Structural variations of 1-(4-(phenoxymethyl)benzyl)piperidines as nonimidazole histamine H3 receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 10, 2004, Pages 2727-2736

  Mikó, Tibor ^a   Ligneau, Xavier ^b   Pertz, Heinz H ^a   Arrang, Jean Michel ^c   Ganellin, C Robin ^d   Schwartz, Jean Charles ^b,c   Schunack, Walter ^a   Stark, Holger ^e  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b Bioproject Biotech   (France)

^c CENTRE PAUL BROCA   (France)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e GOETHE UNIVERSITY   (Germany)

Author keywords

Antagonist; Histamine H3; Medicinal chemistry; Nonimidazole; Receptor

Indexed keywords

BENZENE DERIVATIVE; HISTAMINE H3 RECEPTOR; HISTAMINE H3 RECEPTOR ANTAGONIST; IMIDAZOLE DERIVATIVE; LIGAND; METHYL GROUP; PHENOL DERIVATIVE; PIPERIDINE DERIVATIVE;

ADDITION REACTION; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CELL LINE; CONTROLLED STUDY; CROSS LINKING; DERIVATIZATION; DRUG BINDING; DRUG FORMULATION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; EXPERIMENTAL MODEL; GUINEA PIG; HUMAN; MOLECULAR CLONING; PROTEIN EXPRESSION; REACTION ANALYSIS; REACTION OPTIMIZATION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; GUINEA PIGS; HISTAMINE ANTAGONISTS; IMIDAZOLES; MICE; MOLECULAR STRUCTURE; PIPERIDINES; RECEPTORS, HISTAMINE H3;

CAVIA PORCELLUS; SUS SCROFA;

EID: 2142768757     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.03.009     Document Type: Article

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