Alzheimer's disease and epilepsy: Insight from animal models

Future Neurology

Volumn 7, Issue 2, 2012, Pages 177-192

  Scharfman, Helen E ^a,b  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

amyloid precursor protein; dentate gyrus; hilus; mossy fiber sprouting; neurodegeneration; presenilin 1; seizure; temporal lobe

Indexed keywords

CALBINDIN; PROTEIN C FOS;

ALZHEIMER DISEASE; AMYLOID PLAQUE; BRAIN NERVE CELL; CELL LOSS; COMORBIDITY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE MODEL; DISEASE SEVERITY; GABAERGIC TRANSMISSION; HIPPOCAMPAL SCLEROSIS; HIPPOCAMPUS; HUMAN; IMMUNOREACTIVITY; NERVE SPROUTING; NEUROBIOLOGY; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; TEMPORAL LOBE EPILEPSY;

EID: 84858183199     PISSN: 14796708     EISSN: 17486971     Source Type: Journal    
DOI: 10.2217/fnl.12.8     Document Type: Review

References (62)

1. Friedman D, Honig L, Scarmeas N. Seizures and epilepsy in Alzheimer's disease. CNS Neurosci. Ther. doi:1755- 5949.2011.00251.x (2011) (Epub ahead of print).
2. Noebels J. A perfect storm: converging paths of epilepsy and Alzheimer's dementia intersect in the hippocampal formation. Epilepsia 52(Suppl. 1), 39-46 (2011).
3. Abou-Khalil BW. How important is Azheimer's disease as a risk factor for unprovoked seizures and epilepsy in the elderly? Epilepsy Curr. 10(2), 36-37 (2010).
4. Palop JJ, Mucke L. Epilepsy and cognitive impairments in Azheimer's disease. Arch. Neurol. 66(4), 435-440 (2009).
5. Scarmeas N, Honig LS, Choi H, et al. Seizures in Alzheimer disease: who, when, and how common? Arch. Neurol. 66(8), 992-997 (2009).
6. Palop JJ, Chin J, Roberson ED, et al. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron 55(5), 697-711 (2007). (Pubitemid 47321079)
7. Minkeviciene R, Rheims S, Dobszay MB, et al. Amyloid b-induced neuronal hyperexcitability triggers progressive epilepsy. J. Neurosci. 29(11), 3453-3462 (2009).
8. Bell B, Lin JJ, Seidenberg M, Hermann B. The neurobiology of cognitive disorders in temporal lobe epilepsy. Nat. Rev. Neurol. 7(3), 154-164 (2011).
9. Hauser WA, Hesdorffer DA. Epilepsy: Frequency, Consequences and Causes. Epilepsy Foundation of America, MD, USA (1990).
10. Foster NL. Textbook of Alzheimer's Disease and Other Dementias. Weiner MF, Lipton A (Eds). American Psychiatric Publishing, VA, USA (2009).
11. Scharfman HE, Schwarcz R. Epilepsy: A Comprehensive Guide. Engel J, Pedley TA (Eds). Lippincott Raven, NY, USA (2007).
12. Mrak RE, Griffin WS. Interleukin-1, neuroinflammation, and Alzheimer's disease. Neurobiol Aging 22(6), 903-908 (2001). (Pubitemid 34066557)
13. Friedman D, Honig L, Scarmeas N. Seizures and epilepsy in Alzheimer's disease. CNS Neurosci. Ther. doi:1755- 5949.2011.00251.x (2011) (Epub ahead of print).
14. Noebels J. A perfect storm: converging paths of epilepsy and Alzheimer's dementia intersect in the hippocampal formation. Epilepsia 52(Suppl. 1), 39-46 (2011).
15. Abou-Khalil BW. How important is Azheimer's disease as a risk factor for unprovoked seizures and epilepsy in the elderly? Epilepsy Curr. 10(2), 36-37 (2010).
16. Palop JJ, Mucke L. Epilepsy and cognitive impairments in Azheimer's disease. Arch. Neurol. 66(4), 435-440 (2009).
17. Scarmeas N, Honig LS, Choi H, et al. Seizures in Alzheimer disease: who, when, and how common? Arch. Neurol. 66(8), 992-997 (2009).
18. Palop JJ, Chin J, Roberson ED, et al. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron 55(5), 697-711 (2007). (Pubitemid 47321079)
19. Minkeviciene R, Rheims S, Dobszay MB, et al. Amyloid b-induced neuronal hyperexcitability triggers progressive epilepsy. J. Neurosci. 29(11), 3453-3462 (2009).
20. Bell B, Lin JJ, Seidenberg M, Hermann B. The neurobiology of cognitive disorders in temporal lobe epilepsy. Nat. Rev. Neurol. 7(3), 154-164 (2011).
21. Hauser WA, Hesdorffer DA. Epilepsy: Frequency, Consequences and Causes. Epilepsy Foundation of America, MD, USA (1990).
22. Foster NL. Textbook of Alzheimer's Disease and Other Dementias. Weiner MF, Lipton A (Eds). American Psychiatric Publishing, VA, USA (2009).
23. Scharfman HE, Schwarcz R. Epilepsy: A Comprehensive Guide. Engel J, Pedley TA (Eds). Lippincott Raven, NY, USA (2007).
24. Mrak RE, Griffin WS. Interleukin-1, neuroinflammation, and Alzheimer's disease. Neurobiol Aging 22(6), 903-908 (2001). (Pubitemid 34066557)
25. Vezzani A, French J, Bartfai T, Baram TZ. The role of inflammation in epilepsy. Nat. Rev. Neurol. 7(1), 31-40 (2011).
26. Dickstein DL, Walsh J, Brautigam H, Stockton SD Jr, Gandy S, Hof PR. Role of vascular risk factors and vascular dysfunction in Alzheimer's disease. Mt Sinai J. Med. 77(1), 82-102 (2010).
27. McNaull BB, Todd S, McGuinness B, Passmore AP. Inflammation and anti-inflammatory strategies for Alzheimer's disease - a mini-review. Gerontology 56(1), 3-14 (2010).
28. Rothman SM, Mattson MP. Adverse stress, hippocampal networks, and Alzheimer's disease. Neuromolecular Med. 12(1), 56-70 (2010).
29. Caraci F, Copani A, Nicoletti F, Drago F. Depression and Alzheimer's disease: neurobiological links and common pharmacological targets. Eur. J. Pharmacol. 626(1), 64-71 (2010).
30. Kanner AM. Depression in epilepsy: prevalence, clinical semiology, pathogenic mechanisms, and treatment. Biol. Psychiatry 54(3), 388-398 (2003). (Pubitemid 37267865)
31. Hebb DO. The Organization of Behavior. Psychology Press, NY, USA (1949).
32. Hasselmo ME. What is the function of hippocampal theta rhythm? Linking behavioral data to phasic properties of field potential and unit recording data. Hippocampus 15(7), 936-949 (2005). (Pubitemid 41556423)
33. Nyhus E, Curran T. Functional role of gamma and theta oscillations in episodic memory. Neurosci. Biobehav. Rev. 34(7), 1023-1035 (2010).
34. Colgin LL, Moser EI. Gamma oscillations in the hippocampus. Physiology (Bethesda) 25(5), 319-329 (2010).
35. Wilson MA, McNaughton BL. Reactivation of hippocampal ensemble memories during sleep. Science 265(5172), 676-679 (1994). (Pubitemid 24268281)
36. Buhry L, Azizi AH, Cheng S. Reactivation, replay, and preplay: how it might all fit together. Neural Plast. 2011, 203462 (2011).
37. Mackenzie IR, Miller LA. Senile plaques in temporal lobe epilepsy. Acta Neuropathol. 87(5), 504-510 (1994). (Pubitemid 24128978)
38. Thom M, Liu JY, Thompson P, et al. Neurofibrillary tangle pathology and Braak staging in chronic epilepsy in relation to traumatic brain injury and hippocampal sclerosis: a univentricular heartmortem study. Brain 134(Pt 10), 2969-2981 (2011).
39. Kondratyev A, Ved R, Gale K. The effects of repeated minimal electroconvulsive shock exposure on levels of mRNA encoding fibroblast growth factor-2 and nerve growth factor in limbic regions. Neuroscience 114(2), 411-416 (2002). (Pubitemid 35245420)
40. Gale K. Fibroblast growth factors and seizure-induced neuroprotection. In: Growth Factors in Epilepsy. Binder DK, Scharfman HE (Eds). Nova Science Publishers, NY, USA, 159-188 (2006).
41. Nagahara AH, Merrill DA, Coppola G, et al. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat. Med. 15(3), 331-337 (2009).
42. Peng S, Wuu J, Mufson EJ, Fahnestock M. Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease. J. Neurochem. 93(6), 1412-1421 (2005). (Pubitemid 40853264)
43. Scharfman HE, Pedley TA. Temporal lobe epilepsy. In: The Neurobiology of Disease. Gilman A (Ed.). Academic Press, NY, USA (2006).
44. Nelson PT, Schmitt FA, Lin Y, et al. Hippocampal sclerosis in advanced age: clinical and pathological features. Brain 134(Pt 5), 1506-1518 (2011).
45. Honig LS, Scarmeas N. Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia. Neurology 64(6), 1102 (2005). (Pubitemid 40388485)
46. Engler H, Forsberg A, Almkvist O, et al. Two-year follow-up of amyloid deposition in patients with Alzheimer's disease. Brain 129(Pt 11), 2856-2866 (2006). (Pubitemid 44684508)
47. Sutula TP, Pitkanen A. Do Seizures Injure the Brain? (Progress in Brain Research). Elsevier Science Ltd, UK (1992).
48. MacNamara JO, Scharfman HE. BDNF and its receptor TrkB in epilepsy. In: Jasper's Basic Mechanisms of the Epilepsies. Noebels J, Olsen R, Rogawski M (Eds). Oxford University Press, NY, USA (2011).
49. McCloskey DP, Scharfman HE. Progressive, potassium-sensitive epileptiform activity in hippocampal area CA3 of pilocarpine-treated rats with recurrent seizures. Epilepsy Res. 97(1-2), 92-102 (2011).
50. Williams PA, White AM, Clark S, et al. Development of spontaneous recurrent seizures after kainate-induced status epilepticus. J. Neurosci. 29(7), 2103-2112 (2009).
51. Pitkanen A, Nissinen J, Nairismagi J, et al. Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy. Prog. Brain Res. 135, 67-83 (2002). (Pubitemid 35461007)
52. Meyer-Luehmann M, Spires-Jones TL, Prada C, et al. Rapid appearance and local toxicity of amyloid-?plaques in a mouse model of Alzheimer's disease. Nature 451, 720-724 (2008). (Pubitemid 351220570)
53. Garrido Sanabria ER, Castaneda MT, Banuelos C, Perez-Cordova MG, Hernandez S, Colom LV. Septal gabaergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures. Neuroscience 142(3), 871-883 (2006). (Pubitemid 44485907)
54. Schliebs R, Arendt T. The cholinergic system in aging and neuronal degeneration. Behav. Brain Res. 221(2), 555-563 (2011).
55. Toth K, Freund TF, Miles R. Disinhibition of rat hippocampal pyramidal cells by gabaergic afferents from the septum. J. Physiol. 500(Pt 2), 463-474 (1997). (Pubitemid 27193079)
56. deToledo-Morrell L, Stoub TR, Wang C. Hippocampal atrophy and disconnection in incipient and mild Alzheimer's disease. Prog. Brain Res. 163, 741-753 (2007).
57. Kordower J, Chu Y, Stebbins GT, et al. Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment. Ann. Neurol. 49, 202-213 (2001). (Pubitemid 32157996)
58. Scharfman HE. Epileptogenesis in the parahippocampal region. Parallels with the dentate gyrus. Ann. NY Acad. Sci. 911, 305-327 (2000). (Pubitemid 30462090)
59. Du F, Eid T, Lothman EW, Kohler C, Schwarcz R. Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy. J. Neurosci. 15(10), 6301-6313 (1995).
60. Du F, Whetsell WO Jr, Abou-Khalil B, Blumenkopf B, Lothman EW, Schwarcz R. Preferential neuronal loss in layer III of the entorhinal cortex in patients with temporal lobe epilepsy. Epilepsy Res. 16(3), 223-233 (1993). (Pubitemid 24012420)
61. Schwarcz R, Scharfman HE, Bertram EH. Temporal lobe epilepsy: renewed emphasis on extrahippocampal areas. In: Neuropsychopharmacology: The Fifth Generation of Progress. Davis KL, Charney D, Coyle JT, Nemeroff C (Eds). Lippincott, Williams ä Wilkins, NY, USA, 1843-1855 (2002).
62. Moreno-Gonzalez I, Baglietto-Vargas D, Sanchez-Varo R, et al. Extracellular amyloid-b and cytotoxic glial activation induce significant entorhinal neuron loss in young PS1(M146l)/APP(751SL) mice. J. Alzheimers Dis. 18(4), 755-776 (2009)