A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry

Journal of Medicinal Chemistry

Volumn 53, Issue 2, 2010, Pages 616-623

  Colombano, Giampiero ^a   Travelli, Cristina ^a   Galli, Ubaldina ^a   Caldarelli, Antonio ^a   Chini, Maria Giovanna ^b   Canonico, Pier Luigi ^a   Sorba, Giovanni ^a   Bifulco, Giuseppe ^b   Tron, Gian Cesare ^a   Genazzani, Armando A ^a  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYNE; ANTINEOPLASTIC AGENT; AZIDE; COPPER; ENZYME INHIBITOR; GMX 1777; N [4 (1 BENZOYL 4 PIPERIDINYL)BUTYL] 3 (3 PYRIDINYL)ACRYLAMIDE; N [6 (4 CHLOROPHENOXY)HEXYL] N' CYANO N'' (4 PYRIDYL)GUANIDINE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE INHIBITOR; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGY; CATALYSIS; CELL DEATH; CHEMISTRY; CLICK CHEMISTRY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLOADDITION; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING; POLYACRYLAMIDE GEL ELECTROPHORESIS; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

ALKYNES; ANIMALS; ANTINEOPLASTIC AGENTS; AUTOPHAGY; AZIDES; CELL LINE, TUMOR; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77249157805     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm9010669     Document Type: Article

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