Cyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinoma

Journal of Pathology

Volumn 201, Issue 4, 2003, Pages 589-595

  Cassia, Raúl ^a   Moreno Bueno, Gema ^a   Rodríguez Perales, Sandra ^a   Hardisson, David ^b   Cigudosa, Juan C ^a   Palacios, José ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

^b HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

Author keywords

Cyclin E; Cyclin E amplification; Endometrial carcinoma; hCDC4 mutations

Indexed keywords

ARGININE; CYCLIN E; CYTOSINE; F BOX PROTEIN; GLYCINE; PROTEASOME; PROTEIN P53;

ARTICLE; CANCER GRADING; CARCINOGENESIS; CODON; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; ENDOMETRIOID CARCINOMA; ENDOMETRIUM CARCINOMA; ENDOMETRIUM HYPERPLASIA; ENZYME DEGRADATION; EXON; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE FUNCTION; GENE MUTATION; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC CODE; GENETIC SCREENING; HETEROZYGOSITY LOSS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MOLECULAR MECHANICS; MUTATION RATE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

BASE SEQUENCE; CELL CYCLE PROTEINS; CYCLIN E; ENDOMETRIAL NEOPLASMS; EXONS; F-BOX PROTEINS; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; GENES, SUPPRESSOR; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; LOSS OF HETEROZYGOSITY; MUTATION; PHOSPHORYLATION; UBIQUITIN-PROTEIN LIGASES;

EID: 0141523130     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1474     Document Type: Article

References (30)

1. Sherr C. The Pezcoller lecture: cancer cell cycles revisited. Cancer Res 2000; 60: 3689-3695.
2. Sherr C. Cancer cell cycles. Science 1996; 274: 1672-1677.
3. Clurman BE, Sheaf R, Thress K, Groudine M, Roberts JM. Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation. Genes Dev 1996; 10: 1979-1990.
4. Won KA, Reed S. Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E. EMBO J 1996; 15: 4182-4193.
5. Koepp DM, Schaefer L, Ye X, et al. Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science 2001; 294: 173-177.
6. Strohmaier H, Spruck C, Kaiser P, Won KA, Sangfelt O, Reed SI. Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature 2001; 413: 16-22.
7. Moberg KH, Bell D, Wahrer DC, Haber DA, Hariharan IK. Archipelago regulates cyclin E levels in Drosophila and is mutated in human cancer cell lines. Nature 2001; 413: 311-316.
8. Malumbres M, Barbacid M. To cycle or not to cycle: a critical decision in cancer. Nature Rev Cancer 2001; 1: 222-231.
9. Donnellan R, Chetty R. Cyclin E in human cancers. FASEB J 1999; 13: 773-780.
10. Richter J, Wagner U, Kononen J, et al. High-throughput tissue microarray analysis of cyclin E gene amplification and overexpression in urinary bladder cancer. Am J Pathol 2000; 157: 787-794.
11. Akama Y, Yasui W, Yokozaki H, et al. Frequent amplification of the cyclin E gene in human gastric carcinomas. Jpn J Cancer Res 1995; 86: 617-621.
12. Kitahara K, Yasui W, Kuniyasu H, et al. Concurrent amplification of cyclin E and CDK2 genes in colorectal carcinomas. Int J Cancer 1995; 62: 25-28.
13. Jung YJ, Lee K, Choi DW, et al. Reciprocal expressions of cyclin E and cyclin D1 in hepatocellular carcinoma. Cancer Lett 2001; 168: 57-63.
14. Harwell RM, Porter D, Danes C, Keyomarsi K. Processing of cyclin E differs between normal and tumor breast cells. Cancer Res 2000; 60: 481-489.
15. Porter DC, Zhang N, Danes C, et al. Tumor-specific proteolytic processing of cyclin E generates hyperactive lower-molecular-weight forms. Mol Cell Biol 2001; 21: 6254-6269.
16. Nakayama K, Nagahama H, Minamishima YA, et al. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J 2000; 19: 2069-2081.
17. Minella AC, Swanger J, Bryant E, Welcker M, Hwang H, Clurman BE. p53 and p21 form an inducible barrier that protects cells against cyclin E-cdk2 deregulation. Curr Biol 2002; 12: 1817-1827.
18. Ahn H, Kwon K, Choi Y, Cho N. Expression of cyclin E and cyclin-dependent kinase inhibitor, p27Kip1, in uterine endometrial carcinoma: relation with p53 status. Int J Surg Pathol 1998; 6: 205-212.
19. Li SF, Shiozawa T, Nakayama K, Nikaido T, Fujii S. Stepwise abnormality of sex steroid hormone receptors, tumor suppressor gene products (p53 and Rb), and cyclin E in uterine endometrioid carcinoma. Cancer 1996; 77: 321-329.
20. Shiozawa T, Li S, Nakayama K, Nikaido T, Fujii S. Relationship between the expression of cyclins/cyclin-dependent kinases and sex-steroid receptors/Ki67 in normal human endometrial glands and stroma during the menstrual cycle. Mol Hum Reprod 1996; 2: 745-752.
21. Spruck CH, Strohmaier H, Sangfelt O, et al. hCDC4 gene mutations in endometrial cancer. Cancer Res 2002; 15: 435-439.
22. Moreno-Bueno G, Hardisson D, Sánchez C, et al. Abnormalities of the APC/β-catenin pathway in endometrial cancer. Oncogene 2002; 21: 7981-7990.
23. Moreno-Bueno G, Hardisson D, Sarrió D, et al. Abnormalities of E- and P-cadherin and catenin (β-, γ-catenin, and p120ctn) expression in endometrial cancer and endometrial atypical hyperplasia. J Pathol 2003; 199: 471-478.
24. Canzian F, Salovaara R, Hemminki A, et al. Semiautomated assessment of loss of heterozygosity and replication error in tumors. Cancer Res 1996; 56: 3331-3337.
25. Dib C, Faure S, Fizames C, et al. A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature 1996; 380: 152-154.
26. Gyapay G, Morissette J, Vignal A, et al. The 1993-94 Genethon human genetic linkage map. Nature Genet 1994; 7: 246-339.
27. Matias-Guiu X, Catasus L, Bussaglia E, et al. Molecular pathology of endometrial hyperplasia and carcinoma. Hum Pathol 2001; 32: 569-577.
28. Pere H, Tapper J, Wahlstrom T, Knuutila S, Butzow R. Distinct chromosomal imbalances in uterine serous and endometrioid carcinomas. Cancer Res 1998; 58: 892-895.
29. Alt JR, Cleveland JL, Hannink M, Diehl JA. Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation. Genes Dev 2000; 24: 3102-3114.
30. Diehl JA, Cheng M, Roussel MF, Sherr C. Glycogen synthase kinase-3 beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 1998; 12: 3499-3511.