High-throughput discovery of mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitors using click chemistry

Organic Letters

Volumn 11, Issue 22, 2009, Pages 5102-5105

  Tan, Lay Pheng ^a   Wu, Hao ^a   Yang, Peng Yu ^a   Kalesh, Karunakaran A ^a   Zhang, Xiaohua ^a   Hu, Mingyu ^a   Srinivasan, Rajavel ^a   Yao, Shao Q ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; ENZYME INHIBITOR; MPTPA PROTEIN, MYCOBACTERIUM TUBERCULOSIS; PROTEIN TYROSINE PHOSPHATASE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DEVELOPMENT; HIGH THROUGHPUT SCREENING; METHODOLOGY; MOLECULAR LIBRARY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

BACTERIAL PROTEINS; DRUG DISCOVERY; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; MOLECULAR STRUCTURE; PROTEIN TYROSINE PHOSPHATASES; SMALL MOLECULE LIBRARIES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 70749146770     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol9023419     Document Type: Article

References (19)

1. (a) Montalibet, J.; Kennedy, B. P. Drug Discovery Today: Ther. Strategies 2005,2, 129-135.
2. (b) Blume-Jensen, P.; Hunter, T. Nature 2001, 411, 355-365.
3. (c) Cook, W. S.; Unger, R. H. Dev. Cell 2002, 2, 385-387.
4. (d) Zhang, Z.-Y. Curr. Opin. Chem. Biol. 2001, 5, 416-423.
5. (e) Hunter, T. Cell 2000, 100, 113-127.
6. Greenstein, A. E.; Grundner, C.; Echols, N.; Gay, L. M.; Lombana, T. N.; Miecskowski, C. A.; Pullen, K. E.; Sung, P. Y.; Alber, T. J. Mol . Microbiol. Biotechnol. 2005, 9, 167-181.
7. Puius, Y. A.; Sullivan, M.; Lawrence, D. S.; Almo, S. C.; Zhang, Z.-Y. Proc. Natl. Acad. Sci. U.S.A 1997, 94, 13420-13425.
8. (a) Liu, G.; Xin, Z.; Pei, Z.; Hajduk, P. J.; Abad-Zapatero, C.; Hutchins, C. W.; Zhao, H.; Lubben, T. H.; Ballaron, S. J.; Haasch, D. L.; Kaszubska, W.; Ronodinone, C. M.; Trevillyan, J. M.; Jirousek, M. R. J. Med. Chem. 2003, 46, 4232-4235.
9. (b) Liu, G.; Xin, Z.; Liang, H.; AbadZapatero, C.; Hajduk, P. J.; Janowick, D. A.; Szczepankiewicz, B. G.; Pei, Z.; Hutchins, C. W.; Ballaron, S. J.; Stashko, M. A.; Lubben, T. H.; Berg, C. E.; Rondinone, C. M.; Trevillyan, J. M.; Jirousek, M. R. J. Med. Chem. 2003, 46, 3437-3440.
10. Srinivasan, R.; Uttamchandani, M.; Yao, S. Q. Org. Lett. 2006, 8, 713-716.
11. For reviews, see; (a) Kolb, H. C.; Sharpless, K. B. Drug Discovery Today 2003, 8, 1128-1137.
12. (b) Meldal, M.; Tornoe, C. W. Chem. Rev. 2008, 108, 2952-3015.
13. (a) Kalesh, K. A.; Yang, P.-Y.; Srinivasan, R.; Yao, S. Q. QSAR Comb. Sci. 2007, 26, 1135-1144.
14. (b) Birk, A.; Wu, C. Y.; Wong, C. H. Org. Biomol. Chem. 2006, 4, 1446-1457.
15. (c) Krasiñski, A.; Radik, Z.; Manetsch, R.; Raushel, J.; Taylor, P.; Sharpless, K. B.; Kolb, H. C. J. Am. Chem. Soc. 2005, 127, 6686-6692.
16. Srinivasan, R.; Tan, L. P.; Wu, H.; Yang, P.-Y.; Kalesh, K. A.; Yao, S. Q. Org. Biol. Chem. 2009, 7, 1821-1828.
17. Grundner, C.; Petrin, D.; van Huijsduijnen, R. H.; Swinnen, D.; Gonzalez, J.; Gee, C. L.; Wells, T. N.; Alber, T. Structure 2007, 15, 499-509.
18. Soellner, M. B.; Rawls, K. A.; Grundner, C.; Alber, T.; Ellman, J. A. J. Am. Chem. Soc. 2007, 129, 9613-9615.
19. Srinivasan, R.; Li, J.; Ng, S. L.; Kalesh, K. A.; Yao, S. Q. Nat. Protoc. 2007, 2, 2655-2664.