Changes in insulin-signaling transduction pathway underlie learning/memory deficits in an Alzheimer's disease rat model

Journal of Neural Transmission

Volumn 119, Issue 11, 2012, Pages 1407-1416

  Han, Xiaojuan ^a   Ma, Yan ^b   Liu, Xiaohui ^a   Wang, Lu ^a   Qi, Shen ^a   Zhang, Qinghua ^a   Du, Yifeng ^a  

^a SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^b No 1 Central Hospital of Bao Ding City   (China)

Author keywords

Alzheimer's disease; Insulin signaling transduction pathway; Rats; Soluble A oligomers

Indexed keywords

AMYLOID BETA PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; PROTEIN KINASE B;

ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B CELL LEUKEMIA; B CELL LYMPHOMA; BRAIN VENTRICLE; CONTROLLED STUDY; HIPPOCAMPUS; IN VIVO STUDY; LEARNING; LEARNING DISORDER; MALE; MAZE TEST; MEMORY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANALYSIS OF VARIANCE; ANIMALS; CREB-BINDING PROTEIN; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HIPPOCAMPUS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; LEARNING DISORDERS; MALE; MAZE LEARNING; MEMORY DISORDERS; ONCOGENE PROTEIN V-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

EID: 84869501606     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-012-0803-1     Document Type: Article

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