Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 2, 2011, Pages 680-685

  Geiler Samerotte, Kerry A ^a,b   Dion, Michael F ^b   Budnik, Bogdan A ^b   Wang, Stephanie M ^b   Hartl, Daniel L ^a   Drummond, D Allan ^b  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

Evolutionary rate; Heat shock; Proteomics; Stability

Indexed keywords

CELL PROTEIN; CHAPERONE; FUNGAL PROTEIN; OROTIDINE 5' PHOSPHATE DECARBOXYLASE;

ARTICLE; BUDDING; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; CYTOSOL; DOSE RESPONSE; FUNCTIONAL PROTEOMICS; FUNGUS GROWTH; GROWTH RATE; MICROBIAL ATTENUATION; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; SACCHAROMYCES CEREVISIAE; STEADY STATE; STRESS; UNFOLDED PROTEIN RESPONSE; YEAST CELL;

BACTERIAL PROTEINS; CYTOSOL; EVOLUTION, MOLECULAR; FUNGAL PROTEINS; HOT TEMPERATURE; LUMINESCENT PROTEINS; MOLECULAR CHAPERONES; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEINS; PROTEOMICS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION, GENETIC;

SACCHAROMYCETALES;

EID: 79551674254     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1017570108     Document Type: Article

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