In vitro modulatory effects on three major human cytochrome P450 enzymes by multiple active constituents and extracts of Centella asiatica

Journal of Ethnopharmacology

Volumn 130, Issue 2, 2010, Pages 275-283

  Pan, Yan ^a   Abd Rashid, Badrul Amini ^b   Ismail, Zakiah ^b   Ismail, Rusli ^c   Mak, Joon Wah ^a   Pook, Peter C K ^a   Er, Hui Meng ^a   Ong, Chin Eng ^d  

^a INTERNATIONAL MEDICAL UNIVERSITY   (Malaysia)

^b INSTITUTE FOR MEDICAL RESEARCH   (Malaysia)

^c INSTITUTE FOR RESEARCH IN MOLECULAR MEDICINE INFORMM   (Malaysia)

^d MONASH UNIVERSITY MALAYSIA   (Malaysia)

Author keywords

Apiaceae; Centella asiatica; Cytochrome P450; Drug herb interaction; Enzyme inhibition

Indexed keywords

ALCOHOL; ASIATIC ACID; ASIATICOSIDE; CENTELLA ASIATICA EXTRACT; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DICHLOROMETHANE; HEXANE; MADECASSIC ACID; CYP2C9 PROTEIN, HUMAN; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 2D6 INHIBITOR; CYTOCHROME P450 3A; CYTOCHROME P450 3A INHIBITOR; DEXTROMETHORPHAN; ENZYME INHIBITOR; PENTACYCLIC TRITERPENE; PLANT EXTRACT; RECOMBINANT PROTEIN; TESTOSTERONE; TOLBUTAMIDE; TRITERPENE; UNSPECIFIC MONOOXYGENASE;

AQUEOUS SOLUTION; ARTICLE; CENTELLA ASIATICA; DRUG SELECTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; IN VITRO STUDY; NONHUMAN; ANTAGONISTS AND INHIBITORS; CENTELLA; CHEMISTRY; DEALKYLATION; DOSE RESPONSE; ENZYME SPECIFICITY; HERB DRUG INTERACTION; HUMAN; HYDROXYLATION; ISOLATION AND PURIFICATION; KINETICS; METABOLISM; METHYLATION;

ARYL HYDROCARBON HYDROXYLASES; CENTELLA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 CYP3A; DEALKYLATION; DEXTROMETHORPHAN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HERB-DRUG INTERACTIONS; HUMANS; HYDROXYLATION; KINETICS; METHYLATION; PENTACYCLIC TRITERPENES; PLANT EXTRACTS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TESTOSTERONE; TOLBUTAMIDE; TRITERPENES; CYTOCHROME P-450 CYP2C9; CYTOCHROME P-450 CYP2D6 INHIBITORS; CYTOCHROME P-450 CYP3A INHIBITORS;

APIACEAE; CENTELLA ASIATICA;

EID: 77954951438     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.05.002     Document Type: Article

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