"Untangling" Alzheimer's disease and epilepsy

Epilepsy Currents

Volumn 12, Issue 5, 2012, Pages 178-183

  Scharfman, Helen E ^a,b  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; SODIUM CHANNEL NAV1.1;

ALZHEIMER DISEASE; ARTICLE; EPILEPSY; GENE MUTATION; GENE OVEREXPRESSION; HIPPOCAMPAL MOSSY FIBER; HIPPOCAMPUS; HUMAN; NERVE CELL; NONHUMAN; SEIZURE; SIGNAL TRANSDUCTION;

EID: 84870275464     PISSN: 15357597     EISSN: 15357511     Source Type: Journal    
DOI: 10.5698/1535-7511-12.5.178     Document Type: Article

References (53)

1. Palop JJ, Chin J, Roberson ED, Wang J, Thwin MT, Bien-Ly N, Yoo J, Ho KO, Yu GQ, Kreitzer A, Finkbeiner S, Noebels JL, Mucke L. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron 2007;55:697-711.
2. Palop JJ, Chin J, Mucke L. A network dysfunction perspective on neurodegenerative diseases. Nature 2006;443:768-773.
3. Palop JJ, Mucke L. Epilepsy and cognitive impairments in Alzheimer disease. Arch Neurol 2009;66:435-440.
4. Noebels J. A perfect storm: Converging paths of epilepsy and Alzheimer's dementia intersect in the hippocampal formation. Epilepsia 2011;52(suppl 1):39-46.
5. Scarmeas N, Honig LS, Choi H, Cantero J, Brandt J, Blacker D, Albert M, Amatniek JC, Marder K, Bell K, Hauser WA, Stern Y. Seizures in Alzheimer disease: Who, when, and how common? Arch Neurol 2009;66:992-997.
6. Friedman D, Honig L, Scarmeas N. Seizures and epilepsy in Alzheimer's disease. CNS Neurosci Ther 2012;18:285-294.
7. Hsiao KK, Borchelt DR, Olson K, Johannsdottir R, Kitt C, Yunis W, Xu S, Eckman C, Younkin S, Price D. Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins. Neuron 1995;15:1203-1218.
8. Moechars D, Lorent K, De Strooper B, Dewachter I, Van Leuven F. Expression in brain of amyloid precursor protein mutated in the asecretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice. EMBO J 1996;15:1265-1274.
9. Steinbach JP, Muller U, Leist M, Li ZW, Nicotera P, Aguzzi A. Hypersensitivity to seizures in β-amyloid precursor protein deficient mice. Cell Death Differ 1998;5:858-866.
10. Del Vecchio RA, Gold LH, Novick SJ, Wong G, Hyde LA. Increased seizure threshold and severity in young transgenic CRND8 mice. Neurosci Lett 2004;367:164-167.
11. Thom M, Liu JY, Thompson P, Phadke R, Narkiewicz M, Martinian L, Marsdon D, Koepp M, Caboclo L, Catarino CB, Sisodiya SM. Neurofibrillary tangle pathology and braak staging in chronic epilepsy inrelation to traumatic brain injury and hippocampal sclerosis: A postmortem study. Brain 2011;134:2969-2981.
12. Kleen JK, Scott RC, Holmes GL, Lenck-Santini PP. Hippocampal interictal spikes disrupt cognition in rats. Ann Neurol 2010;67:250-257.
13. Holmes GL, Lenck-Santini PP. Role of interictal epileptiform abnormalities in cognitive impairment. Epilepsy Behav 2006;8:504-515.
14. Minkeviciene R, Rheims S, Dobszay MB, Zilberter M, Hartikainen J, Fulop L, Penke B, Zilberter Y, Harkany T, Pitkanen A, Tanila H. Amyloid β-induced neuronal hyperexcitability triggers progressive epilepsy. J Neurosci 2009;29:3453-3462.
15. Mendez M, Lim G. Seizures in elderly patients with dementia: Epidemiology and management. Drugs Aging 2003;20:791-803.
16. Dickerson BC, Sperling RA. Large-scale functional brain network abnormalities in Alzheimer's disease: Insights from functional neuroimaging. Behav Neurol 2009;21:63-75.
17. Bakker A, Krauss GL, Albert MS, Speck CL, Jones LR, Stark CE, Yassa MA, Bassett SS, Shelton AL, Gallagher M. Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment. Neuron 2012;74:467-474.
18. Zeman A, Butler C. Transient epileptic amnesia. Curr Opin Neurol 2010;23:610-616.
19. Du F, Whetsell WO, Abou-Khalil B, Blumenkopf B, Lothman EW, Schwarcz R. Preferential neuronal loss in layer III of the entorhinal cortex in patients with temporal lobe epilepsy. Epilepsy Res 1993;16:223-233.
20. Kordower J, Chu Y, Stebbins GT, DeKosky ST, Cochran EJ, Bennet D, Mufson EJ. Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment. Ann Neurol 2001;49:202-213.
21. Scharfman HE, Chao MV. The entorhinal cortex in Alzheimer's disease. Eur J Neurodegen Dis. 2012;1:53-65.
22. Sperk G, Bellmann R, Gruber B, Greber S, Marksteiner J, Roder C, Rupp E. Neuropeptide Y expression in animal models of temporal lobe epilepsy. Epilepsy Res Suppl 1996;12:197-203.
23. Palop JJ, Jones B, Kekonius L, Chin J, Yu GQ, Raber J, Masliah E, Mucke L. Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits. Proc Natl Acad Sci U S A 2003;100:9572-9577.
24. Nagerl UV, Mody I, Jeub M, Lie AA, Elger CE, Beck H. Surviving granule cells of the sclerotic human hippocampus have reduced Ca(2+) influx because of a loss of calbindin-d(28k) in temporal lobe epilepsy. J Neurosci 2000;20:1831-1836.
25. Scharfman HE. Alzheimer's disease and epilepsy: Insight from animal models. Future Neurol 2012;7:177-192.
26. Roberson ED, Halabisky B, Yoo JW, Yao J, Chin J, Yan F, Wu T, Hamto P, Devidze N, Yu GQ, Palop JJ, Noebels JL, Mucke L. Amyloid-β/fyninduced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease. J Neurosci 2011;31:700-711.
27. Takahashi H, Brasnjevic I, Rutten BP, Van Der Kolk N, Perl DP, Bouras C, Steinbusch HW, Schmitz C, Hof PR, Dickstein DL. Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer's disease. Brain Struct Funct. 2010; 214:145-160.
28. DaRocha-Souto B, Scotton TC, Coma M, Serrano-Pozo A, Hashimoto T, Serená L, Rodríguez M, Sánchez B, Hyman BT, Gámez-Isla T. Brain oligomeric β-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice. JNeuropath Exp Neurol 2011;70:360-376.
29. Sutula TP, Pitkanen A. Do Seizures Damage the Brain? New York:Elsevier, 2002.
30. McNamara JO, Scharfman HE. Temporal lobe epilepsy and the BDNF receptor, TrkB. In: Jasper's Basic Mechanisms of the Epilepsies, 4th edition. (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds.) Oxford: Oxford University Press. pp. 514-531.
31. Nissinen J, Lukasiuk K, Pitkanen A. Is mossy fiber sprouting present at the time of the first spontaneous seizures in rat experimental temporal lobe epilepsy? Hippocampus 2001;11:299-310.
32. Buckmaster PS, Lew FH. Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy. J Neurosci 2011;31:2337-2347.
33. Scharfman HE, Sollas AL, Smith KL, Jackson MB, Goodman JH. Structural and functional asymmetry in the epileptic rat dentate gyrus. J Comp Neurol 2002;454:424-439.
34. Cirrito JR, Yamada KA, Finn MB, Sloviter RS, Bales KR, May PC, Schoepp DD, Paul SM, Mennerick S, Holtzman DM. Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. Neuron 2005;48:913-922.
35. Puzzo D, Privitera L, Leznik E, Fa M, Staniszewski A, Palmeri A, Arancio O. Picomolar amyloid-β positively modulates synaptic plasticity and memory in hippocampus. J Neurosci 2008;28:14537-14545.
36. Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R. APP processing and synaptic function. Neuron 2003;37:925-937.
37. Busche MA, Eichhoff G, Adelsberger H, Abramowski D, Wiederhold KH, Haass C, Staufenbiel M, Konnerth A, Garaschuk O. Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease. Science 2008;321:1686-1689.
38. Busche MA, Chen X, Henning HA, Reichwald J, Staufenbiel M, Sakmann B, Konnerth A. Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 2012;109:8740-8745.
39. Vogt DL, Thomas D, Galvan V, Bredesen DE, Lamb BT, Pimplikar SW. Abnormal neuronal networks and seizure susceptibility inmice overexpressing the APP intracellular domain. Neurobiol Aging 2009;32:1725-1729.
40. Ghosal K, Pimplikar SW. Aging and excitotoxic stress exacerbate neural circuit reorganization in amyloid precursor protein intracellular domain transgenic mice. Neurobiol Aging 2010;32:2320-2329
41. Clement AB, Hanstein R, Schroder A, Nagel H, Endres K, Fahrenholz F, Behl C. Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress. Neuroscience 2008;152:459-468.
42. Kobayashi D, Zeller M, Cole T, Buttini M, McConlogue L, Sinha S, Freedman S, Morris RG, Chen KS. BACE1 gene deletion: Impact on behavioral function in a model of Alzheimer's disease. Neurobiol Aging 2008;29:861-873.
43. Hu X, Zhou X, He W, Yang J, Xiong W, Wong P, Wilson CG, Yan R. BACE1 deficiency causes altered neuronal activity and neurodegeneration. J Neurosci 2010;30:8819-8829.
44. Catterall WA, Kalume F, Oakley JC. Nav1.1 channels and epilepsy. J Physiol 2010;588:1849-1859.
45. Kim DY, Carey BW, Wang H, Ingano LA, Binshtok AM, Wertz MH, Pettingell WH, He P, Lee VM, Woolf CJ, Kovacs DM. BACE1 regulates voltage-gated sodium channels and neuronal activity. Nat Cell Biol 2007;9:755-764.
46. Verret L, Mann EO, Hang GB, Barth AM, Cobos I, Ho K, Devidze N, Masliah E, Kreitzer AC, Mody I, Mucke L, Palop JJ. Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model. Cell 2012;149:708-721.
47. Bender AC, Morse RP, Scott RC, Holmes GL, Lenck-Santini PP. SCN1A mutations in Dravet syndrome: Impact of interneuron dysfunction on neural networks and cognitive outcome. Epilepsy Behav 2012;23:177-186.
48. Guerrini R, Belmonte A, Genton P. Antiepileptic drug-induced worsening of seizures in children. Epilepsia 1998;39(suppl 3):S2-10.
49. Loscher W. Molecular mechanisms of drug resistance in status epilepticus. Epilepsia 2009;50(suppl 12):19-21.
50. Ziyatdinova S, Gurevicius K, Kutchiashvili N, Bolkvadze T, Nissinen J, Tanila H, Pitkanen A. Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels. Epilepsy Res 2011;94:75-85.
51. Rapoport M, Dawson HN, Binder LI, Vitek MP, Ferreira A. Tau is essential to β-amyloid-induced neurotoxicity. Proc Natl Acad Sci U S A 2002;99:6364-6369.
52. Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L. Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science 2007;316:750-754.
53. Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J, Wolfing H, Chieng BC, Christie MJ, Napier IA, Eckert A, Staufenbiel M, Hardeman E, Gotz J. Dendritic function of tau mediates amyloid-β toxicity in Alzheimer's disease mouse models. Cell 2010;142:387-397.