Quantitative 1H MRI, 19F MRI, and 19F MRS of cell-internalized perfluorocarbon paramagnetic nanoparticles

Contrast Media and Molecular Imaging

Volumn 6, Issue 1, 2011, Pages 19-27

  Kok, Maarten B ^a   De Vries, Anke ^a,b   Abdurrachim, Desiree ^a   Prompers, Jeanine J ^a   Grüll, Holger ^a,b   Nicolay, Klaas ^a   Strijkers, Gustav J ^a  

^a EINDHOVEN UNIVERSITY OF TECHNOLOGY   (Netherlands)

^b PHILIPS RESEARCH LABORATORIES   (Netherlands)

Author keywords

3; Emulsion; Fluorine; Gadolinium; Molecular imaging; MRI; MRS; RGD

Indexed keywords

FLUORINE; FLUOROCARBON; NANOPARTICLE; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; VITRONECTIN RECEPTOR;

ARTICLE; CONTROLLED STUDY; CYTOPLASM; CYTOPLASM VESICLE; EMULSION; ENDOTHELIUM CELL; FLUORINE NUCLEAR MAGNETIC RESONANCE; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IN VITRO STUDY; LIMIT OF QUANTITATION; MOLECULAR IMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SPECTROSCOPY;

CELLS, CULTURED; CONTRAST MEDIA; CROWN ETHERS; EMULSIONS; ENDOTHELIAL CELLS; FLUORINE RADIOISOTOPES; FLUOROCARBONS; GADOLINIUM; HUMANS; INTEGRIN ALPHAVBETA3; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MAGNETITE NANOPARTICLES; OLIGOPEPTIDES; PROTONS;

EID: 79951970817     PISSN: 15554309     EISSN: 15554317     Source Type: Journal    
DOI: 10.1002/cmmi.398     Document Type: Article

References (35)

1. Weissleder R. Molecular imaging in cancer. Science 2006; 312(5777): 1168-1171.
2. Sanz J, Fayad ZA. Imaging of atherosclerotic cardiovascular disease. Nature 2008; 451(7181): 953-957.
3. Jaffer FA, Sosnovik DE, Nahrendorf M, Weissleder R. Molecular imaging of myocardial infarction. J Mol Cell Cardiol 2006; 41(6): 921-933.
4. 2 relaxivity. Magn Reson Med 2009; 61(5): 1022-1032.
5. 1 relaxation model for intracellular paramagnetic contrast agents. Magn Reson Med 2009; 61(5): 1049-1058.
6. Modo M, Mellodew K, Cash D, Fraser SE, Meade TJ, Price J, Williams SC. Mapping transplanted stem cell migration after a stroke: a serial, in vivo magnetic resonance imaging study. Neuroimage 2004; 21(1): 311-317.
7. Shyu WC, Chen CP, Lin SZ, Lee YJ, Li H. Efficient tracking of non-iron-labeled mesenchymal stem cells with serial MRI in chronic stroke rats. Stroke 2007; 38(2): 367-374.
8. Kustermann E, Roell W, Breitbach M, Wecker S, Wiedermann D, Buehrle C, Welz A, Hescheler J, Fleischmann BK, Hoehn M. Stem cell implantation in ischemic mouse heart: a high-resolution magnetic resonance imaging investigation. NMR Biomed 2005; 18(6): 362-370.
9. Yeh TC, Zhang W, Ildstad ST, Ho C. In vivo dynamic MRI tracking of rat T-cells labeled with superparamagnetic iron-oxide particles. Magn Reson Med 1995; 33(2): 200-208.
10. Brekke C, Williams SC, Price J, Thorsen F, Modo M. Cellular multiparametric MRI of neural stem cell therapy in a rat glioma model. Neuroimage 2007; 37(3): 769-782.
11. Nasongkla N, Bey E, Ren J, Ai H, Khemtong C, Guthi JS, Chin SF, Sherry AD, Boothman DA, Gao J. Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems. Nano Lett 2006; 6(11): 2427-2430.
12. Viglianti BL, Ponce AM, Michelich CR, Yu D, Abraham SA, Sanders L, Yarmolenko PS, Schroeder T, MacFall JR, Barboriak DP, Colvin OM, Bally MB, Dewhirst MW. Chemodosimetry of in vivo tumor liposomal drug concentration using MRI. Magn Reson Med 2006; 56(5): 1011-1018.
13. Du W, Xu Z, Nystrom AM, Zhang K, Leonard JR, Wooley KL. 19F- and fluorescently labeled micelles as nanoscopic assemblies for chemotherapeutic delivery. Bioconjug Chem 2008; 19(12): 2492-2498.
14. Langereis S, Keupp J, van Velthoven JL, de Roos IH, Burdinski D, Pikkemaat JA, Grüll H. A temperature-sensitive liposomal 1H CEST and 19F contrast agent for MR image-guided drug delivery. J Am Chem Soc 2009; 131(4): 1380-1381.
15. Partlow KC, Lanza GM, Wickline SA. Exploiting lipid raft transport with membrane targeted nanoparticles: a strategy for cytosolic drug delivery. Biomaterials 2008; 29(23): 3367-3375.
16. Morawski AM, Winter PM, Crowder KC, Caruthers SD, Fuhrhop RW, Scott MJ, Robertson JD, Abendschein DR, Lanza GM, Wickline SA. Targeted nanoparticles for quantitative imaging of sparse molecular epitopes with MRI. Magn Reson Med 2004; 51(3): 480-486.
17. Morawski AM, Winter PM, Yu X, Fuhrhop RW, Scott MJ, Hockett F, Robertson JD, Gaffney PJ, Lanza GM, Wickline SA. Quantitative 'magnetic resonance immunohistochemistry' with ligand-targeted (19)F nanoparticles. Magn Reson Med 2004; 52(6): 1255-1262.
18. Kimura A, Narazaki M, Kanazawa Y, Fujiwara H. 19F Magnetic resonance imaging of perfluorooctanoic acid encapsulated in liposome for biodistribution measurement. Magn Reson Imaging 2004; 22(6): 855-860.
19. Srinivas M, Morel PA, Ernst LA, Laidlaw DH, Ahrens ET. Fluorine-19 MRI for visualization and quantification of cell migration in a diabetes model. Magn Reson Med 2007; 58(4): 725-734.
20. Flogel U, Ding Z, Hardung H, Jander S, Reichmann G, Jacoby C, Schubert R, Schrader J. In vivo monitoring of inflammation after cardiac and cerebral ischemia by fluorine magnetic resonance imaging. Circulation 2008; 118(2): 140-148.
21. Srinivas M, Turner MS, Janjic JM, Morel PA, Laidlaw DH, Ahrens ET. In vivo cytometry of antigen-specific t cells using 19F MRI. Magn Reson Med 2009; 62(3): 747-753.
22. Ruiz-Cabello J, Walczak P, Kedziorek DA, Chacko VP, Schmieder AH, Wickline SA, Lanza GM, Bulte JW. In vivo 'hot spot' MR imaging of neural stem cells using fluorinated nanoparticles. Magn Reson Med 2008; 60(6): 1506-1511.
23. Ahrens ET, Flores R, Xu H, Morel PA. In vivo imaging platform for tracking immunotherapeutic cells. Nat Biotechnol 2005; 23(8): 983-987.
24. Partlow KC, Chen J, Brant JA, Neubauer AM, Meyerrose TE, Creer MH, Nolta JA, Caruthers SD, Lanza GM, Wickline SA. 19F magnetic resonance imaging for stem/progenitor cell tracking with multiple unique perfluorocarbon nanobeacons. FASEB J 2007; 21(8): 1647-1654.
25. Janjic JM, Srinivas M, Kadayakkara DK, Ahrens ET. Self-delivering nanoemulsions for dual fluorine-19 MRI and fluorescence detection. J Am Chem Soc 2008; 130(9): 2832-2841.
26. Janjic JM, Ahrens ET. Fluorine-containing nanoemulsions for MRI cell tracking. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2009; 1(5): 492-501.
27. Venkataramani D, Chen J, Neubauer AM, Crowder Brant J, Lanza GM, Wickline SA. Does endocytosis of perfluorocarbon nanoparticles by progenitor/stem cells alter 19F relaxation at 11.7T? Proc Intl Soc Mag Reson Med 2006; 14: 1890.
28. Winter PM, Caruthers SD, Kassner A, Harris TD, Chinen LK, Allen JS, Lacy EK, Zhang H, Robertson JD, Wickline SA, Lanza GM. Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel alpha(nu)beta3-targeted nanoparticle and 1.5 tesla magnetic resonance imaging. Cancer Res 2003; 63(18): 5838-5843.
29. Mulder WJ, Strijkers GJ, Habets JW, Bleeker EJ, van der Schaft DW, Storm G, Koning GA, Griffioen AW, Nicolay K. MR molecular imaging and fluorescence microscopy for identification of activated tumor endothelium using a bimodal lipidic nanoparticle. Faseb J 2005; 19(14): 2008-2010.
30. Schmieder AH, Caruthers SD, Zhang H, Williams TA, Robertson JD, Wickline SA, Lanza GM. Three-dimensional MR mapping of angiogenesis with alpha5beta1(alpha nu beta3)-targeted theranostic nanoparticles in the MDA-MB-435 xenograft mouse model. FASEB J 2008; 22(12): 4179-4189.
31. Neubauer AM, Myerson J, Caruthers SD, Hockett FD, Winter PM, Chen J, Gaffney PJ, Robertson JD, Lanza GM. Wickline SA. Gadolinium-modulated 19F signals from perfluorocarbon nanoparticles as a new strategy for molecular imaging. Magn Reson Med 2008; 60(5): 1066-1072.
32. Mulder WJ, Strijkers GJ, van Tilborg GA, Cormode DP, Fayad ZA, Nicolay K. Nanoparticulate assemblies of amphiphiles and diagnostically active materials for multimodality imaging. Acc Chem Res 2009; 42(7): 904-914.
33. Pan D, Lanza GM, Wickline SA, Caruthers SD. Nanomedicine: perspective and promises with ligand-directed molecular imaging. Eur J Radiol 2009; 70(2): 274-285.
34. Hak S, Sanders HM, Agrawal P, Langereis S, Grüll H, Keizer HM, Arena F, Terreno E, Strijkers GJ, Nicolay K. A high relaxivity Gd(III)DOTA-DSPE-based liposomal contrast agent for magnetic resonance imaging. Eur J Pharm Biopharm 2009; 72(2): 397-404.
35. Rouser G, Fkeischer S, Yamamoto A. Two dimensional thin layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots. Lipids 1970; 5(5): 494-496.