Conformation of surface-decorating dextran chains affects the pharmacokinetics and biodistribution of doxorubicin-loaded nanoparticles

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 81, Issue 2, 2012, Pages 453-457

  Alhareth, Khairallah ^a,b,d   Vauthier, Christine ^a,b   Bourasset, Fanchon ^c   Gueutin, Claire ^a,b   Ponchel, Gilles ^a,b   Moussa, Fathi ^c  

^a UNIV PARIS SUD   (France)

^b CNRS   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

^d IUST   (Syrian Arab Republic)

Author keywords

Anionic emulsion polymerization; Dextran; Nanoparticle surface; Polysaccharide coating; Stealth nanoparticles

Indexed keywords

DEXTRAN DERIVATIVE; DOXORUBICIN; NANOPARTICLE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONFORMATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG TISSUE LEVEL; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; RAT; STEADY STATE;

ANIMALS; ANIONS; ANTIBIOTICS, ANTINEOPLASTIC; CHEMISTRY, PHARMACEUTICAL; DEXTRANS; DOXORUBICIN; DRUG CARRIERS; EMULSIONS; MALE; NANOPARTICLES; OXIDATION-REDUCTION; POLYMERIZATION; RATS; RATS, WISTAR; SURFACE PROPERTIES; TISSUE DISTRIBUTION;

EID: 84861593302     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2012.03.009     Document Type: Article

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