Prnp knockdown in transgenic mice using RNA interference

Transgenic Research

Volumn 17, Issue 5, 2008, Pages 783-791

  Gallozzi, Micaela ^a   Chapuis, Jérome ^b   Le Provost, Fabienne ^a   Le Dur, Annick ^b   Morgenthaler, Caroline ^a   Peyre, Coralie ^c   Daniel Carlier, Nathalie ^d   Pailhoux, Eric ^d   Vilotte, Marthe ^a   Passet, Bruno ^a   Herzog, Laetitia ^b   Beringue, Vincent ^b   Costa, José ^a   Tixador, Philippe ^b   Tilly, Gaëlle ^a   Laude, Hubert ^b   Vilotte, Jean Luc ^a  

^a CEMAGREF   (France)

^b INRA Institut National de la Recherche Agronomique   (France)

^c IERP Infectiologie Expérimentale des Rongeurs et Poissons   (France)

^d INRA Institut National de la Recherche Agronomique   (France)

Author keywords

Prion; RNA interference; Transgenic mice

Indexed keywords

ANIMALIA; MUS MUSCULUS;

EID: 50849102657     PISSN: 09628819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11248-008-9179-2     Document Type: Article

References (59)

1. M Amarzguioui T Holen E Babaie H Prydz 2003 Tolerance for mutations and chemical modifications in a siRNA Nucleic Acids Res 31 589 595
2. F Archer C Bachelin O Andreoletti N Besnard G Perrot C Langevin A Le Dur D Vilette A Baron-Van Evercooren JL Vilotte H Laude 2004 Cultured peripheral neuroglial cells are highly permissive to sheep prion infection J Virol 78 482 490
3. EA Asante I Gowland JM Linehan SP Mahal J Collinge 2002 Expression pattern of a mini human PrP gene promoter in transgenic mice Neurobiol Dis 10 1 7
4. S Bagga J Bracht S Hunter K Massirer J Holtz R Eachus AE Pasquinelli 2005 Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation Cell 122 553 563
5. V Beringue G Mallinson M Kaisar M Tayebi Z Sattar G Jackson D Anstee J Collinge S Hawke 2003 Regional heterogeneity of cellular prion protein isoforms in the mouse brain Brain 126 2065 2073
6. H Bueler M Fischer Y Lang H Bluethmann HP Lipp SJ DeArmond SB Prusiner M Aguet C Weissmann 1992 Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein Nature 356 577 582
7. X Coumoul V Shukla C Li RH Wang CX Deng 2005 Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference Nucleic Acids Res 33 e102
8. N Daude M Marella J Chabry 2003 Specific inhibition of pathological prion protein accumulation by small interfering RNAs J Cell Sci 116 2775 2779
9. RA Dickins MT Hemann JT Zilfou DR Simpson I Ibarra GJ Hannon SW Lowe 2005 Probing tumor phenotypes using stable and regulated synthetic microRNA precursors Nat Genet 37 1289 1295
10. D Dormont 2002 Prions, BSE and food Int J Food Microbiol 78 181 189
11. SM Elbashir J Martinez A Patkaniowska W Lendeckel T Tuschl 2001 Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate Embo J 20 6877 6888
12. M Fischer T Rulicke A Raeber A Sailer M Moser B Oesch S Brandner A Aguzzi C Weissmann 1996 Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie Embo J 15 1255 1264
13. MC Golding CR Long MA Carmell GJ Hannon ME Westhusin 2006 Suppression of prion protein in livestock by RNA interference Proc Natl Acad Sci USA 103 5285 5290
14. M Gossen H Bujard 1992 Tight control of gene expression in mammalian cells by tetracycline-responsive promoters Proc Natl Acad Sci USA 89 5547 5551
15. D Grimm KL Streetz CL Jopling TA Storm K Pandey CR Davis P Marion F Salazar MA Kay 2006 Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways Nature 441 537 541
16. GJ Hannon JJ Rossi 2004 Unlocking the potential of the human genome with RNA interference Nature 431 371 378
17. T Holen SE Moe JG Sorbo TJ Meza OP Ottersen A Klungland 2005 Tolerated wobble mutations in siRNAs decrease specificity, but can enhance activity in vivo Nucleic Acids Res 33 4704 4710
18. AL Jackson SR Bartz J Schelter SV Kobayashi J Burchard M Mao B Li G Cavet PS Linsley 2003 Expression profiling reveals off-target gene regulation by RNAi Nat Biotechnol 21 635 637
19. RT Johnson 2005 Prion diseases Lancet Neurol 4 635 642
20. T Kobayashi S Hisajima J Stougaard H Ichikawa 1995 A conditional negative selection for Arabidopsis expressing a bacterial cytosine deaminase gene Jpn J Genet 70 409 422
21. S Krasemann MH Groschup S Harmeyer G Hunsmann W Bodemer 1996 Generation of monoclonal antibodies against human prion proteins in PrP0/0 mice Mol Med 2 725 734
22. M Lagos-Quintana R Rauhut W Lendeckel T Tuschl 2001 Identification of novel genes coding for small expressed RNAs Science 294 853 858
23. R Lathe JL Vilotte AJ Clark 1987 Plasmid and bacteriophage vectors for excision of intact inserts Gene 57 193 201
24. NS Lee T Dohjima G Bauer H Li MJ Li A Ehsani P Salvaterra J Rossi 2002 Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells Nat Biotechnol 20 500 505
25. LP Lim NC Lau P Garrett-Engele A Grimson JM Schelter J Castle DP Bartel PS Linsley JM Johnson 2005 Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs Nature 433 769 773
26. KJ Livak TD Schmittgen 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Methods 25 402 408
27. G Mallucci J Collinge 2005 Rational targeting for prion therapeutics Nat Rev Neurosci 6 23 34
28. G Mallucci A Dickinson J Linehan PC Klohn S Brandner J Collinge 2003 Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis Science 302 871 874
29. GR Mallucci MD White M Farmer A Dickinson H Khatun AD Powell S Brandner JG Jefferys J Collinge 2007 Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice Neuron 53 325 335
30. JC Manson AR Clarke ML Hooper L Aitchison I McConnell J Hope 1994 129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal Mol Neurobiol 8 121 127
31. MT McManus PA Sharp 2002 Gene silencing in mammals by small interfering RNAs Nat Rev Genet 3 737 747
32. G Meister T Tuschl 2004 Mechanisms of gene silencing by double-stranded RNA Nature 431 343 349
33. CC Mello D Conte Jr 2004 Revealing the world of RNA interference Nature 431 338 342
34. M Miyagishi K Taira 2002 U6 promoter-driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells Nat Biotechnol 20 497 500
35. M Nunziante S Gilch HM Schätzl 2003 Essential role of the prion protein N terminus in subcellular trafficking and half-life of cellular prion protein J Biol Chem 728 3726 3734
36. P Oberdoerffer C Kanellopoulou V Heissmeyer C Paeper C Borowski I Aifantis A Rao K Rajewsky 2005 Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages Mol Cell Biol 25 3896 3905
37. CP Paul PD Good I Winer DR Engelke 2002 Effective expression of small interfering RNA in human cells Nat Biotechnol 20 505 508
38. S Peng JP York P Zhang 2006 A transgenic approach for RNA interference-based genetic screening in mice Proc Natl Acad Sci USA 103 2252 2256
39. A Pfeifer S Eigenbrod S Al-Khadra A Hofmann G Mitteregger M Moser U Bertsch H Kretzschmar 2006 Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice J Clin Invest 116 3204 3210
40. MK Rao MF Wilkinson 2006 Tissue-specific and cell type-specific RNA interference in vivo Nat Protoc 1 1494 1501
41. C Raoul T Abbas-Terki JC Bensadoun S Guillot G Haase J Szulc CE Henderson P Aebischer 2005 Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS Nat Med 11 423 428
42. JG Safar SJ DeArmond K Kociuba C Deering S Didorenko E Bouzamondo-Bernstein SB Prusiner P Tremblay 2005 Prion clearance in bigenic mice J Gen Virol 86 2913 2923
43. S Samakoglu L Lisowski T Budak-Alpdogan Y Usachenko S Acuto R Di Marzo A Maggio P Zhu JF Tisdale I Riviere M Sadelain 2006 A genetic strategy to treat sickle cell anemia by coregulating globin transgene expression and RNA interference Nat Biotechnol 24 89 94
44. PC Scacheri O Rozenblatt-Rosen NJ Caplen TG Wolfsberg L Umayam JC Lee CM Hughes KS Shanmugam A Bhattacharjee M Meyerson FS Collins 2004 Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells Proc Natl Acad Sci USA 101 1892 1897
45. J Seibler B Kuter-Luks H Kern S Streu L Plum J Mauer R Kuhn JC Bruning F Schwenk 2005 Single copy shRNA configuration for ubiquitous gene knockdown in mice Nucleic Acids Res 33 e67
46. R Shi VL Chiang 2005 Facile means for quantifying microRNA expression by real-time PCR BioTechniques 39 519 525
47. T Shinagawa S Ishii 2003 Generation of Ski-knockdown mice by expressing a long double-strand RNA from an RNA polymerase II promoter Genes Dev 17 1340 1345
48. JM Silva MZ Li K Chang W Ge MC Golding RJ Rickles D Siolas G Hu PJ Paddison MR Schlabach N Sheth J Bradshaw J Burchard A Kulkarni G Cavet R Sachidanandam WR McCombie MA Cleary SJ Elledge GJ Hannon 2005 Second-generation shRNA libraries covering the mouse and human genomes Nat Genet 37 1281 1288
49. G Sui C Soohoo B Affar el F Gay Y Shi WC Forrester Y Shi 2002 A DNA vector-based RNAi technology to suppress gene expression in mammalian cells Proc Natl Acad Sci USA 99 5515 5520
50. D Sun M Melegari S Sridhar CE Rogler L Zhu 2006 Multi-miRNA hairpin method that improves gene knockdown efficiency and provides linked multi-gene knockdown Biotechniques 41 59 63
51. G Tilly J Chapuis D Vilette H Laude JL Vilotte 2003 Efficient and specific down-regulation of prion protein expression by RNAi Biochem Biophys Res Commun 305 548 551
52. D Vilette O Andreoletti F Archer MF Madelaine JL Vilotte S Lehmann H Laude 2001 Ex vivo propagation of infectious sheep scrapie agent in heterologous epithelial cells expressing ovine prion protein Proc Natl Acad Sci USA 98 4055 4059
53. JL Vilotte S Soulier R Essalmani MG Stinnakre D Vaiman L Lepourry JC Da Silva N Besnard M Dawson A Buschmann M Groschup S Petit MF Madelaine S Rakatobe A Le Dur D Vilette H Laude 2001 Markedly increased susceptibility to natural sheep scrapie of transgenic mice expressing ovine prp J Virol 75 5977 5984
54. C Weissmann M Enari PC Klohn D Rossi E Flechsig 2002 Transmission of prions Proc Natl Acad Sci USA 99 Suppl 4 16378 16383
55. M Wiznerowicz D Trono 2003 Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference J Virol 77 8957 8961
56. XG Xia H Zhou E Samper S Melov Z Xu 2006 Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice PLoS Genet 2 e10
57. S Yekta IH Shih DP Bartel 2004 MicroRNA-directed cleavage of HOXB8 mRNA Science 304 594 596
58. Y Zeng BR Cullen 2003 Sequence requirements for micro RNA processing and function in human cells RNA 9 112 123
59. Y Zeng EJ Wagner BR Cullen 2002 Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells Mol Cell 9 1327 1333