A microtiter-plate-based cytochrome P450 3A activity assay in fish cell lines

Environmental Toxicology and Chemistry

Volumn 28, Issue 12, 2009, Pages 2632-2638

  Christen, Verena ^a   Oggier, Daniela M ^a,b   Fent, Karl ^a,c  

^a UNIVERSITY OF APPLIED SCIENCES AND ARTS NORTHWESTERN SWITZERLAND   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c ETH ZURICH   (Switzerland)

Author keywords

Cytochrome P450 3A; Fish cell lines; High throughput assay; Pharmaceuticals

Indexed keywords

96-WELL PLATE; ACTIVITY ASSAYS; CELL NUMBER; CELL-BASED ASSAYS; CYTOCHROME P450; ENDOGENOUS SUBSTANCES; ENVIRONMENTAL RISK ASSESSMENT; FISH CELLS; FLUORESCENT PRODUCTS; HIGH-THROUGHPUT ASSAYS; INCUBATION TIME; LARGE SCALE EXPERIMENTS;

ASSAYS; BIOCHEMISTRY; CATALYSTS; CELL CULTURE; ENZYME INHIBITION; ENZYMES; FISH; FLUORESCENCE; MEATS; RISK ASSESSMENT; RISK MANAGEMENT; THROUGHPUT;

ENZYME ACTIVITY;

COUMARIN DERIVATIVE; CYTOCHROME P450 3A; XENOBIOTIC AGENT;

BIOMARKER; CYTOCHROME; DRUG; ENVIRONMENTAL RISK; FISH; GENE EXPRESSION; METABOLISM; POLLUTION EXPOSURE; RISK ASSESSMENT; XENOBIOTICS;

ANIMAL CELL; ARTICLE; CELL COUNT; CELL LINE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME SUBSTRATE; FISH; FLUORESCENCE ANALYSIS; HIGH THROUGHPUT SCREENING; MICROTITER PLATE ASSAY; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT;

ANIMALS; CELL LINE; CYTOCHROME P-450 CYP3A; ENVIRONMENTAL MONITORING; FISHES; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS;

EID: 73449125482     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1897/08-483.1     Document Type: Article

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