Brain oligomeric β-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice

Journal of Neuropathology and Experimental Neurology

Volumn 70, Issue 5, 2011, Pages 360-376

  Darocha Souto, Bibiana ^a,c   Scotton, Thomas C ^a   Coma, Mireia ^a   Serrano Pozo, Alberto ^a   Hashimoto, Tadafumi ^a   Serenó, Lidia ^b   Rodríguez, Marta ^b   Sánchez, Belen ^b   Hyman, Bradley T ^a   Gómez Isla, Teresa ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Alzheimer disease; Amyloid plaques; Astrocytes; Neuronal cell death; Oligomeric temp ; Transgenic mice

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANTIBODY; EPITOPE; GLIAL FIBRILLARY ACIDIC PROTEIN; OLIGOMER; TAU PROTEIN;

AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BIOACCUMULATION; BRAIN NERVE CELL; CELL COUNT; COGNITION; CONDITIONING; CONTROLLED STUDY; ENCEPHALITIS; ENTORHINAL CORTEX; FEAR; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LEARNING; MEMORY DISORDER; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ASTROCYTES; BRAIN; CELL COUNT; CONDITIONING, CLASSICAL; DISEASE MODELS, ANIMAL; FEAR; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MAZE LEARNING; MEMORY; MICE; MICE, TRANSGENIC; NEURONS; PLAQUE, AMYLOID; SPACE PERCEPTION; TAU PROTEINS;

EID: 79955524573     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0b013e318217a118     Document Type: Article

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