Azabenzthiazole inhibitors of leukotriene A4 hydrolase

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 24, 2012, Pages 7504-7511

  Tanis, Virginia M ^a   Bacani, Genesis M ^a   Blevitt, Jonathan M ^a   Chrovian, Christa C ^a   Crawford, Shelby ^a   De Leon, Aimee ^a   Fourie, Anne M ^a   Gomez, Laurent ^a   Grice, Cheryl A ^a   Herman, Krystal ^a   Kearney, Aaron M ^a   Landry Bayle, Adrienne M ^a   Lee Dutra, Alice ^a   Nelson, Jay ^a   Riley, Jason P ^a   Santillán Jr , Alejandro ^a   Wiener, John J M ^a   Xue, Xiaohua ^a   Young, Arlene L ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Antiinflammatory; hERG; Leukotriene A4 hydrolase; Log D; LTA4H

Indexed keywords

ANTIINFLAMMATORY AGENT; AZABENZTHIAZOLE DERIVATIVE; BENZOTHIAZOLE DERIVATIVE; DOFETILIDE; HYDROLASE INHIBITOR; LEUKOTRIENE A4 HYDROLASE; LEUKOTRIENE A4 HYDROLASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG HALF LIFE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; OTITIS; RAT;

ANIMALS; AZA COMPOUNDS; BENZOTHIAZOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; EPOXIDE HYDROLASES; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; MICE; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84870245941     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.10.036     Document Type: Article

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