Glucocorticoid-xenobiotic interactions: Dexamethasone-mediated potentiation of cytochrome P4501A induction by β-naphthoflavone in a fish hepatoma cell line (PLHC-1)

Environmental Toxicology and Chemistry

Volumn 16, Issue 5, 1997, Pages 900-907

  Celander, Malin ^a   Bremer, Jessica ^a   Hahn, Mark E ^a   Stegeman, John J ^a  

^a WOODS HOLE OCEANOGRAPHIC INSTITUTION   (United States)

Author keywords

CYP1A; Cytochrome P450; Hepatoma cell line; Polycyclic aromatic hydrocarbon; Teleost fish

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; BETA NAPHTHOFLAVONE; CYTOCHROME P450 ISOENZYME; DEXAMETHASONE; ETHOXYRESORUFIN DEETHYLASE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; XENOBIOTIC AGENT;

ANIMAL CELL; ARTICLE; DOSE RESPONSE; DRUG POTENTIATION; ENZYME INDUCTION; NONHUMAN; PRIORITY JOURNAL; TELEOST; XENOBIOTIC METABOLISM;

ANIMALIA; POECILIOPSIS LUCIDA; TELEOSTEI;

EID: 0030904205     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1002/etc.5620160509     Document Type: Article

References (34)

1. Nelson, D.R., et al. 1996. P450 superfamily: Update on new sequences, gene mapping, accession numbers, and nomenclature. Pharmacogenetics 6:1-42.
2. Whitlock, J.P., Jr. 1993. Mechanistic aspects of dioxin action. Chem. Res. Toxicol. 6:754-763.
3. Morrison, H.G., M.F. Oleksiak, N.W. Cornell, M.L. Sogin and J.J. Stegeman. 1995. Identification of cytochrome P-450 1A (CYP1A) genes from two teleost fish, toadfish (Opsanus tau) and scup (Stenotomus chrysops), and phylogenetic analysis of CYP1A genes. Biochem. J. 308:97-104.
4. Stegeman, J.J. and M.E. Hahn. 1994. Biochemistry and molecular biology of monooxygenases: Current perspectives on forms, functions, and regulation of cytochrome P450 in aquatic species. In D.C. Malins and G.K. Ostrander, eds., Aquatic Toxicology: Molecular, Biochemical, and Cellular Perspectives. CRC, Boca Raton, FL, USA, pp. 87-206.
5. Pesonen, M., A. Goksøyr and T. Andersson. 1992. Expression of P4501A1 in a primary culture of rainbow trout hepatocytes exposed to β-naphthoflavone or 2,3,7,8-tetrachlorodibenzo-p-dioxin. Arch. Biochem. Biophys. 292:228-233.
6. Hahn, M.E., T.M. Lamb, M.E. Schultz, R.M. Smolowitz and J.J. Stegeman. 1993. Cytochrome P4501A induction and inhibition by 3,3′,4,4′-tetrachlorobiphenyl in an Ah receptor-containing fish hepatoma cell line (PLHC-1). Aquat. Toxicol. 26: 185-208.
7. Stegeman, J.J., M.E. Hahn, R. Weisbrod, B.R. Woodin, J.S. Joy, S. Najib and R.A. Cohen. 1995. Induction of cytochrome P4501A1 by aryl hydrocarbon receptor agonists in porcine aorta endothelial cells in culture and cytochrome P4501A1 activity in intact cells. Mol. Pharmacol. 47:296-306.
8. Mathis, J.M., R.A. Prough, R.N. Hines, E. Bresnick and E.R. Simpson. 1986. Regulation of cytochrome P-450c by glucocorticoids and polycyclic aromatic hydrocarbons in cultured fetal rat hepatocytes. Arch. Biochem. Biophys. 246:439-448.
9. Mathis, J.M., R.A. Prough and E.R. Simpson. 1986. Synergistic induction of monooxygenase activity by glucocorticoids and polycyclic aromatic hydrocarbons in human fetal hepatocytes in primary monolayer culture. Arch. Biochem. Biophys. 244:650-661.
10. Mathis, J.M., W.H. Houser, E. Bresnick, J.A. Cidlowski, R.N. Hines, R.A. Prough and E.R. Simpson 1989. Glucocorticoid regulation of the rat cytochrome P450c (P450IA1) gene: Receptor binding within intron I. Arch. Biochem. Biophys. 269:93-105.
11. Prough, R.A., A.J. Sherratt, D.E. Banet and M.W. Linder. 1989. Modulation of the polycyclic aromatic hydrocarbon-dependent induction of cytochrome P450IA1 by glucocorticoids. Drug Metab. Rev. 20:585-599.
12. Sidhu, J.S. and C.J. Omiecinski. 1995. Modulation of xenobiotic-inducible cytochrome P450 gene expression by dexamethasone in primary rat hepatocytes. Pharmacogenetics 5:24-36.
13. Xiao, G.H., J.A. Pinaire, A.D. Rodrigues and R.A. Prough. 1995. Regulation of the Ah gene battery via Ah receptor-dependent and independent processes in cultured adult rat hepatocytes. Drug Metab. Dispos. 23:642-650.
14. Devaux, A., M. Pesonen, G. Monod and T. Andersson. 1992. Glucocorticoid-mediated potentiation of P450 induction in primary culture of rainbow trout hepatocytes. Biochem. Pharmacol. 43:898-901.
15. Celander, M., M.E. Hahn and J.J. Stegeman. Cytochromes P450 (CYP) in the Poeciliopsis lucida hepatocellular carcinoma (PLHC-1) cell line: Dose-and time-dependent glucocorticoid potentiation of CYP1A induction without induction of CYP3A. Arch. Biochem. Biophys. 392:113-122.
16. Hightower, L.E. and J.L. Renfro. 1988. Recent applications of fish cell culture to biomedical research. J. Exp. Zool. 248:290-302.
17. Hahn, M.E., B.L. Woodward, J.J. Stegeman and S.W. Kennedy. 1996. Rapid assessment of cytochrome P4501A (CYP1A) protein and catalytic activity induced by Ah receptor agonists in fish hepatoma cells grown in multi-well plates. Environ. Toxicol. Chem. 15:582-591.
18. Kennedy, S.W. and S.P. Jones. 1994. Simultaneous measurement of cytochrome P4501A catalytic activity and total protein concentration with a fluorescence plate reader. Anal. Biochem. 222:217-223.
19. Park, S.S., H. Miller, A.V. Klotz, P.J. Kloepper-Sams, J.J. Stegeman and H.V. Gelboin. 1986. Monoclonal antibodies to liver microsomal cytochrome P-450E of the marine fish Stenotomus chrysops (scup): Cross reactivity with 3-methylcholanthrene induced rat cytochrome P-450. Arch. Biochem. Biophys. 249:339-350.
20. Celander, M., M.J. Leaver, S.G. George and L. Förlin. 1993. Induction of cytochrome P450 1A1 and conjugating enzymes in rainbow trout liver: A time course study. Comp. Biochem. Physiol. C 106:343-349.
21. Haasch, M.L., E.M. Quardokus, L.A. Sutherland, M.S. Goodrich and J.J. Lech. 1993. Hepatic CYP1A1 induction in rainbow trout by continuous flowthrough exposure to β-naphthoflavone. Fundam. Appl. Toxicol. 20:72-82.
22. Brüschweiler, B.J., F.E. Würgler and K. Fent. 1996. An ELISA assay for cytochrome P4501A in fish liver cells. Environ. Toxicol. Chem. 15:592-596.
23. Stegeman, J.J., M.J. Melancon and B.R. Woodin. 1984. In vitro and in vivo metabolism of α-naphthoflavone (ANF) and β-naphthoflavone (BNF) in fish. Pharmacologist 26:172.
24. Kloepper-Sams, P.J. and J.J. Stegeman. 1989. The temporal relationships between P450E protein content, catalytic activity, and mRNA levels in the teleost Fundulus heteroclitus following treatment with β-naphthoflavone. Arch. Biochem. Biophys. 268: 525-535.
25. Hahn, M.E. and J.J. Stegeman. 1994. Regulation of cytochrome P4501A1 in teleosts: Sustained induction of CYP1A1 mRNA, protein, and catalytic activity by 2,3,7,8-tetrachlorodibenzofuran in the marine fish Stenotomus chrysops. Toxicol. Appl. Pharmacol. 127:187-198.
26. Collodi, P., C.L. Miranda, X. Zhao, D.R. Buhler and D.W. Barnes. 1994. Induction of zebrafish (Brachydanio rerio) P450 in vivo and in cell culture. Xenobiotica 24:487-493.
27. Miranda, C.L., P. Collodi, X. Zhao, D.W. Barnes and D.R. Buhler. 1993. Regulation of cytochrome P450 expression in a novel liver cell line from zebrafish (Brachydanio rerio). Arch. Biochem. Biophys. 305:320-327.
28. Kloepper-Sams, P.J. and J.J. Stegeman. 1994. Turnover of hepatic microsomal cytochrome P4501A protein and heme in β-naphthoflavone-induced Fundulus heteroclitus. Mol. Mar. Biol. Biotechnol. 3:171-183.
29. 450 1A1 (CYP1A1) by glucocorticoids in rainbow trout liver. Comp. Biochem. Physiol. C 104: 457-461.
30. Dasmahapatra, A.K. and P.C. Lee. 1993. Down regulation of CYP 1A1 by glucocorticoids in trout hepatocytes in vitro. In Vitro Cell. Dev. Biol. 29:643-648.
31. Silver, G., L.M. Reid and K.S. Krauter. 1990. Dexamethasone-mediated regulation of 3-methylcholanthrene-induced P-450d mRNA accumulation in primary rat hepatocyte cultures. J. Biol. Chem. 265:3134-3138.
32. Wiebel, F.J. and P. Cikryt. 1990. Dexamethasone-mediated potentiation of P450IA1 induction in H4IIEC3/T hepatoma cells is dependent on a time-consuming process and associated with induction of Ah receptor. Chem. Biol. Interact. 76:307-320.
33. Biron, M. and T.J. Benfey. 1994. Cortisol, glucose and hematocrit changes during acute stress, cohort sampling, and the diel cycle in diploid and triploid brook trout (Salvelinus fontinalis Mitchill). Fish Physiol. Biochem. 13:153-160.
34. Narnaware, Y.K., B.I. Baker and M.G. Tomlinson. 1994. The effect of various stresses, corticosteroids and adrenergic agents on phagocytosis in the rainbow trout Oncorhynchus mykiss. Fish Physiol. Biochem. 13:31-40.