Systematic study of protein detection mechanism of self-assembling 19F NMR/MRI nanoprobes toward rational design and improved sensitivity

Journal of the American Chemical Society

Volumn 133, Issue 30, 2011, Pages 11725-11731

  Takaoka, Yousuke ^a   Kiminami, Keishi ^a   Mizusawa, Keigo ^a   Matsuo, Kazuya ^a   Narazaki, Michiko ^a   Matsuda, Tetsuya ^a   Hamachi, Itaru ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE AGENTS; AGGREGATE STABILITY; BACKGROUND SIGNALS; DETECTION MECHANISM; HIGH SENSITIVITY; IMAGE INTENSITIES; NMR PROBE; PROTEIN DETECTION; PROTEIN RESPONSE; RATIONAL DESIGN; SELECTIVE SENSING; SELF-ASSEMBLING; STRUCTURE AND PROPERTIES; SYSTEMATIC INVESTIGATIONS; SYSTEMATIC STUDY; TARGET PROTEINS;

AGGLOMERATION; CHEMICAL DETECTION; MAGNETIC RESONANCE IMAGING; NANOPROBES; PROBES; PROTEINS; SIGNAL DETECTION;

BIOSYNTHESIS;

3,5 BIS(TRIFLUOROMETHYL)BENZENE DERIVATIVE; AVIDIN; BENZENE DERIVATIVE; BENZENESULFONAMIDE DERIVATIVE; BENZOIC ACID DERIVATIVE; BIOTIN DERIVATIVE; CARBONATE DEHYDRATASE I; DIHYDROFOLATE REDUCTASE; ETHYLENE GLYCOL DERIVATIVE; FLUORINE DERIVATIVE; METHOTREXATE DERIVATIVE; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CORRELATION ANALYSIS; DRUG DESIGN; FLUORINE NUCLEAR MAGNETIC RESONANCE; HUMAN; HYDROPHILICITY; HYDROPHOBICITY; MOLECULAR STABILITY; NANOPROBE; NUCLEAR MAGNETIC RESONANCE IMAGING; PH; PROTEIN ANALYSIS; REACTION ANALYSIS; SELF ASSEMBLING NANOPROBE; SENSITIVITY ANALYSIS; SIGNAL NOISE RATIO; STRUCTURE ACTIVITY RELATION;

CARBONIC ANHYDRASE I; FLUORESCENT DYES; FLUORINE; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; NANOPARTICLES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; WATER; WETTABILITY;

EID: 79960853658     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja203996c     Document Type: Article

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