Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 47, 2008, Pages 18507-18512

  Herold, Marco J ^a,d   Van Den Brandt, Jens ^b   Seibler, Jost ^c   Reichardt, Holger M ^a,b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^c TaconicArtemis GmbH   (Germany)

^d WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Diabetes; RNAi; Transgenesis

Indexed keywords

DOXYCYCLINE; GLUCOSE; INSULIN RECEPTOR; LENTIVIRUS VECTOR; SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EMBRYO; FEMALE; GENE SILENCING; GLUCOSE BLOOD LEVEL; LENTIVIRINAE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSGENIC RAT;

ANIMALS; BASE SEQUENCE; CELL LINE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DNA PRIMERS; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; GENETIC VECTORS; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; LENTIVIRUS; RATS; RATS, TRANSGENIC; RNA, VIRAL; SIGNAL TRANSDUCTION; VIRUS INTEGRATION;

LENTIVIRUS; RATTUS;

EID: 57449112781     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0806213105     Document Type: Article

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