Interactions of pharmaceuticals and other xenobiotics on key detoxification mechanisms and cytoskeleton in Poeciliopsis lucida hepatocellular carcinoma, PLHC-1 cell line

Toxicology in Vitro

Volumn 27, Issue 1, 2013, Pages 111-120

  Wassmur, Britt ^a   Gräns, Johanna ^a   Norström, Elisabeth ^a   Wallin, Margareta ^a   Celander, Malin C ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

ABC transporters; CYP1A; CYP3A; Cytoskeleton; Microtubules; P glycoprotein

Indexed keywords

ALPHA NAPHTHOFLAVONE; BETA NAPHTHOFLAVONE; CLOTRIMAZOLE; COMPLEMENTARY DNA; CYTOCHROME P450 1A; CYTOCHROME P450 3A; DICLOFENAC; ETHINYLESTRADIOL; FULVESTRANT; IBUPROFEN; KETOCONAZOLE; LITHOCHOLIC ACID; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 2; NOCODAZOLE; OMEPRAZOLE; RIFAMPICIN; TROLEANDOMYCIN;

ANIMAL CELL; ARTICLE; CARCINOMA CELL; CELL DAMAGE; CONTROLLED STUDY; CYTOCHROME P450 3A GENE; DNA ISOLATION; DNA SEQUENCE; DRUG DETOXIFICATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; MICROTUBULE; MOLECULAR INTERACTION; MULTIDRUG RESISTANCE PROTEIN 2 GENE; NONHUMAN; XENOBIOTIC METABOLISM;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP3A; CYTOSKELETON; DNA, COMPLEMENTARY; DRUG INTERACTIONS; FISHES; LIVER NEOPLASMS; METABOLIC DETOXICATION, DRUG; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEINS; PHARMACEUTICAL PREPARATIONS; RNA, MESSENGER; XENOBIOTICS;

POECILIOPSIS LUCIDA;

EID: 84869478513     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2012.10.002     Document Type: Article

References (55)

1. Aspengren S., Wielbass L., Wallin M. Effects of acrylamide, latrunculin, and nocodazole on intracellular transport and cytoskeletal organization in melanophores. Cell. Motil. Cytoskeleton. 2006, 63:423-436.
2. Brockdorff B.L., Skouv J., Reiter B.E., Lykkesfeldt A.E. Increased expression of cytochrome p450 1A1 and 1B1 genes in anti-estrogen-resistant human breast cancer cell lines. Int. J. Cancer 2000, 88:902-906.
3. Brown J.N., Paxeus N., Förlin L., Larsson D.G. Variations in bioconcentration of human pharmaceuticals from sewage effluents into fish blood plasma. Environ. Toxicol. Pharmacol. 2007, 24:267-274.
4. Caminada D., Zaja R., Smital T., Fent K. Human pharmaceuticals modulate P-gp1 (ABCB1) transport activity in the fish cell line PLHC-1. Aquat. Toxicol. 2008, 90:214-222.
5. Celander M.C. Cocktail effects on biomarker responses in fish. Aquat. Toxicol. 2011, 105:72-77.
6. Celander M., Bremer J., Hahn M.E., Stegeman J.J. Glucocorticoid-xenobiotic interactions: Dexamethasone-mediated potentiation of cytochrome P4501A induction by β-naphthoflavone in a fish hepatoma cell line (PLHC-1). Environ. Toxicol. Chem. 1997, 16:900-907.
7. Celander M., Buhler D.R., Förlin L., Goksøyr A., Miranda C.L., Woodin B.R., Stegeman J.J. Immunochemical relationships of cytochrome P4503A-like proteins in teleost fish. Fish. Physiol. Biochem. 1996, 15:323-332.
8. Celander M., Hahn M.E., Stegeman J.J. Cytochromes P450 (CYP) in the Poeciliopsis lucida hepatocellular carcinoma cell line (PLHC-1): Dose- and time-dependent glucocorticoid potentiation of CYP1A induction without induction of CYP3A. Arch. Biochem. Biophys. 1996, 329:113-122.
9. Celander M., Leaver M.J., George S., Förlin L. Induction of cytochrome P450 1A1 and conjugating enzymes in rainbow trout (Oncorhynchus mykiss) liver: A time course study. Comp. Biochem. Physiol. 1993, 106C:343-349.
10. Christen V., Oggier D.M., Fent K. A microtiter-plate based cytochrome P4503A activity assay in fish cell lines. Environ. Toxicol. Chem. 2009, 12:2632-2638.
11. Corcoran J., Winter M.J., Tyler C.R. Pharmaceuticals in the aquatic environment: A critical review of the evidence for health effects in fish. Crit. Rev. Toxicol. 2010, 40:287-304.
12. Denison M.S., Nagy S.R. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu. Rev. Pharmacol. Toxicol. 2003, 43:309-334.
13. Dvořák Z., Vrzal R., Ulrichova J., Pascussi J.M., Maurel P., Modrianský M. Involvement of cytoskeleton in AhR-dependent CYP1A1 expression. Curr. Drug Metab. 2006, 7:301-313.
14. Fent K. Fish cell lines as versatile tools in ecotoxicology: Assessment of cytotoxicity, cytochrome P4501A induction potential and estrogenic activity of chemicals and environmental samples. Toxicol. In Vitro 2001, 15:477-488.
15. Fick, J., Lindberg, R. H., Kaj, L., Brorström-Lundén, E., 2011. Results from the Swedish National Screening Programme 2010. Subreport 3. Pharmaceuticals. IVL B2014.
16. Gräns J., Wassmur B., Celander M.C. One-way inhibiting cross-talk between aryl hydrocarbon receptor (AhR) and estrogen receptor (ER) signaling in primary cultures of rainbow trout hepatocytes. Aquat. Toxicol. 2010, 100:263-270.
17. Guengerich F. Human cytochrome P450 enzymes. Cytochrome P450: Structure, Mechanism and Biochemistry 2005, 377-463. Plenum press, New York. P.R. Ortiz de Montellano (Ed.).
18. Hahn M.E., Lamb T.M., Schultz M.E., Smolowitz R.M., Stegeman J.J. Cytochrome P4501A induction and inhibition by 3,3',4,4'-tetrachlorobiphenyl in an Ah receptor-containing fish hepatoma cell line (PLHC-1). Aquat. Toxicol. 1993, 26:185-208.
19. Harlow G.R., Halpert J.R. Alanine-scanning mutagenesis of a putative substrate recognition site in human cytochrome P450 3A4. Role of residues 210 and 211 in flavonoid activation and substrate specificity. J. Biol. Chem. 1997, 272:5396-5402.
20. Hasselberg L., Grøsvik B.E., Goksøyr A., Celander M.C. Interactions between xenoestrogens and ketoconazole on hepatic CYP1A and CYP3A, in juvenile Atlantic cod (Gadus morhua). Comp. Hepatol. 2005, 4:2.
21. Hasselberg L., Westerberg S., Wassmur B., Celander M.C. Ketoconazole, an antifungal imidazole, increases the sensitivity of rainbow trout to 17alpha-ethynylestradiol exposure. Aquat. Toxicol. 2008, 86:256-264.
22. Hegelund, T., 2003. Characterization of CYP3A in fish - expression, inhibition, induction and analyses of gene evolution. PhD Thesis, University of Gothenburg. ISBN 91-628-5695-2.
23. Hegelund T., Celander M.C. Hepatic versus extrahepatic expression of CYP3A30 and CYP3A56 in adult killifish (Fundulus heteroclitus). Aquat. Toxicol. 2003, 64:277-291.
24. Hegelund T., Ottosson K., Rådinger M., Tomberg P., Celander M.C. Effects of the antifungal imidazole ketoconazole on CYP1A and CYP3A in rainbow trout and killifish. Environ. Toxicol. Chem. 2004, 23:1326-1334.
25. Hestermann E.V., Stegeman J.J., Hahn M.E. Relationships among the cell cycle, cell proliferation, and aryl hydrocarbon receptor expression in PLHC-1 cells. Aquat. Toxicol. 2002, 58:201-213.
26. Jin H., Audus K.L. Effect of bisphenol A on drug efflux in BeWo, a human trophoblast-like cell line. Placenta 2005, 26(Suppl. A):S96-S103.
27. Kleinow K.M., Hummelke G.C., Zhang Y., Uppu P., Baillif C. Inhibition of P-glycoprotein transport: A mechanism for endocrine disruption in the channel catfish?. Mar. Environ. Res. 2004, 58:205-208.
28. Kliewer S.A., Goodwin B., Willson T.M. The nuclear pregnane X receptor: A key regulator of xenobiotic metabolism. Endocrinol. Rev. 2002, 23:687-702.
29. Kliewer S.A., Moore J.T., Wade L., Staudinger J.L., Watson M.A., Jones S.A., McKee D.D., Oliver B.B., Willson T.M., Zetterstrom R.H., Perlmann T., Lehmann J.M. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 1998, 92:73-82.
30. Kostrubsky V.E., Strom S.C., Hanson J., Urda E., Rose K., Burliegh J., Zocharski P., Cai H., Sinclair J.F., Sahi J. Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats. Toxicol. Sci. 2003, 76:220-228.
31. Kümmerer K. The presence of pharmaceuticals in the environment due to human use - present knowledge and future challenges. J. Environ. Manage. 2009, 90:2354-2366.
32. Leslie E.M., Deeley R.G., Cole S.P. Multidrug resistance proteins: Role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol. Appl. Pharmacol. 2005, 204:216-237.
33. Maher J.M., Cheng X., Slitt A.L., Dieter M.Z., Klaassen C.D. Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver. Drug Metab. Dispos. 2005, 33:956-962.
34. Miller V.P., Stresser D.M., Blanchard A.P., Turner S., Crespi C.L. Fluorometric high-throughput screening for inhibitors of cytochrome P450. Ann. N.Y. Acad. Sci. 2000, 919:26-32.
35. Navas J.M., Chana A., Herradon B., Segner H. Induction of cytochrome P4501A (CYP1A) by clotrimazole, a non-planar aromatic compound. Computational studies on structural features of clotrimazole and related imidazole derivatives. Life Sci. 2004, 76:699-714.
36. Phillips A., Hood S.R., Gibson G.G., Plant N.J. Impact of transcription factor profile and chromatin conformation on human hepatocyte CYP3A gene expression. Drug Metab. Dispos. 2005, 33:233-242.
37. Price R.J., Surry D., Renwick A.B., Meneses-Lorente G., Lake B.G., Evans D.C. CYP isoform induction screening in 96-well plates: Use of 7-benzyloxy-4-trifluoromethylcoumarin as a substrate for studies with rat hepatocytes. Xenobiotica 2000, 30:781-795.
38. Rodriguez-Antona C., Donato M.T., Boobis A., Edwards R.J., Watts P.S., Castell J.V., Gomez-Lechon M.J. Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: Molecular mechanisms that determine lower expression in cultured cells. Xenobiotica 2002, 32:505-520.
39. Schlenk D., George S., James M., Hurk P.v.d., Willet K., Kullman S., Celander M., Gallagher E. Biotransformations. The Toxicology of Fishes 2008, 153-234. Taylor and Francis Publishers, Washington, DC. R.D. Giulio, D. Hinton (Eds.).
40. Schwaiger J., Ferling H., Mallow U., Wintermayr H., Negele R.D. Toxic effects of the non-steroidal anti-inflammatory drug diclofenac. Part I: Histopathological alterations and bioaccumulation in rainbow trout. Aquat. Toxicol. 2004, 68:141-150.
41. Schöller A., Hong N.J., Bischer P., Reiners J.J. Short and long term effects of cytoskeleton-disrupting drugs on cytochrome P450 Cyp1a-1 induction in murine hepatoma 1c1c7 cells: Suppression by the microtubule inhibitor nocodazole. Mol. Pharmacol. 1994, 45:944-954.
42. Shapiro A.B., Fox K., Lam P., Ling V. Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site. Eur. J. Biochem. 1999, 259:841-850.
43. Shapiro A.B., Ling V. The mechanism of ATP-dependent multidrug transport by P-glycoprotein. Acta Physiol. Scand. Suppl. 1998, 643:227-234.
44. Sharp D.J., Ross J.L. Microtubule-severing enzymes at the cutting edge. J. Cell Sci. 2012, 125:1-9.
45. Smital T., Kurelec B. The chemosensitizers of multixenobiotic resistance mechanism in aquatic invertebrates: A new class of pollutants. Mutat. Res. 1998, 399:43-53.
46. Stöckel B., König J., Nies A.T., Cui Y., Brom M., Keppler D. Characterization of the 5'-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison with the multidrug resistance protein 3 (MRP3) gene. Eur. J. Biochem. 2000, 267:1347-1358.
47. Stresser D.M., Turner S.D., Blanchard A.P., Miller V.P., Crespi C.L. Cytochrome P450 fluorometric substrates: Identification of isoform-selective probes for rat CYP2D2 and human CYP3A4. Drug Metab. Dispos. 2002, 30:845-852.
48. Thibaut R., Schnell S., Porte C. Assessment of metabolic capabilities of PLHC-1 and RTL-W1 fish liver cell lines. Cell Biol. Toxicol. 2009, 25:611-622.
49. Tolson A.H., Wang H. Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR. Adv. Drug Deliv. Rev. 2010, 62:1238-1249.
50. Vollrath V., Wielandt A.M., Iruretagoyena M., Chianale J. Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene. Biochem. J. 2006, 395:599-609.
51. Vrzal R., Daujat-Chavanieu M., Pascussi J.M., Ulrichová J., Maurel P., Dvořák Z. Microtubules-interfering agents restrict aryl hydrocarbon receptor-mediated CYP1A2 induction in primary cultures of human hepatocytes via c-jun-N-terminal kinase and glucocorticoid receptor. Eur. J. Pharmacol. 2008, 581:244-254.
52. Wassmur B., Gräns J., Kling P., Celander M.C. Interactions of pharmaceuticals and other xenobiotics on hepatic pregnane X receptor and cytochrome P450 3A signaling pathway in rainbow trout (Oncorhynchus mykiss). Aquat. Toxicol. 2010, 100:91-100.
53. Xu C., Li C.Y., Kong A.N. Induction of phase I, II and III drug metabolism/transport by xenobiotics. Arch. Pharm. Res. 2005, 28:249-268.
54. Yang H., Ganguly A., Cabral F. Inhibition of cell migration and cell division correlates with distinct effects of microtubule inhibiting drugs. J. Biol. Chem. 2010, 285:32242-33250.
55. Zaja R., Klobučar R.S., Smital T. Detection and functional characterization of Pgp1 (ABCB1) and MRP3 (ABCC3) efflux transporters in the PLHC-1 fish hepatoma cell line. Aquat. Toxicol. 2007, 81:365-376.