Eosinophil chemotaxis inhibited by 5-lipoxygenase blockade and leukotriene receptor antagonism

American Journal of Respiratory and Critical Care Medicine

Volumn 155, Issue 4, 1997, Pages 1398-1403

  Muñoz, Nilda M ^b   Douglas, Ivor ^b   Mayer, Diane ^b   Herrnreiter, Anja ^b   Zhu, Xiangdong ^b   Leff, Alan R ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOTAXIN; FORMYLMETHIONYLLEUCYLPHENYLALANINE; LEUKOTRIENE B4; LEUKOTRIENE B4 DIMETHYLAMIDE; LEUKOTRIENE B4 RECEPTOR ANTAGONIST; LEUKOTRIENE D4; LEUKOTRIENE RECEPTOR BLOCKING AGENT; LIPOXYGENASE INHIBITOR; UNCLASSIFIED DRUG; ZAFIRLUKAST; ZILEUTON;

AIRWAY OBSTRUCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CHEMOTAXIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; EOSINOPHIL; GUINEA PIG; INTRATRACHEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; TRACHEA;

EID: 0030896244     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.155.4.9105085     Document Type: Article

References (19)

1. Wegner, C. D., R. H. Gundel, P. Reilly, L. G. Letts, and R. Rothlein. 1990. Intercellular adhesion molecule (ICAM-1) in the pathogenesis of asthma. Science 247:456-459.
2. Pretolani, M., C. Ruffie, D. Joseph, M. G. Campos, M. K. Church, J. Lefort, and B. B. Vargaftig. 1994. Role of eosinophil activation in the bronchial reactivity of allergic guinea pigs. Am. J. Respir. Crit. Care Med. 149:1167-1174.
3. Coffman, R. L., B. W. P. Seymour, S. Hudak, J. Jackson, and D. Rennick. 1988. Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice. Science 245:308-310.
4. Griffun, E., L. Hakansson, H. Formgren, K. Jorgensen, C. Peterson, and P. Venge. 1991. Blood eosinophils number and activity in relation to lung function in patients with asthma and eosinophils. J. Allergy Clin. Immunol. 897:548-557.
5. Wardlaw, A. J., S. Dunnette, G. J. Gleich, J. V. Collins, and A. B. Kay. 1988. Eosinophil and mast cells in bronchoalveolar lavage fluid and mild asthma: relationship to bronchial hyperreactivity. Am. Rev. Respir. Dis. 137:62-69.
6. Gleich, G. J. 1990. The eosinophil and bronchial asthma: current understanding. J. Allergy Clin. Immunol. 85:422-436.
7. Ferguson, A. C., and F. W. Wong. 1989. Bronchial hyperresponsiveness in asthmatic children. Correlation with macrophages and eosinophils in broncholavage fluid. Chest 96:988-991.
8. Muñoz, N. M., and A. R. Leff. 1995. Blockade of eosinophil migration by 5-lipoxygenase and cyclooxygenase inhibition in explanted guinea pig trachealis. Am. J. Physiol.: Lung Cell. Mol. Physiol. 268:L446-L454.
9. Rabe, K. J., N. M. Muñoz, A. J. Vita, B. E. Morton, H. Magnussen, and A. R. Leff. 1995. Contraction of human bronchial smooth muscle caused by activated human eosinophils. Am. J. Physiol.: Lung Cell. Mol. Physiol. 267:L326-L334.
10. Strek, M. E., S. R. White, T.-R. Hsiue, G. V. P. Kulp, F. S. Williams, and A. R. Leff. 1993. Effect of mode of activation of human eosinophils on tracheal smooth muscle contraction in guinea pigs. Am. J. Physiol.: Lung Cell. Mol. Physiol. 264:L475-L481.
11. 4 and its 20-w-oxidation products in vitro. Prostaglandins 31:851-858.
12. Sun, F. F., N. J. Crittenden, C. I. Czuk, B. M. Taylor, B. K. Stout, and H. G. Johnson. 1991. Biochemical and functional differences between eosinophils from animal species and man. J. Leukoc. Biol. 50:140-150.
13. 4 antagonism in a primate model of asthma. J. Clin. Invest. 97:381-387.
14. Mitchell, R. W., I. Ndukwu, A. Herrnreiter, K. Uzendowski, B. Gitter, J. Solway, and A. R. Leff. 1995. Differential tachykinin receptor subtype activation in capsaicin and KCl contraction of guinea pig trachealis. Am. J. Physiol.: Lung Cell Mol. Physiol. 269:L837-L842.
15. Israel, E., P. Rubin, J. P. Kemp, J. Groomsman, W. Pierson, S. C. Siegel, D. Tinkelman, J. J. Murray, W. Busse, A. T. Segal, and J. M. Drazen. 1993. The effect of inhibition of 5-lipoxygenase by zileuton in mild-to-moderate asthma. Ann. Intern. Med. 119:1059-1066.
16. Israel, E., R. Demarkarian, M. Rosenberg, R. Sperling, G. Taylor, P. Rubin, and J. M. Drazen. 1990. The effect of a 5-lipoxygenase inhibitor on asthma induced by cold, dry air. N. Engl. J. Med. 323:1740-1744.
17. Galens, S., N. M. Muñoz, K. F. Rabe, A. Herrnreiter, D. Mayer, B. Morton, K. McAllister, and A. R. Leff. 1995. Assessment of agonist- and cell-mediated responses in airway microsections by computerized videomicrometry. Am. J. Physiol.: Lung Cell. Mol. Physiol. 12:L519-L525.
18. 4 antagonist LY293111 on the inflammatory response to allergen challenge in atopic asthmatics (abstract). Am. J. Respir. Crit. Care Med. 151:A680.
19. 4 but not peptido-leukotriene. J. Immunol. 144:1880-1885.