FBXW7-mediated degradation of CCDC6 is impaired by ATM during DNA damage response in lung cancer cells

FEBS Letters

Volumn 586, Issue 24, 2012, Pages 4257-4263

  Jungang, Zhao ^a   Jun, Tang ^a   Wanfu, Men ^a   Kaiming, Ren ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

ATM; CCDC6; FBXW7; Lung cancer cell; Phosphorylation

Indexed keywords

ATM PROTEIN; COILED COIL DOMAIN CONTAINING 6 PROTEIN; F BOX AND WD REPEAT DOMAIN CONTAINING 7 PROTEIN; F BOX PROTEIN; PROTEIN PATCHED 1; THREONINE; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; DNA DAMAGE; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN CELL; LUNG CANCER; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; UBIQUITINATION;

CELL CYCLE PROTEINS; CELL LINE, TUMOR; CYTOSKELETAL PROTEINS; DNA DAMAGE; DNA-BINDING PROTEINS; F-BOX PROTEINS; HUMANS; LUNG NEOPLASMS; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN-SERINE-THREONINE KINASES; PROTEOLYSIS; THREONINE; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 84870524558     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.10.029     Document Type: Article

References (38)

1. M. Grieco, A. Cerrato, M. Santoro, A. Fusco, R.M. Melillo, and G. Vecchio Cloning and characterization of H4 (D10S170), a gene involved in RET rearrangements in vivo Oncogene 9 1994 2531 2535
2. Q. Tong, Y. Li, P.A. Smanik, L.J. Fithian, S. Xing, E.L. Mazzaferri, and S.M. Jhiang Characterization of the promoter region and oligomerization domain of H4 (D10S170), a gene frequently rearranged with the ret proto-oncogene Oncogene 10 1995 1781 1787
3. G. Portella Development of mammary and cutaneous gland tumors in transgenic mice carrying the RET/PTC1 oncogene Oncogene 13 1996 2021 2026
4. M.N. Nikiforova, J.R. Stringer, R. Blough, M. Medvedovic, J.A. Fagin, and Y.E. Nikiforov Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells Science 290 2000 138 141
5. J.R. Savage Cancer. Proximity matters Science 290 2000 62 63
6. J. Schwaller H4(D10S170), a gene frequently rearranged in papillary thyroid carcinoma, is fused to the platelet-derived growth factor receptor beta gene in atypical chronic myeloid leukemia with t(5;10)(q33;q22) Blood 97 2001 3910 3918
7. K. Takeuchi RET, ROS1 and ALK fusions in lung cancer Nat. Med. 18 2012 378 381
8. F. Merolla, C. Luise, M.T. Muller, R. Pacelli, A. Fusco, and A. Celetti Loss of CCDC6, the first identified RET partner gene, affects pH2AX S139 levels and accelerates mitotic entry upon DNA damage PLoS ONE 7 2012 e36177
9. J.V. Olsen, B. Blagoev, F. Gnad, B. Macek, C. Kumar, P. Mortensen, and M. Mann Global, in vivo, and site-specific phosphorylation dynamics in signaling networks Cell 127 2006 635 648
10. S.A. Beausoleil Large-scale characterization of HeLa cell nuclear phosphoproteins Proc. Natl. Acad. Sci. USA 101 2004 12130 12135
11. S.A. Beausoleil, J. Villen, S.A. Gerber, J. Rush, and S.P. Gygi A probability-based approach for high-throughput protein phosphorylation analysis and site localization Nat. Biotechnol. 24 2006 1285 1292
12. F. Giorgianni, Y. Zhao, D.M. Desiderio, and S. Beranova-Giorgianni Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line Electrophoresis 28 2007 2027 2034
13. L.R. Yu, Z. Zhu, K.C. Chan, H.J. Issaq, D.S. Dimitrov, and T.D. Veenstra Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra J. Proteome Res. 6 2007 4150 4162
14. N. Dephoure, C. Zhou, J. Villen, S.A. Beausoleil, C.E. Bakalarski, S.J. Elledge, and S.P. Gygi A quantitative atlas of mitotic phosphorylation Proc. Natl. Acad. Sci. USA 105 2008 10762 10767
15. F.S. Oppermann, F. Gnad, J.V. Olsen, R. Hornberger, Z. Greff, G. Keri, M. Mann, and H. Daub Large-scale proteomics analysis of the human kinome Mol. Cell. Proteomics 8 2009 1751 1764
16. F. Merolla, F. Pentimalli, R. Pacelli, G. Vecchio, A. Fusco, M. Grieco, and A. Celetti Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage Oncogene 26 2007 6167 6175
17. S.I. Reed Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover Nat. Rev. Mol. Cell Biol. 4 2003 855 864
18. M. Welcker, and B.E. Clurman FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation Nat. Rev. Cancer 8 2008 83 93
19. D.M. Koepp, L.K. Schaefer, X. Ye, K. Keyomarsi, C. Chu, J.W. Harper, and S.J. Elledge Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase Science 294 2001 173 177
20. M. Yada Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7 EMBO J. 23 2004 2116 2125
21. E.J. Hubbard, G. Wu, J. Kitajewski, and I. Greenwald Sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins Genes Dev. 11 1997 3182 3193
22. A.S. Nateri, L. Riera-Sans, C. Da Costa, and A. Behrens The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling Science 303 2004 1374 1378
23. J.H. Mao, I.J. Kim, D. Wu, J. Climent, H.C. Kang, R. DelRosario, and A. Balmain FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression Science 321 2008 1499 1502
24. H. Inuzuka SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction Nature 471 2011 104 109
25. I.E. Wertz Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7 Nature 471 2011 110 114
26. E.L. Kwak Infrequent mutations of archipelago (hAGO, hCDC4, Fbw7) in primary ovarian cancer Gynecol. Oncol. 98 2005 124 128
27. J.C. Yu Genetic susceptibility to the development and progression of breast cancer associated with polymorphism of cell cycle and ubiquitin ligase genes Carcinogenesis 30 2009 1562 1570
28. R. Cassia, G. Moreno-Bueno, S. Rodriguez-Perales, D. Hardisson, J.C. Cigudosa, and J. Palacios Cyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinoma J. Pathol. 201 2003 589 595
29. A. Malyukova The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling Cancer Res. 67 2007 5611 5616
30. Z. Kemp CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability Cancer Res. 65 2005 11361 11366
31. R.J. Deshaies, and J.E. Ferrell Jr. Multisite phosphorylation and the countdown to S phase Cell 107 2001 819 822
32. M. Welcker, J. Singer, K.R. Loeb, J. Grim, A. Bloecher, M. Gurien-West, B.E. Clurman, and J.M. Roberts Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation Mol. Cell 12 2003 381 392
33. W. Wei, J. Jin, S. Schlisio, J.W. Harper, and W.G. Kaelin Jr. The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase Cancer Cell 8 2005 25 33
34. N. Pashkova, L. Gakhar, S.C. Winistorfer, L. Yu, S. Ramaswamy, and R.C. Piper WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins Mol. Cell 40 2010 433 443
35. A. Celetti, A. Cerrato, F. Merolla, D. Vitagliano, G. Vecchio, and M. Grieco H4(D10S170), a gene frequently rearranged with RET in papillary thyroid carcinomas: functional characterization Oncogene 23 2004 109 121
36. A.N. Milne, R. Leguit, W.E. Corver, F.H. Morsink, M. Polak, W.W. de Leng, R. Carvalho, and G.J. Offerhaus Loss of CDC4/FBXW7 in gastric carcinoma Cell Oncol. 32 2010 347 359
37. C.H. Spruck HCDC4 gene mutations in endometrial cancer Cancer Res. 62 2002 4535 4539
38. J.H. Mao Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene Nature 432 2004 775 779