In vitro effects of active constituents and extracts of Orthosiphon stamineus on the activities of three major human cDNA-expressed cytochrome P450 enzymes

Chemico-Biological Interactions

Volumn 190, Issue 1, 2011, Pages 1-8

  Pan, Yan ^a   Abd Rashid, Badrul Amini ^b   Ismail, Zakiah ^b   Ismail, Rusli ^c   Mak, Joon Wah ^a   Pook, Peter C K ^a   Er, Hui Meng ^a   Ong, Chin Eng ^d  

^a INTERNATIONAL MEDICAL UNIVERSITY   (Malaysia)

^b INSTITUTE FOR MEDICAL RESEARCH   (Malaysia)

^c INSTITUTE FOR RESEARCH IN MOLECULAR MEDICINE INFORMM   (Malaysia)

^d MONASH UNIVERSITY MALAYSIA   (Malaysia)

Author keywords

Cytochrome P450; Drug herb interaction; High performance liquid chromatography; Lamiaceae; Orthosiphon stamineus

Indexed keywords

COMPLEMENTARY DNA; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; CYTOCHROME P450 INHIBITOR; DICHLOROMETHANE; EUPATORIN; ORTHOSIPHON STAMINEUS EXTRACT; PETROLEUM ETHER; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; ROSMARINIC ACID; SINENSETIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG DETERMINATION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; IN VITRO STUDY; NONHUMAN; ORTHOSIPHON; ORTHOSIPHON STAMINEUS; PROTEIN EXPRESSION;

ARYL HYDROCARBON HYDROXYLASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CINNAMATES; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 CYP3A; DEPSIDES; HUMANS; ORTHOSIPHON; PLANT EXTRACTS;

LAMIACEAE; ORTHOSIPHON STAMINEUS;

EID: 79952702675     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2011.01.022     Document Type: Article

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