Virol. , vol.65 , pp. 1863-1869
    • Salvato, M.1    Borrow, P.2    Shimomaye, E.3    Oldstone, M.B.4
  • 30
    • 0029861655 scopus 로고    scopus 로고
    • A single amino acid change in the glycoprotein of lymphocytic choriomeningitis virus is associated with the ability to cause growth hormone deficiency syndrome
    • Teng, M.N.; Borrow, P.; Oldstone, M.B.; de la Torre, J.C. A single amino acid change in the glycoprotein of lymphocytic choriomeningitis virus is associated with the ability to cause growth hormone deficiency syndrome. J. Virol. 1996, 70, 8438-8443.
    • (1996) J. Virol. , vol.70 , pp. 8438-8443
    • Teng, M.N.1    Borrow, P.2    Oldstone, M.B.3    de la Torre, J.C.4
  • 32
    • 0030247470 scopus 로고    scopus 로고
    • Suppression of lymphocytic choriomeningitis virus-induced growth hormone deficiency syndrome by disease-negative virus variants
    • Teng, M.N.; Oldstone, M.B.; de la Torre, J.C. Suppression of lymphocytic choriomeningitis virus-induced growth hormone deficiency syndrome by disease-negative virus variants. Virology 1996, 223, 113-119.
    • (1996) Virology , vol.223 , pp. 113-119
    • Teng, M.N.1    Oldstone, M.B.2    de la Torre, J.C.3
  • 33
    • 0036189270 scopus 로고    scopus 로고
    • Contribution of LCMV towards deciphering biology of quasispecies in vivo
    • Sevilla, N.; Domingo, E.; de la Torre, J.C. Contribution of LCMV towards deciphering biology of quasispecies in vivo. Curr. Top. Microbiol. Immunol. 2002, 263, 197-220.
    • (2002) Curr. Top. Microbiol. Immunol. , vol.263 , pp. 197-220
    • Sevilla, N.1    Domingo, E.2    de la Torre, J.C.3
  • 34
    • 30644470969 scopus 로고    scopus 로고
    • Arenavirus Diversity And Evolution: Quasispecies In Vivo
    • In
    • Sevilla, N.; de la Torre, J.C., Arenavirus Diversity And Evolution: Quasispecies In Vivo. In Cur. Top. Microbiol. Immunol. 2006; Vol. 299, pp 315-335.
    • (2006) Cur. Top. Microbiol. Immunol. , vol.299 , pp. 315-335
    • Sevilla, N.1    de la Torre, J.C.2
  • 35
    • 0036789885 scopus 로고    scopus 로고
    • Molecular indetermination in the transition to error catastrophe: Systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity
    • Grande-Pérez, A.; Sierra, S.; Castro, M.G.; Domingo, E.; Lowenstein, P.R. Molecular indetermination in the transition to error catastrophe: systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity. Proc. Natl. Acad. Sci. USA 2002, 99, 12938-12943.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 12938-12943
    • Grande-Pérez, A.1    Sierra, S.2    Castro, M.G.3    Domingo, E.4    Lowenstein, P.R.5
  • 36
    • 23244443638 scopus 로고    scopus 로고
    • Mutagenesis-induced, large fitness variations with an invariant arenavirus consensus genomic nucleotide sequence
    • Grande-Pérez, A.; Gómez-Mariano, G.; Lowenstein, P.R.; Domingo, E. Mutagenesis-induced, large fitness variations with an invariant arenavirus consensus genomic nucleotide sequence. J. Virol. 2005, 79, 10451-10459.
    • (2005) J. Virol. , vol.79 , pp. 10451-10459
    • Grande-Pérez, A.1    Gómez-Mariano, G.2    Lowenstein, P.R.3    Domingo, E.4
  • 37
    • 0345578679 scopus 로고    scopus 로고
    • Lethal mutagenesis of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV)
    • Ruiz-Jarabo, C.M.; Ly, C.; Domingo, E.; de la Torre, J.C. Lethal mutagenesis of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV). Virology 2003, 308, 37-47.
    • (2003) Virology , vol.308 , pp. 37-47
    • Ruiz-Jarabo, C.M.1    Ly, C.2    Domingo, E.3    de la Torre, J.C.4
  • 38
    • 77949527717 scopus 로고    scopus 로고
    • An interfering activity against lymphocytic choriomeningitis virus replication associated with enhanced mutagenesis
    • Martin, V.; Abia, D.; Domingo, E.; Grande-Perez, A. An interfering activity against lymphocytic choriomeningitis virus replication associated with enhanced mutagenesis. J. Gen. Virol. 2010, 91, 990-1003.
    • (2010) J. Gen. Virol. , vol.91 , pp. 990-1003
    • Martin, V.1    Abia, D.2    Domingo, E.3    Grande-Perez, A.4
  • 40
    • 84858602051 scopus 로고    scopus 로고
    • Mutagenesis-mediated virus extinction: Virus-dependent effect of viral load on sensitivity to lethal defection
    • Moreno, H.; Tejero, H.; de la Torre, J.C.; Domingo, E.; Martin, V. Mutagenesis-mediated virus extinction: virus-dependent effect of viral load on sensitivity to lethal defection. PLoS One 2012, 7, e32550.
    • (2012) PLoS One , vol.7
    • Moreno, H.1    Tejero, H.2    de la Torre, J.C.3    Domingo, E.4    Martin, V.5
  • 41
    • 70350132524 scopus 로고    scopus 로고
    • Therapeutically targeting RNA viruses via lethal mutagenesis
    • Graci, J.D.; Cameron, C.E. Therapeutically targeting RNA viruses via lethal mutagenesis. Future Virol. 2008, 3, 553-566.
    • (2008) Future Virol. , vol.3 , pp. 553-566
    • Graci, J.D.1    Cameron, C.E.2
  • 42
    • 0003901399 scopus 로고
    • A principle of natural self-organization. Springer: Berlin
    • Eigen, M.; Schuster, P. The hypercycle. A principle of natural self-organization. Springer: Berlin, 1979.
    • (1979) The hypercycle
    • Eigen, M.1    Schuster, P.2
  • 43
    • 11844274684 scopus 로고    scopus 로고
    • The error threshold
    • Biebricher, C.K.; Eigen, M. The error threshold. Virus Res. 2005, 107, 117-127.
    • (2005) Virus Res. , vol.107 , pp. 117-127
    • Biebricher, C.K.1    Eigen, M.2
  • 44
    • 80052836937 scopus 로고    scopus 로고
    • Safety, Tolerability, and Pharmacokinetics of KP-1461 in Phase I Clinical Studies: A Single Oral Dose Study in Non-HIV-Infected Adults, and a 14-Day Dose-Escalating Study in Highly Antiretroviral-Experienced HIV-Infected Adults
    • Clay, P.G.; McRae, M.; Laurent, J.P. Safety, Tolerability, and Pharmacokinetics of KP-1461 in Phase I Clinical Studies: A Single Oral Dose Study in Non-HIV-Infected Adults, and a 14-Day Dose-Escalating Study in Highly Antiretroviral-Experienced HIV-Infected Adults. J. Int. Assoc. Physicians AIDS Care (Chic) 2011, 10, 232-238.
    • (2011) J. Int. Assoc. Physicians AIDS Care (Chic) , vol.10 , pp. 232-238
    • Clay, P.G.1    McRae, M.2    Laurent, J.P.3
  • 45
    • 20444414897 scopus 로고    scopus 로고
    • KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis
    • Harris, K.S.; Brabant, W.; Styrchak, S.; Gall, A.; Daifuku, R. KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis. Antiviral Res. 2005, 67, 1-9.
    • (2005) Antiviral Res. , vol.67 , pp. 1-9
    • Harris, K.S.1    Brabant, W.2    Styrchak, S.3    Gall, A.4    Daifuku, R.5
  • 47
    • 34548124606 scopus 로고    scopus 로고
    • Synthesis of a universal 5-nitroindole ribonucleotide and incorporation into RNA by a viral RNA-dependent RNA polymerase
    • Harki, D.A.; Graci, J.D.; Edathil, J.P.; Castro, C.; Cameron, C.E.; Peterson, B.R. Synthesis of a universal 5-nitroindole ribonucleotide and incorporation into RNA by a viral RNA-dependent RNA polymerase. Biochemistry 2007, 8, 1359-1362.
    • (2007) Biochemistry , vol.8 , pp. 1359-1362
    • Harki, D.A.1    Graci, J.D.2    Edathil, J.P.3    Castro, C.4    Cameron, C.E.5    Peterson, B.R.6
  • 48
    • 33750111990 scopus 로고    scopus 로고
    • Synthesis and antiviral activity of 5-substituted cytidine analogues: Identification of a potent inhibitor of viral RNA-dependent RNA polymerases
    • Harki, D.A.; Graci, J.D.; Galarraga, J.E.; Chain, W.J.; Cameron, C.E.; Peterson, B.R. Synthesis and antiviral activity of 5-substituted cytidine analogues: identification of a potent inhibitor of viral RNA-dependent RNA polymerases. J. Med. Chem. 2006, 49, 6166-6169.
    • (2006) J. Med. Chem. , vol.49 , pp. 6166-6169
    • Harki, D.A.1    Graci, J.D.2    Galarraga, J.E.3    Chain, W.J.4    Cameron, C.E.5    Peterson, B.R.6
  • 49
    • 0037162434 scopus 로고    scopus 로고
    • Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-beta-D-Ribofuranosyl-3-nitropyrrole
    • Harki, D.A.; Graci, J.D.; Korneeva, V.S.; Ghosh, S.K.; Hong, Z.; Cameron, C.E.; Peterson, B.R. Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-beta-D-Ribofuranosyl-3-nitropyrrole. Biochemistry 2002, 41, 9026-9033.
    • (2002) Biochemistry , vol.41 , pp. 9026-9033
    • Harki, D.A.1    Graci, J.D.2    Korneeva, V.S.3    Ghosh, S.K.4    Hong, Z.5    Cameron, C.E.6    Peterson, B.R.7
  • 52
    • 0023244181 scopus 로고
    • Sindbis virus mutants resistant to mycophenolic acid and ribavirin
    • Scheidel, L.M.; Durbin, R.K.; Stollar, V. Sindbis virus mutants resistant to mycophenolic acid and ribavirin. Virology 1987, 158, 1-7.
    • (1987) Virology , vol.158 , pp. 1-7
    • Scheidel, L.M.1    Durbin, R.K.2    Stollar, V.3
  • 53
    • 0025752329 scopus 로고
    • Mutations that confer resistance to mycophenolic acid and ribavirin on Sindbis virus map to the nonstructural protein nsP1
    • Scheidel, L.M.; Stollar, V. Mutations that confer resistance to mycophenolic acid and ribavirin on Sindbis virus map to the nonstructural protein nsP1. Virology 1991, 181, 490-499.
    • (1991) Virology , vol.181 , pp. 490-499
    • Scheidel, L.M.1    Stollar, V.2
  • 54
    • 0033587193 scopus 로고    scopus 로고
    • SVMPA, a mutant of sindbis virus resistant to mycophenolic acid and ribavirin, shows an increased sensitivity to chick interferon
    • Rosenblum, C.I.; Stollar, V. SVMPA, a mutant of sindbis virus resistant to mycophenolic acid and ribavirin, shows an increased sensitivity to chick interferon. Virology 1999, 259, 228-233.
    • (1999) Virology , vol.259 , pp. 228-233
    • Rosenblum, C.I.1    Stollar, V.2
  • 55
    • 77958122066 scopus 로고    scopus 로고
    • A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape
    • Agudo, R.; Ferrer-Orta, C.; Arias, A.; de la Higuera, I.; Perales, C.; Perez-Luque, R.; Verdaguer, N.; Domingo, E. A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape. PLoS Pathog. 2010, 6, e1001072.
    • (2010) PLoS Pathog. , vol.6
    • Agudo, R.1    Ferrer-Orta, C.2    Arias, A.3    de la Higuera, I.4    Perales, C.5    Perez-Luque, R.6    Verdaguer, N.7    Domingo, E.8
  • 56
    • 0038809107 scopus 로고    scopus 로고
    • A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity
    • Pfeiffer, J.K.; Kirkegaard, K. A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity. Proc. Natl. Acad. Sci. USA 2003, 100, 7289-7294.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 7289-7294
    • Pfeiffer, J.K.1    Kirkegaard, K.2
  • 57
    • 33745490138 scopus 로고    scopus 로고
    • Increased fidelity reduces poliovirus fitness under selective pressure in mice
    • Pfeiffer, J.K.; Kirkegaard, K. Increased fidelity reduces poliovirus fitness under selective pressure in mice. PLoS Pathog. 2005, 1, 102-110.
    • (2005) PLoS Pathog. , vol.1 , pp. 102-110
    • Pfeiffer, J.K.1    Kirkegaard, K.2
  • 58
    • 31144465690 scopus 로고    scopus 로고
    • Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population
    • Vignuzzi, M.; Stone, J.K.; Arnold, J.J.; Cameron, C.E.; Andino, R. Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population. Nature 2006, 439, 344-348.
    • (2006) Nature , vol.439 , pp. 344-348
    • Vignuzzi, M.1    Stone, J.K.2    Arnold, J.J.3    Cameron, C.E.4    Andino, R.5
  • 59
    • 57349131683 scopus 로고    scopus 로고
    • Determinants of RNA-dependent RNA polymerase (in)fidelity revealed by kinetic analysis of the polymerase encoded by a foot-and-mouth disease virus mutant with reduced sensitivity to ribavirin
    • Arias, A.; Arnold, J.J.; Sierra, M.; Smidansky, E.D.; Domingo, E.; Cameron, C.E. Determinants of RNA-dependent RNA polymerase (in)fidelity revealed by kinetic analysis of the polymerase encoded by a foot-and-mouth disease virus mutant with reduced sensitivity to ribavirin. J. Virol. 2008, 82, 12346-12355.
    • (2008) J. Virol. , vol.82 , pp. 12346-12355
    • Arias, A.1    Arnold, J.J.2    Sierra, M.3    Smidansky, E.D.4    Domingo, E.5    Cameron, C.E.6
  • 61
    • 33846813925 scopus 로고    scopus 로고
    • Foot-and-mouth disease virus mutant with decreased sensitivity to ribavirin: Implications for error catastrophe
    • Sierra, M.; Airaksinen, A.; González-López, C.; Agudo, R.; Arias, A.; Domingo, E. Foot-and-mouth disease virus mutant with decreased sensitivity to ribavirin: implications for error catastrophe. J. Virol. 2007, 81, 2012-2024.
    • (2007) J. Virol. , vol.81 , pp. 2012-2024
    • Sierra, M.1    Airaksinen, A.2    González-López, C.3    Agudo, R.4    Arias, A.5    Domingo, E.6
  • 64
    • 13444310882 scopus 로고    scopus 로고
    • Ribavirin resistance in hepatitis C virus replicon-containing cell lines conferred by changes in the cell line or mutations in the replicon RNA
    • Pfeiffer, J.K.; Kirkegaard, K. Ribavirin resistance in hepatitis C virus replicon-containing cell lines conferred by changes in the cell line or mutations in the replicon RNA. J. Virol. 2005, 79, 2346-2355.
    • (2005) J. Virol. , vol.79 , pp. 2346-2355
    • Pfeiffer, J.K.1    Kirkegaard, K.2
  • 65
    • 78449244303 scopus 로고    scopus 로고
    • Fidelity variants of RNA dependent RNA polymerases uncover an indirect, mutagenic activity of amiloride compounds
    • Levi, L.I.; Gnadig, N.F.; Beaucourt, S.; McPherson, M.J.; Baron, B.; Arnold, J.J.; Vignuzzi, M. Fidelity variants of RNA dependent RNA polymerases uncover an indirect, mutagenic activity of amiloride compounds. PLoS Pathog. 2010, 6, e1001163.
    • (2010) PLoS Pathog. , vol.6
    • Levi, L.I.1    Gnadig, N.F.2    Beaucourt, S.3    McPherson, M.J.4    Baron, B.5    Arnold, J.J.6    Vignuzzi, M.7
  • 66
    • 0141755411 scopus 로고    scopus 로고
    • Identification of a ribavirin-resistant NS5B mutation of hepatitis C virus during ribavirin monotherapy
    • Young, K.C.; Lindsay, K.L.; Lee, K.J.; Liu, W.C.; He, J.W.; Milstein, S.L.; Lai, M.M. Identification of a ribavirin-resistant NS5B mutation of hepatitis C virus during ribavirin monotherapy. Hepatology 2003, 38, 869-878.
    • (2003) Hepatology , vol.38 , pp. 869-878
    • Young, K.C.1    Lindsay, K.L.2    Lee, K.J.3    Liu, W.C.4    He, J.W.5    Milstein, S.L.6    Lai, M.M.7
  • 68
    • 0037108885 scopus 로고    scopus 로고
    • Error catastrophe and antiviral strategy
    • Eigen, M. Error catastrophe and antiviral strategy. Proc. Natl. Acad. Sci. USA 2002, 99, 13374-13376.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 13374-13376
    • Eigen, M.1
  • 69
    • 0025284804 scopus 로고
    • Mutation frequencies at defined single codon sites in vesicular stomatitis virus and poliovirus can be increased only slightly by chemical mutagenesis
    • Holland, J.J.; Domingo, E.; de la Torre, J.C.; Steinhauer, D.A. Mutation frequencies at defined single codon sites in vesicular stomatitis virus and poliovirus can be increased only slightly by chemical mutagenesis. J. Virol. 1990, 64, 3960-3962.
    • (1990) J. Virol. , vol.64 , pp. 3960-3962
    • Holland, J.J.1    Domingo, E.2    de la Torre, J.C.3    Steinhauer, D.A.4
  • 71
    • 0033850837 scopus 로고    scopus 로고
    • Response of foot-and-mouth disease virus to increased mutagenesis. Influence of viral load and fitness in loss of infectivity
    • Sierra, S.; Dávila, M.; Lowenstein, P.R.; Domingo, E. Response of foot-and-mouth disease virus to increased mutagenesis. Influence of viral load and fitness in loss of infectivity. J. Virol. 2000, 74, 8316-8323.
    • (2000) J. Virol. , vol.74 , pp. 8316-8323
    • Sierra, S.1    Dávila, M.2    Lowenstein, P.R.3    Domingo, E.4
  • 73
    • 73549116556 scopus 로고    scopus 로고
    • Potential benefits of sequential inhibitor-mutagen treatments of RNA virus infections
    • Perales, C.; Agudo, R.; Tejero, H.; Manrubia, S.C.; Domingo, E. Potential benefits of sequential inhibitor-mutagen treatments of RNA virus infections. PLoS Pathog. 2009, 5, e1000658.
    • (2009) PLoS Pathog. , vol.5
    • Perales, C.1    Agudo, R.2    Tejero, H.3    Manrubia, S.C.4    Domingo, E.5
  • 75
    • 80053158199 scopus 로고    scopus 로고
    • Tempo and mode of inhibitor-mutagen antiviral therapies: A multidisciplinary approach
    • Iranzo, J.; Perales, C.; Domingo, E.; Manrubia, S.C. Tempo and mode of inhibitor-mutagen antiviral therapies: A multidisciplinary approach. Proc. Natl. Acad. Sci. USA 2011, 108, 16008-16013.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 16008-16013
    • Iranzo, J.1    Perales, C.2    Domingo, E.3    Manrubia, S.C.4
  • 76
    • 70350291512 scopus 로고    scopus 로고
    • 5-Azacytidine can induce lethal mutagenesis in human immunodeficiency virus type 1
    • Dapp, M.J.; Clouser, C.L.; Patterson, S.; Mansky, L.M. 5-Azacytidine can induce lethal mutagenesis in human immunodeficiency virus type 1. J. Virol. 2009, 83, 11950-11958.
    • (2009) J. Virol. , vol.83 , pp. 11950-11958
    • Dapp, M.J.1    Clouser, C.L.2    Patterson, S.3    Mansky, L.M.4
  • 77
    • 76549118168 scopus 로고    scopus 로고
    • Stochastic extinction of viral infectivity through the action of defectors
    • Iranzo, J.; Manrubia, S.C. Stochastic extinction of viral infectivity through the action of defectors. Europhys. Lett. 2009, 85, 18001.
    • (2009) Europhys. Lett. , vol.85 , pp. 18001
    • Iranzo, J.1    Manrubia, S.C.2
  • 78
    • 0033119814 scopus 로고    scopus 로고
    • Prisoner's dilemma in an RNA virus
    • Turner, P.E.; Chao, L. Prisoner's dilemma in an RNA virus. Nature 1999, 398, 441-443.
    • (1999) Nature , vol.398 , pp. 441-443
    • Turner, P.E.1    Chao, L.2
  • 79
    • 0346922470 scopus 로고    scopus 로고
    • Replication at periodically changing multiplicity of infection promotes stable coexistence of competing viral populations
    • Wilke, C.O.; Reissig, D.D.; Novella, I.S. Replication at periodically changing multiplicity of infection promotes stable coexistence of competing viral populations. Evolution Int. J. Org. Evolution 2004, 58, 900-905.
    • (2004) Evolution Int. J. Org. Evolution , vol.58 , pp. 900-905
    • Wilke, C.O.1    Reissig, D.D.2    Novella, I.S.3
  • 80
    • 34248577724 scopus 로고    scopus 로고
    • Insights into RNA virus mutant spectrum and lethal mutagenesis events: Replicative interference and complementation by multiple point mutants
    • Perales, C.; Mateo, R.; Mateu, M.G.; Domingo, E. Insights into RNA virus mutant spectrum and lethal mutagenesis events: replicative interference and complementation by multiple point mutants. J. Mol. Biol. 2007, 369, 985-1000.
    • (2007) J. Mol. Biol. , vol.369 , pp. 985-1000
    • Perales, C.1    Mateo, R.2    Mateu, M.G.3    Domingo, E.4
  • 81
    • 0242608085 scopus 로고    scopus 로고
    • Interference
    • In, Granoff, A.; Webster, R.G., Eds. Academic Press: San Diego, California
    • Youngner, J.S.; Whitaker-Dowling, P. Interference. In Encyclopedia of Virology, Granoff, A.; Webster, R.G., Eds. Academic Press: San Diego, California, 1999; Vol. 2, pp 850-854.
    • (1999) Encyclopedia of Virology , vol.2 , pp. 850-854
    • Youngner, J.S.1    Whitaker-Dowling, P.2
  • 82
    • 0025570214 scopus 로고
    • RNA virus quasispecies populations can suppress vastly superior mutant progeny
    • de la Torre, J.C.; Holland, J.J. RNA virus quasispecies populations can suppress vastly superior mutant progeny. J. Virol. 1990, 64, 6278-6281.
    • (1990) J. Virol. , vol.64 , pp. 6278-6281
    • de la Torre, J.C.1    Holland, J.J.2
  • 83
    • 0026025541 scopus 로고
    • Correlation between amount of virus with altered nucleotide sequence and the monkey test for acceptability of oral poliovirus vaccine
    • Chumakov, K.M.; Powers, L.B.; Noonan, K.E.; Roninson, I.B.; Levenbook, I.S. Correlation between amount of virus with altered nucleotide sequence and the monkey test for acceptability of oral poliovirus vaccine. Proc. Natl. Acad. Sci. USA 1991, 88, 199-203.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 199-203
    • Chumakov, K.M.1    Powers, L.B.2    Noonan, K.E.3    Roninson, I.B.4    Levenbook, I.S.5
  • 84
    • 22844440540 scopus 로고    scopus 로고
    • Trans-dominant inhibition of RNA viral replication can slow growth of drug-resistant viruses
    • Crowder, S.; Kirkegaard, K. Trans-dominant inhibition of RNA viral replication can slow growth of drug-resistant viruses. Nature Genetics 2005, 37, 701-709.
    • (2005) Nature Genetics , vol.37 , pp. 701-709
    • Crowder, S.1    Kirkegaard, K.2
  • 87
    • 81555214151 scopus 로고    scopus 로고
    • Quasispecies as a matter of fact: Viruses and beyond
    • Ojosnegros, S.; Perales, C.; Mas, A.; Domingo, E. Quasispecies as a matter of fact: viruses and beyond. Virus. Res. 2011, 162, 203-215.
    • (2011) Virus. Res. , vol.162 , pp. 203-215
    • Ojosnegros, S.1    Perales, C.2    Mas, A.3    Domingo, E.4
  • 88
    • 84866701494 scopus 로고    scopus 로고
    • Anti-tumor Monoclonal Antibodies in Conjunction with beta-Glucans: A Novel Anti-cancer Immunotherapy
    • in press
    • Xiang, D.; Sharma, V.R.; Freter, C.E.; Yan, J. Anti-tumor Monoclonal Antibodies in Conjunction with beta-Glucans: a Novel Anti-cancer Immunotherapy. Current medicinal chemistry 2012, in press.
    • (2012) Current medicinal chemistry
    • Xiang, D.1    Sharma, V.R.2    Freter, C.E.3    Yan, J.4
  • 89
    • 84864413311 scopus 로고    scopus 로고
    • Recent advances in novel targeted therapies for HER2-positive breast cancer
    • Murphy, C.G.; Morris, P.G. Recent advances in novel targeted therapies for HER2-positive breast cancer. Anti-cancer drugs 2012, 23, 765-776.
    • (2012) Anti-cancer drugs , vol.23 , pp. 765-776
    • Murphy, C.G.1    Morris, P.G.2
  • 90
    • 0034813056 scopus 로고    scopus 로고
    • Efficient virus extinction by combinations of a mutagen and antiviral inhibitors
    • Pariente, N.; Sierra, S.; Lowenstein, P.R.; Domingo, E. Efficient virus extinction by combinations of a mutagen and antiviral inhibitors. J. Virol. 2001, 75, 9723-9730.
    • (2001) J. Virol. , vol.75 , pp. 9723-9730
    • Pariente, N.1    Sierra, S.2    Lowenstein, P.R.3    Domingo, E.4
  • 91
  • 92
    • 50149100514 scopus 로고    scopus 로고
    • Molecular characterization of a dual inhibitory and mutagenic activity of 5-fluorouridine triphosphate on viral RNA synthesis. Implications for lethal mutagenesis
    • Agudo, R.; Arias, A.; Pariente, N.; Perales, C.; Escarmis, C.; Jorge, A.; Marina, A.; Domingo, E. Molecular characterization of a dual inhibitory and mutagenic activity of 5-fluorouridine triphosphate on viral RNA synthesis. Implications for lethal mutagenesis. J. Mol. Biol. 2008, 382, 652-666.
    • (2008) J. Mol. Biol. , vol.382 , pp. 652-666
    • Agudo, R.1    Arias, A.2    Pariente, N.3    Perales, C.4    Escarmis, C.5    Jorge, A.6    Marina, A.7    Domingo, E.8
  • 93
    • 65849141020 scopus 로고    scopus 로고
    • Counteracting quasispecies adaptability: Extinction of a ribavirin-resistant virus mutant by an alternative mutagenic treatment
    • Perales, C.; Agudo, R.; Domingo, E. Counteracting quasispecies adaptability: extinction of a ribavirin-resistant virus mutant by an alternative mutagenic treatment. PLoS ONE 2009, 4, e5554.
    • (2009) PLoS ONE , vol.4
    • Perales, C.1    Agudo, R.2    Domingo, E.3
  • 94
    • 84860782445 scopus 로고    scopus 로고
    • Concomitant lethal mutagenesis of human immunodeficiency virus type 1
    • Dapp, M.J.; Holtz, C.M.; Mansky, L.M. Concomitant lethal mutagenesis of human immunodeficiency virus type 1. J. Mol. Biol. 2012, 419, 158-170.
    • (2012) J. Mol. Biol. , vol.419 , pp. 158-170
    • Dapp, M.J.1    Holtz, C.M.2    Mansky, L.M.3
  • 96
    • 84855341533 scopus 로고    scopus 로고
    • Evaluation of the anti-arenaviral activity of the subtilisin kexin isozyme-1/site-1 protease inhibitor PF-429242
    • Pasquato, A.; Rochat, C.; Burri, D.J.; Pasqual, G.; de la Torre, J.C.; Kunz, S. Evaluation of the anti-arenaviral activity of the subtilisin kexin isozyme-1/site-1 protease inhibitor PF-429242. Virology 2012, 423, 14-22.
    • (2012) Virology , vol.423 , pp. 14-22
    • Pasquato, A.1    Rochat, C.2    Burri, D.J.3    Pasqual, G.4    de la Torre, J.C.5    Kunz, S.6
  • 97
    • 84855338260 scopus 로고    scopus 로고
    • Inhibition of Lassa virus and Ebola virus infection in host cells treated with the kinase inhibitors genistein and tyrphostin
    • Kolokoltsov, A.A.; Adhikary, S.; Garver, J.; Johnson, L.; Davey, R.A.; Vela, E.M. Inhibition of Lassa virus and Ebola virus infection in host cells treated with the kinase inhibitors genistein and tyrphostin. Arch. Virol. 2012, 157, 121-127.
    • (2012) Arch. Virol. , vol.157 , pp. 121-127
    • Kolokoltsov, A.A.1    Adhikary, S.2    Garver, J.3    Johnson, L.4    Davey, R.A.5    Vela, E.M.6
  • 98
    • 79952067922 scopus 로고    scopus 로고
    • Novel approaches in anti-arenaviral drug development
    • Lee, A.M.; Pasquato, A.; Kunz, S. Novel approaches in anti-arenaviral drug development. Virology 2011, 411, 163-169.
    • (2011) Virology , vol.411 , pp. 163-169
    • Lee, A.M.1    Pasquato, A.2    Kunz, S.3
  • 99
    • 79951929147 scopus 로고    scopus 로고
    • Developments in antivirals against influenza, smallpox and hemorrhagic fever viruses
    • Narayanan, A.; Bailey, C.; Kashanchi, F.; Kehn-Hall, K. Developments in antivirals against influenza, smallpox and hemorrhagic fever viruses. Expert. Opin. Investig. Drugs 2011, 20, 239-254.
    • (2011) Expert. Opin. Investig. Drugs , vol.20 , pp. 239-254
    • Narayanan, A.1    Bailey, C.2    Kashanchi, F.3    Kehn-Hall, K.4
  • 101
    • 78650655132 scopus 로고    scopus 로고
    • Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease
    • Urata, S.; Yun, N.; Pasquato, A.; Paessler, S.; Kunz, S.; de la Torre, J.C. Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease. J. Virol. 2011, 85, 795-803.
    • (2011) J. Virol. , vol.85 , pp. 795-803
    • Urata, S.1    Yun, N.2    Pasquato, A.3    Paessler, S.4    Kunz, S.5    de la Torre, J.C.6
  • 102
    • 0015133749 scopus 로고
    • Self-organization of matter and the evolution of biological macromolecules
    • Eigen, M. Self-organization of matter and the evolution of biological macromolecules. Naturwissenschaften. 1971, 58, 465-523.
    • (1971) Naturwissenschaften. , vol.58 , pp. 465-523
    • Eigen, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.