High sensitivity 19F MRI of a perfluorooctyl bromide emulsion: Application to a dynamic biodistribution study and oxygen tension mapping in the mouse liver and spleen

NMR in Biomedicine

Volumn 25, Issue 4, 2012, Pages 654-660

  Giraudeau, Céline ^a   Djemaï, Boucif ^a   Ghaly, Mohamed Ahmed ^a   Boumezbeur, Fawzi ^a   Mériaux, Sébastien ^a   Robert, Philippe ^b   Port, Marc ^b   Robic, Caroline ^b   Bihan, Denis Le ^a   Lethimonnier, Franck ^a   Valette, Julien ^a  

^a CEA SACLAY   (France)

^b Laboratoire Guerbet   (France)

Author keywords

19F; Biodistribution; Emulsion; Liver; Mouse; Oximetry; PFOB; Spleen

Indexed keywords

BIODISTRIBUTIONS; MOUSE; OXIMETRY; PFOB; SPLEEN;

BROMINE COMPOUNDS; EMULSIFICATION; EMULSIONS; LIVER; OXYGEN; OXYGENATION; POLYETHYLENE OXIDES;

POLYETHYLENE GLYCOLS;

MACROGOL; PERFLUOROOCTYL BROMIDE; DIAGNOSTIC AGENT; FLUORINE; FLUOROCARBON; OXYGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CIRCULATION; EMULSION; FLUORINE NUCLEAR MAGNETIC RESONANCE; IMAGE ANALYSIS; IN VIVO STUDY; LIVER; MALE; MOUSE; NONHUMAN; OXIMETRY; OXYGEN TENSION; PARTICLE SIZE; PRIORITY JOURNAL; SIGNAL NOISE RATIO; SPLEEN; ANIMAL; ANTIBODY SPECIFICITY; HISTOLOGY; INTRAVENOUS DRUG ADMINISTRATION; METABOLIC CLEARANCE RATE; METABOLISM; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION;

ANIMALS; EMULSIONS; FLUORINE; FLUOROCARBONS; INJECTIONS, INTRAVENOUS; LIVER; MAGNETIC RESONANCE IMAGING; METABOLIC CLEARANCE RATE; MICE; ORGAN SPECIFICITY; OXYGEN; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPLEEN; TISSUE DISTRIBUTION;

EID: 84858866473     PISSN: 09523480     EISSN: 10991492     Source Type: Journal    
DOI: 10.1002/nbm.1781     Document Type: Article

References (25)

1. Clark LC Jr, Gollan F. Survival of mammals breathing organic liquids equilibrated with oxygen at atmospheric pressure. Science 1966; 152: 1755-1756.
2. Riess JG. Perfluorocarbon-based oxygen delivery. Artif. Cells Blood Substit. Immobil. Biotechnol. 2006; 34: 567-580.
3. Mattrey RF. The potential role of perfluorochemicals (PFCs) in diagnostic imaging. Artif. Cells Blood Substit. Immobil. Biotechnol. 1994; 22: 295-313.
4. Kaneda MM, Caruthers S, Lanza GM, Wickline SA. Perfluorocarbon nanoemulsions for quantitative molecular imaging and targeted therapeutics. Ann. Biomed. Eng. 2009; 37: 1922-1933.
5. Caruthers SD, Cyrus T, Winter PM, Wickline SA, Lanza GM. Anti-angiogenic perfluorocarbon nanoparticles for diagnosis and treatment of atherosclerosis. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 2009; 1: 311-323.
6. Chen J, Lanza GM, Wickline SA. Quantitative magnetic resonance fluorine imaging: today and tomorrow. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 2010; 2: 431-440.
7. Dardzinski BJ, Sotak CH. Rapid tissue oxygen tension mapping using 19F inversion-recovery echo-planar imaging of perfluoro-15-crown-5-ether. Magn. Reson. Med. 1994; 32: 88-97.
8. Robinson SP, Griffiths JR. Current issues in the utility of 19F nuclear magnetic resonance methodologies for the assessment of tumour hypoxia. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2004; 359: 987-996.
9. Janjic JM, Ahrens ET. Fluorine-containing nanoemulsions for MRI cell tracking. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 2009; 1: 492-501.
10. Mattrey RF. Perfluorooctylbromide: a new contrast agent for CT, sonography, and MR imaging. Am. J. Roentgenol. 1989; 152: 247-252.
11. Ratner AV, Hurd R, Muller HH, Bradley-Simpson B, Pitts W, Shibata D, Sotak C, Young SW. 19F magnetic resonance imaging of the reticuloendothelial system. Magn. Reson. Med. 1987; 5: 548-554.
12. Giraudeau C, Flament J, Marty B, Boumezbeur F, Mériaux S, Robic C, Port M, Tsapis N, Fattal E, Giacomini E, Lethimonnier F, Le Bihan D, Valette J. A new paradigm for high-sensitivity 19F magnetic resonance imaging of perfluorooctylbromide. Magn. Reson. Med. 2010; 63: 1119-1124
13. Shukla HP, Mason RP, Woessner DE, Antich PP. A comparison of three commercial perfluorocarbon emulsions as high-field 19F NMR probes of oxygen tension and temperature. J. Magn. Reson. 1995; 106: 131-141
14. Barker BR, Mason RP, Bansal N, Peshock RM. Oxygen tension mapping with F-19 echo-planar MR imaging of sequestered perfluorocarbon. J. Magn. Reson. Imaging 1994; 4: 595-602.
15. Holland SK, Kennan RP, Schaub MM, D'Angelo MJ, Gore JC. Imaging oxygen tension in liver and spleen by 19F NMR. Magn. Reson. Med. 1993; 29: 446-458.
16. Börnert P, Norris DG, Koch H, Dreher W, Reichelt H, Leibfritz D. Fast perfluorocarbon imaging using 19F U-FLARE. Magn. Reson. Med. 1993; 29: 226-234.
17. Young SW, Enzmann DR, Long DM, Muller HH. Perfluoroctylbromide contrast enhancement of malignant neoplasms: preliminary observations. Am. J. Roentgenol. 1981; 137: 141-146.
18. Keipert PE, Otto S, Flaim SF, Weers JG, Schutt EA, Pelura TJ, Klein DH, Yaksh TL. Influence of perflubron emulsion particle size on blood half-life and febrile response in rats. Artif. Cells Blood Substit. Immobil. Biotechnol. 1994; 22: 1169-1174.
19. Harned RK 2nd, Fruman SA, Swenson RB, Bernardino ME. Time versus density enhancement of liver, spleen, and great vessels following rapid intravenous infusion of perflubron emulsion. Acad. Radiol. 1995; 2: 38-42.
20. Mattrey RF, Long DM, Peck WW, Slutsky RA, Higgins CB. Perfluoroctylbromide as a blood pool contrast agent for liver, spleen, and vascular imaging in computed tomography. J. Comput. Assist. Tomogr. 1984; 8: 739-744.
21. Mattrey RF, Long DM, Multer F, Mitten R, Higgins CB. Perfluoroctylbromide: a reticuloendothelial-specific and tumor-imaging agent for computed tomography. Radiology 1982; 145: 755-758.
22. Owens DE 3rd, Peppas NA. Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int. J. Pharm. 2006; 307: 93-102.
23. Kong CF, Holloway GM, Parhami P, Fung BM. Carbon-13 and fluorine-19 nuclear magnetic resonance study of perfluoro chemical emulsions. J. Phys. Chem. 1984; 88: 6308-6311.
24. Fan X, Medved M, River JN, Zamora M, Corot C, Robert P, Bourrinet P, Lipton M, Culp RM, Karczmar GS. New model for analysis of dynamic contrast-enhanced MRI data distinguishes metastatic from nonmetastatic transplanted rodent prostate tumors. Magn. Reson. Med. 2004; 51: 487-494.
25. Fishman JE, Joseph PM, Floyd TF, Mukherji B, Sloviter HA. Oxygen-sensitive 19F NMR imaging of the vascular system in vivo. Magn. Reson. Imaging 1987; 5: 279-285.