In-vitro inhibitory effect of Tualang honey on cytochrome P450 2C8 activity

Journal of Pharmacy and Pharmacology

Volumn 64, Issue 12, 2012, Pages 1761-1769

  Muthiah, Yasotha Devi ^a   Ong, Chin Eng ^b   Sulaiman, Siti Amrah ^c   Tan, Soo Choon ^a   Ismail, Rusli ^a  

^a INSTITUTE FOR RESEARCH IN MOLECULAR MEDICINE INFORMM   (Malaysia)

^b MONASH UNIVERSITY MALAYSIA   (Malaysia)

^c SCHOOL OF MEDICAL SCIENCES   (Malaysia)

Author keywords

CYP2C8; drug interaction; in vitro; Tualang honey

Indexed keywords

AMODIAQUINE; AMODIAQUINE N DESETHYLASE; CYTOCHROME P450 2C8; DEETHYLAMODIAQUINE; ENZYME; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; MAGNESIUM CHLORIDE; NATURAL PRODUCT; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; POTASSIUM DIHYDROGEN PHOSPHATE; RECOMBINANT PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME KINETICS; FOOD DRUG INTERACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HONEY; IC 50; IN VITRO STUDY; MICHAELIS MENTEN KINETICS; NONHUMAN; PROTEIN EXPRESSION; TUALANG HONEY;

AMODIAQUINE; ARYL HYDROCARBON HYDROXYLASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; FOOD-DRUG INTERACTIONS; HONEY; INHIBITORY CONCENTRATION 50; KINETICS; RECOMBINANT PROTEINS;

EID: 84869081573     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2012.01551.x     Document Type: Article

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