Targeted nanotheranostics for personalized cancer therapy

Expert Opinion on Drug Delivery

Volumn 9, Issue 12, 2012, Pages 1475-1487

  Diou, Odile ^a,b   Tsapis, Nicolas ^a,b   Fattal, Elias ^a,b  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b UNIV PARIS SUD   (France)

Author keywords

19F MRI; 1H MRI; Chemotherapy; Drug efficacy monitoring; Nanotheranostics; Personalized medicine; Stimuli sensitive release; Ultrasonography

Indexed keywords

APTAMER; DOXORUBICIN; FOLIC ACID; LIPOSOME; NANOPARTICLE; PEPTIDE; POLY(ACRYLATE METHACRYLATE); PROTEIN; SUPERPARAMAGNETIC IRON OXIDE;

ANTINEOPLASTIC ACTIVITY; CANCER CELL; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG RELEASE; ECHOGRAPHY; NANOTHERANOSTIC DRUG DELEIVERY SYSTEM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PERSONALIZED MEDICINE; REVIEW; TARGET CELL DESTRUCTION; TUMOR GROWTH;

ANIMALS; DIAGNOSTIC IMAGING; DRUG DELIVERY SYSTEMS; HUMANS; INDIVIDUALIZED MEDICINE; MAGNETIC RESONANCE IMAGING; NANOMEDICINE; NANOSTRUCTURES; NEOPLASMS;

EID: 84869792625     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2012.736486     Document Type: Review

References (95)

1. Ponce AM, Viglianti BL, Yu D, et al. Magnetic resonance imaging of temperature-sensitive liposome release: drug dose painting and antitumor effects. J Natl Cancer Inst 2007;99(1):53-63
2. de Smet M, Heijman E, Langereis S, et al. Magnetic resonance imaging of high intensity focused ultrasound mediated drug delivery from temperature-sensitive liposomes: an in vivo proof-of-concept study. J Control Release 2011;150(1):102-10
3. Bates S. Progress towards personalized medicine. Drug Discov Today 2010;15(3-4):115-20
4. Barreto JA, O'Malley W, Kubeil M, et al. Nanomaterials: applications in cancer imaging and therapy. Adv Mater 2011;23(12):H18-40
5. Bae KH, Chung HJ, Park TG. Nanomaterials for cancer therapy and imaging. Mol Cells 2011;31(4):295-302
6. Kateb B, Chiu K, Black KL, et al. Nanoplatforms for constructing new approaches to cancer treatment, imaging, and drug delivery: what should be the policy? Neuroimage 2011;54(Suppl 1):S106-24
7. Keupp J, Rahmer J, Grasslin I, et al. Simultaneous dual-nuclei imaging for motion corrected detection and quantification of 19F imaging agents. Magn Reson Med 2011;66(4):1116-22
8. Hu L, Hockett FD, Chen J, et al. A generalized strategy for designing (19) F/(1)H dual-frequency MRI coil for small animal imaging at 4.7 Tesla. J Magn Reson Imaging 2011;34(1):245-52
9. Neubauer AM, Myerson J, Caruthers SD, et al. Gadolinium-modulated 19F signals from perfluorocarbon nanoparticles as a new strategy for molecular imaging. Magn Reson Med 2008;60(5):1066-72
10. Fang C, Bhattarai N, Sun C, et al. Functionalized nanoparticles with long-term stability in biological media. Small 2009;5(14):1637-41
11. Bhadra D, Bhadra S, Jain NK. Pegylated lysine based copolymeric dendritic micelles for solubilization and delivery of artemether. J Pharm Pharm Sci 2005;8(3):467-82 (Pubitemid 41529323)
12. Alhareth K, Vauthier C, Bourasset F, et al. Conformation of surface-decorating dextran chains affects the pharmacokinetics and biodistribution of doxorubicin-loaded nanoparticles. Eur J Pharm Biopharm 2012;81(2):453-7
13. Amoozgar Z, Park J, Lin Q, et al. Low molecular-weight chitosan as a pH-sensitive stealth coating for tumor-specific drug delivery. Mol Pharm 2012;9(5):1262-70
14. Jokerst JV, Lobovkina T, Zare RN, et al. Nanoparticle PEGylation for imaging and therapy. Nanomedicine (Lond) 2011;6(4):715-28
15. Kenny GD, Kamaly N, Kalber TL, et al. Novel multifunctional nanoparticle mediates siRNA tumour delivery, visualisation and therapeutic tumour reduction in vivo. J Control Release 2011;149(2):111-16
16. Du W, Nystrom AM, Zhang L, et al. Amphiphilic hyperbranched fluoropolymers as nanoscopic 19F magnetic resonance imaging agent assemblies. Biomacromolecules 2008;9(10):2826-33
17. Du W, Xu Z, Nystrom AM, et al. 19Fand fluorescently labeled micelles as nanoscopic assemblies for chemotherapeutic delivery. Bioconjug Chem 2008;19(12):2492-8
18. Nystrom AM, Bartels JW, Du W, et al. Perfluorocarbon-loaded shell crosslinked knedel-like nanoparticles: lessons regarding polymer mobility and self assembly. J Polym Sci A Polym Chem 2009;47(4):1023-37
19. Diou O, Tsapis N, Giraudeau C, et al. Long-circulating perfluorooctyl bromide nanocapsules for tumor imaging by 19FMRI. Biomaterials 2012;33(22):5593-602
20. Kuznetsov AA, Filippov VI, Alyautdin RN, et al. Application of magnetic liposomes for magnetically guided transport of muscle relaxants and anti-cancer photodynamic drugs. J Magn Magn Mater 2001;225(1-2):95-100 (Pubitemid 32335280)
21. Fortin-Ripoche JP, Martina MS, Gazeau F, et al. Magnetic targeting of magnetoliposomes to solid tumors with MR imaging monitoring in mice: feasibility. Radiology 2006;239(2):415-24
22. Gultepe E, Reynoso FJ, Jhaveri A, et al. Monitoring of magnetic targeting to tumor vasculature through MRI and biodistribution. Nanomedicine (Lond) 2010;5(8):1173-82
23. Medarova Z, Rashkovetsky L, Pantazopoulos P, et al. Multiparametric monitoring of tumor response to chemotherapy by noninvasive imaging. Cancer Res 2009;69(3):1182-9
24. Kumar M, Yigit M, Dai G, et al. Image-guided breast tumor therapy using a small interfering RNA nanodrug. Cancer Res 2010;70(19):7553-61
25. Bartlett DW, Su H, Hildebrandt IJ, et al. Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging. Proc Natl Acad Sci USA 2007;104(39):15549-54 (Pubitemid 47502954)
26. Wang AZ, Bagalkot V, Vasilliou CC, et al. Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy. ChemMedChem 2008;3(9):1311-15
27. Yang X, Grailer JJ, Rowland IJ, et al. Multifunctional SPIO/DOX-loaded wormlike polymer vesicles for cancer therapy and MR imaging. Biomaterials 2010;31(34):9065-73
28. Takaoka Y, Kiminami K, Mizusawa K, et al. Systematic study of protein detection mechanism of self-assembling 19F NMR/MRI nanoprobes toward rational design and improved sensitivity. J Am Chem Soc 2011;133(30):11725-31
29. Waters EA, Chen J, Yang X, et al. Detection of targeted perfluorocarbon nanoparticle binding using 19F diffusion weighted MR spectroscopy. Magn Reson Med 2008;60(5):1232-6
30. Anderson CR, Hu X, Zhang H, et al. Ultrasound molecular imaging of tumor angiogenesis with an integrin targeted microbubble contrast agent. Invest Radiol 2011;46(4):215-24
31. Marsh JN, Partlow KC, Abendschein DR, et al. Molecular imaging with targeted perfluorocarbon nanoparticles: quantification of the concentration dependence of contrast enhancement for binding to sparse cellular epitopes. Ultrasound Med Biol 2007;33(6):950-8 (Pubitemid 46823947)
32. Kok MB, de Vries A, Abdurrachim D, et al. Quantitative (1)H MRI, (19)F MRI, and (19)F MRS of cell-internalized perfluorocarbon paramagnetic nanoparticles. Contrast Media Mol Imaging 2011;6(1):19-27
33. Jokerst JV, Gambhir SS. Molecular imaging with theranostic nanoparticles. Acc Chem Res 2011;44(10):1050-60
34. Park JO, Stephen Z, Sun C, et al. Glypican-3 targeting of liver cancer cells using multifunctional nanoparticles. Mol Imaging 2011;10(1):69-77
35. El-Haibi CP, Karnoub AE. Mesenchymal stem cells in the pathogenesis and therapy of breast cancer. J Mammary Gland Biol Neoplasia 2010;15(4):399-409
36. Chen R, Yu H, Jia ZY, et al. Efficient nano iron particle-labeling and noninvasive MR imaging of mouse bone marrow-derived endothelial progenitor cells. Int J Nanomedicine 2011;6:511-19
37. Partlow KC, Chen J, Brant JA, et al. 19F magnetic resonance imaging for stem/progenitor cell tracking with multiple unique perfluorocarbon nanobeacons. FASEB J 2007;21(8):1647-54 (Pubitemid 46855610)
38. Ruiz-Cabello J, Walczak P, Kedziorek DA, et al. In vivo "hot spot" MR imaging of neural stem cells using fluorinated nanoparticles. Magn Reson Med 2008;60(6):1506-11
39. de Vries IJM, Lesterhuis WJ, Barentsz JO, et al. Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy. Nat Biotechnol 2005;23(11):1407-13 (Pubitemid 41679393)
40. Bonetto F, Srinivas M, Heerschap A, et al. A novel (19)F agent for detection and quantification of human dendritic cells using magnetic resonance imaging. Int J Cancer 2011;129(2):365-73
41. Hitchens TK, Ye Q, Eytan DF, et al. 19F MRI detection of acute allograft rejection with in vivo perfluorocarbon labeling of immune cells. Magn Reson Med 2011;65(4):1144-53
42. Kornmann LM, Curfs DM, Hermeling E, et al. Perfluorohexaneloaded macrophages as a novel ultrasound contrast agent: a feasibility study. Mol Imaging Biol 2008;10(5):264-70
43. Kircher MF, Mahmood U, King RS, et al. A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation. Cancer Res 2003;63(23):8122-5 (Pubitemid 37549457)
44. Davda S, Bezabeh T. Advances in methods for assessing tumor hypoxia in vivo: implications for treatment planning. Cancer Metastasis Rev 2006;25(3):469-80 (Pubitemid 44922362)
45. Parhami P, Fung BM. F-19 Relaxation study of perfluoro chemicals as oxygen carriers. J Phys Chem Us 1983;87(11):1928-31
46. Liu S, Shah SJ, Wilmes LJ, et al. Quantitative tissue oxygen measurement in multiple organs using 19F MRI in a rat model. Magn Reson Med 2011;66(6):1722-30
47. Diepart C, Magat J, Jordan BF, et al. In vivo mapping of tumor oxygen consumption using (19)F MRI relaxometry. NMR Biomed 2011;24(5):458-63
48. Giraudeau C, Djemai B, Ghaly MA, et al. High sensitivity 19F MRI of a perfluorooctyl bromide emulsion: application to a dynamic biodistribution study and oxygen tension mapping in the mouse liver and spleen. NMR Biomed 2012;25(4):654-60
49. Mason RP, Antich PP. Tumor oxygen tension: measurement using oxygent as a 19F NMR probe at 4.7 T. Artif Cells Blood Substit Immobil Biotechnol 1994;22(4):1361-7 (Pubitemid 24291572)
50. Aguilera TA, Olson ES, Timmers MM, et al. Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides. Integr Biol (Camb) 2009;1(5-6):371-81
51. Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 1989;49(23):6449-65 (Pubitemid 20008770)
52. Oishi M, Sumitani S, Nagasaki Y. On-off regulation of 19F magnetic resonance signals based on pH-sensitive PEGylated nanogels for potential tumor-specific smart 19F MRI probes. Bioconjug Chem 2007;18(5):1379-82 (Pubitemid 47464043)
53. Mizukami S, Takikawa R, Sugihara F, et al. Paramagnetic relaxation-based 19f MRI probe to detect protease activity. J Am Chem Soc 2008;130(3):794-5
54. Berridge MJ, Bootman MD, Roderick HL. Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 2003;4(7):517-29 (Pubitemid 36773404)
55. Atanasijevic T, Shusteff M, Fam P, et al. Calcium-sensitive MRI contrast agents based on superparamagnetic iron oxide nanoparticles and calmodulin. Proc Natl Acad Sci USA 2006;103(40):14707-12 (Pubitemid 44527794)
56. Orsi F, Arnone P, Chen W, et al. High intensity focused ultrasound ablation: a new therapeutic option for solid tumors. J Cancer Res Ther 2010;6(4):414-20
57. McDannold NJ, Vykhodtseva NI, Hynynen K. Microbubble contrast agent with focused ultrasound to create brain lesions at low power levels: MR imaging and histologic study in rabbits. Radiology 2006;241(1):95-106 (Pubitemid 44433339)
58. Huang J, Xu JS, Xu RX. Heat-sensitive microbubbles for intraoperative assessment of cancer ablation margins. Biomaterials 2010;31(6):1278-86
59. Lartigue L, Innocenti C, Kalaivani T, et al. Water-dispersible sugar-coated iron oxide nanoparticles. An evaluation of their relaxometric and magnetic hyperthermia properties. J Am Chem Soc 2011;133(27):10459-72
60. Rachakatla RS, Balivada S, Seo GM, et al. Attenuation of mouse melanoma by A/C magnetic field after delivery of bi-magnetic nanoparticles by neural progenitor cells. ACS Nano 2010;4(12):7093-104
61. Hilger I, Hiergeist R, Hergt R, et al. Thermal ablation of tumors using magnetic nanoparticles: an in vivo feasibility study. Invest Radiol 2002;37(10):580-6
62. Gneveckow U, Jordan A, Scholz R, et al. Description and characterization of the novel hyperthermia-and thermoablation-system MFH 300F for clinical magnetic fluid hyperthermia. Med Phys 2004;31(6):1444-51 (Pubitemid 38808512)
63. Waite CL, Roth CM. Nanoscale drug delivery systems for enhanced drug penetration into solid tumors: current progress and opportunities. Crit Rev Biomed Eng 2012;40(1):21-41
64. Blanco E, Hsiao A, Ruiz-Esparza GU, et al. Molecular-targeted nanotherapies in cancer: enabling treatment specificity. Mol Oncol 2011;5(6):492-503
65. Yang J, Lee CH, Ko HJ, et al. Multifunctional magneto-polymeric nanohybrids for targeted detection and synergistic therapeutic effects on breast cancer. Angew Chem Int Ed Engl 2007;46(46):8836-9 (Pubitemid 350207937)
66. Yu MK, Kim D, Lee IH, et al. Image-guided prostate cancer therapy using aptamer-functionalized thermally cross-linked superparamagnetic iron oxide nanoparticles. Small 2011;7(15):2241-9
67. Rapoport N, Nam KH, Gupta R, et al. Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions. J Control Release 2011;153(1):4-15
68. Soman NR, Lanza GM, Heuser JM, et al. Synthesis and characterization of stable fluorocarbon nanostructures as drug delivery vehicles for cytolytic peptides. Nano Lett 2008;8(4):1131-6
69. Soman NR, Baldwin SL, Hu G, et al. Molecularly targeted nanocarriers deliver the cytolytic peptide melittin specifically to tumor cells in mice, reducing tumor growth. J Clin Invest 2009;119(9):2830-42
70. Eisenbrey JR, Huang P, Hsu J, et al. Ultrasound triggered cell death in vitro with doxorubicin loaded poly lactic-acid contrast agents. Ultrasonics 2009;49(8):628-33
71. Gautier J, Munnier E, Paillard A, et al. A pharmaceutical study of doxorubicin-loaded PEGylated nanoparticles for magnetic drug targeting. Int J Pharm 2012;423(1):16-25
72. Kamm YJ, Heerschap A, Rosenbusch G, et al. 5-Fluorouracil metabolite patterns in viable and necrotic tumor areas of murine colon carcinoma determined by 19F NMR spectroscopy. Magn Reson Med 1996;36(3):445-50
73. Onuki Y, Jacobs I, Artemov D, et al. Noninvasive visualization of in vivo release and intratumoral distribution of surrogate MR contrast agent using the dual MR contrast technique. Biomaterials 2010;31(27):7132-8
74. Viglianti BL, Ponce AM, Michelich CR, et al. Chemodosimetry of in vivo tumor liposomal drug concentration using MRI. Magn Reson Med 2006;56(5):1011-18 (Pubitemid 44691343)
75. Castelletto V, McKendrick JE, Hamley IW, et al. PEGylated amyloid peptide nanocontainer delivery and release system. Langmuir 2010;26(14):11624-7
76. Criscione JM, Le BL, Stern E, et al. Self-assembly of pH-responsive fluorinated dendrimer-based particulates for drug delivery and noninvasive imaging. Biomaterials 2009;30(23-24):3946-55
77. Zou P, Yu Y, Wang YA, et al. Superparamagnetic iron oxide nanotheranostics for targeted cancer cell imaging and pH-dependent intracellular drug release. Mol Pharm 2010;7(6):1974-84
78. Du L, Jin Y, Zhou W, et al. Ultrasound-triggered drug release and enhanced anticancer effect of doxorubicin-loaded poly(D,L-lactide-coglycolide)- methoxy-poly(ethylene glycol) nanodroplets. Ultrasound Med Biol 2011;37(8):1252-8
79. Chappell JC, Song J, Burke CW, et al. Targeted delivery of nanoparticles bearing fibroblast growth factor-2 by ultrasonic microbubble destruction for therapeutic arteriogenesis. Small 2008;4(10):1769-77
80. Klibanov AL, Shevchenko TI, Raju BI, et al. Ultrasound-triggered release of materials entrapped in microbubbleliposome constructs: a tool for targeted drug delivery. J Control Release 2010;148(1):13-17
81. Schroeder A, Kost J, Barenholz Y. Ultrasound, liposomes, and drug delivery: principles for using ultrasound to control the release of drugs from liposomes. Chem Phys Lipids 2009;162(1-2):1-16
82. Fabiilli ML, Lee JA, Kripfgans OD, et al. Delivery of water-soluble drugs using acoustically triggered perfluorocarbon double emulsions. Pharm Res 2010;27(12):2753-65
83. Fang JY, Hung CF, Hua SC, et al. Acoustically active perfluorocarbon nanoemulsions as drug delivery carriers for camptothecin: drug release and cytotoxicity against cancer cells. Ultrasonics 2009;49(1):39-46
84. Dromi S, Frenkel V, Luk A, et al. Pulsed-high intensity focused ultrasound and low temperature-sensitive liposomes for enhanced targeted drug delivery and antitumor effect. Clin Cancer Res 2007;13(9):2722-7 (Pubitemid 46788041)
85. Negussie AH, Yarmolenko PS, Partanen A, et al. Formulation and characterisation of magnetic resonance imageable thermally sensitive liposomes for use with magnetic resonance-guided high intensity focused ultrasound. Int J Hyperther 2011;27(2):140-55
86. Babincova M, Cicmanec P, Altanerova V, et al. AC-magnetic field controlled drug release from magnetoliposomes: design of a method for site-specific chemotherapy. Bioelectrochemistry 2002;55(1-2):17-19 (Pubitemid 34084742)
87. Langereis S, Keupp J, van Velthoven JL, et al. A temperature-sensitive liposomal 1H CEST and 19F contrast agent for MR image-guided drug delivery. J Am Chem Soc 2009;131(4):1380-1
88. Grull H, Langereis S. Hyperthermia-triggered drug delivery from temperature-sensitive liposomes using MRI-guided high intensity focused ultrasound. J Control Release 2012;161(2):317-27
89. Kievit FM, Zhang M. Cancer nanotheranostics: improving imaging and therapy by targeted delivery across biological barriers. Adv Mater 2011;23(36):H217-47
90. Veiseh O, Kievit FM, Fang C, et al. Chlorotoxin bound magnetic nanovector tailored for cancer cell targeting, imaging, and siRNA delivery. Biomaterials 2010;31(31):8032-42
91. Liu G, Swierczewska M, Lee S, et al. Functional nanoparticles for molecular imaging guided gene delivery. Nano Today 2010;5(6):524-39
92. Bartusik D, Tomanek B. Application of 19F magnetic resonance to study the efficacy of fluorine labeled drugs in the three-dimensional cultured breast cancer cells. Arch Biochem Biophys 2010;493(2):234-41
93. Bartusik D, Tomanek B. Detection of fluorine labeled herceptin using cellular (19)F MRI ex vivo. J Pharm Biomed Anal 2010;51(4):894-900
94. Lee JH, Lee K, Moon SH, et al. All-in-one target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery. Angew Chem Int Ed Engl 2009;48(23):4174-9
95. Valencia PM, Basto PA, Zhang L, et al. Single-step assembly of homogenous lipid-polymeric and lipid-quantum dot nanoparticles enabled by microfluidic rapid mixing. ACS Nano 2010;4(3):1671