Synthesis and histone deacetylase inhibitory activity of new benzamide derivatives

Journal of Medicinal Chemistry

Volumn 42, Issue 15, 1999, Pages 3001-3003

  Suzuki, Tsuneji ^a   Ando, Tomoyuki ^a   Tsuchiya, Katsutoshi ^a   Fukazawa, Nobuyuki ^a   Saito, Akiko ^b   Mariko, Yukiyasu ^b   Yamashita, Takashi ^b   Nakanishi, Osamu ^b  

^a MITSUI CHEMICALS INC   (Japan)

^b Institute of Biological Science Mitsui Pharmaceuticals Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANILIDE; BENZAMIDE DERIVATIVE; BUTYRIC ACID; HISTONE DEACETYLASE INHIBITOR; N (2 AMINOPHENYL) 4 (3 PYRIDINYLMETHOXYCARBONYLAMINOMETHYL)BENZAMIDE; N (2 AMINOPHENYL) 4 [N (PYRIDIN 3 YLMETHOXYCARBONYL)AMINOMETHYL]BENZAMIDE; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; STRUCTURE ACTIVITY RELATION;

EID: 0033614993     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980565u     Document Type: Article

References (5)

1. Wade, P. A.; Pruss, D.; Wolfe, A. Histone Acetylation: Chromatin in Action. Trends Biochem. Sci. 1997, 22, 128-132.
2. Kruh, J. Effects of Sodium Butyrate, a New Pharmacological Agent, On Cells in Culture. Mol Cell. Biochem. 1982, 42, 65-82.
3. Yoshida, M.; Kijima, M.; Akita, M.; Beppu, T. Potent and Specific Inhibition of Mammalian Histone Deacetylase both In Vivo and In Vitro by Trichostatin A. J. Biol. Chem. 1990, 265, 17174-17179.
4. Kijima, M.; Yoshida, M.; Suguta, K.; Horinouchi, S.; Beppu, T. Trapoxin, an Antitumor Cyclic Tetrapeptide, Is an Irreversible Inhibitor of Mammalian Histone Deacetylase. J. Biol. Chem. 1993, 268, 22429-22435.
5. Saito, A.; Yamashita, T.; Mariko, Y.; Tsuchiya, K.; Ando, T.; Suzuki, T.; Tsuruo, T.; Nakanishi, O. A Novel Synthetic Inhibitor of Histone Deacetylase, MS-27-275, with Marked In Vivo Antitumor Activity against Human Tumors. Proc. Natl. Acad. Sci. U.S.A. 1999, 96, 4592-4597. After submission of ref 5, MS-27-275, the company code of compound 1, had been changed to MS-275.